{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:06:25Z","timestamp":1789574785084,"version":"build-2803163510"},"reference-count":115,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,9,16]],"date-time":"2027-09-16T00:00:00Z","timestamp":1821052800000},"content-version":"am","delay-in-days":380,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023581","name":"National Science Foundation Graduate Research Fellowship Program","doi-asserted-by":"publisher","award":["DGE-2038238"],"award-info":[{"award-number":["DGE-2038238"]}],"id":[{"id":"10.13039\/100023581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006132","name":"US Department of Energy Office of Science","doi-asserted-by":"publisher","award":["DE-AC36-08GO28308"],"award-info":[{"award-number":["DE-AC36-08GO28308"]}],"id":[{"id":"10.13039\/100006132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM069811"],"award-info":[{"award-number":["R01GM069811"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20CC0035580"],"award-info":[{"award-number":["NNF20CC0035580"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Systems"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cels.2026.101702","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T19:30:13Z","timestamp":1787081413000},"page":"101702","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A diversified consortium of engineered biosensors enables multi-target quantification"],"prefix":"10.1016","volume":"17","author":[{"given":"Alyssa Jasmine","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Csicsery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"O\u2019Laughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Baumgart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Stasiowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuc","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Doughty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raegan","family":"Mink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina C.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ferry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Feist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Zengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-0473","authenticated-orcid":false,"given":"Jeff","family":"Hasty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cels.2026.101702_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.marpolbul.2019.02.004","article-title":"Spatiotemporal characterization of metals in small craft harbour sediments in Nova Scotia, Canada","volume":"140","author":"Zhang","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cels.2026.101702_bib2","article-title":"Heavy metal pollution in coastal wetlands: A systematic review of studies globally over the past three decades","volume":"424","author":"Li","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cels.2026.101702_bib3","series-title":"Heavy Metals in Scleractinian Corals","first-page":"1","article-title":"Heavy Metals in the Marine Environment\u2014An Overview","author":"Shah","year":"2021"},{"key":"10.1016\/j.cels.2026.101702_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2024.116707","article-title":"Understanding heavy metal toxicity: Implications on human health, marine ecosystems and bioremediation strategies","volume":"206","author":"Fulke","year":"2024","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cels.2026.101702_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2021.101653","article-title":"Health and environmental effects of heavy metals","volume":"34","author":"Zaynab","year":"2022","journal-title":"J. King Saud Univ. Sci."},{"key":"10.1016\/j.cels.2026.101702_bib6","series-title":"Heavy Metals-Their Environmental Impacts and Mitigation","first-page":"771","article-title":"Environmental pollution with heavy metals: A public health concern","author":"Ali","year":"2021"},{"key":"10.1016\/j.cels.2026.101702_bib7","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1073\/pnas.1913003117","article-title":"Genome-scale transcriptional dynamics and environmental biosensing","volume":"117","author":"Graham","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cels.2026.101702_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/bios11120500","article-title":"On demand biosensors for early diagnosis of cancer and immune checkpoints blockade therapy monitoring from liquid biopsy","volume":"11","author":"Mummareddy","year":"2021","journal-title":"Biosensors"},{"key":"10.1016\/j.cels.2026.101702_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-11051-9","article-title":"Detection of environmental pollutant cadmium in water using a visual bacterial biosensor","volume":"12","author":"Hui","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cels.2026.101702_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25538-y","article-title":"Programmable receptors enable bacterial biosensors to detect pathological biomarkers in clinical samples","volume":"12","author":"Chang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cels.2026.101702_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137306","article-title":"A novel biosensor-based method for the detection of p-nitrophenol in agricultural soil","volume":"313","author":"Ma","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.cels.2026.101702_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.aac.2022.08.002","article-title":"Biosensor for agriculture and food safety: Recent advances and future perspectives","volume":"1","author":"Wang","year":"2022","journal-title":"Adv. Agrochem."