{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:48:12Z","timestamp":1792097292481,"version":"4.4.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470737"],"award-info":[{"award-number":["32470737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32230007"],"award-info":[{"award-number":["32230007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0407901"],"award-info":[{"award-number":["2024ZD0407901"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB1820000"],"award-info":[{"award-number":["XDB1820000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.celrep.2026.117972","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:46:22Z","timestamp":1789001182000},"page":"117972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic and metabolomic profiling depicts the functional landscape of the Medicago truncatula symbiosome"],"prefix":"10.1016","volume":"45","author":[{"given":"Jingxia","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-7883","authenticated-orcid":false,"given":"Zhaosheng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.117972_bib1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1126\/science.aav8215","article-title":"Nitrogen in the environment","volume":"363","author":"Stevens","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117972_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.xplc.2024.100829","article-title":"Metal nutrition and transport in the process of symbiotic nitrogen fixation","volume":"5","author":"Li","year":"2024","journal-title":"Plant Commun."},{"key":"10.1016\/j.celrep.2026.117972_bib3","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev-arplant-050312-120235","article-title":"Transport and metabolism in legume-rhizobia symbioses","volume":"64","author":"Udvardi","year":"2013","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.celrep.2026.117972_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ncrops.2024.100015","article-title":"In the symbiosome: Cross-kingdom dating under the moonlight","volume":"1","author":"Ma","year":"2024","journal-title":"New Crops"},{"key":"10.1016\/j.celrep.2026.117972_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2014.00699","article-title":"Transport processes of the legume symbiosome membrane","volume":"5","author":"Clarke","year":"2014","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.celrep.2026.117972_bib6","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/plphys\/kiab280","article-title":"A roadmap of plant membrane transporters in arbuscular mycorrhizal and legume\u2013rhizobium symbioses","volume":"187","author":"Banasiak","year":"2021","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20130271","article-title":"Symbiosomes: temporary moonlighting organelles","volume":"460","author":"Emerich","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2026.117972_bib8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3390\/ijms22010432","article-title":"Iron transport across symbiotic membranes of nitrogen-fixing legumes","volume":"22","author":"Day","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2026.117972_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2017.00201","article-title":"Interface symbiotic membrane formation in root nodules of Medicago truncatula: the role of synaptotagmins MtSyt1, MtSyt2 and MtSyt3","volume":"8","author":"Gavrin","year":"2017","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.celrep.2026.117972_bib10","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1105\/tpc.108.064410","article-title":"Medicago N2-fixing symbiosomes acquire the endocytic identity marker Rab7 but delay the acquisition of vacuolar identity","volume":"21","author":"Limpens","year":"2009","journal-title":"Plant Cell"},{"key":"10.1016\/j.celrep.2026.117972_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/nplants.2015.197","article-title":"A symbiotic SNARE protein generated by alternative termination of transcription","volume":"2","author":"Pan","year":"2016","journal-title":"Nat. Plants"},{"key":"10.1016\/j.celrep.2026.117972_bib12","doi-asserted-by":"crossref","first-page":"8316","DOI":"10.1073\/pnas.1200407109","article-title":"Rhizobium -legume symbiosis shares an exocytotic pathway required for arbuscule formation","volume":"109","author":"Ivanov","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117972_bib13","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1073\/pnas.0913320107","article-title":"A remorin protein interacts with symbiotic receptors and regulates bacterial infection","volume":"107","author":"Lefebvre","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117972_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1094\/MPMI.2000.13.3.325","article-title":"Identification with proteomics of novel proteins associated with the peribacteroid membrane of soybean root nodules","volume":"13","author":"Panter","year":"2000","journal-title":"Mol. Plant. Microbe. Interact."},{"key":"10.1016\/j.celrep.2026.117972_bib15","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1074\/mcp.M114.043166","article-title":"Proteomic analysis of the soybean symbiosome identifies new symbiotic proteins","volume":"14","author":"Clarke","year":"2015","journal-title":"Mol. Cell. Proteomics."