{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T08:36:49Z","timestamp":1792917409753,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.celrep.2026.118193","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:18:13Z","timestamp":1792675093000},"page":"118193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["ALKBH8 promotes acute myeloid leukemia progression by coupling codon-dependent translation elongation to mRNA stability"],"prefix":"10.1016","volume":"45","author":[{"given":"Songyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunguang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songze","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guocai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aibing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-8797","authenticated-orcid":false,"given":"Zhanghui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2026.118193_bib1","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.celrep.2026.118193_bib2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute Myeloid Leukemia","volume":"373","author":"D\u00f6hner","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2026.118193_bib3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11864-020-00765-5","article-title":"Treatment of Relapsed Acute Myeloid Leukemia","volume":"21","author":"Thol","year":"2020","journal-title":"Curr. Treat. Options Oncol."},{"key":"10.1016\/j.celrep.2026.118193_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ccell.2016.11.017","article-title":"FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase","volume":"31","author":"Li","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2026.118193_bib5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2020.04.009","article-title":"RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia","volume":"27","author":"Shen","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.118193_bib6","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nm.4416","article-title":"The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells","volume":"23","author":"Vu","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.118193_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.stem.2017.11.016","article-title":"METTL14 Inhibits Hematopoietic Stem\/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification","volume":"22","author":"Weng","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.118193_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.stem.2019.03.021","article-title":"Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia","volume":"25","author":"Paris","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.118193_bib9","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1182\/blood.2021011707","article-title":"A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication","volume":"138","author":"Sheng","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.118193_bib10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1158\/0008-5472.CAN-21-4249","article-title":"The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression","volume":"83","author":"Hong","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.118193_bib11","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.stem.2023.07.001","article-title":"TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal","volume":"30","author":"Li","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.118193_bib12","article-title":"The m((5))C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism","volume":"44","author":"Li","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2026.118193_bib13","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1038\/s41556-024-01548-y","article-title":"NAT10-mediated mRNA N(4)-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia","volume":"26","author":"Zhang","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118193_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40164-024-00477-8","article-title":"METTL1 mediated tRNA m(7)G modification promotes leukaemogenesis of AML via tRNA regulated translational control","volume":"13","author":"Zhao","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.celrep.2026.118193_bib15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.trecan.2017.02.004","article-title":"tRNA Modification: Is Cancer Having a Wobble?","volume":"3","author":"Rapino","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.celrep.2026.118193_bib16","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41586-018-0243-7","article-title":"Codon-specific translation reprogramming promotes resistance to targeted therapy","volume":"558","author":"Rapino","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118193_bib17","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1084\/jem.20142288","article-title":"Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine","volume":"212","author":"Ladang","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.118193_bib18","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1038\/s41467-019-13420-x","article-title":"Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer","volume":"10","author":"Xu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118193_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005706","article-title":"Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation","volume":"11","author":"Deng","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2026.118193_bib20","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.molmed.2022.09.007","article-title":"Dysfunctional tRNA reprogramming and codon-biased translation in cancer","volume":"28","author":"Dedon","year":"2022","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2026.118193_bib21","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1128\/MCB.01602-09","article-title":"Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding","volume":"30","author":"Songe-M\u00f8ller","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2026.118193_bib22","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.1002\/anie.201001242","article-title":"The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA","volume":"49","author":"Fu","year":"2010","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.celrep.2026.118193_bib23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ncomms1173","article-title":"ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA","volume":"2","author":"van den Born","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118193_bib24","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1080\/15592294.2020.1750213","article-title":"The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene","volume":"15","author":"Leonardi","year":"2020","journal-title":"Epigenetics"},{"key":"10.1016\/j.celrep.2026.118193_bib25","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.ajhg.2019.03.026","article-title":"Recessive Truncating Mutations in ALKBH8 Cause Intellectual Disability and Severe Impairment of Wobble Uridine