{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:50:01Z","timestamp":1793307001531,"version":"4.5.0"},"reference-count":127,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T00:00:00Z","timestamp":1680912000000},"content-version":"am","delay-in-days":342,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","geriatric.theclinics.com","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Geriatric Medicine"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.cger.2021.11.013","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T16:05:36Z","timestamp":1649433936000},"page":"221-238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":150,"title":["The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain"],"prefix":"10.1016","volume":"38","author":[{"given":"Matthew J.","family":"Wood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Malfait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"36","key":"10.1016\/j.cger.2021.11.013_bib1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.15585\/mmwr.mm6736a2","article-title":"Prevalence of chronic pain and high-impact chronic pain among adults \u2014 United States, 2016","volume":"67","author":"Dahlhamer","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"8","key":"10.1016\/j.cger.2021.11.013_bib2","first-page":"715","article-title":"The economic costs of pain in the United States","volume":"13","author":"Gaskin","year":"2012","journal-title":"J\u00a0Pain"},{"issue":"12","key":"10.1016\/j.cger.2021.11.013_bib3","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/acr.22897","article-title":"Number of Persons with symptomatic knee osteoarthritis in the US: impact of Race and Ethnicity, age, sex, and obesity","volume":"68","author":"Deshpande","year":"2016","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.cger.2021.11.013_bib4","unstructured":"United States Bone and Joint Initiative. The burden of musculoskeletal diseases in the United States (BMUS). Fourth Edition."},{"issue":"10258","key":"10.1016\/j.cger.2021.11.013_bib5","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Vos","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.cger.2021.11.013_bib6","article-title":"Epidemiology of osteoarthritis","author":"Allen","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.cger.2021.11.013_bib7","doi-asserted-by":"crossref","first-page":"819 LP","DOI":"10.1136\/annrheumdis-2019-216515","article-title":"Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017","volume":"79","author":"Safiri","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cger.2021.11.013_bib8","unstructured":"Osteoarthritis: A Serious Disease. Pre Compet Consort Osteoarthr Osteoarthr Res Soc Int. Published online 2016.Available at: https:\/\/oarsi.org\/education\/oarsi-resources\/oarsi-white-paper-oa-serious-disease (White Paper submitted to the FDA)."},{"issue":"3","key":"10.1016\/j.cger.2021.11.013_bib9","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/art.20390","article-title":"Health-related quality of life and health service use among older adults with osteoarthritis","volume":"51","author":"Dominick","year":"2004","journal-title":"Arthritis Care Res"},{"issue":"9","key":"10.1016\/j.cger.2021.11.013_bib10","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.joca.2011.06.003","article-title":"Riddle, Xiangrong Kong GKF. Psychological health impact on two-year changes in pain and function in Persons with knee pain: Data from the osteoarthritis initiative","volume":"19","author":"Daniel","year":"2011","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"10.1016\/j.cger.2021.11.013_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/ggi.13879","article-title":"Knee osteoarthritis and its association with mental health and health-related quality of life: a nationwide cross-sectional study","volume":"20","author":"Park","year":"2020","journal-title":"Geriatr Gerontol Int"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/acr.23239","article-title":"Dynamic effects of depressive symptoms on osteoarthritis knee pain","volume":"70","author":"Rathbun","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"7719","key":"10.1016\/j.cger.2021.11.013_bib13","first-page":"498","article-title":"Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies","volume":"339","author":"Neogi","year":"2009","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.cger.2021.11.013_bib14","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/annrheumdis-2020-217363","article-title":"Does cartilage loss cause pain in osteoarthritis and if so, how much?","volume":"79","author":"Bacon","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib15","first-page":"1","article-title":"Radiographic knee osteoarthritis and knee pain: cross-sectional study from five different Racial\/Ethnic populations","volume":"8","author":"Wang","year":"2018","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s11914-018-0477-1","article-title":"Mechanisms of osteoarthritis (OA) pain","volume":"16","author":"O\u2019Neill","year":"2018","journal-title":"Curr Osteoporos Rep"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib17","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/acr.22734","article-title":"Determination of pain phenotypes in knee osteoarthritis: a