{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:55:45Z","timestamp":1772812545407,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.cgh.2007.08.014","type":"journal-article","created":{"date-parts":[[2007,12,3]],"date-time":"2007-12-03T14:06:28Z","timestamp":1196690788000},"page":"1385-1391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["A Randomized, Comparative Study of Three Doses of AZD0865 and Esomeprazole for Healing of Reflux Esophagitis"],"prefix":"10.1016","volume":"5","author":[{"given":"Peter J.","family":"Kahrilas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Lauritsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Malfertheiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Denison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Franz\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Hasselgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2007.08.014_bib1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1365-2036.2004.01957.x","article-title":"Review article: new pharmacological agents for the treatment of gastro-oesophageal reflux disease","volume":"19","author":"Vakil","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2007.08.014_bib2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0006-2952(91)90690-7","article-title":"SK&F 96067 is a reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase","volume":"42","author":"Keeling","year":"1991","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.cgh.2007.08.014_bib3","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/S0021-9258(18)61620-5","article-title":"Inhibition of gastric H+, K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2a)imidazole","volume":"262","author":"Wallmark","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cgh.2007.08.014_bib4","first-page":"A333","article-title":"Mechanism of action of AZD0865, an H+, K+-ATPase selective, potassium-competitive acid blocker","volume":"126","author":"Briving","year":"2004","journal-title":"Gastroenterology"},{"issue":"Suppl 10","key":"10.1016\/j.cgh.2007.08.014_bib5","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.14309\/00000434-200410001-00022","article-title":"AZD0865, a potassium-competitive acid blocker (P-CAB), has a long duration of effect in the rat","volume":"99","author":"Holstein","year":"2004","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 1","key":"10.1016\/j.cgh.2007.08.014_bib6","first-page":"S8","article-title":"AZD0865, a potassium-competitive acid blocker (P-CAB), provides predictable inhibition of acid secretion with repeated dosing in the dog","volume":"23","author":"Holstein","year":"2004","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.cgh.2007.08.014_bib7","doi-asserted-by":"crossref","first-page":"P55","DOI":"10.1016\/j.clpt.2004.12.101","article-title":"Consistent inhibition of acid ouput with repeated dosing of AZD0865 in rats","volume":"77","author":"Holstein","year":"2005","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.cgh.2007.08.014_bib8","first-page":"A334","article-title":"AZD0865\u2013a new potassium-competitive acid blocker -exhibits maximal gastric antisecretory effects from first dose","volume":"126","author":"Holstein","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2007.08.014_bib9","first-page":"A528","article-title":"Tolerability, pharmacokinetics and effects on gastric acid secretion after single oral doses of the potassium-competitive acid blocker AZD0865 in healthy male subjects","volume":"128","author":"Nilsson","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2007.08.014_bib10","first-page":"1749","article-title":"Efficacy and safety of lansoprazole in the treatment of erosive reflux esophagitis: the Lansoprazole Group","volume":"91","author":"Castell","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2007.08.014_bib11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/gut.45.2.172","article-title":"Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification","volume":"45","author":"Lundell","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2007.08.014_bib12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1572-0241.2001.03451.x","article-title":"Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease","volume":"96","author":"Shaw","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2007.08.014_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000200931","article-title":"Is a fluoroscopic verification of the electrode position necessary in ambulatory intragastric pH monitoring?","volume":"52","author":"Wilder-Smith","year":"1992","journal-title":"Digestion"},{"key":"10.1016\/j.cgh.2007.08.014_bib14","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1046\/j.1365-2036.2000.00856.x","article-title":"Esomeprazole improves healing and symptom resolution as compared with omeprazole in reflux oesophagitis patients: a randomized controlled trial","volume":"14","author":"Kahrilas","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2007.08.014_bib15","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1572-0241.2001.03600.x","article-title":"Efficacy and safety of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomized controlled trial","volume":"96","author":"Richter","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2007.08.014_bib16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1572-0241.2002.05532.x","article-title":"Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis","volume":"97","author":"Castell","year":"2002","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 1","key":"10.1016\/j.cgh.2007.08.014_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000200917","article-title":"Appropriate acid suppression for the management of gastro-oesophageal reflux disease","volume":"51","author":"Bell","year":"1992","journal-title":"Digestion"},{"key":"10.1016\/j.cgh.2007.08.014_bib18","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1111\/j.1572-0241.2003.08783.x","article-title":"Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study","volume":"98","author":"Miner","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2007.08.014_bib19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1365-2036.2005.02432.x","article-title":"Intragastric acidity during treatment with esomeprazole 40 mg twice daily or pantoprazole 40 mg twice daily: a randomized, two-way crossover study","volume":"21","author":"Miehlke","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2007.08.014_bib20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1365-2036.2004.02272.x","article-title":"Esomeprazole 40 mg iv provides faster and more effective intragastric acid control than pantoprazole 40 mg iv: results of a randomized study","volume":"20","author":"Wilder-Smith","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2007.08.014_bib21","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1365-2036.2005.02368.x","article-title":"A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg for healing erosive oesophagitis: the EXPO study","volume":"21","author":"Labenz","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2007.08.014_bib22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-2036.2005.02339.x","article-title":"Efficacy of esomeprazole 40 mg vs lansoprazole 30 mg for healing moderate to severe erosive oesophagitis","volume":"21","author":"Fennerty","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2007.08.014_bib23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1046\/j.1365-2036.2003.01756.x","article-title":"Direct comparative trials of the efficacy of proton pump inhibitors in the management of gastro-oesophageal reflux disease and peptic ulcer disease","volume":"18","author":"Vakil","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2007.08.014_bib24","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1365-2036.2006.03074.x","article-title":"Systematic review: proton pump inhibitors (PPIs) for the healing of reflux oesophagitis: a comparison of esomeprazole with other PPIs","volume":"24","author":"Edwards","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2007.08.014_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/oxfordjournals.jncimonographs.a003443","article-title":"Biology of oral mucosa and esophagus","volume":"29","author":"Squier","year":"2001","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.cgh.2007.08.014_bib26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1080\/003655299750026155","article-title":"Is the esophageal squamous epithelial barrier function impaired in patients with gastroesophageal reflux disease?","volume":"34","author":"Carlsson","year":"1999","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cgh.2007.08.014_bib27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1572-0241.2005.40476.x","article-title":"Reversibility of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment","volume":"100","author":"Calabrese","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2007.08.014_bib28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1517\/13543784.14.4.411","article-title":"Novel approaches to the pharmacological blockade of gastric acid secretion","volume":"14","author":"Parsons","year":"2005","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.cgh.2007.08.014_bib29","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1136\/bmj.318.7192.1179","article-title":"Hepatotoxicity associated with zolpidem treatment","volume":"318","author":"Karsenti","year":"1999","journal-title":"BMJ"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356507007720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356507007720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:00:24Z","timestamp":1761541224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356507007720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S1542356507007720"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2007.08.014","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Randomized, Comparative Study of Three Doses of AZD0865 and Esomeprazole for Healing of Reflux Esophagitis","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2007.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 AGA Institute. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}