{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T06:27:19Z","timestamp":1794032839526,"version":"4.8.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273118"],"award-info":[{"award-number":["82273118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.celrep.2026.118059","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:06:17Z","timestamp":1790370377000},"page":"118059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histone lactylation regulates macrophage polarization and metabolic homeostasis during hypoxic lung injury"],"prefix":"10.1016","volume":"45","author":[{"given":"Xingwang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.118059_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1165\/rcmb.2012-0137TR","article-title":"Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?","volume":"48","author":"Fr\u00f6hlich","year":"2013","journal-title":"Am J Respir Cell Mol Biol. Mar"},{"key":"10.1016\/j.celrep.2026.118059_bib2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41590-022-01216-z","article-title":"Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation","volume":"23","author":"Mirchandani","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.118059_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.smim.2016.10.004","article-title":"Integrating immunometabolism and macrophage diversity","volume":"28","author":"Artyomov","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.celrep.2026.118059_bib4","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.apsb.2020.12.014","article-title":"Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses","volume":"11","author":"Hu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.celrep.2026.118059_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2023.12.042","article-title":"Efficient pulmonary fibrosis therapy via regulating macrophage polarization using respirable cryptotanshinone-loaded liposomal microparticles","volume":"366","author":"Wang","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.celrep.2026.118059_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.celrep.2026.118059_bib7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s42255-025-01259-0","article-title":"The emerging role of protein L-lactylation in metabolic regulation and cell signalling","volume":"7","author":"Ren","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.celrep.2026.118059_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41580-025-00876-7","article-title":"Biochemistry and regulation of histone lysine L-lactylation","volume":"27","author":"Sheng","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118059_bib9","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1038\/s41467-024-47900-6","article-title":"HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription","volume":"15","author":"Niu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118059_bib10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118059_bib11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/brv.13135","article-title":"Unlocking the multifaceted molecular functions and diverse disease implications of lactylation","volume":"100","author":"Jing","year":"2025","journal-title":"Biol. Rev. Camb. Phil. Soc."},{"key":"10.1016\/j.celrep.2026.118059_bib12","article-title":"Lactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis-Induced Acute Lung Injury","volume":"12","author":"Lu","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2026.118059_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103252","article-title":"An active peptide from yak inhibits hypoxia-induced lung injury via suppressing VEGF\/MAPK\/inflammatory signaling","volume":"75","author":"Yang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2026.118059_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2404899122","article-title":"Dynamic investigation of hypoxia-induced L-lactylation","volume":"122","author":"Gao","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.118059_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107641","article-title":"Modulation of circRNA Metabolism by m6A Modification","volume":"31","author":"Di Timoteo","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.118059_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202204784","article-title":"METTL3 Mediates Epithelial-Mesenchymal Transition by Modulating FOXO1 mRNA N6-Methyladenosine-Dependent YTHDF2 Binding: A Novel Mechanism of Radiation-Induced Lung Injury","volume":"10","author":"Feng","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2026.118059_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13054-024-04966-4","article-title":"Exploring the lung-gut direction of the gut-lung axis in patients with ARDS","volume":"28","author":"Ziaka","year":"2024","journal-title":"Crit. Care"},{"key":"10.1016\/j.celrep.2026.118059_bib18","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41576-025-00816-3","article-title":"Intrinsically disordered regions as facilitators of the transcription factor target search","volume":"26","author":"Jonas","year":"2025","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celrep.2026.118059_bib19","doi-asserted-by":"crossref","first-page":"6261","DOI":"10.1038\/s41467-025-61560-0","article-title":"YY1 enhances HIF-1\u03b1stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118059_bib20","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118059_bib21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nri.2017.86","article-title":"Innate lymphoid cells: major players in inflammatory diseases","volume":"17","author":"Ebbo","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.118059_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ni.1962","article-title":"The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling","volume":"12","author":"Spits","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.118059_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2014.06.016","article-title":"MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion","volume":"41","author":"Oliphant","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.118059_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abl9041","article-title":"Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages","volume":"8","author":"Loos","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2026.118059_bib25","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.4818","article-title":"Differentiation of Bone Marrow Monocytes into Alveolar Macrophages-like Cells through Co-culture with Lung Epithelial Cells and Group 2 Innate Lymphoid Cells","volume":"13","author":"Loos","year":"2023","journal-title":"Bio. Protoc."