{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:41:08Z","timestamp":1792492868811,"version":"4.5.0"},"reference-count":113,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371354"],"award-info":[{"award-number":["32371354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["QY26465"],"award-info":[{"award-number":["QY26465"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.celrep.2026.118159","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:37:18Z","timestamp":1791981438000},"page":"118159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["NONO mitigates transcription-replication conflicts during replication stress by restraining BRD4-dependent transcription elongation"],"prefix":"10.1016","volume":"45","author":[{"given":"Wenchi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duhan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3751-3283","authenticated-orcid":false,"given":"Hailong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.118159_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2897","article-title":"Causes and consequences of replication stress","volume":"16","author":"Zeman","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41573-022-00558-5","article-title":"Targeting replication stress in cancer therapy","volume":"22","author":"da Costa","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2026.118159_bib3","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.molcel.2022.05.004","article-title":"Hallmarks of DNA replication stress","volume":"82","author":"Saxena","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib4","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/s41589-025-02023-x","article-title":"Decoding replication stress responses through post-translational modifications","volume":"21","author":"Han","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41568-022-00518-6","article-title":"Leveraging the replication stress response to optimize cancer therapy","volume":"23","author":"Cybulla","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2026.118159_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-genet-080320-031523","article-title":"Transcription-replication conflicts as a source of genome instability","volume":"57","author":"Goehring","year":"2023","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.celrep.2026.118159_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-biochem-030222-115809","article-title":"Replication-transcription conflicts: a perpetual war on the chromosome","volume":"93","author":"Browning","year":"2024","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2026.118159_bib8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrm.2016.88","article-title":"Transcription-replication conflicts: how they occur and how they are resolved","volume":"17","author":"Garc\u00eda-Muse","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nsmb.2543","article-title":"Transcription-replication encounters, consequences and genomic instability","volume":"20","author":"Helmrich","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib10","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.cell.2017.07.043","article-title":"Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses","volume":"170","author":"Hamperl","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2017.07.040","article-title":"Transcription-replication conflicts: orientation matters","volume":"170","author":"Lin","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib12","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.cell.2016.09.053","article-title":"Conflict resolution in the genome: how transcription and replication make it work","volume":"167","author":"Hamperl","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.tig.2021.09.008","article-title":"Preventing excess replication origin activation to ensure genome stability","volume":"38","author":"Thakur","year":"2022","journal-title":"Trends Genet."},{"key":"10.1016\/j.celrep.2026.118159_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrg.2016.141","article-title":"Order from clutter: selective interactions at mammalian replication origins","volume":"18","author":"Aladjem","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celrep.2026.118159_bib15","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1101\/gad.285114.116","article-title":"DNA replication origins-where do we begin?","volume":"30","author":"Prioleau","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2026.118159_bib16","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrm4002","article-title":"DNA replication origin activation in space and time","volume":"16","author":"Fragkos","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41594-018-0171-0","article-title":"Transcription shapes DNA replication initiation and termination in human cells","volume":"26","author":"Chen","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13059-021-02390-3","article-title":"Transcription shapes DNA replication initiation to preserve genome integrity","volume":"22","author":"Liu","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10208","article-title":"Replication landscape of the human genome","volume":"7","author":"Petryk","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118159_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add3686","article-title":"DNA replication initiation shapes the mutational landscape and expression of the human genome","volume":"8","author":"Murat","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.118159_bib21","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3390\/life11070637","article-title":"Consequences and resolution of transcription-replication conflicts","volume":"11","author":"Lalonde","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.celrep.2026.118159_bib22","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1038\/s41467-024-48286-1","article-title":"Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency","volume":"15","author":"Goehring","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118159_bib23","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.1093\/nar\/gkac734","article-title":"Dynamic switching of crotonylation to ubiquitination of H2A at lysine 119 attenuates transcription-replication conflicts caused by replication stress","volume":"50","author":"Hao","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002386","article-title":"Genome instability and transcription elongation impairment in human cells depleted of THO\/TREX","volume":"7","author":"Dom\u00ednguez-S\u00e1nchez","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2026.118159_bib25","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1038\/s41467-024-51784-x","article-title":"RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability","volume":"15","author":"Jalan","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118159_bib26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.cell.2005.06.008","article-title":"Inactivation of the SR protein splicing factor ASF\/SF2 results in genomic instability","volume":"122","author":"Li","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102672","article-title":"RNases H: structure and mechanism","volume":"84","author":"Hyjek","year":"2019","journal-title":"DNA Repair"},{"key":"10.1016\/j.celrep.2026.118159_bib28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00294-018-0806-z","article-title":"R-loops: targets for nuclease cleavage and repeat instability","volume":"64","author":"Freudenreich","year":"2018","journal-title":"Curr. Genet."