},{"key":"10.1016\/j.cels.2026.101702_bib13","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1462-2920.2004.00655.x","article-title":"Illuminating the detection chain of bacterial bioreporters","volume":"6","author":"Van Der Meer","year":"2004","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.cels.2026.101702_bib14","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1039\/D0AY01577F","article-title":"Review of the distribution and detection methods of heavy metals in the environment","volume":"12","author":"Jin","year":"2020","journal-title":"Anal. Methods"},{"key":"10.1016\/j.cels.2026.101702_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113359","article-title":"Microbial whole-cell biosensors: Current applications, challenges, and future perspectives","volume":"191","author":"Moraskie","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cels.2026.101702_bib16","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0925-4005(96)01906-5","article-title":"Whole cell biosensors","volume":"34","author":"Bousse","year":"1996","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.cels.2026.101702_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0956-5663(01)00125-7","article-title":"Microbial biosensors","volume":"16","author":"D\u2019Souza","year":"2001","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cels.2026.101702_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature18930","article-title":"Synchronized cycles of bacterial lysis for in vivo delivery","volume":"536","author":"Din","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cels.2026.101702_bib19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41551-021-00772-3","article-title":"Enhancing the tropism of bacteria via genetically programmed biosensors","volume":"6","author":"Chien","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.cels.2026.101702_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134341","article-title":"Removal of toxic heavy metals using genetically engineered microbes: Molecular tools, risk assessment and management strategies","volume":"298","author":"Saravanan","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.cels.2026.101702_bib21","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.adf3974","article-title":"Engineered bacteria detect tumor DNA","volume":"381","author":"Cooper","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.cels.2026.101702_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2021.107902","article-title":"Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment","volume":"55","author":"Qi","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.cels.2026.101702_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21716-0","article-title":"A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors","volume":"12","author":"Townshend","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cels.2026.101702_bib24","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1021\/acssynbio.0c00582","article-title":"Engineering alternate ligand recognition in the PurR topology: a system of novel caffeine biosensing transcriptional antirepressors","volume":"10","author":"Rondon","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.copbio.2021.01.008","article-title":"Transcription factor-based biosensors: a molecular-guided approach for natural product engineering","volume":"69","author":"Mitchler","year":"2021","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.cels.2026.101702_bib26","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1021\/acssynbio.0c00252","article-title":"Transcription-factor-based biosensor engineering for applications in synthetic biology","volume":"10","author":"Ding","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib27","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1039\/C9AN01998G","article-title":"Optical biosensors: An exhaustive and comprehensive review","volume":"145","author":"Chen","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.cels.2026.101702_bib28","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.aej.2022.12.040","article-title":"Optical biosensors: A decade in review","volume":"67","author":"Singh","year":"2023","journal-title":"Alex. Eng. J."},{"key":"10.1016\/j.cels.2026.101702_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2023.102380","article-title":"Design of synthetic bacterial biosensors","volume":"76","author":"Chiang","year":"2023","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.cels.2026.101702_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2016.00011","article-title":"Recent advances in biosensor technology for potential applications\u2013an overview","volume":"4","author":"Vigneshvar","year":"2016","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cels.2026.101702_bib31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/cphc.201900739","article-title":"Synthetic biology enables programmable cell-based biosensors","volume":"21","author":"Hicks","year":"2020","journal-title":"ChemPhysChem"},{"key":"10.1016\/j.cels.2026.101702_bib32","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1021\/cr990115p","article-title":"Genetically engineered whole-cell sensing systems: coupling biological recognition with reporter genes","volume":"100","author":"Daunert","year":"2000","journal-title":"Chem. Rev."},{"key":"10.1016\/j.cels.2026.101702_bib33","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nrmicro2392","article-title":"Where microbiology meets microengineering: design and applications of reporter bacteria","volume":"8","author":"Van Der Meer","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cels.2026.101702_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.799781","article-title":"Highly sensitive whole-cell biosensor for cadmium detection based on a negative feedback circuit","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cels.2026.101702_bib35","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1021\/acssensors.3c01811","article-title":"Development of a Highly Sensitive, Visual Platform for the Detection of Cadmium in Actual Wastewater Based on Evolved Whole-Cell Biosensors","volume":"9","author":"Shen","year":"2024","journal-title":"ACS Sens."