latent class Analysis using Data from the osteoarthritis initiative","volume":"68","author":"Kittelson","year":"2017","journal-title":"Arthritis Care Res"},{"issue":"11","key":"10.1016\/j.cger.2021.11.013_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0079988","article-title":"\u201cLet\u2019s talk about OA pain\u201d: a qualitative analysis of the perceptions of people suffering from OA. Towards the development of a specific pain OA-related questionnaire, the Osteoarthritis Symptom Inventory Scale (OASIS)","volume":"8","author":"Cedraschi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cger.2021.11.013_bib19","doi-asserted-by":"crossref","DOI":"10.1097\/j.pain.0000000000001923","article-title":"Peripheral pain mechanisms in osteoarthritis","volume":"161","author":"Vincent","year":"2020","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.cger.2021.11.013_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.rdc.2020.12.002","article-title":"Basic mechanisms of pain in osteoarthritis: experimental Observations and new Perspectives","volume":"47","author":"Malfait","year":"2021","journal-title":"Rheum Dis Clin North Am"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib21","first-page":"S79","article-title":"The role of centralised pain in osteoarthritis","volume":"35","author":"Clauw","year":"2017","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib22","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.joca.2019.11.006","article-title":"The innate immune response as a mediator of osteoarthritis pain","volume":"28","author":"Miller","year":"2020","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib23","first-page":"S75","article-title":"Structural correlates of pain in osteoarthritis","volume":"35","author":"Neogi","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.cger.2021.11.013_bib24","first-page":"57","article-title":"Innate inflammation and synovial macrophages in osteoarthritis pathophysiology","volume":"37","author":"Griffin","year":"2019","journal-title":"Clin Exp Rheumatol"},{"issue":"11","key":"10.1016\/j.cger.2021.11.013_bib25","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"15","key":"10.1016\/j.cger.2021.11.013_bib26","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1056\/NEJMoa1905877","article-title":"Physical Therapy versus Glucocorticoid injection for osteoarthritis of the knee","volume":"382","author":"Deyle","year":"2020","journal-title":"N\u00a0Engl J Med"},{"issue":"19","key":"10.1016\/j.cger.2021.11.013_bib27","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1001\/jama.2017.5283","article-title":"Effect of intra-articular Triamcinolone vs Saline on knee cartilage Volume and pain in patients with knee osteoarthritis: a randomized clinical trial","volume":"317","author":"McAlindon","year":"2017","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.cger.2021.11.013_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-cellbio-101011-155833","article-title":"TRP channels and pain","volume":"29","author":"Julius","year":"2013","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.cger.2021.11.013_bib30","first-page":"40","article-title":"An overview of pathways encoding nociception","volume":"35","author":"Woller","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.cger.2021.11.013_bib31","article-title":"Quantitative sensory testing: identifying pain characteristics in patients with osteoarthritis","author":"Arant","year":"2021","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.berh.2018.03.003","article-title":"Osteoarthritis pain: what are we learning from animal models?","volume":"31","author":"Miller","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.cger.2021.11.013_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2021.10.001","article-title":"Can we prevent chronic osteoarthritis pain? A view from the bench","author":"Miller","year":"2021","journal-title":"Osteoarthr Cartil Published Online"},{"key":"10.1016\/j.cger.2021.11.013_bib34","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/978-3-540-79090-7_12","article-title":"Cytokine and chemokine regulation of sensory neuron function","volume":"194","author":"Miller","year":"2009","journal-title":"Handb Exp Pharmacol"},{"issue":"4","key":"10.1016\/j.cger.2021.11.013_bib35","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/jor.23471","article-title":"Chemokines and inflammation in osteoarthritis: insights from patients and animal models","volume":"35","author":"Scanzello","year":"2017","journal-title":"J\u00a0Orthop Res"},{"issue":"3","key":"10.1016\/j.cger.2021.11.013_bib36","first-page":"662","article-title":"Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain","volume":"59","author":"Chakrabarti","year":"2020","journal-title":"Rheumatology"},{"issue":"9","key":"10.1016\/j.cger.2021.11.013_bib37","article-title":"Synovial cytokines significantly correlate with osteoarthritis-related knee pain and disability: inflammatory mediators of potential clinical Relevance","volume":"8","author":"Nees","year":"2019","journal-title":"J\u00a0Clin