{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:38:51Z","timestamp":1792532331637,"version":"4.5.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["CA222064"],"award-info":[{"award-number":["CA222064"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["CA163910"],"award-info":[{"award-number":["CA163910"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015190","name":"Houston Methodist Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["HL103827"],"award-info":[{"award-number":["HL103827"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM130317"],"award-info":[{"award-number":["GM130317"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.celrep.2026.117953","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:54:01Z","timestamp":1789088041000},"page":"117953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endothelial PERK restricts lymphoid regeneration by reducing DLL4-NOTCH3 signaling at the Pre-B niche"],"prefix":"10.1016","volume":"45","author":[{"given":"Bingqing","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mofei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Adoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-hang Anthony","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-chi Andrew","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Ravi","family":"Kiran Pingali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith Syson","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youli","family":"Zu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Jafar-Nejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-534X","authenticated-orcid":false,"given":"Lan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117953_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41580-019-0103-9","article-title":"Haematopoietic stem cell activity and interactions with the niche","volume":"20","author":"Pinho","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117953_bib2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib3","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1182\/blood-2015-07-533588","article-title":"The hematopoietic stem cell niche in homeostasis and disease","volume":"126","author":"Calvi","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117953_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11885","article-title":"Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches","volume":"495","author":"Ding","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature11926","article-title":"CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance","volume":"495","author":"Greenbaum","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib7","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.immuni.2016.11.004","article-title":"Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation","volume":"45","author":"Cordeiro Gomes","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117953_bib8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.stem.2018.11.022","article-title":"Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow","volume":"24","author":"Comazzetto","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117953_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41556-019-0439-6","article-title":"Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization","volume":"22","author":"Baccin","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117953_bib10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.stem.2010.02.001","article-title":"Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells","volume":"6","author":"Butler","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117953_bib11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41586-019-1104-8","article-title":"The bone marrow microenvironment at single-cell resolution","volume":"569","author":"Tikhonova","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib12","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/wsbm.145","article-title":"Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies","volume":"3","author":"Warr","year":"2011","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.celrep.2026.117953_bib13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nature13228","article-title":"The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress","volume":"510","author":"van Galen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib14","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1038\/sj.onc.1206663","article-title":"Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms","volume":"22","author":"Mikkelsen","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2026.117953_bib15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbrc.2012.01.037","article-title":"Reactive oxygen species-mediated endoplasmic reticulum stress contributes to aldosterone-induced apoptosis in tubular epithelial cells","volume":"418","author":"Ding","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2026.117953_bib16","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1089\/ars.2007.1782","article-title":"Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?","volume":"9","author":"Malhotra","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.celrep.2026.117953_bib17","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.12688\/f1000research.12138.1","article-title":"Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum","volume":"6","author":"McQuiston","year":"2017","journal-title":"F1000Research"},{"key":"10.1016\/j.celrep.2026.117953_bib18","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.7150\/thno.67710","article-title":"Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.celrep.2026.117953_bib19","doi-asserted-by":"crossref","first-page":"19366","DOI":"10.18632\/oncotarget.4358","article-title":"Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic","volume":"6","author":"Nicolay","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2026.117953_bib20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2141.2004.04891.x","article-title":"Clinical impact of early absolute lymphocyte count after allogeneic stem cell transplantation","volume":"125","author":"Kim","year":"2004","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.celrep.2026.117953_bib21","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1021\/jm5002452","article-title":"Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity","volume":"57","author":"Ranatunga","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.celrep.2026.117953_bib22","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1172\/JCI73448","article-title":"Inhibition of ER stress-associated IRE-1\/XBP-1 pathway reduces leukemic cell survival","volume":"124","author":"Tang","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.celrep.2026.117953_bib23","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nature05313","article-title":"Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis","volume":"444","author":"Ridgway","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib24","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1002\/stem.2031","article-title":"Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention","volume":"33","author":"Wang","year":"2015","journal-title":"Stem Cell."