},{"key":"10.1016\/j.cels.2026.101702_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10534-004-5787-3","article-title":"Biosensors for heavy metals","volume":"18","author":"Verma","year":"2005","journal-title":"Biometals"},{"key":"10.1016\/j.cels.2026.101702_bib37","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cels.2021.10.006","article-title":"Engineering ligand-specific biosensors for aromatic amino acids and neurochemicals","volume":"13","author":"Rottinghaus","year":"2022","journal-title":"Cell Syst."},{"key":"10.1016\/j.cels.2026.101702_bib38","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1021\/acssensors.1c00329","article-title":"Tunable multiplexed whole-cell biosensors as environmental diagnostics for ppb-level detection of aromatic pollutants","volume":"6","author":"Roy","year":"2021","journal-title":"ACS Sens."},{"key":"10.1016\/j.cels.2026.101702_bib39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1021\/acssynbio.0c00491","article-title":"A whole-cell biosensor for point-of-care detection of waterborne bacterial pathogens","volume":"10","author":"Wu","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nmeth.3696","article-title":"Engineering an allosteric transcription factor to respond to new ligands","volume":"13","author":"Taylor","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cels.2026.101702_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkz954","article-title":"Evolution-guided engineering of small-molecule biosensors","volume":"48","author":"Snoek","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cels.2026.101702_bib42","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.csbj.2024.05.002","article-title":"Computation-guided transcription factor biosensor specificity engineering for adipic acid detection","volume":"23","author":"Pham","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.cels.2026.101702_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-024-05849-8","article-title":"Snowprint: a predictive tool for genetic biosensor discovery","volume":"7","author":"d\u2019Oelsnitz","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib44","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1021\/acssynbio.1c00316","article-title":"Evolving small-molecule biosensors with improved performance and reprogrammed ligand preference using OrthoRep","volume":"10","author":"Javanpour","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biotno.2020.01.002","article-title":"Directed evolution of VanR biosensor specificity in yeast","volume":"1","author":"D\u2019Ambrosio","year":"2020","journal-title":"Biotechnology notes"},{"key":"10.1016\/j.cels.2026.101702_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.108019","article-title":"Engineering whole-cell microbial biosensors: Design principles and applications in monitoring and treatment of heavy metals and organic pollutants","volume":"60","author":"Liu","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.cels.2026.101702_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/anse.202200095","article-title":"Pushing Differential Sensing Further: The Next Steps in Design and Analysis of Bio-Inspired Cross-Reactive Arrays","volume":"3","author":"Fargher","year":"2023","journal-title":"Analysis & Sensing"},{"key":"10.1016\/j.cels.2026.101702_bib48","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1021\/sb500286r","article-title":"Environmental sensing of heavy metals through whole cell microbial biosensors: a synthetic biology approach","volume":"4","author":"Bereza-Malcolm","year":"2015","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib49","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1007\/s12010-021-03734-2","article-title":"Engineered whole-cell-based biosensors: sensing environmental heavy metal pollutants in water\u2014a review","volume":"194","author":"Kannappan","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.cels.2026.101702_bib50","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1021\/acssynbio.9b00149","article-title":"Displaced by deceivers: prevention of biosensor cross-talk is pivotal for successful biosensor-based high-throughput screening campaigns","volume":"8","author":"Flachbart","year":"2019","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib51","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.1007\/s00216-015-8830-z","article-title":"Detection of bioavailable cadmium, lead, and arsenic in polluted soil by tailored multiple Escherichia coli whole-cell sensor set","volume":"407","author":"Hou","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.cels.2026.101702_bib52","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6750-9-41","article-title":"A suite of recombinant luminescent bacterial strains for the quantification of bioavailable heavy metals and toxicity testing","volume":"9","author":"Ivask","year":"2009","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.cels.2026.101702_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2022.102880","article-title":"Stability, robustness, and containment: preparing synthetic biology for real-world deployment","volume":"79","author":"Kumar","year":"2023","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.cels.2026.101702_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10071385","article-title":"Bacterial stress responses as potential targets in overcoming antibiotic resistance","volume":"10","author":"Dawan","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.cels.2026.101702_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112670","article-title":"Machine learning linked evolutionary biosensor array for highly sensitive and specific molecular identification","volume":"170","author":"Kim","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cels.2026.101702_bib56","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1021\/acssensors.9b01227","article-title":"Machine learning-assisted array-based biomolecular sensing using surface-functionalized carbon dots","volume":"4","author":"Pandit","year":"2019","journal-title":"ACS Sens."