Med"},{"issue":"10","key":"10.1016\/j.cger.2021.11.013_bib38","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/rheumatology\/key131","article-title":"Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials","volume":"57","author":"Persson","year":"2018","journal-title":"Rheumatology"},{"issue":"12","key":"10.1016\/j.cger.2021.11.013_bib39","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1002\/art.37695","article-title":"Interleukin-17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin-17 receptors in rodents","volume":"64","author":"Richter","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib40","doi-asserted-by":"crossref","first-page":"10334","DOI":"10.1038\/s41598-017-10509-5","article-title":"Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis","volume":"7","author":"Ebbinghaus","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.cger.2021.11.013_bib41","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3389\/fimmu.2020.00730","article-title":"Interleukin-1-Interleukin-17 signaling Axis induces cartilage Destruction and promotes experimental osteoarthritis","volume":"11","author":"Na","year":"2020","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.cger.2021.11.013_bib42","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nri.2016.95","article-title":"Interleukin-33 in health and disease","volume":"16","author":"Liew","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"10.1016\/j.cger.2021.11.013_bib43","doi-asserted-by":"crossref","first-page":"e1185","DOI":"10.1002\/cti2.1187","article-title":"Blockade of IL-33 signalling attenuates osteoarthritis","volume":"9","author":"He","year":"2020","journal-title":"Clin Transl Immunol"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib44","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13075-019-1923-x","article-title":"Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation","volume":"21","author":"Haraden","year":"2019","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.cger.2021.11.013_bib45","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/0004563214545117","article-title":"Serum and synovial fluid chemokine ligand 2\/monocyte chemoattractant protein 1 concentrations correlates with symptomatic severity in patients with knee osteoarthritis","volume":"52","author":"Li","year":"2014","journal-title":"Ann Clin Biochem"},{"issue":"6","key":"10.1016\/j.cger.2021.11.013_bib46","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.joca.2017.01.019","article-title":"Can we target CCR2 to treat osteoarthritis? The trick is in the timing","volume":"25","author":"Miller","year":"2017","journal-title":"Osteoarthr Cartil"},{"issue":"50","key":"10.1016\/j.cger.2021.11.013_bib47","doi-asserted-by":"crossref","first-page":"20602","DOI":"10.1073\/pnas.1209294110","article-title":"CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis","volume":"109","author":"Miller","year":"2012","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"3","key":"10.1016\/j.cger.2021.11.013_bib48","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.joca.2016.10.008","article-title":"CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy","volume":"25","author":"Miotla Zarebska","year":"2017","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13075-021-02486-y","article-title":"The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice","volume":"23","author":"Ishihara","year":"2021","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.cger.2021.11.013_bib50","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.joca.2020.10.008","article-title":"NF-\u03baB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis","volume":"29","author":"Berke","year":"2021","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"10.1016\/j.cger.2021.11.013_bib51","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.rdc.2020.12.003","article-title":"Targeting nerve growth factor for pain management in osteoarthritis\u2014clinical Efficacy and Safety","volume":"47","author":"Dietz","year":"2021","journal-title":"Rheum Dis Clin North Am"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib52","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41584-020-00528-4","article-title":"The evolution of nerve growth factor inhibition in clinical medicine","volume":"17","author":"Wise","year":"2021","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"10.1016\/j.cger.2021.11.013_bib53","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tips.2005.12.001","article-title":"Novel class of pain drugs based on antagonism of NGF","volume":"27","author":"Hefti","year":"2006","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"10.1016\/j.cger.2021.11.013_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.pain.2009.11.022","article-title":"NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin","volume":"148","author":"Rukwied","year":"2010","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.cger.2021.11.013_bib55","first-page":"789","article-title":"Differential time course of NGF-induced hyperalgesia to heat versus mechanical and electrical stimulation in human skin","volume":"19","author":"Weinkauf","year":"2015","journal-title":"Eur J Pain (United Kingdom)"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib56","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/papr.12267","article-title":"Intradermal injection with nerve growth factor: a Reproducible model to induce experimental allodynia and