{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:46:43Z","timestamp":1790696803263,"version":"4.1.0"},"reference-count":118,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019771","name":"European Union&apos;s Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Systems"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.cels.2025.101198","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T10:59:56Z","timestamp":1739876396000},"page":"101198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cold and hot fibrosis define clinically distinct cardiac pathologies"],"prefix":"10.1016","volume":"16","author":[{"given":"Shoval","family":"Miyara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miri","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kfir B.","family":"Umansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"H\u00e4u\u00dfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Bassat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Divinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Elkahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Lendengolts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo O.","family":"Ramirez Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Bueno-Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofra","family":"Golani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Shalit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gershovits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eviatar","family":"Weizman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Genzelinakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"Kimchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Shakked","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Petrover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Sarig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Dorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Saez-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kupatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elly M.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Medzhitov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-9956","authenticated-orcid":false,"given":"Uri","family":"Alon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5212-9426","authenticated-orcid":false,"given":"Eldad","family":"Tzahor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cels.2025.101198_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.cels.2025.101198_bib2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cels.2025.101198_bib3","series-title":"Systems Medicine, Physiological Circuits and the Dynamics of Disease","author":"Alon","year":"2023"},{"key":"10.1016\/j.cels.2025.101198_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yjmcc.2013.10.019","article-title":"Myofibroblasts: Trust your heart and let fate decide","volume":"70","author":"Davis","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.cels.2025.101198_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/kisup.2014.2","article-title":"Overview of the cellular and molecular basis of kidney fibrosis","volume":"4","author":"Eddy","year":"2014","journal-title":"Kidney Int. Suppl. (2011)"},{"key":"10.1016\/j.cels.2025.101198_bib6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tox.2008.06.013","article-title":"Hepatic fibrosis\u2014Overview","volume":"254","author":"Friedman","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.cels.2025.101198_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2044-5040-1-21","article-title":"Aberrant repair and fibrosis development in skeletal muscle","volume":"1","author":"Mann","year":"2011","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.cels.2025.101198_bib8","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1172\/JCI60323","article-title":"Pulmonary fibrosis: patterns and perpetrators","volume":"122","author":"Noble","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cels.2025.101198_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1983","article-title":"Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis","volume":"6","author":"Adams","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cels.2025.101198_bib10","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 Heart Disease and Stroke Statistics:\u00a0A Report of US and Global Data From the American Heart Association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.cels.2025.101198_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev-pathol-020712-163930","article-title":"Host Responses in Tissue Repair and Fibrosis","volume":"8","author":"Duffield","year":"2013","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cels.2025.101198_bib12","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in Tissue Repair, Regeneration, and Fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cels.2025.101198_bib13","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/path.4104","article-title":"The myofibroblast matrix: implications for tissue repair and fibrosis","volume":"229","author":"Klingberg","year":"2013","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.cels.2025.101198_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.matbio.2018.01.019","article-title":"The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication","volume":"68","author":"Pakshir","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.cels.2025.101198_bib15","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.immuni.2021.04.021","article-title":"Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer","volume":"54","author":"Buechler","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.cels.2025.101198_bib16","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bbadis.2012.12.001","article-title":"Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair","volume":"1832","author":"Lech","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cels.2025.101198_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm4443","article-title":"A coalition to heal\u2014the impact of the cardiac microenvironment","volume":"377","author":"Tzahor","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.cels.2025.101198_bib18","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1113\/JP283346","article-title":"Intercellular model predicts mechanisms of inflammation-fibrosis coupling after myocardial infarction","volume":"601","author":"Chowkwale","year":"2023","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.cels.2025.101198_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.100841","article-title":"Principles of Cell Circuits for Tissue Repair and Fibrosis","volume":"23","author":"Adler","year":"2020","journal-title":"Iscience"},{"key":"10.1016\/j.cels.2025.101198_bib20","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.cell.2018.01.015","article-title":"Circuit Design Features of a Stable Two-Cell System","volume":"172","author":"Zhou","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cels.2025.101198_bib21","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1038\/s41467-022-34241-5","article-title":"Understanding fibrosis pathogenesis via modeling macrophage-fibroblast interplay in immune-metabolic context","volume":"13","author":"Setten","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cels.2025.101198_bib22","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/cphy.c150006","article-title":"Pathophysiology of Myocardial Infarction","volume":"5","author":"Frangogiannis","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.cels.2025.101198_bib23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cels.2025.101198_bib24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1752-0509-5-60","article-title":"Combining experimental and mathematical modeling to reveal mechanisms of macrophage-dependent left ventricular remodeling","volume":"5","author":"Jin","year":"2011","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.cels.2025.101198_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-13-S6-S21","article-title":"Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling post-myocardial infarction","volume":"13","author":"Wang","year":"2012","journal-title":"BMC Genom."