},{"key":"10.1016\/j.cels.2026.101702_bib57","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1016\/S0043-1354(97)00169-3","article-title":"A panel of stress-responsive luminous bacteria for the detection of selected classes of toxicants","volume":"31","author":"Belkin","year":"1997","journal-title":"Water Res."},{"key":"10.1016\/j.cels.2026.101702_bib58","doi-asserted-by":"crossref","DOI":"10.1007\/s40820-021-00610-w","article-title":"Sniffing bacteria with a carbon-dot artificial nose","volume":"13","author":"Shauloff","year":"2021","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.cels.2026.101702_bib59","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jfca.2018.09.014","article-title":"Rapid sensing of total theaflavins content in black tea using a portable electronic tongue system coupled to efficient variables selection algorithms","volume":"75","author":"Ouyang","year":"2019","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.cels.2026.101702_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41522-023-00424-1","article-title":"A three-colour stress biosensor reveals multimodal response in single cells and spatiotemporal dynamics of biofilms","volume":"9","author":"Zoheir","year":"2023","journal-title":"npj Biofilms Microbiomes"},{"key":"10.1016\/j.cels.2026.101702_bib61","doi-asserted-by":"crossref","first-page":"8557","DOI":"10.1021\/ac071311w","article-title":"Versatile, fully automated, microfluidic cell culture system","volume":"79","author":"G\u00f3mez-Sj\u00f6berg","year":"2007","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cels.2026.101702_bib62","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1128\/jb.177.8.2050-2056.1995","article-title":"An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteria","volume":"177","author":"Diorio","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cels.2026.101702_bib63","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1128\/jb.177.15.4437-4441.1995","article-title":"CadC, the transcriptional regulatory protein of the cadmium resistance system of Staphylococcus aureus plasmid pI258","volume":"177","author":"Endo","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cels.2026.101702_bib64","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1128\/jb.174.7.2160-2171.1992","article-title":"Genetic analysis of the Tn21 mer operator-promoter","volume":"174","author":"Park","year":"1992","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cels.2026.101702_bib65","doi-asserted-by":"crossref","first-page":"5864","DOI":"10.1128\/JB.182.20.5864-5871.2000","article-title":"Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12","volume":"182","author":"Munson","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cels.2026.101702_bib66","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/jmbi.2000.4451","article-title":"The hydH\/G genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system","volume":"307","author":"Leonhartsberger","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib67","doi-asserted-by":"crossref","first-page":"14326","DOI":"10.1073\/pnas.94.26.14326","article-title":"The zntA gene of Escherichia coli encodes a Zn (II)-translocating P-type ATPase","volume":"94","author":"Rensing","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cels.2026.101702_bib68","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1021\/acssensors.0c00855","article-title":"Bioluminescence-triggered photoswitchable bacterial adhesions enable higher sensitivity and dual-readout bacterial biosensors for mercury","volume":"5","author":"Chen","year":"2020","journal-title":"ACS Sens."},{"key":"10.1016\/j.cels.2026.101702_bib69","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/s41587-020-0571-7","article-title":"Cell-free biosensors for rapid detection of water contaminants","volume":"38","author":"Jung","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cels.2026.101702_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210940","article-title":"A paper-based, cell-free biosensor system for the detection of heavy metals and date rape drugs","volume":"14","author":"Gr\u00e4we","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.cels.2026.101702_bib71","article-title":"Fabrication of microfluidic devices for continuously monitoring yeast aging","volume":"13","author":"O\u2019Laughlin","year":"2023","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.cels.2026.101702_bib72","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/B978-0-12-385075-1.00014-7","article-title":"Microfluidics for synthetic biology: from design to execution","volume":"497","author":"Ferry","year":"2011"},{"key":"10.1016\/j.cels.2026.101702_bib73","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz8344","article-title":"Interfacing gene circuits with microelectronics through engineered population dynamics","volume":"6","author":"Din","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cels.2026.101702_bib74","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.cels.2022.02.005","article-title":"Design, mutate, screen: multiplexed creation and arrayed screening of synchronized genetic clocks","volume":"13","author":"Lezia","year":"2022","journal-title":"Cell Syst."