{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:33:19Z","timestamp":1793147599374,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202206010063"],"award-info":[{"award-number":["202206010063"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031918","name":"State Key Laboratory of Natural and Biomimetic Drugs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031918","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["KJZD20240903100304007"],"award-info":[{"award-number":["KJZD20240903100304007"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.celrep.2026.117889","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:53:56Z","timestamp":1788850436000},"page":"117889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Berberine, a natural molecular glue degrader, overcomes CML resistance via TRIM28-mediated HIF1\u03b1 ubiquitination and subsequent ferroptosis"],"prefix":"10.1016","volume":"45","author":[{"given":"Rui","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingri","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6650-7870","authenticated-orcid":false,"given":"Jia","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117889_bib1","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1001\/jama.2025.0220","article-title":"Chronic Myeloid Leukemia: A Review","volume":"333","author":"Jabbour","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2026.117889_bib2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1182\/blood.2024026312","article-title":"Novel treatment strategies for chronic myeloid leukemia","volume":"145","author":"Cruz-Rodriguez","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117889_bib3","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1182\/blood.V128.22.1119.1119","article-title":"Characterization of the Genomic Landscape of BCR-ABL1 Kinase-Independent Mechanisms of Resistance to ABL1 Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia","volume":"128","author":"Eide","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117889_bib4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.trecan.2026.01.005","article-title":"The redox paradox in HGGs: ROS as drivers and destroyers","volume":"12","author":"Kumari","year":"2026","journal-title":"Trends Cancer"},{"key":"10.1016\/j.celrep.2026.117889_bib5","article-title":"Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications","volume":"11","author":"Akter","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2026.117889_bib6","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1182\/blood-2012-11-466938","article-title":"Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells","volume":"121","author":"Bolton-Gillespie","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117889_bib7","doi-asserted-by":"crossref","first-page":"51651","DOI":"10.18632\/oncotarget.10541","article-title":"Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia","volume":"7","author":"Laidlaw","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2026.117889_bib8","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1182\/blood-2013-07-511907","article-title":"Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition","volume":"123","author":"Ng","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117889_bib9","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/leu.2012.353","article-title":"The influence of hypoxia on CML trafficking through modulation of CXCR4 and E-cadherin expression","volume":"27","author":"Azab","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2026.117889_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2023.105688","article-title":"Role and regulation of GLUT1\/3 during oral cancer progression and therapy resistance","volume":"150","author":"Kumari","year":"2023","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.celrep.2026.117889_bib11","article-title":"HIF-1\u03b1 inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1\/P-glycoprotein","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2026.117889_bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12013-014-0434-2","article-title":"HIF-\u03b1 Promotes Chronic Myelogenous Leukemia Cell Proliferation by Upregulating p21 Expression","volume":"72","author":"Chen","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.celrep.2026.117889_bib13","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1182\/blood-2011-10-387381","article-title":"HIF1\u03b1 is required for survival maintenance of chronic myeloid leukemia stem cells","volume":"119","author":"Zhang","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117889_bib14","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1038\/s41418-023-01228-8","article-title":"USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A","volume":"30","author":"Mu","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2026.117889_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1053\/j.gastro.2024.10.042","article-title":"Hypoxic and Acidic Tumor Microenvironment-Driven AVL9 Promotes Chemoresistance of Pancreatic Ductal Adenocarcinoma via the AVL9-I\u03baB\u03b1-SKP1 Complex","volume":"168","author":"Ding","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2026.117889_bib16","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1016\/j.apsb.2025.07.003","article-title":"USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination","volume":"15","author":"Xu","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.celrep.2026.117889_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27144523","article-title":"Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review","volume":"27","author":"Xiong","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.celrep.2026.117889_bib18","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1039\/D2CS00197G","article-title":"Chasing molecular glue degraders: screening approaches","volume":"51","author":"Domostegui","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.celrep.2026.117889_bib19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pharmthera.2019.06.004","article-title":"Molecular mechanisms of cereblon-based drugs","volume":"202","author":"Asatsuma-Okumura","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.celrep.2026.117889_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41392-022-00966-4","article-title":"Targeted protein degradation: mechanisms, strategies and