{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:15:08Z","timestamp":1790648108419,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.cgh.2008.01.006","type":"journal-article","created":{"date-parts":[[2008,3,21]],"date-time":"2008-03-21T11:00:46Z","timestamp":1206097246000},"page":"521-524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["An Analysis of Persistent Symptoms in Acid-Suppressed Patients Undergoing Impedance-pH Monitoring"],"prefix":"10.1016","volume":"6","author":[{"given":"Neeraj","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo F.","family":"Vela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Castell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2008.01.006_bib1","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s10620-005-3001-2","article-title":"A prospective study of gastric acid analysis and esophageal acid exposure in patients with gastroesophageal reflux refractory to medical therapy","volume":"50","author":"Ahlawat","year":"2005","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.cgh.2008.01.006_bib2","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1001\/archinte.1995.00430160156016","article-title":"Empiric therapy for gastroesophageal reflux disease","volume":"155","author":"Schindlbeck","year":"1995","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cgh.2008.01.006_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0002-9343(99)00219-3","article-title":"The cost-effectiveness of the omeprazole test in patients with noncardiac chest pain","volume":"107","author":"Ofman","year":"1999","journal-title":"Am J Med"},{"key":"10.1016\/j.cgh.2008.01.006_bib4","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S1542-3565(04)00288-5","article-title":"Effectiveness of proton pump inhibitors in nonerosive reflux disease","volume":"2","author":"Dean","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2008.01.006_bib5","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gut.2003.033290","article-title":"Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux","volume":"53","author":"Sifrim","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2008.01.006_bib6","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1136\/gut.2005.087668","article-title":"Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring","volume":"55","author":"Mainie","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2008.01.006_bib7","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/j.1572-0241.2006.00711.x","article-title":"Esophageal pH-impedance monitoring and symptom analysis in GERD: a study in patients off and on therapy","volume":"101","author":"Zerbib","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2008.01.006_bib8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.cgh.2006.11.015","article-title":"Combined multichannel intraluminal impedance and pH esophageal testing compared to pH alone for diagnosing both acid and weakly acidic gastroesophageal reflux","volume":"5","author":"Hila","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2008.01.006_bib9","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1046\/j.1365-2036.2001.01050.x","article-title":"Bedtime H2 blockers improve nocturnal gastric acid control in GERD patients on proton pump inhibitors","volume":"15","author":"Xue","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2008.01.006_bib10","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1053\/gast.2001.24840","article-title":"Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: effect of omeprazole","volume":"120","author":"Vela","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2008.01.006_bib11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1365-2036.2003.01394.x","article-title":"Baclofen decreases acid and non-acid post-prandial gastroesophageal reflux measured by combined multichannel intraluminal impedance and pH","volume":"17","author":"Vela","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2008.01.006_bib12","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1136\/gut.52.4.464","article-title":"Effect of acute and chronic administration of the GABA agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease","volume":"52","author":"Ciccaglione","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2008.01.006_bib13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1136\/thx.2005.040139","article-title":"Fundoplication eliminates chronic cough due to non-acid reflux identified by impedance-pH monitoring","volume":"60","author":"Mainie","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.cgh.2008.01.006_bib14","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/bjs.5493","article-title":"Combined multichannel intraluminal impedance-pH monitoring to select patients with persistent gastro-oesophageal reflux for laparoscopic Nissen fundoplication","volume":"93","author":"Mainie","year":"2006","journal-title":"Br J Surg"},{"key":"10.1016\/j.cgh.2008.01.006_bib15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00464-006-9121-8","article-title":"Endoscopic full-thickness plication for the treatment of GERD: long-term multicenter results","volume":"21","author":"Pleskow","year":"2007","journal-title":"Surg Endosc"},{"key":"10.1016\/j.cgh.2008.01.006_bib16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cgh.2006.01.011","article-title":"Surgical fundoplication in laryngopharyngeal reflux unresponsive to aggressive acid suppression: a controlled study","volume":"4","author":"Swoger","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2008.01.006_bib17","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1572-0241.1999.00925.x","article-title":"Esophageal hypersensitivity may be a major cause of heartburn","volume":"94","author":"Rodriguez-Stanley","year":"1999","journal-title":"Am J Gastroenterol"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235650800044X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235650800044X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:02:04Z","timestamp":1761541324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154235650800044X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S154235650800044X"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2008.01.006","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Analysis of Persistent Symptoms in Acid-Suppressed Patients Undergoing Impedance-pH Monitoring","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2008.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2008.04.002","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2008.02.010","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 AGA Institute. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}