},{"key":"10.1016\/j.celrep.2026.118059_bib26","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1161\/ATVBAHA.124.321173","article-title":"Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension","volume":"45","author":"Liu","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2026.118059_bib27","doi-asserted-by":"crossref","first-page":"5855","DOI":"10.2147\/JIR.S479051","article-title":"Role of Lipopolysaccharides in the Inflammation and Pyroptosis of Alveolar Epithelial Cells in Acute Lung Injury and Acute Respiratory Distress Syndrome","volume":"17","author":"Shen","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.celrep.2026.118059_bib28","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/s41590-025-02217-4","article-title":"Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injury","volume":"26","author":"Abe","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2026.118059_bib29","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1084\/jem.20131199","article-title":"Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF","volume":"210","author":"Guilliams","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.118059_bib30","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2013.04.004","article-title":"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes","volume":"38","author":"Hashimoto","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.118059_bib31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41577-024-01098-2","article-title":"The roles of arginases and arginine in immunity","volume":"25","author":"Can\u00e8","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.118059_bib32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s10020-025-01149-x","article-title":"Epitranscriptomic regulation of HIF-1: bidirectional regulatory pathways","volume":"31","author":"Benak","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.celrep.2026.118059_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq8381","article-title":"Sequence-based prediction of intermolecular interactions driven by disordered regions","volume":"388","author":"Ginell","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.118059_bib34","article-title":"ROS-Driven Nanoventilator for MRSA-Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti-Inflammation and Immunomodulation","volume":"12","author":"Luo","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celrep.2026.118059_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109955","article-title":"Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors","volume":"37","author":"He","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.118059_bib36","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1021\/acschembio.4c00248","article-title":"The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation","volume":"19","author":"Nu\u00f1ez","year":"2024","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.celrep.2026.118059_bib37","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301722R","article-title":"Lactate produced by alveolar type II cells suppresses inflammatory alveolar macrophages in acute lung injury","volume":"37","author":"Roy","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2026.118059_bib38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12964-025-02244-6","article-title":"Lactylation-regulated biomolecular condensates: metabolic control of phase separation in physiology and disease","volume":"23","author":"Wang","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.celrep.2026.118059_bib39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2165\/00822942-200403020-00005","article-title":"Natively disordered proteins: functions and predictions","volume":"3","author":"Romero","year":"2004","journal-title":"Appl. Bioinf."},{"key":"10.1016\/j.celrep.2026.118059_bib40","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.4110\/in.2025.25.e9","article-title":"Mitochondrial Regulator CRIF1 Plays a Critical Role in the Development and Homeostasis of Alveolar Macrophages via Maintaining Metabolic Fitness","volume":"25","author":"Lee","year":"2025","journal-title":"Immune Netw."},{"key":"10.1016\/j.celrep.2026.118059_bib41","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1038\/s41467-019-10044-z","article-title":"A RASSF1A-HIF1\u03b1loop drives Warburg effect in cancer and pulmonary hypertension","volume":"10","author":"Dabral","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118059_bib42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.phrs.2009.04.007","article-title":"Penehyclidine hydrochloride attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway","volume":"60","author":"Shen","year":"2009","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.celrep.2026.118059_bib43","doi-asserted-by":"crossref","first-page":"315","DOI":"10.15171\/apb.2015.044","article-title":"Ghrelin Decreases Angiogenesis, HIF-1\u03b1 and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats","volume":"5","author":"Mirzaei Bavil","year":"2015","journal-title":"Adv. Pharmaceut. Bull."