},{"key":"10.1016\/j.cels.2026.101702_bib75","article-title":"A Microfluidic Platform for Screening Gene Expression Dynamics across Yeast Strain Libraries","volume":"13","author":"Stasiowski","year":"2023","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.cels.2026.101702_bib76","series-title":"Microfluidic technologies for investigating dynamics-based regulation in S. cerevisiae","author":"O\u2019Laughlin","year":"2020"},{"key":"10.1016\/j.cels.2026.101702_bib77","article-title":"Ultra-multiplexed analysis of single-cell dynamics reveals logic rules in differentiation","volume":"5","author":"Zhang","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cels.2026.101702_bib78","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15056-8","article-title":"Inducible cell-to-cell signaling for tunable dynamics in microbial communities","volume":"11","author":"Miano","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cels.2026.101702_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2017.00044","article-title":"Limitations of sulforhodamine 101 for brain imaging","volume":"11","author":"H\u00fclsmann","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.cels.2026.101702_bib80","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1074\/jbc.275.6.3873","article-title":"The ATP hydrolytic activity of purified ZntA, a Pb (II)\/Cd (II)\/Zn (II)-translocating ATPase from Escherichia coli","volume":"275","author":"Sharma","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cels.2026.101702_bib81","first-page":"51","article-title":"Effect of salt concentrations on the growth of heat-stressed and unstressed Escherichia coli","volume":"7","author":"Abdulkarim","year":"2009","journal-title":"J. Food Agric. Environ."},{"key":"10.1016\/j.cels.2026.101702_bib82","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1021\/acssynbio.2c00079","article-title":"A framework for the systematic selection of biosensor chassis for environmental synthetic biology","volume":"11","author":"Sridhar","year":"2022","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib83","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1021\/acssynbio.6b00256","article-title":"The next generation of synthetic biology chassis: moving synthetic biology from the laboratory to the field","volume":"5","author":"Adams","year":"2016","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib84","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8832","article-title":"A portable expression resource for engineering cross-species genetic circuits and pathways","volume":"6","author":"Kushwaha","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cels.2026.101702_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2021.107795","article-title":"Adaptive laboratory evolution principles and applications in industrial biotechnology","volume":"54","author":"Mavrommati","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.cels.2026.101702_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymben.2019.08.004","article-title":"The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology","volume":"56","author":"Sandberg","year":"2019","journal-title":"Metab. Eng."},{"key":"10.1016\/j.cels.2026.101702_bib87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1128\/AEM.02246-14","article-title":"Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium","volume":"81","author":"LaCroix","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cels.2026.101702_bib88","doi-asserted-by":"crossref","DOI":"10.1186\/s12934-019-1165-2","article-title":"Generation of an E. coli platform strain for improved sucrose utilization using adaptive laboratory evolution","volume":"18","author":"Mohamed","year":"2019","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.cels.2026.101702_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13068-020-01825-6","article-title":"Evolutionary engineering of E. coli MG1655 for tolerance against isoprenol","volume":"13","author":"Babel","year":"2020","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.cels.2026.101702_bib90","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1134\/S1022795410030075","article-title":"Construction of the new Escherichia coli K-12 MG 1655 novel strain with improved growth characteristics for application in metabolic engineering","volume":"46","author":"Biryukova","year":"2010","journal-title":"Russ. J. Genet."},{"key":"10.1016\/j.cels.2026.101702_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114296","article-title":"Progress of engineered bacteria for tumor therapy","volume":"185","author":"Fan","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.cels.2026.101702_bib92","doi-asserted-by":"crossref","first-page":"14698","DOI":"10.1073\/pnas.1902217116","article-title":"Predicting microbial relative growth in a mixed culture from growth curve data","volume":"116","author":"Ram","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cels.2026.101702_bib93","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00697-18","article-title":"Lag phase is a dynamic, organized, adaptive, and evolvable period that prepares bacteria for cell division","volume":"201","author":"Bertrand","year":"2019","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cels.2026.101702_bib115","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/2041-210X.14269","article-title":"Microbial lag calculator: a shiny-based application and an R package for calculating the duration of microbial lag phase","volume":"15","author":"Smug","year":"2024","journal-title":"Methods Ecol. Evol."