},{"key":"10.1016\/j.cels.2025.101198_bib26","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/ejhf.312","article-title":"Searching for new mechanisms of myocardial fibrosis with diagnostic and\/or therapeutic potential","volume":"17","author":"Heymans","year":"2015","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.cels.2025.101198_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2019.05.011","article-title":"Cardiac fibrosis\u00a0\u2013 A short review of causes and therapeutic strategies","volume":"146","author":"Hinderer","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.cels.2025.101198_bib28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yjmcc.2015.12.024","article-title":"The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction","volume":"91","author":"Francis Stuart","year":"2016","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.cels.2025.101198_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.cels.2025.101198_bib30","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient Regenerative Potential of the Neonatal Mouse Heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cels.2025.101198_bib31","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1161\/CIRCULATIONAHA.118.034886","article-title":"Regenerative Potential of Neonatal Porcine Hearts","volume":"138","author":"Zhu","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cels.2025.101198_bib32","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.117.031542","article-title":"Early Regenerative Capacity in the Porcine Heart","volume":"138","author":"Ye","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cels.2025.101198_bib33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCRESAHA.115.307017","article-title":"Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction","volume":"118","author":"Haubner","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.cels.2025.101198_bib34","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1126\/science.aam5894","article-title":"Cardiac regeneration strategies: Staying young at heart","volume":"356","author":"Tzahor","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.cels.2025.101198_bib35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","article-title":"The extracellular matrix protein agrin promotes heart regeneration in mice","volume":"547","author":"Bassat","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cels.2025.101198_bib36","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ncb3149","article-title":"ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation","volume":"17","author":"D\u2019Uva","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cels.2025.101198_bib37","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-019-1546-z","article-title":"Targeting Cardiac Fibrosis with Engineered T\u00a0cells","volume":"573","author":"Aghajanian","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cels.2025.101198_bib38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-019-1802-2","article-title":"An acute immune response underlies the benefit of cardiac stem cell therapy","volume":"577","author":"Vagnozzi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cels.2025.101198_bib39","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41586-021-03674-1","article-title":"A transcriptional switch governs fibroblast activation in heart disease","volume":"595","author":"Alexanian","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cels.2025.101198_bib40","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/s41556-020-00588-4","article-title":"ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration","volume":"22","author":"Aharonov","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cels.2025.101198_bib41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.stem.2019.12.004","article-title":"Toward the Goal of Human Heart Regeneration","volume":"26","author":"Sadek","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cels.2025.101198_bib42","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature24045","article-title":"Hippo pathway deficiency reverses systolic heart failure after infarction","volume":"550","author":"Leach","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cels.2025.101198_bib43","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41586-019-1191-6","article-title":"MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs","volume":"569","author":"Gabisonia","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cels.2025.101198_bib44","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature20173","article-title":"Hypoxia induces heart regeneration in adult mice","volume":"541","author":"Nakada","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cels.2025.101198_bib45","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tcb.2022.08.005","article-title":"Cut loose TIMP-1: an emerging cytokine in inflammation","volume":"33","author":"Schoeps","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cels.2025.101198_bib46","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1016\/j.celrep.2020.02.008","article-title":"Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice","volume":"30","author":"Forte","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cels.2025.101198_bib47","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cels.2025.101198_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12260","article-title":"Genetic lineage tracing defines myofibroblast origin and function in the injured heart","volume":"7","author":"Kanisicak","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cels.2025.101198_bib49","article-title":"Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease","volume":"4","author":"Orrskog","year":"2012","journal-title":"mBio"},{"key":"10.1016\/j.cels.2025.101198_bib50","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1172\/JCI98215","article-title":"Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart","volume":"128","author":"Fu","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cels.2025.101198_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036814","article-title":"An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile","volume":"7","author":"Pinto","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cels.2025.101198_bib52","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1084\/jem.20140639","article-title":"Progressive replacement of embryo-derived cardiac macrophages with\u00a0age","volume":"211","author":"Molawi","year":"2014","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cels.2025.101198_bib53","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cels.2025.101198_bib54","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cels.2025.101198_bib55","series-title":"Handbook of Biomaterials Biocompatibility","first-page":"573","article-title":"Cardiac responses to biomaterials","author":"O\u2019Dwyer","year":"2020"},{"key":"10.1016\/j.cels.2025.101198_bib56","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.cels.2025.101198_bib57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1021\/acsbiomaterials.8b00252","article-title":"The Foreign Body Response