{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:42:58Z","timestamp":1790617378449,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.cgh.2006.06.009","type":"journal-article","created":{"date-parts":[[2006,7,30]],"date-time":"2006-07-30T02:37:50Z","timestamp":1154227070000},"page":"192-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of a Real-Time Polymerase Chain Reaction Assay for Lactase Genetic Polymorphism With Standard Indirect Tests for Lactose Maldigestion"],"prefix":"10.1016","volume":"5","author":[{"given":"Andrew","family":"Szilagyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Malolepszy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Hamard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Hilzenrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ponniah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"MacNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2006.06.009_bib1","first-page":"369","article-title":"Lactase deficiency: the world pattern today","volume":"15","author":"Gilat","year":"1979","journal-title":"Isr J Med Sci"},{"key":"10.1016\/j.cgh.2006.06.009_bib2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0140-6736(73)90862-3","article-title":"Recessive inheritance of adult-type lactose malabsorption","volume":"2","author":"Sahi","year":"1973","journal-title":"Lancet"},{"issue":"Suppl","key":"10.1016\/j.cgh.2006.06.009_bib3","first-page":"1079","article-title":"The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance","volume":"48","author":"Scrimshaw","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cgh.2006.06.009_bib4","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1046\/j.1365-2036.2002.01321.x","article-title":"Review article: lactose\u2014a potential prebiotic","volume":"16","author":"Szilagyi","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2006.06.009_bib5","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1093\/ajcn\/65.5.1502","article-title":"Tolerance to the daily ingestion of two cups of milk by individuals claiming lactose intolerance","volume":"65","author":"Suarez","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cgh.2006.06.009_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199507063330101","article-title":"A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance","volume":"333","author":"Suarez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cgh.2006.06.009_bib7","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1056\/NEJM197512112932405","article-title":"Prospective comparison of indirect methods for detecting lactase deficiency","volume":"293","author":"Newcomer","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cgh.2006.06.009_bib8","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(75)93135-9","article-title":"Breath hydrogen as a diagnostic method for hypolactasia","volume":"1","author":"Metz","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/j.cgh.2006.06.009_bib9","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1572-0241.2002.05664.x","article-title":"Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation","volume":"97","author":"Romagnuolo","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2006.06.009_bib10","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1111\/j.1572-0241.2003.08670.x","article-title":"Testing to evaluate irritable bowel syndrome correlates with lactulose testing and may not reflect true lactose malabsorption","volume":"98","author":"Pimentel","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2006.06.009_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ng826","article-title":"Identification of a variant associated with adult-type hypolactasia","volume":"30","author":"Enattah","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.cgh.2006.06.009_bib12","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1136\/gut.2004.040048","article-title":"A genetic test which can be used to diagnose adult-type hypolactasia in children","volume":"53","author":"Rasinpera","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2006.06.009_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-5793(88)80352-1","article-title":"The human lactase-phlorizin hydrolase gene is located on chromosome 2","volume":"240","author":"Kruse","year":"1988","journal-title":"FEBS Lett"},{"key":"10.1016\/j.cgh.2006.06.009_bib14","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/gut.52.5.647","article-title":"Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia","volume":"52","author":"Kuokkanen","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2006.06.009_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/00365520310008304","article-title":"A novel method for diagnosis of adult hypolactasia by genotyping of the \u221213910 C\/T polymorphism with Pyrosequencing technology","volume":"39","author":"Nilsson","year":"2004","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cgh.2006.06.009_bib16","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1089\/gte.2004.8.190","article-title":"PCR-RFLP genotyping assay for a lactase persistence polymorphism upstream of the lactase-phlorizin hydrolase gene","volume":"8","author":"Chao","year":"2004","journal-title":"Genet Test"},{"key":"10.1016\/j.cgh.2006.06.009_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/scientificamerican1072-70","article-title":"Lactose and lactase","volume":"227","author":"Kretchmer","year":"1972","journal-title":"Sci Am"},{"key":"10.1016\/j.cgh.2006.06.009_bib18","series-title":"Common food intolerances 2: milk in human nutrition and adult type hypolactasia","first-page":"352","article-title":"Lactase persistence, galactose metabolism, and milk consumption as risk factors for ovarian