},{"key":"10.1016\/j.celrep.2026.118159_bib29","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.molcel.2014.10.020","article-title":"Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability","volume":"56","author":"Sollier","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105307","article-title":"Helicases in R-loop formation and resolution","volume":"299","author":"Yang","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.118159_bib31","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.cell.2014.03.048","article-title":"RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress","volume":"157","author":"Saponaro","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib32","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.molcel.2023.05.015","article-title":"Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability","volume":"83","author":"Bhowmick","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.201507099","article-title":"RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells","volume":"214","author":"Urban","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108469","article-title":"WDR82\/PNUTS-PP1 prevents transcription-replication conflicts by promoting RNA polymerase II degradation on chromatin","volume":"33","author":"Landsverk","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.118159_bib35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molcel.2019.07.037","article-title":"Elongation factor TFIIS prevents transcription stress and R-loop accumulation to maintain genome stability","volume":"76","author":"Zatreanu","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib36","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1042\/BST20210691","article-title":"The role of chromatin at transcription-replication conflicts as a genome safeguard","volume":"49","author":"Bayona-Feliu","year":"2021","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.celrep.2026.118159_bib37","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1038\/s41467-020-17858-2","article-title":"Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites","volume":"11","author":"Promonet","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118159_bib38","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/ncb1984","article-title":"Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription","volume":"11","author":"Tuduri","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib39","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.molcel.2015.01.011","article-title":"BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair","volume":"57","author":"Hatchi","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib40","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nature13374","article-title":"BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2","volume":"511","author":"Bhatia","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118159_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108166","article-title":"BRD4 prevents R-loop formation and transcription-replication conflicts by ensuring efficient transcription elongation","volume":"32","author":"Edwards","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.118159_bib42","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.molcel.2015.09.012","article-title":"The Fanconi Anemia pathway maintains genome stability by coordinating replication and transcription","volume":"60","author":"Schwab","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib43","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.molcel.2019.10.026","article-title":"Fork cleavage-religation cycle and active transcription mediate replication restart after fork stalling at co-transcriptional R-loops","volume":"77","author":"Chappidi","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005674","article-title":"The fanconi anemia pathway protects genome integrity from R-loops","volume":"11","author":"Garc\u00eda-Rubio","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2026.118159_bib45","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.chembiol.2023.07.001","article-title":"Small molecule targeting of transcription-replication conflict for selective chemotherapy","volume":"30","author":"Gu","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41586-024-07217-2","article-title":"Transcription-replication conflicts underlie sensitivity to PARP inhibitors","volume":"628","author":"Petropoulos","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118159_bib47","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1128\/MCB.02144-06","article-title":"Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb","volume":"27","author":"Dong","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib48","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1261\/rna.2213506","article-title":"p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation","volume":"12","author":"Liang","year":"2006","journal-title":"RNA"},{"key":"10.1016\/j.celrep.2026.118159_bib49","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1101\/gad.1565207","article-title":"The multifunctional protein p54nrb\/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination","volume":"21","author":"Kaneko","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2026.118159_bib50","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0092-8674(01)00466-4","article-title":"The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs","volume":"106","author":"Zhang","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib51","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1073\/pnas.1213317110","article-title":"NONO couples the circadian clock to the cell cycle","volume":"110","author":"Kowalska","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.118159_bib52","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1093\/nar\/gkp741","article-title":"Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance","volume":"37","author":"Li","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib53","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/nar\/gky1166","article-title":"RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling","volume":"47","author":"Deshar","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib54","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000687","article-title":"Paraspeckles","volume":"2","author":"Fox","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib55","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41467-019-08863-1","article-title":"SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability","volume":"10","author":"Petti","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118159_bib56","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1093\/nar\/gkae022","article-title":"Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts","volume":"52","author":"Trifault","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib57","first-page":"2838","article-title":"NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation","volume":"11","author":"Fan","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.celrep.2026.118159_bib58","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202254977","article-title":"NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma","volume":"24","author":"Zhang","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2026.118159_bib59","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.molcel.2022.05.010","article-title":"Condensates