Demystified","volume":"5","author":"Chandorkar","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.cels.2025.101198_bib58","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-immunol-032712-095937","article-title":"The Immunology of Fibrosis","volume":"31","author":"Wick","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cels.2025.101198_bib59","doi-asserted-by":"crossref","first-page":"16029","DOI":"10.1073\/pnas.1406508111","article-title":"Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart","volume":"111","author":"Lavine","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cels.2025.101198_bib60","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1172\/JCI72181","article-title":"Macrophages are required for neonatal heart regeneration","volume":"124","author":"Aurora","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cels.2025.101198_bib61","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41590-018-0272-2","article-title":"Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction","volume":"20","author":"Dick","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cels.2025.101198_bib62","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41586-022-05060-x","article-title":"Spatial multi-omic map of human myocardial infarction","volume":"608","author":"Kuppe","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cels.2025.101198_bib63","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jacc.2015.04.064","article-title":"Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation An Experimental Study in a Pre-Clinical Pig Model","volume":"66","author":"Hinkel","year":"2015","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.cels.2025.101198_bib64","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCULATIONAHA.119.045116","article-title":"Agrin Promotes Coordinated Therapeutic Processes Leading to Improved Cardiac Repair in Pigs","volume":"142","author":"Baehr","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.cels.2025.101198_bib65","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nmeth.3254","article-title":"Inferring biological tasks using Pareto analysis of high-dimensional data","volume":"12","author":"Hart","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cels.2025.101198_bib66","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cels.2025.101198_bib67","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abf7777","article-title":"Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles","volume":"7","author":"Dick","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cels.2025.101198_bib68","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cels.2025.101198_bib69","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrcardio.2017.57","article-title":"Redefining the identity of cardiac fibroblasts","volume":"14","author":"Tallquist","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cels.2025.101198_bib70","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.yjmcc.2016.05.002","article-title":"Molecular networks underlying myofibroblast fate and fibrosis","volume":"97","author":"Stempien-Otero","year":"2016","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.cels.2025.101198_bib71","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1038\/s41467-019-10859-w","article-title":"Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M","volume":"10","author":"Abe","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cels.2025.101198_bib72","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2045-3701-1-14","article-title":"Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production","volume":"1","author":"Wang","year":"2011","journal-title":"Cell Biosci."},{"key":"10.1016\/j.cels.2025.101198_bib73","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tcb.2018.08.006","article-title":"Recognizing the Molecular Multifunctionality and Interactome of TIMP-1","volume":"29","author":"Gr\u00fcnwald","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cels.2025.101198_bib74","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/1523-1747.ep12286457","article-title":"Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) May Be an Autocrine Growth Factor in Scleroderma Fibroblasts","volume":"108","author":"Kikuchi","year":"1997","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.cels.2025.101198_bib75","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1073\/pnas.1208863110","article-title":"Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family","volume":"110","author":"Porrello","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cels.2025.101198_bib76","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/s41556-024-01469-w","article-title":"LIANA+ provides an all-in-one framework for cell\u2013cell communication inference","volume":"26","author":"Dimitrov","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cels.2025.101198_bib77","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202206095","article-title":"TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a proinflammatory phenotype in human monocytes","volume":"222","author":"Eckfeld","year":"2023","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cels.2025.101198_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103839","article-title":"Low-Density Lipoprotein Receptor-Related Protein-1 Mediates Endocytic Clearance of Tissue Inhibitor of Metalloproteinases-1 and Promotes Its Cytokine-Like Activities","volume":"9","author":"Thevenard","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cels.2025.101198_bib79","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/CIRCULATIONAHA.118.038944","article-title":"Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program","volume":"140","author":"Van Duijvenboden","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.cels.2025.101198_bib80","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/s44161-022-00160-3","article-title":"Single-cell and spatial transcriptomics of the infarcted heart define the dynamic onset of the border zone in response to mechanical destabilization","volume":"1","author":"Calcagno","year":"2022","journal-title":"Nat CardioVasc Res"},{"key":"10.1016\/j.cels.2025.101198_bib81","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s44161-022-00140-7","article-title":"Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction","volume":"1","author":"Yamada","year":"2022","journal-title":"Nat CardioVasc Res"},{"key":"10.1016\/j.cels.2025.101198_bib82","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1158\/0008-5472.CAN-20-4125","article-title":"TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer","volume":"81","author":"Schoeps","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.cels.2025.101198_bib83","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2015.06.025","article-title":"Galectin-3 and post-myocardial infarction cardiac remodeling","volume":"763","author":"Meijers","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cels.2025.101198_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11897-010-0004-x","article-title":"Galectin-3 in Cardiac Remodeling and Heart Failure","volume":"7","author":"de Boer","year":"2010","journal-title":"Curr. Heart Fail. Rep."