},{"key":"10.1016\/j.celrep.2026.118059_bib44","doi-asserted-by":"crossref","first-page":"8943","DOI":"10.1021\/acsnano.8b02037","article-title":"Targeted Therapy of Atherosclerosis by a Broad-Spectrum Reactive Oxygen Species Scavenging Nanoparticle with Intrinsic Anti-inflammatory Activity","volume":"12","author":"Wang","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.celrep.2026.118059_bib45","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.actbio.2023.05.027","article-title":"ROS scavenging and immunoregulative EGCG@Cerium complex loaded in antibacterial polyethylene glycol-chitosan hydrogel dressing for skin wound healing","volume":"166","author":"Ye","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.celrep.2026.118059_bib46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1126\/science.adi8828","article-title":"Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage","volume":"389","author":"Hoagland","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.118059_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41423-025-01261-2","article-title":"Type 2 immunity in allergic diseases","volume":"22","author":"Ogulur","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2026.118059_bib48","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.immuni.2019.10.008","article-title":"Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability","volume":"51","author":"Dubrovskaya","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.118059_bib49","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2017.09.019","article-title":"Lactate Metabolism in Human Lung Tumors","volume":"171","author":"Faubert","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118059_bib50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41420-024-02092-2","article-title":"Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming","volume":"10","author":"Han","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.celrep.2026.118059_bib51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.yjmcc.2024.05.013","article-title":"Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced pulmonary arterial hypertension via inhibiting Cyp1a1 mRNA decay","volume":"194","author":"Gu","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.celrep.2026.118059_bib52","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41577-024-01087-5","article-title":"How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia","volume":"25","author":"Mirchandani","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2026.118059_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101923","article-title":"Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration","volume":"83","author":"Desgeorges","year":"2024","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.celrep.2026.118059_bib54","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1016\/j.cell.2025.03.048","article-title":"Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory","volume":"188","author":"Ziogas","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118059_bib55","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/s12964-025-02366-x","article-title":"Lactylation modification of HIF-1\u03b1enhances its stability by blocking VHL recognition","volume":"23","author":"Li","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.celrep.2026.118059_bib56","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1016\/j.molcel.2024.11.018","article-title":"Lactylation as a post-translational regulator of cGAS and immunity","volume":"84","author":"Liu","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118059_bib57","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/s41586-024-07992-y","article-title":"AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases","volume":"634","author":"Li","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118059_bib58","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/j.cell.2024.03.023","article-title":"Dual-role transcription factors stabilize intermediate expression levels","volume":"187","author":"He","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118059_bib59","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41586-019-1374-1","article-title":"m6A enhances the phase separation potential of mRNA","volume":"571","author":"Ries","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118059_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103202","article-title":"Novel tracers for molecular imaging of interstitial lung disease: A state of the art review","volume":"21","author":"Broens","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.celrep.2026.118059_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118059_bib62","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41569-022-00805-7","article-title":"Single-cell transcriptomics for the assessment of cardiac disease","volume":"20","author":"Miranda","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.celrep.2026.118059_bib63","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12864-024-10072-0","article-title":"Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions","volume":"25","author":"Li","year":"2024","journal-title":"BMC Genom."},{"key":"10.1016\/j.celrep.2026.118059_bib64","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118059_bib65","doi-asserted-by":"crossref","first-page":"D400","DOI":"10.1093\/nar\/gkr1132","article-title":"PubChem's BioAssay Database","volume":"40","author":"Wang","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118059_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100246","article-title":"Preparation and culture of bone marrow-derived macrophages from mice for functional analysis","volume":"2","author":"Toda","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2026.118059_bib67","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1164\/ajrccm.163.3.2003065","article-title":"Fas\/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice","volume":"163","author":"Kitamura","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726011381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726011381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:53:27Z","timestamp":1794030807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726011381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2211124726011381"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.118059","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone lactylation regulates macrophage polarization and metabolic homeostasis during hypoxic lung injury","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.118059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118059"}}