Modification","volume":"104","author":"Monies","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2026.118193_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101375","article-title":"Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming(\u2606)","volume":"28","author":"Lee","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.celrep.2026.118193_bib27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbrc.2016.06.084","article-title":"ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin","volume":"477","author":"Ohshio","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2026.118193_bib28","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1158\/0008-5472.CAN-08-3530","article-title":"A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression","volume":"69","author":"Shimada","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2026.118193_bib29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.stem.2020.04.001","article-title":"Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2026.118193_bib30","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/blood-2016-10-696039","article-title":"Therapeutic targeting of acute myeloid leukemia stem cells","volume":"129","author":"Pollyea","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.118193_bib31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature20598","article-title":"A 17-gene stemness score for rapid determination of risk in acute leukaemia","volume":"540","author":"Ng","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118193_bib32","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/nm.2415","article-title":"Stem cell gene expression programs influence clinical outcome in human leukemia","volume":"17","author":"Eppert","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2026.118193_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1182\/blood.2020009676","article-title":"YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner","volume":"138","author":"Feng","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.118193_bib34","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1182\/blood-2015-01-623645","article-title":"Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation","volume":"126","author":"Cheng","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2026.118193_bib35","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.molcel.2018.12.009","article-title":"High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation during Cellular Stress","volume":"73","author":"Wu","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2026.118193_bib36","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/nar\/gkz763","article-title":"Ribosome pausing, a dangerous necessity for co-translational events","volume":"48","author":"Collart","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118193_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf049","article-title":"The ribosome as a platform to coordinate mRNA decay","volume":"53","author":"M\u00fcller","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2026.118193_bib38","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature04530","article-title":"Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation","volume":"440","author":"Doma","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118193_bib39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00018-020-03594-9","article-title":"Multi-substrate selectivity based on key loops and non-homologous domains: new insight into ALKBH family","volume":"78","author":"Xu","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2026.118193_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature13483","article-title":"DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier","volume":"514","author":"Santos","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2026.118193_bib41","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.trecan.2024.06.008","article-title":"PARPi, BRCA, and gaps: controversies and future research","volume":"10","author":"Dibitetto","year":"2024","journal-title":"Trends Cancer"},{"key":"10.1016\/j.celrep.2026.118193_bib42","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Cancer Genome Atlas Research","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2026.118193_bib43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/hon.3076","article-title":"DNA damage accumulation and repair defects in FLT3-ITD acute myeloid leukemia: Implications for clonal evolution and disease progression","volume":"41","author":"Lagunas-Rangel","year":"2023","journal-title":"Hematol. Oncol."},{"key":"10.1016\/j.celrep.2026.118193_bib44","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/febs.17217","article-title":"Dysregulated ribosome quality control in human diseases","volume":"292","author":"McGirr","year":"2025","journal-title":"FEBS J."},{"key":"10.1016\/j.celrep.2026.118193_bib45","doi-asserted-by":"crossref","first-page":"9075","DOI":"10.1038\/s41467-025-64144-0","article-title":"ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis","volume":"16","author":"Qian","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118193_bib46","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200662","article-title":"Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis","volume":"218","author":"Rosu","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2026.118193_bib47","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/sj.emboj.7601109","article-title":"Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA","volume":"25","author":"Ringvoll","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2026.118193_bib48","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1073\/pnas.022042899","article-title":"Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo","volume":"99","author":"Winkler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2026.118193_bib49","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41467-019-08579-2","article-title":"The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase","volume":"10","author":"Lin","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2026.118193_bib50","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1016\/j.csbj.2022.11.045","article-title":"N(1)-methyladenosine modification in cancer biology: Current status and future perspectives","volume":"20","author":"Li","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.celrep.2026.118193_bib51","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s10020-026-01496-3","article-title":"TRMT6\/61A-mediated tRNA m1A methylation promotes codon-dependent TAB2 translation and drives AML progression","volume":"32","author":"Jia","year":"2026","journal-title":"Molecular medicine"},{"key":"10.1016\/j.celrep.2026.118193_bib52","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/s41589-020-0601-2","article-title":"NADP modulates RNA m(6)A methylation and adipogenesis via enhancing FTO activity","volume":"16","author":"Wang","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2026.118193_bib53","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41419-020-2408-1","article-title":"Pan-cancer analysis reveals synergistic effects of CDK4\/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726012726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124726012726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T08:09:58Z","timestamp":1792915798000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124726012726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2211124726012726"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2026.118193","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ALKBH8 promotes acute myeloid leukemia progression by coupling codon-dependent translation elongation to mRNA stability","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2026.118193","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118193"}}