application","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celrep.2026.117889_bib21","doi-asserted-by":"crossref","first-page":"7126","DOI":"10.1016\/j.cell.2024.10.015","article-title":"Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders","volume":"187","author":"Lu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117889_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103515","article-title":"Applications and enhancement strategies of ROS-based non-invasive therapies in cancer treatment","volume":"80","author":"Guo","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2026.117889_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101238","article-title":"Role of the sulfur-containing amino acid-ROS axis in cancer chemotherapeutic drug resistance","volume":"81","author":"Wu","year":"2025","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.celrep.2026.117889_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154918","article-title":"System analysis of Huang-Lian-Jie-Du-Tang and their key active ingredients for overcoming CML resistance by suppression of leukemia stem cells","volume":"117","author":"Huang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.celrep.2026.117889_bib25","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.jep.2013.10.038","article-title":"Protective effects of Huang-Lian-Jie-Du-Tang and its component group on collagen-induced arthritis in rats","volume":"150","author":"Hu","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.celrep.2026.117889_bib26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bcp.2004.10.009","article-title":"Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation","volume":"69","author":"Tiwari","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2026.117889_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13045-018-0645-x","article-title":"The roles of metallothioneins in carcinogenesis","volume":"11","author":"Si","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2026.117889_bib28","doi-asserted-by":"crossref","first-page":"13495","DOI":"10.1021\/ja1057136","article-title":"Folding catalysis by transient coordination of Zn2+ to the Cu ligands of the ALS-associated enzyme Cu\/Zn superoxide dismutase 1","volume":"132","author":"Leinartaite","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.celrep.2026.117889_bib29","article-title":"Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia","volume":"5","author":"Adnan Awad","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.celrep.2026.117889_bib30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-8722-4-6","article-title":"BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance","volume":"4","author":"Quentmeier","year":"2011","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2026.117889_bib31","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.leukres.2015.07.006","article-title":"MRP1 and P-glycoprotein expression assays would be useful in the additional detection of treatment non-responders in CML patients without ABL1 mutation","volume":"39","author":"Park","year":"2015","journal-title":"Leuk. Res."},{"key":"10.1016\/j.celrep.2026.117889_bib32","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1080\/21691401.2018.1490310","article-title":"Low-dose staurosporine selectively reverses BCR-ABL-independent IM resistance through PKC-\u03b1-mediated G2\/M phase arrest in chronic myeloid leukaemia","volume":"46","author":"Ma","year":"2018","journal-title":"Artif. Cells, Nanomed. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117889_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13040461","article-title":"Oxidative Stress and Chronic Myeloid Leukemia: A Balance between ROS-Mediated Pro- and Anti-Apoptotic Effects of Tyrosine Kinase Inhibitors","volume":"13","author":"Allegra","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.celrep.2026.117889_bib34","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.62347\/RWLJ3990","article-title":"mTOR inhibition by AZD2014 alleviates BCR::ABL1 independent imatinib resistance through enhancing autophagy in CML resistant cells","volume":"14","author":"He","year":"2024","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.celrep.2026.117889_bib35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.omtn.2023.04.026","article-title":"PPFIA1-targeting miR-181a mimic and saRNA overcome imatinib resistance in BCR-ABL1-independent chronic myeloid leukemia by suppressing leukemia stem cell regeneration","volume":"32","author":"Su","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.celrep.2026.117889_bib36","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41419-024-07006-9","article-title":"Small RNA activation of CDH13 expression overcome BCR-ABL1-independent imatinib-resistance and their signaling pathway studies in chronic myeloid leukemia","volume":"15","author":"Su","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2026.117889_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052470","article-title":"Oxidative Stress and ROS-Mediated Signaling in Leukemia: Novel Promising Perspectives to Eradicate Chemoresistant Cells in Myeloid Leukemia","volume":"22","author":"Trombetti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2026.117889_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102452","article-title":"Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS\/p38 MAPK\/DGAT1 pathway and inhibiting M2 macrophage polarization","volume":"56","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2026.117889_bib39","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13046-025-03372-0","article-title":"Tetrahydrobenzimidazole TMQ0153 targets OPA1 and restores drug sensitivity in AML via ROS-induced mitochondrial metabolic reprogramming","volume":"44","author":"Park","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2026.117889_bib40","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1038\/onc.2010.67","article-title":"Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming","volume":"29","author":"Zhao","year":"2010","journal-title":"Oncogene"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726009678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:44:16Z","timestamp":1792529056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726009678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2211124726009678"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117889","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine, a natural molecular glue degrader, overcomes CML resistance via TRIM28-mediated HIF1\u03b1 ubiquitination and subsequent ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117889","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117889"}}