hyperalgesia","volume":"16","author":"Andresen","year":"2016","journal-title":"Pain Pract"},{"issue":"9","key":"10.1016\/j.cger.2021.11.013_bib57","doi-asserted-by":"crossref","first-page":"1710 LP","DOI":"10.1136\/annrheumdis-2013-203416","article-title":"Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis","volume":"73","author":"Ashraf","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev-neuro-072116-031121","article-title":"Nerve growth factor and pain mechanisms","volume":"40","author":"Denk","year":"2017","journal-title":"Annu Rev Neurosci"},{"issue":"11","key":"10.1016\/j.cger.2021.11.013_bib59","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/ard.2006.063354","article-title":"Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis","volume":"66","author":"Suri","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.cger.2021.11.013_bib60","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.joca.2013.06.031","article-title":"Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis","volume":"21","author":"Mapp","year":"2013","journal-title":"Osteoarthr Cartil"},{"issue":"9","key":"10.1016\/j.cger.2021.11.013_bib61","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.joca.2020.05.010","article-title":"Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats","volume":"28","author":"Aso","year":"2020","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"10.1016\/j.cger.2021.11.013_bib62","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.joca.2019.07.012","article-title":"The nociceptive innervation of the normal and osteoarthritic mouse knee","volume":"27","author":"Obeidat","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.cger.2021.11.013_bib63","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1172\/JCI121561","article-title":"Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain","volume":"129","author":"Zhu","year":"2019","journal-title":"J\u00a0Clin Invest"},{"issue":"12","key":"10.1016\/j.cger.2021.11.013_bib64","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/rheumatology\/41.12.1413","article-title":"Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes","volume":"41","author":"Iannone","year":"2002","journal-title":"Rheumatology"},{"issue":"4","key":"10.1016\/j.cger.2021.11.013_bib65","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/art.39523","article-title":"Nociceptive Sensitizers are regulated in damaged joint tissues, including articular cartilage, when osteoarthritic mice Display pain behavior","volume":"68","author":"Driscoll","year":"2016","journal-title":"Arthritis Rheumatol (Hoboken, Nj)"},{"issue":"11","key":"10.1016\/j.cger.2021.11.013_bib66","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1002\/art.38778","article-title":"Structural associations of symptomatic knee osteoarthritis","volume":"66","author":"Stoppiello","year":"2014","journal-title":"Arthritis Rheumatol (Hoboken, Nj)"},{"issue":"6","key":"10.1016\/j.cger.2021.11.013_bib67","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/art.40820","article-title":"Associations of symptomatic knee osteoarthritis with Histopathologic features in subchondral bone","volume":"71","author":"Aso","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib68","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.joca.2020.01.016","article-title":"Identifying effector molecules, cells, and cytokines of innate immunity in OA","volume":"28","author":"van den Bosch","year":"2020","journal-title":"Osteoarthr Cartil"},{"issue":"10","key":"10.1016\/j.cger.2021.11.013_bib69","doi-asserted-by":"crossref","first-page":"1804 LP","DOI":"10.1136\/ard.2011.150243","article-title":"Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study","volume":"70","author":"Roemer","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.cger.2021.11.013_bib70","doi-asserted-by":"crossref","first-page":"1263 LP","DOI":"10.1136\/ard.2004.025270","article-title":"Synovial tissue inflammation in early and late osteoarthritis","volume":"64","author":"Benito","year":"2005","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.cger.2021.11.013_bib71","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1136\/ard.2009.121426","article-title":"Relation of synovitis to knee pain using contrast-enhanced MRIs","volume":"69","author":"Baker","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.cger.2021.11.013_bib72","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.39488","article-title":"Association of joint inflammation with pain sensitization in knee osteoarthritis: the Multicenter osteoarthritis study","volume":"68","author":"Neogi","year":"2016","journal-title":"Arthritis Rheumatol (Hoboken, Nj)"},{"issue":"3","key":"10.1016\/j.cger.2021.11.013_bib73","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/art.38965","article-title":"Association of pain in knee osteoarthritis with distinct patterns of synovitis","volume":"67","author":"de Lange-Brokaar","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib74","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","article-title":"Synovitis in osteoarthritis: current understanding with therapeutic implications","volume":"19","author":"Mathiessen","year":"2017","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"10.1016\/j.cger.2021.11.013_bib75","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.joca.2016.04.010","article-title":"Direct