},{"key":"10.1016\/j.cels.2026.101702_bib94","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1128\/jb.175.11.3401-3407.1993","article-title":"The Escherichia coli K-12 \u2018wild types\u2019 W3110 and MG1655 have an rph frameshift mutation that leads to pyrimidine starvation due to low pyrE expression levels","volume":"175","author":"Jensen","year":"1993","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cels.2026.101702_bib95","doi-asserted-by":"crossref","first-page":"9316","DOI":"10.1016\/S0021-9258(18)67656-2","article-title":"Regulation of the ompC gene of Escherichia coli. Involvement of three tandem promoters","volume":"261","author":"Ikenaka","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cels.2026.101702_bib96","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0378-1119(90)90057-X","article-title":"Outer-membrane PhoE protein of Escherichia coli K-12 as an exposure vector: possibilities and limitations","volume":"88","author":"Agterberg","year":"1990","journal-title":"Gene"},{"key":"10.1016\/j.cels.2026.101702_bib97","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.csbj.2021.01.030","article-title":"Stressed out: Bacterial response to high salinity using compatible solute biosynthesis and uptake systems, lessons from Vibrionaceae","volume":"19","author":"Gregory","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.cels.2026.101702_bib98","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003617","article-title":"Bacterial adaptation through loss of function","volume":"9","author":"Hottes","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cels.2026.101702_bib99","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1128\/AEM.01542-14","article-title":"Combinatorial strategies for improving multiple-stress resistance in industrially relevant Escherichia coli strains","volume":"80","author":"Lennen","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cels.2026.101702_bib100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ymben.2023.01.012","article-title":"Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals","volume":"76","author":"Lennen","year":"2023","journal-title":"Metab. Eng."},{"key":"10.1016\/j.cels.2026.101702_bib101","doi-asserted-by":"crossref","DOI":"10.3390\/batteries7020036","article-title":"Determination of the distribution of relaxation times by means of pulse evaluation for offline and online diagnosis of lithium-ion batteries","volume":"7","author":"Goldammer","year":"2021","journal-title":"Batteries"},{"key":"10.1016\/j.cels.2026.101702_bib102","doi-asserted-by":"crossref","DOI":"10.1007\/s13205-017-0613-0","article-title":"Analysis of znt A gene in environmental Escherichia coli and additional implications on its role in zinc translocation","volume":"7","author":"Vidhyaparkavi","year":"2017","journal-title":"3 Biotech."},{"key":"10.1016\/j.cels.2026.101702_bib103","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1046\/j.1365-2958.1999.01229.x","article-title":"ZntR is a Zn(II)-responsive MerR-like transcriptional regulator of zntA in Escherichia coli","volume":"31","author":"Brocklehurst","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.cels.2026.101702_bib104","first-page":"2825","article-title":"Scikit-learn: Machine Learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"10.1016\/j.cels.2026.101702_bib105","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.tig.2020.03.005","article-title":"Opening the black box: interpretable machine learning for geneticists","volume":"36","author":"Azodi","year":"2020","journal-title":"Trends Genet."},{"key":"10.1016\/j.cels.2026.101702_bib106","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1021\/acssynbio.7b00088","article-title":"A microfluidic biodisplay","volume":"6","author":"Volpetti","year":"2017","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib107","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1039\/C2MB25483B","article-title":"Building synthetic gene circuits from combinatorial libraries: screening and selection strategies","volume":"9","author":"Schaerli","year":"2013","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.cels.2026.101702_bib108","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41586-019-1321-1","article-title":"A universal biomolecular integral feedback controller for robust perfect adaptation","volume":"570","author":"Aoki","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cels.2026.101702_bib109","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1021\/acssynbio.7b00463","article-title":"Plug-and-play multicellular circuits with time-dependent dynamic responses","volume":"7","author":"Urrios","year":"2018","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib110","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1073\/pnas.1716920115","article-title":"Layered dynamic regulation for improving metabolic pathway productivity in Escherichia coli","volume":"115","author":"Doong","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cels.2026.101702_bib111","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20188605","article-title":"Dynamic control of endogenous metabolism with combinatorial logic circuits","volume":"14","author":"Moser","year":"2018","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.cels.2026.101702_bib112","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF01569936","article-title":"Interaction of lead nitrate and cadmium chloride with Escherichia coli K-12 and Salmonella typhimurium global regulatory mutants","volume":"14","author":"LaRossa","year":"1995","journal-title":"J. Ind. Microbiol."},{"key":"10.1016\/j.cels.2026.101702_bib113","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature10722","article-title":"A sensing array of radically coupled genetic \u2018biopixels\u2019","volume":"481","author":"Prindle","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cels.2026.101702_bib114","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405471226001845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405471226001845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:15:41Z","timestamp":1789571741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405471226001845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":115,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2405471226001845"],"URL":"https:\/\/doi.org\/10.1016\/j.cels.2026.101702","relation":{},"ISSN":["2405-4712"],"issn-type":[{"value":"2405-4712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A diversified consortium of engineered biosensors enables multi-target quantification","name":"articletitle","label":"Article Title"},{"value":"Cell Systems","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cels.2026.101702","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101702"}}