{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:50:19Z","timestamp":1793022619234,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG040061"],"award-info":[{"award-number":["R01AG040061"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG047182"],"award-info":[{"award-number":["R01AG047182"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.celrep.2026.118161","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:37:18Z","timestamp":1791981438000},"page":"118161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial stress induces transcription of cytosolic and mitochondrial protein synthesis components via NHR-180"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-7134","authenticated-orcid":false,"given":"Avijit","family":"Mallick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Ramalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1148-7355","authenticated-orcid":false,"given":"Levi","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunguang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1142-8320","authenticated-orcid":false,"given":"Duy","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-1396","authenticated-orcid":false,"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sookyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakeyah","family":"Ahsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala M.","family":"Shaqra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2270-6613","authenticated-orcid":false,"given":"Celia A.","family":"Schiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7416-0590","authenticated-orcid":false,"given":"Lihua Julie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1369-6989","authenticated-orcid":false,"given":"Brian","family":"Kelch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-758X","authenticated-orcid":false,"given":"Kuang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-5648","authenticated-orcid":false,"given":"Cole M.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.118161_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrm.2017.110","article-title":"The mitochondrial UPR: Mechanisms, physiological functions and implications in ageing","volume":"19","author":"Shpilka","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118161_bib2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.tcb.2020.03.001","article-title":"Folding the Mitochondrial UPR into the Integrated Stress Response","volume":"30","author":"Anderson","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2026.118161_bib3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.devcel.2017.12.020","article-title":"A Futile Battle? Protein Quality Control and the Stress of Aging","volume":"44","author":"Higuchi-Sanabria","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.118161_bib4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: Recent advances","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.celrep.2026.118161_bib5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2119\/2007-00100.Irvine","article-title":"Protein aggregation in the brain: The molecular basis for Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"14","author":"Irvine","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.celrep.2026.118161_bib6","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJM198905183202001","article-title":"Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns\u2013Sayre syndrome","volume":"320","author":"Moraes","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2026.118161_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-20784-y","article-title":"UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans","volume":"12","author":"Shpilka","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118161_bib8","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.cub.2016.06.002","article-title":"The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR","volume":"26","author":"Fiorese","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2026.118161_bib9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1223560","article-title":"Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation","volume":"337","author":"Nargund","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.118161_bib10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molcel.2015.02.008","article-title":"Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPRmt","volume":"58","author":"Nargund","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118161_bib11","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1083\/jcb.201702058","article-title":"Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals","volume":"216","author":"Quir\u00f3s","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118161_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111875","article-title":"Mitochondrial genome recovery by ATFS-1 is essential for development after starvation","volume":"41","author":"Uma Naresh","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.118161_bib13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nature13818","article-title":"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection","volume":"516","author":"Pellegrino","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118161_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12915-018-0615-3","article-title":"Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways","volume":"16","author":"Wu","year":"2018","journal-title":"BMC Biol."},{"key":"10.1016\/j.celrep.2026.118161_bib15","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nature17989","article-title":"Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response","volume":"533","author":"Lin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118161_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41556-021-00840-5","article-title":"LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria","volume":"24","author":"Yang","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118161_bib17","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/emboj\/18.7.1783","article-title":"CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans","volume":"18","author":"Felkai","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.118161_bib18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1534-5807(01)00071-5","article-title":"Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans","volume":"1","author":"Feng","year":"2001","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2026.118161_bib19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/bs.mie.2024.07.029","article-title":"Methods to analyze the mitochondrial unfolded protein response (UPRmt)","volume":"707","author":"Mallick","year":"2024","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.celrep.2026.118161_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-021-02498-z","article-title":"Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix","volume":"4","author":"Matsushima","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2026.118161_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cell.2010.12.016","article-title":"The cell-non-autonomous nature of electron transport chain-mediated longevity","volume":"144","author":"Durieux","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118161_bib22","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.cmet.2017.09.024","article-title":"Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling","volume":"26","author":"Weir","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.118161_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003346","article-title":"Surveillance-Activated Defenses Block the ROS-Induced Mitochondrial Unfolded Protein Response","volume":"9","author":"Runkel","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2026.118161_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152632","article-title":"Paraquat exposure over generation affects lifespan and reproduction through mitochondrial disruption in C. elegans","volume":"447","author":"Bora","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.celrep.2026.118161_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000556","article-title":"A mitochondrial superoxide signal triggers increased longevity in caenorhabditis elegans","volume":"8","author":"Yang","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2026.118161_bib26","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1073\/pnas.1218778110","article-title":"The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway","volume":"110","author":"Rauthan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.118161_bib27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.molcel.2013.12.013","article-title":"Extensive Oscillatory Gene Expression during C.elegans Larval Development","volume":"53","author":"Hendriks","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118161_bib28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1534\/g3.113.009522","article-title":"Use of an activated beta-catenin to identify wnt pathway target genes in Caenorhabditis elegans, including a subset of collagen genes expressed in late larval development","volume":"4","author":"Jackson","year":"2014","journal-title":"G3 (Bethesda)."},{"key":"10.1016\/j.celrep.2026.118161_bib29","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cell.2014.02.055","article-title":"The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C elegans","volume":"157","author":"Yee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118161_bib30","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1126\/science.1077780","article-title":"Rates of behavior and aging specified by mitochondrial function during development","volume":"298","author":"Dillin","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.118161_bib31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118161_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102477","article-title":"Protocol to assess receptor-ligand binding in C. elegans using adapted thermal shift assays. STAR Protoc","volume":"4","author":"Tse","year":"2023","journal-title":"STAR Protoc."