in\u00a0vivo evidence of activated macrophages in human osteoarthritis","volume":"24","author":"Kraus","year":"2016","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"10.1016\/j.cger.2021.11.013_bib76","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10067-019-04768-y","article-title":"Alterations in peripheral T\u00a0cell and B cell subsets in patients with osteoarthritis","volume":"39","author":"Zhu","year":"2020","journal-title":"Clin Rheumatol"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib77","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13075-020-02410-w","article-title":"Proinflammatory T\u00a0cell polarization is already present in patients with early knee osteoarthritis","volume":"23","author":"Rosshirt","year":"2021","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"10.1016\/j.cger.2021.11.013_bib78","first-page":"2423","article-title":"T\u00a0helper cell infiltration in osteoarthritis-related knee pain and disability","volume":"9","author":"Nees","year":"2020","journal-title":"J\u00a0Clin Med"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib79","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.joca.2017.08.006","article-title":"Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model","volume":"26","author":"Sousa-Valente","year":"2018","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib80","doi-asserted-by":"crossref","first-page":"R199","DOI":"10.1186\/ar4037","article-title":"Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development","volume":"14","author":"Cook","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.cger.2021.11.013_bib81","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.joca.2020.01.012","article-title":"Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice","volume":"28","author":"Lee","year":"2020","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"10.1016\/j.cger.2021.11.013_bib82","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1523\/JNEUROSCI.2268-19.2020","article-title":"Granulocyte-macrophage colony stimulating factor As an Indirect mediator of nociceptor activation and pain","volume":"40","author":"Tewari","year":"2020","journal-title":"J\u00a0Neurosci"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib83","doi-asserted-by":"crossref","first-page":"10868","DOI":"10.1038\/s41598-020-67730-y","article-title":"Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis","volume":"10","author":"Chou","year":"2020","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.cger.2021.11.013_bib84","doi-asserted-by":"crossref","first-page":"e125325","DOI":"10.1172\/jci.insight.125325","article-title":"Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients","volume":"4","author":"Wood","year":"2019","journal-title":"JCI insight"},{"key":"10.1016\/j.cger.2021.11.013_bib85","doi-asserted-by":"crossref","first-page":"103618","DOI":"10.1016\/j.ebiom.2021.103618","article-title":"Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets","volume":"72","author":"Nanus","year":"2021","journal-title":"EBioMedicine"},{"issue":"7","key":"10.1016\/j.cger.2021.11.013_bib86","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3390\/genes9070338","article-title":"Pain-associated transcriptome changes in synovium of knee osteoarthritis patients","volume":"9","author":"Bratus-Neuenschwander","year":"2018","journal-title":"Genes (Basel)"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib87","first-page":"131","article-title":"Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain","volume":"33","author":"Matsuda","year":"2019","journal-title":"J\u00a0Anesth"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib88","doi-asserted-by":"crossref","first-page":"e892","DOI":"10.1097\/PR9.0000000000000892","article-title":"Neuroimmune interactions and osteoarthritis pain: focus on macrophages","volume":"6","author":"Geraghty","year":"2021","journal-title":"Pain Rep"},{"key":"10.1016\/j.cger.2021.11.013_bib89","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916688219","article-title":"Glial activation in the collagenase model of\u00a0nociception associated with osteoarthritis","volume":"13","author":"Ad\u00e3es","year":"2017","journal-title":"Mol Pain"},{"key":"10.1016\/j.cger.2021.11.013_bib90","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1787-20.2021","article-title":"Dorsal root ganglia macrophages maintain osteoarthritis pain","author":"Raoof","year":"2021","journal-title":"J\u00a0Neurosci"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib91","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joca.2020.01.008","article-title":"Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis","volume":"28","author":"Miller","year":"2020","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.cger.2021.11.013_bib92","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11357-015-9792-y","article-title":"Development of monosodium acetate-induced osteoarthritis and inflammatory pain in ageing mice","volume":"37","author":"Ogbonna","year":"2015","journal-title":"Age (Omaha)"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib93","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.joca.2016.09.007","article-title":"Spinal