},{"key":"10.1016\/j.celrep.2026.117972_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jgg.2022.04.004","article-title":"Quantitative proteomics reveals key pathways in the symbiotic interface and the likely extracellular property of soybean symbiosome","volume":"50","author":"Luo","year":"2023","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.celrep.2026.117972_bib17","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1104\/pp.102.015362","article-title":"Proteome analysis. novel proteins identified at the peribacteroid membrane from Lotus japonicus root nodules","volume":"131","author":"Wienkoop","year":"2003","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/1615-9861(200203)2:3<325::AID-PROT325>3.0.CO;2-W","article-title":"Characterisation by proteomics of peribacteroid space and peribacteroid membrane preparations from pea (Pisum sativum) symbiosomes","volume":"2","author":"Saalbach","year":"2002","journal-title":"Proteomics"},{"key":"10.1016\/j.celrep.2026.117972_bib19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/elps.200305711","article-title":"Biochemical characterization of symbiosome membrane proteins from Medicago truncatula root nodules","volume":"25","author":"Catalano","year":"2004","journal-title":"Electrophoresis"},{"key":"10.1016\/j.celrep.2026.117972_bib20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.molp.2024.12.015","article-title":"Medicago2035: Genomes, functional genomics, and molecular breeding","volume":"18","author":"Ye","year":"2025","journal-title":"Mol. Plant"},{"key":"10.1016\/j.celrep.2026.117972_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11240-022-02357-7","article-title":"Retrotransposon and CRISPR\/Cas9-mediated knockout of NOD26 impairs the legume-rhizobia symbiosis","volume":"151","author":"Frare","year":"2022","journal-title":"Plant Cell Tissue Organ Cult."},{"key":"10.1016\/j.celrep.2026.117972_bib22","doi-asserted-by":"crossref","first-page":"23880","DOI":"10.1074\/jbc.M110.135657","article-title":"Interaction of cytosolic glutamine synthetase of soybean root nodules with the C-terminal domain of the symbiosome membrane nodulin 26 aquaglyceroporin","volume":"285","author":"Masalkar","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117972_bib23","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00438-003-0840-4","article-title":"The Lotus japonicus Sen1 gene controls rhizobial differentiation into nitrogen-fixing bacteroids in nodules","volume":"269","author":"Suganuma","year":"2003","journal-title":"Mol. Genet. Genomics."},{"key":"10.1016\/j.celrep.2026.117972_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/pcp\/pcr167","article-title":"The integral membrane protein SEN1 is required for symbiotic nitrogen fixation in Lotus japonicus nodules","volume":"53","author":"Hakoyama","year":"2012","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib25","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/nph.16735","article-title":"The Medicago truncatula Vacuolar iron Transporter-Like proteins VTL4 and VTL8 deliver iron to symbiotic bacteria at different stages of the infection process","volume":"228","author":"Walton","year":"2020","journal-title":"New Phytol."},{"key":"10.1016\/j.celrep.2026.117972_bib26","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1104\/pp.17.01538","article-title":"An iron-activated citrate transporter, MtMATE67, is required for symbiotic nitrogen fixation","volume":"176","author":"Kryvoruchko","year":"2018","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib27","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1105\/tpc.111.086389","article-title":"Symbiotic rhizobia bacteria trigger a change in localization and dynamics of the Medicago truncatula receptor kinase LYK3","volume":"23","author":"Haney","year":"2011","journal-title":"Plant Cell"},{"key":"10.1016\/j.celrep.2026.117972_bib28","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1073\/pnas.1721868115","article-title":"Symbiotic root infections in Medicago truncatula require remorin-mediated receptor stabilization in membrane nanodomains","volume":"115","author":"Liang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.117972_bib29","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1038\/s41467-023-40008-3","article-title":"A signal peptide peptidase is required for ER-symbiosome proximal association and protein secretion","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117972_bib30","article-title":"Control of rhizobia endosymbiosis by coupling ER expansion with enhanced UPR","volume":"12","author":"Ren","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2026.117972_bib31","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.1184096","article-title":"A nodule-specific protein secretory pathway required for nitrogen-fixing symbiosis","volume":"327","author":"Wang","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.117972_bib32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1104\/pp.106.076711","article-title":"Recruitment of novel calcium-binding proteins for root nodule symbiosis in Medicago truncatula","volume":"141","author":"Liu","year":"2006","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib33","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1104\/pp.109.151399","article-title":"Comparison of developmental and stress-induced nodule senescence in Medicago truncatula","volume":"152","author":"P\u00e9rez Guerra","year":"2010","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib34","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1104\/pp.18.01613","article-title":"The nodule-specific PLAT domain protein NPD1 is required for nitrogen-fixing symbiosis","volume":"180","author":"Pislariu","year":"2019","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib35","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1094\/MPMI-21-4-0404","article-title":"Transcription of ENOD8 in Medicago truncatula Nodules Directs ENOD8 Esterase to Developing and Mature Symbiosomes","volume":"21","author":"Coque","year":"2008","journal-title":"Mol. Plant. Microbe. Interact."