},{"key":"10.1016\/j.celrep.2026.117953_bib25","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1158\/1078-0432.CCR-15-1380","article-title":"Balancing Efficacy and Safety of an Anti-DLL4 Antibody through Pharmacokinetic Modulation","volume":"22","author":"Couch","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2026.117953_bib26","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.cell.2009.03.025","article-title":"The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis","volume":"137","author":"Benedito","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.117953_bib27","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1073\/pnas.0611177104","article-title":"The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching","volume":"104","author":"Suchting","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117953_bib28","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1038\/s41467-021-27263-y","article-title":"Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution","volume":"12","author":"Termini","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117953_bib29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.2898810","article-title":"Purification and characterization of mouse hematopoietic stem cells","volume":"241","author":"Spangrude","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117953_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1084\/jem.20140767","article-title":"Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation","volume":"212","author":"Solaimani Kartalaei","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117953_bib31","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1182\/blood.2022016929","article-title":"The tetraspanin CD53 protects stressed hematopoietic stem cells via promotion of DREAM complex-mediated quiescence","volume":"141","author":"Greenberg","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117953_bib32","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.stem.2016.07.004","article-title":"Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem\/Progenitor Cell Regulators","volume":"19","author":"Silberstein","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.117953_bib33","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/s41375-024-02218-6","article-title":"STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response","volume":"38","author":"Patel","year":"2024","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2026.117953_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41590-022-01370-4","article-title":"A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia","volume":"24","author":"Voit","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.117953_bib35","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/bloodadvances.2018022913","article-title":"C\/EBP\u03b2 isoforms sequentially regulate regenerating mouse hematopoietic stem\/progenitor cells","volume":"4","author":"Sato","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.celrep.2026.117953_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54695","article-title":"Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment","volume":"9","author":"Zhong","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2026.117953_bib37","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1084\/jem.20122252","article-title":"PDGFR\u03b1 and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion","volume":"210","author":"Pinho","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117953_bib38","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.bbmt.2007.07.005","article-title":"Absolute lymphocyte count on day 30 is a surrogate for robust hematopoietic recovery and strongly predicts outcome after T cell-depleted allogeneic stem cell transplantation","volume":"13","author":"Savani","year":"2007","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.celrep.2026.117953_bib39","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jcyt.2022.11.008","article-title":"Prognostic impact of the simple L-index and absolute lymphocyte count early after allogeneic hematopoietic stem cell transplantation","volume":"25","author":"Kubo","year":"2023","journal-title":"Cytotherapy"},{"key":"10.1016\/j.celrep.2026.117953_bib40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/sj.bmt.1705891","article-title":"Early lymphocyte recovery post-allogeneic hematopoietic stem cell transplantation is associated with significant graft-versus-leukemia effect without increase in graft-versus-host disease in pediatric acute lymphoblastic leukemia","volume":"41","author":"Ishaqi","year":"2008","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.celrep.2026.117953_bib41","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.bbmt.2009.05.015","article-title":"Lymphocyte recovery is a major determinant of outcome after matched unrelated myeloablative transplantation for myelogenous malignancies","volume":"15","author":"Le Blanc","year":"2009","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.celrep.2026.117953_bib42","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3109\/10428194.2013.823491","article-title":"Lymphocyte recovery on day 100 after allogeneic hematopoietic stem cell transplant predicts non-relapse mortality in patients with acute leukemia or myelodysplastic syndrome","volume":"55","author":"Yamamoto","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.celrep.2026.117953_bib43","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.bbmt.2015.01.019","article-title":"Absolute lymphocyte count recovery after allogeneic hematopoietic stem cell transplantation predicts clinical outcome","volume":"21","author":"Kim","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.celrep.2026.117953_bib44","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.117953_bib45","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41586-021-03298-5","article-title":"A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis","volume":"591","author":"Shen","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib46","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1182\/blood-2010-12-326074","article-title":"Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions","volume":"117","author":"Yao","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117953_bib47","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.3324\/haematol.2017.168674","article-title":"Notch2 blockade enhances hematopoietic stem cell mobilization and homing","volume":"102","author":"Wang","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2026.117953_bib48","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1084\/jem.20141843","article-title":"Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow","volume":"212","author":"Yu","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117953_bib49","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/sctm.21-0086","article-title":"Notch signaling in the dynamics of perivascular stem cells and their niches","volume":"10","author":"Pagella","year":"2021","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.celrep.2026.117953_bib50","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1242\/dev.080614","article-title":"Stem cells living with a Notch","volume":"140","author":"Koch","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.celrep.2026.117953_bib51","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1158\/0008-5472.CAN-23-1183","article-title":"Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma","volume":"84","author":"Xiang","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117953_bib52","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib53","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-020-2222-z","article-title":"Notch