cancer","author":"Cramer","year":"1993"},{"key":"10.1016\/j.cgh.2006.06.009_bib19","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/1047-2797(95)00063-1","article-title":"Measurement of lactose consumption reliability and comparison of two methods","volume":"5","author":"Cooper","year":"1995","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.cgh.2006.06.009_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/00365529309101578","article-title":"Lactose malabsorption: optimalization of investigational methods","volume":"200","author":"Brummer","year":"1993","journal-title":"Scand J Gastroenterol Suppl"},{"key":"10.1016\/j.cgh.2006.06.009_bib21","first-page":"237","article-title":"A simple method of measuring breath hydrogen in carbohydrate malabsorption by end-expiratory sampling","volume":"50","author":"Metz","year":"1976","journal-title":"Clin Sci Mol Med"},{"key":"10.1016\/j.cgh.2006.06.009_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00572764","article-title":"New principle for estimation of hydrogen in expired air","volume":"141","author":"van der Klei-van Moorsel","year":"1984","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.cgh.2006.06.009_bib23","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/0016-5085(93)90145-3","article-title":"Detection of malabsorption of low doses of carbohydrate: accuracy of various breath H2 criteria","volume":"105","author":"Strocchi","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2006.06.009_bib24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3177\/jnsv.51.51","article-title":"Maximum permissive dosage of lactose and lactitol for transitory diarrhea and utilizable capacity for lactose in Japanese female adults","volume":"51","author":"Oku","year":"2005","journal-title":"J Nutr Sci Vitaminol"},{"key":"10.1016\/j.cgh.2006.06.009_bib25","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/jn\/134.8.1881","article-title":"The fermentation of different dietary fibers is associated with fecal clostridia levels in men","volume":"134","author":"Chinda","year":"2004","journal-title":"J Nutr"},{"key":"10.1016\/j.cgh.2006.06.009_bib26","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1348-0421.1983.tb02929.x","article-title":"A selective medium for isolation and presumptive identification of the Bacteriodes fragilis group","volume":"27","author":"Ushijima","year":"1983","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.cgh.2006.06.009_bib27","first-page":"321","article-title":"The faecal SCFAs and lactose tolerance in lactose malabsorbers","volume":"3","author":"Siigur","year":"1991","journal-title":"Eu J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2006.06.009_bib28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2672.1991.tb02739.x","article-title":"The control and consequences of bacterial fermentation in the human colon","volume":"70","author":"Cummings","year":"1991","journal-title":"J Appl Bacteriol"},{"key":"10.1016\/j.cgh.2006.06.009_bib29","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/2121238a0","article-title":"Gases produced by human intestinal flora","volume":"212","author":"Calloway","year":"1966","journal-title":"Nature"},{"key":"10.1016\/j.cgh.2006.06.009_bib30","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI106916","article-title":"Use of pulmonary hydrogen (H2) measurements to quantitate carbohydrate absorption","volume":"51","author":"Bond","year":"1972","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cgh.2006.06.009_bib31","first-page":"1","article-title":"Using a cutoff of <10 ppm for breath hydrogen testing: a review of five years\u2019 experience","volume":"29","author":"Karcher","year":"1999","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.cgh.2006.06.009_bib32","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0016-5085(76)80311-3","article-title":"Quantitative measurement of lactose absorption","volume":"70","author":"Bond","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2006.06.009_bib33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/ajcn\/64.2.232","article-title":"Colonic adaptation to daily lactose feeding in lactose maldigesters reduces lactose intolerance","volume":"64","author":"Hertzler","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cgh.2006.06.009_bib34","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1155\/2004\/763529","article-title":"Deadaption and readaptation with lactose, but no cross-adaptation to lactulose: a case of occult colonic bacterial adaptation","volume":"18","author":"Szilagyi","year":"2004","journal-title":"Can J Gastroenterol"},{"key":"10.1016\/j.cgh.2006.06.009_bib35","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1007\/s10620-005-3028-4","article-title":"Inverse dose effect of pretest dietary lactose intake on breath hydrogen results and symptoms in lactase nonpersistent subjects","author":"Szilagyi","year":"2005","journal-title":"Dig Dis Sci"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356506005647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356506005647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:59:28Z","timestamp":1761541168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356506005647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1542356506005647"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2006.06.009","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of a Real-Time Polymerase Chain Reaction Assay for Lactase Genetic Polymorphism With Standard Indirect Tests for Lactose Maldigestion","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2006.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 AGA Institute. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}