microglial activation in a murine surgical model of knee osteoarthritis","volume":"25","author":"Tran","year":"2017","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib94","article-title":"Pain-related behavior is associated with increased joint innervation, ipsilateral dorsal horn gliosis, and dorsal root ganglia activating transcription factor 3 expression in a rat ankle joint model of osteoarthritis","volume":"5","author":"Bourassa","year":"2020","journal-title":"PAIN Rep"},{"key":"10.1016\/j.cger.2021.11.013_bib95","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbi.2015.07.014","article-title":"Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation","volume":"50","author":"Hartung","year":"2015","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.cger.2021.11.013_bib96","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuropharm.2018.03.004","article-title":"Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1\/CXCR2 signaling pathway","volume":"135","author":"Zhou","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.cger.2021.11.013_bib97","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1742-2094-11-38","article-title":"NF\u03baB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice","volume":"11","author":"Xu","year":"2014","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.cger.2021.11.013_bib98","doi-asserted-by":"crossref","DOI":"10.1177\/1744806920905691","article-title":"Spinal NF-kB upregulation contributes to hyperalgesia in a rat model of advanced osteoarthritis","volume":"16","author":"Li","year":"2020","journal-title":"Mol Pain"},{"issue":"3","key":"10.1016\/j.cger.2021.11.013_bib99","doi-asserted-by":"crossref","DOI":"10.1097\/j.pain.0000000000001445","article-title":"The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation","volume":"160","author":"Burston","year":"2019","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib100","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13075-021-02657-x","article-title":"Sustained microglial activation in the area postrema of collagen-induced arthritis mice","volume":"23","author":"Matsushita","year":"2021","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.cger.2021.11.013_bib101","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.joca.2014.11.019","article-title":"Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis","volume":"23","author":"Silverwood","year":"2015","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.cger.2021.11.013_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2021.06.015","article-title":"A\u00a0lifespan approach to osteoarthritis prevention","author":"Whittaker","year":"2021","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.cger.2021.11.013_bib103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2474-9-132","article-title":"Obesity and osteoarthritis in knee, hip and\/or hand: an epidemiological study in the general population with 10 years follow-up","volume":"9","author":"Grotle","year":"2008","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib104","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/bmb\/ldv028","article-title":"Is osteoarthritis a metabolic disorder?","volume":"115","author":"Kluzek","year":"2015","journal-title":"Br Med Bull"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/art.39842","article-title":"Review: metabolic regulation of inflammation in osteoarthritis","volume":"69","author":"Berenbaum","year":"2017","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10194-019-1057-1","article-title":"Association of diet and headache","volume":"20","author":"Razeghi Jahromi","year":"2019","journal-title":"J\u00a0Headache Pain"},{"issue":"2","key":"10.1016\/j.cger.2021.11.013_bib107","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/art.33332","article-title":"Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise","volume":"64","author":"Griffin","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib108","doi-asserted-by":"crossref","first-page":"10350","DOI":"10.1038\/s41598-017-10458-z","article-title":"High-fat diet increases pain behaviors in rats with or without obesity","volume":"7","author":"Song","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib109","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021096118","article-title":"Adipose tissue is a critical regulator of osteoarthritis","volume":"118","author":"Collins","year":"2021","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib110","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1519\/JPT.0000000000000045","article-title":"Effect of Home exercise Program in patients with knee osteoarthritis: a systematic review and meta-analysis","volume":"39","author":"Anwer","year":"2016","journal-title":"J\u00a0Geriatr Phys Ther"},{"issue":"6","key":"10.1016\/j.cger.2021.11.013_bib111","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1249\/MSS.0000000000001944","article-title":"Effects of physical activity in knee and hip osteoarthritis: a systematic Umbrella review","volume":"51","author":"Kraus","year":"2019","journal-title":"Med Sci Sports