signalling drives synovial fibroblast identity and arthritis pathology","volume":"582","author":"Wei","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib54","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1161\/CIRCRESAHA.119.316476","article-title":"Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis","volume":"126","author":"Yang","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2026.117953_bib55","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nature24998","article-title":"A non-canonical Notch complex regulates adherens junctions and vascular barrier function","volume":"552","author":"Polacheck","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2045-824X-5-19","article-title":"The effects of radiation on angiogenesis","volume":"5","author":"Grabham","year":"2013","journal-title":"Vasc. Cell"},{"key":"10.1016\/j.celrep.2026.117953_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11020142","article-title":"The PERK Branch of the Unfolded Protein Response Promotes DLL4 Expression by Activating an Alternative Translation Mechanism","volume":"11","author":"Jaud","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2026.117953_bib58","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1084\/jem.20050158","article-title":"IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF","volume":"201","author":"Kikuchi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.117953_bib59","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.4049\/jimmunol.154.11.6031","article-title":"IFN-gamma-dependent IL-7 gene regulation in keratinocytes","volume":"154","author":"Ariizumi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2026.117953_bib60","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1078\/0171-2985-00242","article-title":"Enhancement of IL-7 following irradiation of fetal thymus","volume":"207","author":"Toki","year":"2003","journal-title":"Immunobiology"},{"key":"10.1016\/j.celrep.2026.117953_bib61","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1073\/pnas.1114981109","article-title":"Systematic identification of type I and type II interferon-induced antiviral factors","volume":"109","author":"Liu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117953_bib62","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature09135","article-title":"Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection","volume":"465","author":"Baldridge","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib63","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature07815","article-title":"IFNalpha activates dormant haematopoietic stem cells in vivo","volume":"458","author":"Essers","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exphem.2021.02.002","article-title":"Yin and Yang: The dual effects of interferons on hematopoiesis","volume":"96","author":"Demerdash","year":"2021","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.celrep.2026.117953_bib75","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117953_bib76","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2026.117953_bib79","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13059-015-0844-5","article-title":"MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data","volume":"16","author":"Finak","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117953_bib82","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","article-title":"A scalable SCENIC workflow for single-cell gene regulatory network analysis","volume":"15","author":"Van de Sande","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.117953_bib80","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.celrep.2026.117953_bib81","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41596-024-01045-4","article-title":"CellChat for systematic analysis of cell\u2013cell communication from single-cell transcriptomics","volume":"20","author":"Jin","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.117953_bib65","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/gene.10241","article-title":"Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation","volume":"37","author":"Krebs","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2026.117953_bib66","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/MCB.22.11.3864-3874.2002","article-title":"The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas","volume":"22","author":"Zhang","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.117953_bib67","doi-asserted-by":"crossref","first-page":"H1835","DOI":"10.1152\/ajpheart.00293.2018","article-title":"Notch signaling regulates arterial vasoreactivity through opposing functions of Jagged1 and Dll4 in the vessel wall","volume":"315","author":"Basu","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.celrep.2026.117953_bib68","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1182\/blood-2008-08-174508","article-title":"DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries","volume":"113","author":"S\u00f6rensen","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.117953_bib69","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1158\/0008-5472.CAN-15-2092","article-title":"Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function","volume":"76","author":"Wang","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.117953_bib70","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"M\u00e9ndez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib71","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1111\/j.1537-2995.2010.02745.x","article-title":"Fucose-deficient hematopoietic stem cells have decreased self-renewal and aberrant marrow niche occupancy","volume":"50","author":"Myers","year":"2010","journal-title":"Transfusion"},{"key":"10.1016\/j.celrep.2026.117953_bib72","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature12612","article-title":"Arteriolar niches maintain haematopoietic stem cell quiescence","volume":"502","author":"Kunisaki","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117953_bib73","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nm.3155","article-title":"Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration","volume":"19","author":"Lucas","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.117953_bib74","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1667\/RR14444.1","article-title":"A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation","volume":"186","author":"Himburg","year":"2016","journal-title":"Radiat. Res."},{"key":"10.1016\/j.celrep.2026.117953_bib77","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13059-020-1950-6","article-title":"Decontamination of ambient RNA in single-cell RNA-seq with DecontX","volume":"21","author":"Yang","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.117953_bib78","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726010314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726010314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:44:49Z","timestamp":1792529089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726010314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":82,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2211124726010314"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117953","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial PERK restricts lymphoid regeneration by reducing DLL4-NOTCH3 signaling at the Pre-B niche","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117953","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117953"}}