},{"key":"10.1016\/j.celrep.2026.117972_bib36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1094\/MPMI-22-1-0063","article-title":"The signal peptide of the Medicago truncatula modular nodulin MtNOD25 operates as an address label for the specific targeting of proteins to nitrogen-fixing symbiosomes","volume":"22","author":"Hohnjec","year":"2009","journal-title":"Mol. Plant. Microbe. Interact."},{"key":"10.1016\/j.celrep.2026.117972_bib37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1104\/pp.111.191403","article-title":"Multiple domains in MtENOD8 protein including the signal peptide target it to the symbiosome","volume":"159","author":"Meckfessel","year":"2012","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tim.2006.02.005","article-title":"Metabolic changes of rhizobia in legume nodules","volume":"14","author":"Prell","year":"2006","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.celrep.2026.117972_bib39","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1365-313X.2008.03519.x","article-title":"A gene expression atlas of the model legume Medicago truncatula","volume":"55","author":"Benedito","year":"2008","journal-title":"Plant J."},{"key":"10.1016\/j.celrep.2026.117972_bib40","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/tpj.12442","article-title":"An integrated analysis of plant and bacterial gene expression in symbiotic root nodules using laser-capture microdissection coupled to RNA sequencing","volume":"77","author":"Roux","year":"2014","journal-title":"Plant J."},{"key":"10.1016\/j.celrep.2026.117972_bib41","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/nbt.3681","article-title":"A proteomic atlas of the legume Medicago truncatula and its nitrogen-fixing endosymbiont Sinorhizobium meliloti","volume":"34","author":"Marx","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117972_bib42","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.molp.2022.10.019","article-title":"Differentiation trajectories and biofunctions of symbiotic and un-symbiotic fate cells in root nodules of Medicago truncatula","volume":"15","author":"Ye","year":"2022","journal-title":"Mol. Plant"},{"key":"10.1016\/j.celrep.2026.117972_bib43","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0014-5793(91)81183-9","article-title":"Protein phosphorylation stimulates the rate of malate uptake across the peribacteroid membrane of soybean nodules","volume":"293","author":"Ouyang","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2026.117972_bib44","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.3390\/molecules26226876","article-title":"Malate transport and metabolism in nitrogen-fixing legume nodules","volume":"26","author":"Booth","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.celrep.2026.117972_bib45","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/pcp\/pcf109","article-title":"Identifying and characterizing plastidic 2-oxoglutarate\/malate and dicarboxylate transporters in Arabidopsis thaliana","volume":"43","author":"Taniguchi","year":"2002","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib46","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1104\/pp.104.045278","article-title":"Molecular and functional characterization of a family of amino acid transporters from Arabidopsis","volume":"136","author":"Su","year":"2004","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib47","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1016\/S0021-9258(19)44800-X","article-title":"Transport of succinate in Escherichia coli","volume":"247","author":"Lo","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.117972_bib48","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1104\/pp.103.032102","article-title":"A nodule-specific dicarboxylate transporter from alder is a member of the peptide transporter family","volume":"134","author":"Jeong","year":"2004","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib49","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-313X.2011.04587.x","article-title":"Malate transport by the vacuolar AtALMT6 channel in guard cells is subject to multiple regulation","volume":"67","author":"Meyer","year":"2011","journal-title":"Plant J."},{"key":"10.1016\/j.celrep.2026.117972_bib50","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.molp.2015.10.004","article-title":"High-efficiency genome editing in Arabidopsis using YAO promoter-driven CRISPR\/Cas9 system","volume":"8","author":"Yan","year":"2015","journal-title":"Mol. Plant"},{"key":"10.1016\/j.celrep.2026.117972_bib51","doi-asserted-by":"crossref","first-page":"e01561","DOI":"10.1128\/AEM.01561-17","article-title":"Succinate transport is not essential for symbiotic nitrogen fixation by Sinorhizobium meliloti or Rhizobium leguminosarum","volume":"84","author":"Mitsch","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.celrep.2026.117972_bib52","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20199419","article-title":"Co-catabolism of arginine and succinate drives symbiotic nitrogen fixation","volume":"16","author":"Flores-Tinoco","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.celrep.2026.117972_bib53","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-arplant-112619-025827","article-title":"The small GTPase superfamily in plants: a conserved regulatory module with novel functions","volume":"71","author":"Nielsen","year":"2020","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.celrep.2026.117972_bib54","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1111\/nph.13973","article-title":"A symbiosis-dedicated SYNTAXIN OF PLANTS 13II isoform controls the formation of a stable host-microbe interface in symbiosis","volume":"211","author":"Huisman","year":"2016","journal-title":"New Phytol."