{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:05:08Z","timestamp":1794485108456,"version":"4.9.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.cgh.2010.09.016","type":"journal-article","created":{"date-parts":[[2010,10,2]],"date-time":"2010-10-02T05:29:00Z","timestamp":1285997340000},"page":"36-41.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":394,"title":["A Systematic Review of Factors That Contribute to Hepatosplenic T-Cell Lymphoma in Patients With Inflammatory Bowel Disease"],"prefix":"10.1016","volume":"9","author":[{"given":"David S.","family":"Kotlyar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Osterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech C.","family":"Blonski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Wasik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Sampat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mendizabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming V.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary R.","family":"Lichtenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2010.09.016_bib1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/MPG.0b013e3181957a11","article-title":"Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease: update","volume":"48","author":"Mackey","year":"2009","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.cgh.2010.09.016_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/MPG.0b013e31802f6424","article-title":"Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease","volume":"44","author":"Mackey","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.cgh.2010.09.016_bib3","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1136\/gut.2008.163279","article-title":"Hepatosplenic T cell lymphoma in inflammatory bowel disease","volume":"57","author":"Shale","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2010.09.016_bib4","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/annonc\/mdn751","article-title":"Hepatosplenic gamma-delta T-cell lymphoma: clinicopathological features and treatment","volume":"20","author":"Falchook","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1016\/j.cgh.2010.09.016_bib5","unstructured":"Data on file, Centocor, Inc, Horsham, PA."},{"issue":"Suppl 1","key":"10.1016\/j.cgh.2010.09.016_bib6","first-page":"A116","article-title":"Excess risk of lymphoproliferative disorders (LPD) in inflammatory bowel diseases (IBD): interim results of the CESAME cohort","volume":"134","author":"Beaugerie","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2010.09.016_bib7","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/S0140-6736(09)61302-7","article-title":"Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study","volume":"374","author":"Beaugerie","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.cgh.2010.09.016_bib8","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1136\/gut.2004.049460","article-title":"Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine","volume":"54","author":"Kandiel","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2010.09.016_bib9","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1038\/ajg.2010.213","article-title":"Hepatosplenic T-cell lymphoma in inflammatory bowel disease: a possible thiopurine-induced chromosomal abnormality","volume":"105","author":"Kotlyar","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2010.09.016_bib10","doi-asserted-by":"crossref","first-page":"S-675","DOI":"10.1016\/S0016-5085(10)63105-8","article-title":"W1212 hepatosplenic T-cell lymphoma in Crohn's disease","volume":"138","author":"Fowler","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2010.09.016_bib14","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/ibd.20169","article-title":"Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: a cautionary tale?","volume":"13","author":"Rosh","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.cgh.2010.09.016_bib15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.5694\/j.1326-5377.2008.tb02124.x","article-title":"Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease","volume":"189","author":"Drini","year":"2008","journal-title":"Med J Aust"},{"key":"10.1016\/j.cgh.2010.09.016_bib16","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1080\/10428190802087488","article-title":"Long-term survival in two patients with hepatosplenic T cell lymphoma treated with interferon-alpha","volume":"49","author":"Humphreys","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.cgh.2010.09.016_bib17","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1600-0609.2006.00646.x","article-title":"A case of hepatosplenic gamma-delta T-cell lymphoma with a transient response to fludarabine and alemtuzumab","volume":"76","author":"Mittal","year":"2006","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.cgh.2010.09.016_bib18","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/ibd.20802","article-title":"Crohn's disease, hepatosplenic T-cell lymphoma and no biological therapy: are we barking up the wrong tree?","volume":"15","author":"Moran","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.cgh.2010.09.016_bib19","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/1042819021000035662","article-title":"Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine","volume":"44","author":"Navarro","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.cgh.2010.09.016_bib20","first-page":"220","article-title":"Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn disease","volume":"40","author":"Thayu","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.cgh.2010.09.016_bib21","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1080\/10428190701345433","article-title":"Hepatosplenic T-cell lymphoma in a patient with Crohn's disease who received infliximab therapy","volume":"48","author":"Zeidan","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.cgh.2010.09.016_bib22","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V108.11.2460.2460","article-title":"Hepatosplenic T-cell lymphoma: clinical characteristics and treatment outcome","volume":"108","author":"Falchook","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cgh.2010.09.016_bib23","first-page":"259","article-title":"Hepatosplenic T-cell lymphoma in a 15-year-old boy with ulcerative colitis treated with azathioprine for 9 years","volume":"1","author":"Keller","year":"2007","journal-title":"JPGN J Pediatr Gastroenterol Nutr"},{"issue":"Suppl 1","key":"10.1016\/j.cgh.2010.09.016_bib24","first-page":"A1020","article-title":"Intravenous cyclosporine for refractory attacks of Crohn's disease (CD)","volume":"114","author":"Lemann","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2010.09.016_bib25","unstructured":"Rosh JR, Magidson J, Miller M. T-Cell hepatosplenic lymphoma in an adolescent on azathioprine monotherapy for ulcerative colitis and autoimmune hepatitis. NASPGHAN 2006 Clinical Vignette p.81."