induced by transcription inhibition localize active chromatin to nucleoli","volume":"82","author":"Yasuhara","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib60","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.molcel.2018.05.019","article-title":"Functional domains of NEAT1 architectural lncRNA induce paraspeckle assembly through phase separation","volume":"70","author":"Yamazaki","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib61","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/carcin\/bgr103","article-title":"p54nrb is a new regulator of progression of malignant melanoma","volume":"32","author":"Schiffner","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.celrep.2026.118159_bib62","doi-asserted-by":"crossref","first-page":"L677","DOI":"10.1152\/ajplung.00051.2015","article-title":"Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma","volume":"309","author":"Vavougios","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.celrep.2026.118159_bib63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2407-1-15","article-title":"Immunodetection of nmt55\/p54nrb isoforms in human breast cancer","volume":"1","author":"Pavao","year":"2001","journal-title":"BMC Cancer"},{"key":"10.1016\/j.celrep.2026.118159_bib64","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/onc.2015.197","article-title":"p54(nrb)\/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A","volume":"35","author":"Zhu","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2026.118159_bib65","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju113","article-title":"Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression","volume":"106","author":"Liu","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.celrep.2026.118159_bib66","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1093\/nar\/gkw271","article-title":"The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold","volume":"44","author":"Knott","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib67","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/modpathol.2016.204","article-title":"Xp11.2 translocation renal cell carcinoma with NONO-TFE3 gene fusion: morphology, prognosis, and potential pitfall in detecting TFE3 gene rearrangement","volume":"30","author":"Xia","year":"2017","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.celrep.2026.118159_bib68","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1111\/jcmm.15141","article-title":"NONO and tumorigenesis: more than splicing","volume":"24","author":"Feng","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.celrep.2026.118159_bib69","doi-asserted-by":"crossref","first-page":"10461","DOI":"10.1073\/pnas.1706076114","article-title":"Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF","volume":"114","author":"Takayama","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.118159_bib70","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1038\/s41388-018-0302-4","article-title":"Ets-1 promoter-associated noncoding RNA regulates the NONO\/ERG\/Ets-1 axis to drive gastric cancer progression","volume":"37","author":"Li","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2026.118159_bib71","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrm3953","article-title":"Getting up to speed with transcription elongation by RNA polymerase II","volume":"16","author":"Jonkers","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib72","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1016\/S0021-9258(18)94169-4","article-title":"5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro","volume":"264","author":"Chodosh","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2026.118159_bib73","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1021\/acschembio.7b00117","article-title":"DNA replication dynamics and cellular responses to ATP competitive CDC7 kinase inhibitors","volume":"12","author":"Rainey","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib74","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2013.03.036","article-title":"Selective inhibition of tumor oncogenes by disruption of super-enhancers","volume":"153","author":"Lov\u00e9n","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib75","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/21541264.2022.2108302","article-title":"BRD4: a general regulator of transcription elongation","volume":"13","author":"Altendorfer","year":"2022","journal-title":"Transcription"},{"key":"10.1016\/j.celrep.2026.118159_bib76","doi-asserted-by":"crossref","first-page":"E4184","DOI":"10.1073\/pnas.1702086114","article-title":"Ectopic protein interactions within BRD4-chromatin complexes drive oncogenic megadomain formation in NUT midline carcinoma","volume":"114","author":"Alekseyenko","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.118159_bib77","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.molcel.2017.06.004","article-title":"BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment","volume":"67","author":"Winter","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib78","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cell.2013.07.013","article-title":"BET bromodomains mediate transcriptional pause release in heart failure","volume":"154","author":"Anand","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib79","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1016\/j.molcel.2023.06.032","article-title":"Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation","volume":"83","author":"Zheng","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib80","article-title":"Screening membraneless organelle participants with machine-learning models that integrate multimodal features","volume":"119","author":"Chen","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.118159_bib81","article-title":"A natural product targets BRD4 to inhibit phase separation and gene transcription","volume":"25","author":"Wang","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2026.118159_bib82","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1093\/nar\/gkw1209","article-title":"SFPQ\u2217NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining","volume":"45","author":"Jaafar","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib83","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1097-2765(00)80202-6","article-title":"Brca1 controls homology-directed DNA repair","volume":"4","author":"Moynahan","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib84","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1097-2765(00)80035-0","article-title":"Involvement of Brca2 in DNA repair","volume":"1","author":"Patel","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib85","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.cub.2013.06.063","article-title":"Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription","volume":"23","author":"Bertoli","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib86","article-title":"E2F1: cause and consequence