},{"key":"10.1016\/j.celrep.2026.118161_bib33","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.118161_bib34","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1042\/bj3460659","article-title":"Characterization of AMP-activated protein kinase \u03b3-subunit isoforms and their role in AMP binding","volume":"346","author":"Cheung","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2026.118161_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0005-2736(81)90003-1","article-title":"Endogenous phosphorylation Two-dimensional SDS-gel electrophoresis Determination of space accessible to azido-cyclic AMP in SR suspensions","volume":"649","author":"Lord","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2026.118161_bib36","doi-asserted-by":"crossref","first-page":"15046","DOI":"10.1021\/ja044996f","article-title":"A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems","volume":"126","author":"Agard","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.celrep.2026.118161_bib37","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.arr.2011.12.005","article-title":"AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network","volume":"11","author":"Salminen","year":"2012","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.celrep.2026.118161_bib38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cmet.2014.03.002","article-title":"AMPK at the nexus of energetics and aging","volume":"20","author":"Burkewitz","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.118161_bib39","doi-asserted-by":"crossref","first-page":"13091","DOI":"10.1073\/pnas.95.22.13091","article-title":"The genetics of caloric restriction in Caenorhabditis elegans","volume":"95","author":"Lakowski","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.118161_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003651","article-title":"Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans","volume":"9","author":"Heestand","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2026.118161_bib41","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nature09706","article-title":"Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB","volume":"470","author":"Mair","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118161_bib42","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.celrep.2013.11.018","article-title":"Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C.elegans","volume":"5","author":"Chen","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.118161_bib43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: Guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118161_bib44","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cell.2005.10.024","article-title":"mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events","volume":"123","author":"Holz","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2026.118161_bib45","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41467-022-28910-8","article-title":"S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions","volume":"13","author":"Jiang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118161_bib46","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.2814477","article-title":"Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation","volume":"246","author":"King","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.118161_bib47","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1126\/science.abi7495","article-title":"Fumarate is a terminal electron acceptor in the mammalian electron transport chain","volume":"374","author":"Spinelli","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.118161_bib48","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature14859","article-title":"A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death","volume":"524","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118161_bib49","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature14644","article-title":"Surviving import failure","volume":"524","author":"Haynes","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118161_bib50","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nature14951","article-title":"Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol","volume":"524","author":"Wrobel","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118161_bib51","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1244360","article-title":"mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome","volume":"342","author":"Johnson","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.118161_bib52","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.15252\/embr.201642195","article-title":"The integrated stress response","volume":"17","author":"Pakos-Zebrucka","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2026.118161_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: From mechanism to disease","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.celrep.2026.118161_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002760","article-title":"Protective coupling of mitochondrial function and protein synthesis via the eIF2\u03b1 kinase GCN-2","volume":"8","author":"Baker","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2026.118161_bib55","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jnutbio.2005.06.007","article-title":"Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications","volume":"16","author":"Allen","year":"2005","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.celrep.2026.118161_bib56","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2337\/diabetes.52.3.581","article-title":"Glucose Toxicity in _-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection","volume":"52","author":"Robertson","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2026.118161_bib57","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cmet.2007.08.011","article-title":"Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress","volume":"6","author":"Schulz","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.118161_bib58","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1152\/physiol.00010.2011","article-title":"Calorie restriction: Is AMPK a key sensor and effector?","volume":"26","author":"Cant\u00f3","year":"2011","journal-title":"Physiology"},{"key":"10.1016\/j.celrep.2026.118161_bib59","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cmet.2012.11.003","article-title":"Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis","volume":"16","author":"Lanza","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2026.118161_bib60","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1073\/pnas.1817259116","article-title":"Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3","volume":"116","author":"Deng","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.118161_bib61","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1534\/genetics.118.301532","article-title":"Robust genome editing with short single-stranded and long, partially single-stranded DNA donors in caenorhabditis elegans","volume":"210","author":"Dokshin","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2026.118161_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101843","article-title":"Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling","volume":"23","author":"Mallick","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2026.118161_bib63","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ymeth.2014.04.002","article-title":"The C. elegans lifespan assay toolkit","volume":"68","author":"Amrit","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2026.118161_bib64","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1242\/jcs.01275","article-title":"Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones","volume":"117","author":"Yoneda","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.celrep.2026.118161_bib65","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.celrep.2026.118161_bib66","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein-protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2026.118161_bib67","doi-asserted-by":"crossref","first-page":"10481","DOI":"10.3390\/s150510481","article-title":"Surface plasmon resonance: A versatile technique for biosensor applications","volume":"15","author":"Nguyen","year":"2015","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.celrep.2026.118161_bib68","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/abio.1993.1355","article-title":"Determination of rate and equilibrium binding constants for macromolecular interactions by surface plasmon resonance","volume":"212","author":"O\u2019Shannessy","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.celrep.2026.118161_bib69","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.immuni.2023.01.027","article-title":"Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans","volume":"56","author":"Peterson","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2026.118161_bib70","series-title":"SUMO Protocols","first-page":"167","article-title":"Purification of SUMO Conjugating Enzymes and Kinetic Analysis of Substrate Conjugation","author":"Yunus","year":"2009"},{"key":"10.1016\/j.celrep.2026.118161_bib71","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/nprot.2016.106","article-title":"A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans","volume":"11","author":"Koopman","year":"2016","journal-title":"Nat. Protoc."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726012404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726012404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:23:25Z","timestamp":1793021005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726012404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":71,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2211124726012404"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.118161","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial stress induces transcription of cytosolic and mitochondrial protein synthesis components via NHR-180","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.118161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118161"}}