},{"key":"10.1016\/j.cgh.2010.09.016_bib26","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1309\/LRKX8CE7GVPCR1FT","article-title":"Hepatosplenic and other gammadelta T-cell lymphomas","volume":"127","author":"Vega","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.cgh.2010.09.016_bib27","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1182\/blood.V87.4.1474.bloodjournal8741474","article-title":"Natural killer-like T-cell lymphomas: aggressive lymphomas of T-large granular lymphocytes","volume":"87","author":"Macon","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.cgh.2010.09.016_bib29","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/00000478-199707000-00006","article-title":"Hepatosplenic gamma\/delta T-cell lymphoma: a report of two cases in immunocompromised patients, associated with isochromosome 7q","volume":"21","author":"Francois","year":"1997","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.cgh.2010.09.016_bib30","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/(SICI)1097-0142(19980301)82:5<983::AID-CNCR26>3.0.CO;2-W","article-title":"Gamma\/delta hepatosplenic lymphoma in a heart transplant patient after an Epstein\u2013Barr virus positive lymphoproliferative disorder: a case report","volume":"82","author":"Kraus","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.cgh.2010.09.016_bib31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/00000478-198801000-00008","article-title":"The occurrence of a peripheral T-cell lymphoma in a chronically immunosuppressed renal transplant patient","volume":"12","author":"Garvin","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.cgh.2010.09.016_bib32","first-page":"256","article-title":"Epstein\u2013Barr virus infection of a hepatosplenic gamma delta T-cell lymphoma arising in a kidney transplant recipient","volume":"85","author":"Roncella","year":"2000","journal-title":"Haematologica"},{"key":"10.1016\/j.cgh.2010.09.016_bib33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/ajcp\/102.3.310","article-title":"Gamma\/delta T-cell posttransplantation lymphoproliferative disorder primarily in the spleen","volume":"102","author":"Ross","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.cgh.2010.09.016_bib34","first-page":"355","article-title":"Peripheral T-cell lymphoma in a chronically immunosuppressed renal transplant patient","volume":"8","author":"Labouyrie","year":"1995","journal-title":"Mod Pathol"},{"key":"10.1016\/j.cgh.2010.09.016_bib35","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/10428199909058439","article-title":"Post transplant CD8+ gammadelta T-cell lymphoma associated with human herpes virus-6 infection","volume":"33","author":"Lin","year":"1999","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.cgh.2010.09.016_bib36","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/j.1600-6143.2004.00521.x","article-title":"Post transplant T-cell lymphoma: a case series of four patients from a single unit and review of the literature","volume":"4","author":"Rajakariar","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.cgh.2010.09.016_bib37","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1093\/ndt\/13.12.3242","article-title":"Diffuse T-cell lymphoma in a kidney graft recipient 17 years after transplantation","volume":"13","author":"Albalate","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.cgh.2010.09.016_bib38","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1182\/blood-2003-05-1675","article-title":"Hepatosplenic gammadelta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients","volume":"102","author":"Belhadj","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.cgh.2010.09.016_bib39","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1432-2277.1997.tb00727.x","article-title":"Hemophagocytic syndrome and T-cell lymphoma after kidney transplantation: a case report","volume":"10","author":"Peeters","year":"1997","journal-title":"Transpl Int"},{"key":"10.1016\/j.cgh.2010.09.016_bib40","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1182\/blood.V88.9.3626.bloodjournal8893626","article-title":"Posttransplant T-cell lymphoproliferative disorders\u2014an aggressive, late complication of solid-organ transplantation","volume":"88","author":"Hanson","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.cgh.2010.09.016_bib41","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJMoa011110","article-title":"Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent","volume":"345","author":"Keane","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cgh.2010.09.016_bib42","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","article-title":"Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences","volume":"126","author":"Loftus","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2010.09.016_bib43","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1053\/j.gastro.2008.03.004","article-title":"Withdrawal of immunosuppression in Crohn's disease treated with scheduled infliximab maintenance: a randomized trial","volume":"134","author":"Van Assche","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2010.09.016_bib44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2036.2009.04027.x","article-title":"Benefits and risks of immunomodulators and maintenance infliximab for IBD: subgroup analyses across four randomized trials","volume":"30","author":"Lichtenstein","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2010.09.016_bib45","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMoa0904492","article-title":"Infliximab, azathioprine, or combination therapy for Crohn's disease","volume":"362","author":"Colombel","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cgh.2010.09.016_bib46","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1136\/gut.2006.099978","article-title":"Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease","volume":"56","author":"Vermeire","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2010.09.016_bib47","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1136\/gut.2006.115980","article-title":"Risks and benefits of combining immunosuppressives and biological agents in inflammatory bowel disease: is the synergy worth the risk?","volume":"56","author":"Hanauer","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2010.09.016_bib48","doi-asserted-by":"crossref","first-page":"A-196","DOI":"10.1016\/S0016-5085(09)60882-9","article-title":"S1133 hepatosplenic T-cell lymphoma (HSTCL) and IBD: a rare complication after long-term thiopurine exposure: case report and systematic review of the literature","volume":"136","author":"Kotlyar","year":"2009","journal-title":"Gastroenterology"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356510009079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356510009079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:06:19Z","timestamp":1761541579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356510009079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1542356510009079"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2010.09.016","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Systematic Review of Factors That Contribute to Hepatosplenic T-Cell Lymphoma in Patients With Inflammatory Bowel Disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2010.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 AGA Institute. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}