of DNA replication stress","volume":"7","author":"Fouad","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.celrep.2026.118159_bib87","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/genes8030092","article-title":"The role of the transcriptional response to DNA replication stress","volume":"8","author":"Herlihy","year":"2017","journal-title":"Genes"},{"key":"10.1016\/j.celrep.2026.118159_bib88","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.molcel.2006.06.014","article-title":"Controlling the elongation phase of transcription with P-TEFb","volume":"23","author":"Peterlin","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib89","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1016\/j.molcel.2021.06.026","article-title":"A BRD4-mediated elongation control point primes transcribing RNA polymerase II for 3'-processing and termination","volume":"81","author":"Arnold","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib90","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41588-022-01091-2","article-title":"Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals","volume":"54","author":"Sankar","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2026.118159_bib91","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13059-020-01957-w","article-title":"Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells","volume":"21","author":"Zhang","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib92","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf2687","article-title":"CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity","volume":"9","author":"Ciabrelli","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2026.118159_bib93","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2199-14-9","article-title":"Human single-stranded DNA binding proteins are essential for maintaining genomic stability","volume":"14","author":"Ashton","year":"2013","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib94","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.semcdb.2018.03.014","article-title":"Human single-stranded DNA binding protein 1 (hSSB1, OBFC2B), a critical component of the DNA damage response","volume":"86","author":"Croft","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2026.118159_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113489","article-title":"The phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid-liquid phase separation at double-strand breaks","volume":"42","author":"Long","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.118159_bib96","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cell.2020.11.030","article-title":"RNA-mediated feedback control of transcriptional condensates","volume":"184","author":"Henninger","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib97","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar3958","article-title":"Coactivator condensation at super-enhancers links phase separation and gene control","volume":"361","author":"Sabari","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.118159_bib98","doi-asserted-by":"crossref","first-page":"6311","DOI":"10.1038\/s41467-022-34024-y","article-title":"Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer","volume":"13","author":"Ding","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118159_bib99","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1038\/s41467-020-17503-y","article-title":"BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage","volume":"11","author":"Lam","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118159_bib100","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.celrep.2018.10.079","article-title":"BET inhibition induces HEXIM1- and RAD51-dependent conflicts between transcription and replication","volume":"25","author":"Bowry","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.118159_bib101","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1038\/s41388-021-01744-2","article-title":"Exploiting synthetic lethality to target BRCA1\/2-deficient tumors: where we stand","volume":"40","author":"Patel","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2026.118159_bib102","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-med-082523-083843","article-title":"New therapeutic options for BRCA mutant patients","volume":"76","author":"Ghanem","year":"2025","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.celrep.2026.118159_bib103","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/annonc\/mdt384","article-title":"PARP inhibitors for BRCA1\/2 mutation-associated and BRCA-like malignancies","volume":"25","author":"Lee","year":"2014","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.celrep.2026.118159_bib104","doi-asserted-by":"crossref","first-page":"D314","DOI":"10.1093\/nar\/gkaf1114","article-title":"SEA version 4.0: a major expansion and update of the super-enhancer archive","volume":"54","author":"Shi","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib105","doi-asserted-by":"crossref","first-page":"D942","DOI":"10.1093\/nar\/gkac1071","article-title":"GENCODE: reference annotation for the human and mouse genomes in 2023","volume":"51","author":"Frankish","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib106","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.118159_bib107","doi-asserted-by":"crossref","first-page":"W105","DOI":"10.1093\/nar\/gkag469","article-title":"Galaxy for accessible, reproducible, and collaborative data analyses: 2026 update","volume":"54","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib108","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2026.118159_bib109","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib110","doi-asserted-by":"crossref","first-page":"12207","DOI":"10.1093\/nar\/gkad940","article-title":"Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks","volume":"51","author":"Zhao","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib111","first-page":"10724","article-title":"PLK1 targets CtIP to promote microhomology-mediated end joining","volume":"46","author":"Wang","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118159_bib112","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cell.2016.11.054","article-title":"Spatiotemporal control of intracellular phase transitions using light-activated optoDroplets","volume":"168","author":"Shin","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118159_bib113","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2203783119","article-title":"ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress","volume":"119","author":"Wu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726012386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726012386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:13:45Z","timestamp":1792491225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726012386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":113,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2211124726012386"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.118159","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NONO mitigates transcription-replication conflicts during replication stress by restraining BRD4-dependent transcription elongation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.118159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118159"}}