},{"key":"10.1016\/j.celrep.2026.117972_bib55","first-page":"2781","article-title":"\u03b3-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways","volume":"128","author":"Inoue","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.117972_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55067-3","article-title":"Annexin- and calcium-regulated priming of legume root cells for endosymbiotic infection","volume":"15","author":"Guillory","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117972_bib57","article-title":"Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport","volume":"1866","author":"Leonzino","year":"2021","journal-title":"Biochim. Biophys. Acta. Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.celrep.2026.117972_bib58","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/BST20170439","article-title":"ESCRT-mediated sorting and intralumenal vesicle concatenation in plants","volume":"46","author":"Otegui","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.celrep.2026.117972_bib59","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1105\/tpc.108.058933","article-title":"A mobile secretory vesicle cluster involved in mass transport from the golgi to the plant cell exterior","volume":"21","author":"Toyooka","year":"2009","journal-title":"Plant Cell"},{"key":"10.1016\/j.celrep.2026.117972_bib60","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1365-313X.2009.04111.x","article-title":"Vacuolar sorting receptors (VSRs) and secretory carrier membrane proteins (SCAMPs) are essential for pollen tube growth","volume":"61","author":"Wang","year":"2010","journal-title":"Plant J."},{"key":"10.1016\/j.celrep.2026.117972_bib61","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tcb.2007.06.005","article-title":"The SPFH domain-containing proteins: more than lipid raft markers","volume":"17","author":"Browman","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2026.117972_bib62","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pbi.2017.08.008","article-title":"Membrane nanodomains and microdomains in plant-microbe interactions","volume":"40","author":"Ott","year":"2017","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.celrep.2026.117972_bib63","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1105\/tpc.19.00777","article-title":"The Medicago truncatula DREPP protein triggers microtubule fragmentation in membrane nanodomains during symbiotic infections","volume":"32","author":"Su","year":"2020","journal-title":"Plant Cell"},{"key":"10.1016\/j.celrep.2026.117972_bib64","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/nph.18705","article-title":"Pectin modifications at the symbiotic interface","volume":"238","author":"Su","year":"2023","journal-title":"New Phytol."},{"key":"10.1016\/j.celrep.2026.117972_bib65","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.gene.2006.07.015","article-title":"Structure, expression, and mapping of two nodule-specific genes identified by mining public soybean EST databases","volume":"383","author":"Jeong","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2026.117972_bib66","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/pce.12941","article-title":"The Gm FWL1 (FW2-2-like ) nodulation gene encodes a plasma membrane microdomain-associated protein","volume":"40","author":"Qiao","year":"2017","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.celrep.2026.117972_bib67","doi-asserted-by":"crossref","DOI":"10.1111\/tpj.70340","article-title":"RinRK1\u2019 s extracellular domain acts as a host-specific gatekeeper for rhizobial infection in Medicago truncatula","volume":"123","author":"Zheng","year":"2025","journal-title":"Plant J."},{"key":"10.1016\/j.celrep.2026.117972_bib68","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/nph.12881","article-title":"A non receptor-like kinase prevents nodule early senescence and defense-like reactions during symbiosis","volume":"203","author":"Berrabah","year":"2014","journal-title":"New Phytol."},{"key":"10.1016\/j.celrep.2026.117972_bib69","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/jxb\/erm133","article-title":"Molecular cloning of a bifunctional-xylosidase\/-L-arabinosidase from alfalfa roots: heterologous expression in Medicago truncatula and substrate specificity of the purified enzyme","volume":"58","author":"Xiong","year":"2007","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.celrep.2026.117972_bib70","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s10265-016-0834-z","article-title":"Metabolism of L-arabinose in plants","volume":"129","author":"Kotake","year":"2016","journal-title":"J. Plant Res."},{"key":"10.1016\/j.celrep.2026.117972_bib71","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.3390\/plants10081639","article-title":"Genome-wide analysis of glycoside hydrolase family 35 genes and their potential roles in cell wall development in Medicago truncatula","volume":"10","author":"Yang","year":"2021","journal-title":"Plants"},{"key":"10.1016\/j.celrep.2026.117972_bib72","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1111\/pce.14928","article-title":"Medicago truncatula \u03b2 -glucosidase 17 contributes to drought and salt tolerance through antioxidant flavonoid accumulation","volume":"47","author":"Du","year":"2024","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.celrep.2026.117972_bib73","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/07352689.2011.616043","article-title":"Plant chitinases: genetic diversity and physiological roles","volume":"31","author":"Grover","year":"2012","journal-title":"Crit. Rev. Plant Sci."