},{"key":"10.1016\/j.cels.2025.101198_bib85","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbamcr.2010.01.003","article-title":"The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity","volume":"1803","author":"Brew","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cels.2025.101198_bib86","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bbrc.2011.02.009","article-title":"Silencing tissue inhibitors of metalloproteinases (TIMPs) with short interfering RNA reveals a role for TIMP-1 in hepatic stellate cell proliferation","volume":"407","author":"Fowell","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cels.2025.101198_bib87","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/1523-1747.ep12483956","article-title":"Growth\u00a0Stimulation of Human Keratinocytes by Tissue Inhibitor of Metalloproteinases","volume":"97","author":"Bertaux","year":"1991","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.cels.2025.101198_bib88","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-5793(92)80015-9","article-title":"Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells A possible new growth factor in serum","volume":"298","author":"Hayakawa","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cels.2025.101198_bib89","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.ehj.2004.05.029","article-title":"Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study","volume":"25","author":"Sundstr\u00f6m","year":"2004","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cels.2025.101198_bib90","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/HYPERTENSIONAHA.117.09045","article-title":"Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63\u2013Integrin \u03b21 Interaction","volume":"69","author":"Takawale","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.cels.2025.101198_bib91","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.2353\/ajpath.2007.070179","article-title":"Amelioration of Coxsackievirus B3-Mediated Myocarditis by Inhibition of Tissue Inhibitors of Matrix Metalloproteinase-1","volume":"171","author":"Crocker","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cels.2025.101198_bib92","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/s44161-024-00493-1","article-title":"Egr1 regulates regenerative senescence and cardiac repair","volume":"3","author":"Zhang","year":"2024","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.cels.2025.101198_bib93","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add3949","article-title":"An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis","volume":"15","author":"Wang","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cels.2025.101198_bib94","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1053\/j.gastro.2016.07.043","article-title":"Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver","volume":"151","author":"Gr\u00fcnwald","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cels.2025.101198_bib95","article-title":"Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis","author":"Alexanian","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.cels.2025.101198_bib96","article-title":"Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis","author":"Lavine","year":"2023","journal-title":"Res. Sq."},{"key":"10.1016\/j.cels.2025.101198_bib97","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1038\/s41467-023-41518-w","article-title":"The tumor microenvironment shows a hierarchy of cell-cell interactions dominated by fibroblasts","volume":"14","author":"Mayer","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cels.2025.101198_bib98","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s43018-020-0082-y","article-title":"Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome","volume":"1","author":"Friedman","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cels.2025.101198_bib100","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cels.2025.101198_bib101","article-title":"Cell Detection with Star-convex Polygons","author":"Schmidt","year":"2018","journal-title":"arxiv"},{"key":"10.1016\/j.cels.2025.101198_bib102","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cels.2025.101198_bib116","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cels.2025.101198_bib117","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cels.2025.101198_bib118","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cels.2025.101198_bib104","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.cels.2025.101198_bib109","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cels.2025.101198_bib108","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cels.2025.101198_bib110","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cels.2025.101198_bib113","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/s41587-021-00875-x","article-title":"Bayesian inference of gene expression states from single-cell RNA-seq data","volume":"39","author":"Breda","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cels.2025.101198_bib99","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41556-022-00899-8","article-title":"Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors","volume":"24","author":"Poch","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cels.2025.101198_bib103","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s44161-023-00250-w","article-title":"Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury","volume":"2","author":"Shakked","year":"2023","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.cels.2025.101198_bib105","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41587-021-01139-4","article-title":"Cell2location maps fine-grained cell types in spatial transcriptomics","volume":"40","author":"Kleshchevnikov","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cels.2025.101198_bib106","article-title":"decoupleR: ensemble of computational methods to infer biological activities from omics data. Bioinform","volume":"2","author":"Badia-i-Mompel","year":"2022","journal-title":"Adv."},{"key":"10.1016\/j.cels.2025.101198_bib107","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"10.1016\/j.cels.2025.101198_bib111","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1093\/bioinformatics\/bts480","article-title":"Snakemake\u2014a scalable bioinformatics workflow engine","volume":"28","author":"K\u00f6ster","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cels.2025.101198_bib112","doi-asserted-by":"crossref","first-page":"18455","DOI":"10.1073\/pnas.1905824116","article-title":"Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling","volume":"116","author":"Wang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cels.2025.101198_bib114","doi-asserted-by":"crossref","first-page":"37237","DOI":"10.1038\/srep37237","article-title":"MathIOmica: An Integrative Platform for Dynamic Omics","volume":"6","author":"Mias","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cels.2025.101198_bib115","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature20123","article-title":"Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma","volume":"539","author":"Tirosh","year":"2016","journal-title":"Nature"}],"container-title":["Cell Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405471225000316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405471225000316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T08:47:44Z","timestamp":1742633264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405471225000316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":118,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2405471225000316"],"URL":"https:\/\/doi.org\/10.1016\/j.cels.2025.101198","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.01.01.522422","asserted-by":"object"}]},"ISSN":["2405-4712"],"issn-type":[{"value":"2405-4712","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cold and hot fibrosis define clinically distinct cardiac pathologies","name":"articletitle","label":"Article Title"},{"value":"Cell Systems","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cels.2025.101198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101198"}}