Exerc"},{"issue":"12","key":"10.1016\/j.cger.2021.11.013_bib112","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/jama.2013.277669","article-title":"Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial","volume":"310","author":"Messier","year":"2013","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.cger.2021.11.013_bib113","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1007\/s00167-020-06104-3","article-title":"The negative impact of the COVID-19 lockdown on pain and physical function in patients with end-stage hip or knee osteoarthritis","volume":"28","author":"Endstrasser","year":"2020","journal-title":"Knee Surgery, Sport Traumatol Arthrosc"},{"issue":"8","key":"10.1016\/j.cger.2021.11.013_bib114","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.joca.2019.04.009","article-title":"Inflammatory cytokines mediate the effects of diet and exercise on pain and function in knee osteoarthritis independent of BMI","volume":"27","author":"Runhaar","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"10","key":"10.1016\/j.cger.2021.11.013_bib115","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune\u2013metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"10.1016\/j.cger.2021.11.013_bib116","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.joca.2015.01.008","article-title":"Aging-related inflammation in osteoarthritis","volume":"23","author":"Greene","year":"2015","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib117","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.cger.2021.11.013_bib118","doi-asserted-by":"crossref","first-page":"535 LP","DOI":"10.1136\/annrheumdis-2011-201047","article-title":"Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study","volume":"72","author":"Stannus","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.cger.2021.11.013_bib119","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.joca.2005.04.014","article-title":"A\u00a0meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis","volume":"13","author":"Srikanth","year":"2005","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib120","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1089\/jwh.2020.8828","article-title":"Understanding the impact of sex and gender in osteoarthritis: Assessing research Gaps and unmet needs","volume":"30","author":"Laitner","year":"2021","journal-title":"J\u00a0Women\u2019s Heal"},{"issue":"14","key":"10.1016\/j.cger.2021.11.013_bib121","article-title":"Gender and sex are key determinants in osteoarthritis not only Confounding variables. A systematic review of clinical Data","volume":"10","author":"Tschon","year":"2021","journal-title":"J\u00a0Clin Med"},{"issue":"5","key":"10.1016\/j.cger.2021.11.013_bib122","first-page":"731","article-title":"Sex differences in interleukin-6 responses over time following laboratory pain testing among patients with knee osteoarthritis","volume":"21","author":"Mun","year":"2020","journal-title":"J\u00a0Pain"},{"issue":"1","key":"10.1016\/j.cger.2021.11.013_bib123","doi-asserted-by":"crossref","first-page":"100004","DOI":"10.1016\/j.ocarto.2019.100004","article-title":"Sex differences in the relationship between individual systemic markers of inflammation and pain in knee osteoarthritis","volume":"1","author":"Perruccio","year":"2019","journal-title":"Osteoarthr Cartil Open"},{"issue":"3, Supplement","key":"10.1016\/j.cger.2021.11.013_bib124","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.semarthrit.2019.09.018","article-title":"Mechanoflammation in osteoarthritis pathogenesis","volume":"49","author":"Vincent","year":"2019","journal-title":"Semin Arthritis Rheum"},{"issue":"462","key":"10.1016\/j.cger.2021.11.013_bib125","doi-asserted-by":"crossref","first-page":"eaat9897","DOI":"10.1126\/scitranslmed.aat9897","article-title":"The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice","volume":"10","author":"Murthy","year":"2018","journal-title":"Sci Transl Med"},{"issue":"462","key":"10.1016\/j.cger.2021.11.013_bib126","doi-asserted-by":"crossref","first-page":"eaat9892","DOI":"10.1126\/scitranslmed.aat9892","article-title":"PIEZO2 mediates injury-induced tactile pain in mice and humans","volume":"10","author":"Szczot","year":"2018","journal-title":"Sci Transl Med"},{"issue":"11","key":"10.1016\/j.cger.2021.11.013_bib127","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1016\/j.celrep.2017.11.066","article-title":"Functional and molecular characterization of Mechanoinsensitive \u201csilent\u201d nociceptors","volume":"21","author":"Prato","year":"2017","journal-title":"Cell Rep"}],"container-title":["Clinics in Geriatric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749069021001142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749069021001142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:56:28Z","timestamp":1760061388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0749069021001142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":127,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0749069021001142"],"URL":"https:\/\/doi.org\/10.1016\/j.cger.2021.11.013","relation":{},"ISSN":["0749-0690"],"issn-type":[{"value":"0749-0690","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain","name":"articletitle","label":"Article Title"},{"value":"Clinics in Geriatric Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cger.2021.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}