},{"key":"10.1016\/j.celrep.2026.117972_bib74","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1104\/pp.19.01341","article-title":"Receptor-like kinases sustain symbiotic scrutiny","volume":"182","author":"Chiu","year":"2020","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-67404-1","article-title":"Symbiosome functionality in Medicago truncatula nodules requires continuous clearing of pectins from the symbiosome space","volume":"16","author":"Gao","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.117972_bib76","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/jipb.12659","article-title":"Plant glycosylphosphatidylinositol anchored proteins at the plasma membrane-cell wall nexus","volume":"60","author":"Yeats","year":"2018","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.celrep.2026.117972_bib77","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1093\/plcell\/koac257","article-title":"Glycosylphosphatidylinositol anchor lipid remodeling directs proteins to the plasma membrane and governs cell wall mechanics","volume":"34","author":"Xu","year":"2022","journal-title":"Plant Cell"},{"key":"10.1016\/j.celrep.2026.117972_bib78","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1128\/jb.164.1.78-84.1985","article-title":"Accumulation of alpha,alpha-trehalose by Rhizobium bacteria and bacteroids","volume":"164","author":"Streeter","year":"1985","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.celrep.2026.117972_bib79","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0176-1617(88)80133-0","article-title":"Distribution of trehalase in soybean root nodule cells: implications for trehalose metabolism","volume":"133","author":"Mellor","year":"1988","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib80","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/B978-0-12-398264-3.00005-X","article-title":"What determines the efficiency of N2-fixing Rhizobium-legume symbioses?","volume":"60","author":"Terpolilli","year":"2012","journal-title":"Adv. Microb. Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/nplants.2017.48","article-title":"Nodule cysteine-rich peptides maintain a working balance during nitrogen-fixing symbiosis","volume":"3","author":"Pan","year":"2017","journal-title":"Nat. Plants"},{"key":"10.1016\/j.celrep.2026.117972_bib82","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1104\/pp.19.01088","article-title":"MtSSPdb: The Medicago truncatula small secreted peptide database","volume":"183","author":"Boschiero","year":"2020","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib83","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/nph.19180","article-title":"NCR343 is required to maintain the viability of differentiated bacteroids in nodule cells in Medicago truncatula","volume":"240","author":"Gao","year":"2023","journal-title":"New Phytol."},{"key":"10.1016\/j.celrep.2026.117972_bib84","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1111\/nph.19097","article-title":"The Medicago truncatula nodule-specific cysteine-rich peptides, NCR343 and NCR-new35 are required for the maintenance of rhizobia in nitrogen-fixing nodules","volume":"239","author":"Horv\u00e1th","year":"2023","journal-title":"New Phytol."},{"key":"10.1016\/j.celrep.2026.117972_bib85","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1093\/plphys\/kiad454","article-title":"Nodule-specific cysteine-rich peptide 343 is required for symbiotic nitrogen fixation in Medicago truncatula","volume":"193","author":"Zhang","year":"2023","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2026.117972_bib86","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature01527","article-title":"Amino-acid cycling drives nitrogen fixation in the legume-Rhizobium symbiosis","volume":"422","author":"Lodwig","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.117972_bib87","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/nph.15423","article-title":"The host actin cytoskeleton channels rhizobia release and facilitates symbiosome accommodation during nodulation in Medicago truncatula","volume":"221","author":"Zhang","year":"2019","journal-title":"New Phytol."},{"key":"10.1016\/j.celrep.2026.117972_bib88","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2026.117972_bib89","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s41477-022-01261-4","article-title":"A legume kinesin controls vacuole morphogenesis for rhizobia endosymbiosis","volume":"8","author":"Zhang","year":"2022","journal-title":"Nat. Plants"},{"key":"10.1016\/j.celrep.2026.117972_bib90","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1128\/AEM.04023-14","article-title":"Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system","volume":"81","author":"Jiang","year":"2015","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726010508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726010508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:40:30Z","timestamp":1792096830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726010508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":90,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2211124726010508"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117972","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic and metabolomic profiling depicts the functional landscape of the Medicago truncatula symbiosome","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.117972","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117972"}}