{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:43:34Z","timestamp":1790372614032,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.cgh.2008.04.013","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T17:42:15Z","timestamp":1218649335000},"page":"1041-1048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis"],"prefix":"10.1016","volume":"6","author":[{"given":"Kieren G.","family":"Hollingsworth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia L.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Blamire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2008.04.013_bib1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/hep.510300213","article-title":"Primary biliary cirrhosis once rare, now common in the UK?","volume":"30","author":"James","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2008.04.013_bib2","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1572-0241.2000.01857.x","article-title":"Impact of fatigue on the quality of life in patients with primary biliary cirrhosis","volume":"95","author":"Huet","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2008.04.013_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/hep.20276","article-title":"Quality of life in patients with primary biliary cirrhosis","volume":"40","author":"Poupon","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2008.04.013_bib4","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/gut.43.5.705","article-title":"Fatigue in primary biliary cirrhosis","volume":"43","author":"Cauch-Dudek","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2008.04.013_bib5","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1053\/gast.2002.32993","article-title":"The true impact of fatigue in primary biliary cirrhosis: a population study","volume":"122","author":"Goldblatt","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2008.04.013_bib6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1572-0241.2000.01774.x","article-title":"Cholestatic liver diseases and health-related quality of life","volume":"95","author":"Younossi","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2008.04.013_bib7","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1136\/gut.2005.065862","article-title":"Development, validation and evaluation of the PBC-40: a disease specific health related quality of life measure for primary biliary cirrhosis","volume":"54","author":"Jacoby","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2008.04.013_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1478-3231.2005.01214.x","article-title":"Reduced heart rate variability and baroreflex sensitivity in primary biliary cirrhosis","volume":"26","author":"Newton","year":"2005","journal-title":"Liver Int"},{"key":"10.1016\/j.cgh.2008.04.013_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/01.meg.0000252629.96043.67","article-title":"Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity","volume":"19","author":"Newton","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2008.04.013_bib10","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/hep.21609","article-title":"The population prevalence of autonomic dysfunction and daytime somnolence in primary biliary cirrhosis","volume":"47","author":"Newton","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2008.04.013_bib11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/hep.21230","article-title":"Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence","volume":"44","author":"Newton","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2008.04.013_bib12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/hep.510280102","article-title":"Chronic cholestasis in rats induces anhedonia and loss of social interest","volume":"28","author":"Swain","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2008.04.013_bib13","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/hep.510280616","article-title":"Augmented interleukin-1 beta induced depression of locomotor activity in cholestatic rats","volume":"28","author":"Swain","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2008.04.013_bib14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hep.21003","article-title":"TNF-alpha secreting monocytes are recruited into the brain of cholestatic mice","volume":"43","author":"Kerfoot","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2008.04.013_bib15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/gut.2003.016766","article-title":"Fatigue and primary biliary cirrhosis: association of globus pallidus magnetization transfer ratio measurements with fatigue severity and blood manganese levels","volume":"53","author":"Forton","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2008.04.013_bib16","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1001\/jama.285.17.2196","article-title":"Grip strength and subjective fatigue in patients with primary biuliary cirrhosis","volume":"285","author":"Goldblatt","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.cgh.2008.04.013_bib17","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jhep.2005.12.012","article-title":"Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure","volume":"44","author":"Newton","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.cgh.2008.04.013_bib18","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1572-0241.2005.41315.x","article-title":"Evaluation of fatigue in U.S. patients with primary biliary cirrhosis","volume":"100","author":"Stanca","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2008.04.013_bib19","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/ije\/26.4.830","article-title":"Incidence and prevalence of primary biliary cirrhosis in the city of Newcastle upon Tyne, England","volume":"26","author":"Metcalf","year":"1997","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.cgh.2008.04.013_bib20","doi-asserted-by":"crossref","first-page":"953","DOI":"10.7326\/0003-4819-121-12-199412150-00009","article-title":"The chronic fatigue syndrome: a comprehensive approach to its definition and study","volume":"121","author":"Fukuda","year":"1994","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cgh.2008.04.013_bib21","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0168-8278(00)80385-2","article-title":"Validation of a fatigue impact score in primary biliary cirrhosis: towards a standard for clinical and trial use","volume":"32","author":"Prince","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.cgh.2008.04.013_bib22","first-page":"43","article-title":"Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic muscle: an analytical review","volume":"10","author":"Kemp","year":"1994","journal-title":"Magn Reson Quart"},{"key":"10.1016\/j.cgh.2008.04.013_bib23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/jmre.1999.1835","article-title":"Time domain quantification of series of biomedical magnetic resonance spectroscopy signals","volume":"140","author":"Vanhamme","year":"1999","journal-title":"J Magn Reson"},{"key":"10.1016\/j.cgh.2008.04.013_bib24","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s004210050276","article-title":"Proton efflux in human skeletal muscle during recovery from exercise","volume":"76","author":"Kemp","year":"1997","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.cgh.2008.04.013_bib25","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/0016-5085(90)90488-M","article-title":"Primary biliary cirrhosis: quantitation of autoantibodies to purified mitochondrial enzymes and correlation with disease progression","volume":"99","author":"Heseltine","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2008.04.013_bib26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1113\/jphysiol.2007.141838","article-title":"Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance","volume":"586","author":"Amann","year":"2008","journal-title":"J Physiol"},{"key":"10.1016\/j.cgh.2008.04.013_bib27","doi-asserted-by":"crossref","first-page":"R502","DOI":"10.1152\/ajpregu.00114.2004","article-title":"Biochemistry of exercise-induced metabolic acidosis","volume":"287","author":"Robergs","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.cgh.2008.04.013_bib28","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1053\/jhep.2002.33634","article-title":"Defective regulation of cholangiocyte Cl-\/HCO3- and Na+\/H+ exchanger activities in primary biliary cirrhosis","volume":"35","author":"Melero","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2008.04.013_bib29","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S0168-8278(05)80640-3","article-title":"Autonomic and peripheral neuropathy in primary biliary cirrhosis: evidence of small sensory fibre damage and prolongation of the QT interval","volume":"21","author":"Kempler","year":"1994","journal-title":"J Hepatol"},{"key":"10.1016\/j.cgh.2008.04.013_bib30","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.3748\/wjg.v10.i20.3039","article-title":"Autonomic and sensory nerve dysfunction in primary biliary cirrhosis","volume":"10","author":"Keresztes","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cgh.2008.04.013_bib31","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0168-8278(03)00270-8","article-title":"Pathogenesis of primary biliary cirrhosis","volume":"39","author":"Jones","year":"2003","journal-title":"J Hepatol"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235650800356X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235650800356X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:01:33Z","timestamp":1761541293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154235650800356X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S154235650800356X"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2008.04.013","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pilot Study of Peripheral Muscle Function in Primary Biliary Cirrhosis: Potential Implications for Fatigue Pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2008.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 AGA Institute. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}