{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:03:09Z","timestamp":1769828589864,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.cgh.2014.08.044","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T17:35:31Z","timestamp":1411752931000},"page":"1560-1566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Should the Reflex Be Reflux? Throat Symptoms and Alternative Explanations"],"prefix":"10.1016","volume":"13","author":[{"given":"David O.","family":"Francis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Vaezi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2014.08.044_bib1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/S0016-5085(97)70025-8","article-title":"Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota","volume":"112","author":"Locke","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2014.08.044_bib2","unstructured":"Using the proton pump inhibitors to treat heartburn and stomach acid reflux: comparing effectiveness, safety, and price. Consumer Reports: Best Buy Drugs: Consumer Union of US, Inc, 2013:1\u201318."},{"key":"10.1016\/j.cgh.2014.08.044_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1001\/archotol.1970.04310050081012","article-title":"Isolated head and neck symptoms due to hiatus hernia","volume":"92","author":"Hallewell","year":"1970","journal-title":"Arch Otolaryngol"},{"key":"10.1016\/j.cgh.2014.08.044_bib4","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1288\/00005537-197709000-00002","article-title":"Gastro-esophago-pharyngeal reflux","volume":"87","author":"Chodosh","year":"1977","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib5","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/bmj.2.5369.1373","article-title":"Post-cricoid carcinoma: regional incidence in England and Wales","volume":"2","author":"Jacobs","year":"1963","journal-title":"BMJ"},{"key":"10.1016\/j.cgh.2014.08.044_bib6","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1288\/00005537-196811000-00008","article-title":"Experimentally produced vocal cord granulomas","volume":"78","author":"Delahunty","year":"1968","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib7","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1288\/00005537-196811000-00007","article-title":"Contact ulcer of the larynx","volume":"78","author":"Cherry","year":"1968","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/lary.1991.101.s53.1","volume":"101","author":"Koufman","year":"1991","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib9","first-page":"7","article-title":"Laryngopharyngeal reflux is different from classic\u00a0gastroesophageal reflux disease","volume":"81","author":"Koufman","year":"2002","journal-title":"Ear Nose Throat J"},{"key":"10.1016\/j.cgh.2014.08.044_bib10","doi-asserted-by":"crossref","first-page":"E294","DOI":"10.1002\/lary.24538","article-title":"Role of pepsin and pepsinogen: linking laryngopharyngeal reflux with otitis media with effusion in children","volume":"124","author":"Luo","year":"2014","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11882-008-0094-7","article-title":"Gastric pepsin in middle ear fluid of children with otitis media: clinical implications","volume":"8","author":"He","year":"2008","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.cgh.2014.08.044_bib12","doi-asserted-by":"crossref","first-page":"w13544","DOI":"10.4414\/smw.2012.13544","article-title":"Extraesophageal manifestations of gastroesophageal reflux disease: cough, asthma, laryngitis, chest pain","volume":"142","author":"Saritas Yuksel","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.cgh.2014.08.044_bib13","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/ajg.2013.69","article-title":"High economic burden of caring for patients with suspected extraesophageal reflux","volume":"108","author":"Francis","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2014.08.044_bib14","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1097\/01.mlg.0000184325.44968.b1","article-title":"Prevalence of laryngeal irritation signs associated with reflux in asymptomatic volunteers: impact of endoscopic technique (rigid vs. flexible laryngoscope)","volume":"115","author":"Milstein","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib15","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1097\/01.mlg.0000176547.90094.ac","article-title":"Correlation between symptoms and laryngeal signs in laryngopharyngeal reflux","volume":"115","author":"Qadeer","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/lary.23693","article-title":"Mucosal changes in laryngopharyngeal reflux\u2013prevalence, sensitivity, specificity and assessment","volume":"123","author":"Powell","year":"2013","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib17","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ajg.2012.444","article-title":"Guidelines for the diagnosis and management of gastroesophageal reflux disease","volume":"108","author":"Katz","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2014.08.044_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0095-4543(21)01253-7","article-title":"Chronic cough. Diagnosis and treatment","volume":"12","author":"Braman","year":"1985","journal-title":"Prim Care"},{"key":"10.1016\/j.cgh.2014.08.044_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.amjoto.2005.07.010","article-title":"Gastroesophageal reflux and laryngeal cancer: causation or association? A critical review","volume":"27","author":"Qadeer","year":"2006","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.cgh.2014.08.044_bib20","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.amjmed.2006.01.019","article-title":"Laryngeal cancer and gastroesophageal reflux disease: a case-control study","volume":"119","author":"Vaezi","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.cgh.2014.08.044_bib21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/01.mlg.0000157851.24272.41","article-title":"Is GERD a risk factor for laryngeal cancer?","volume":"115","author":"Qadeer","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib22","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1158\/1055-9965.EPI-13-0183","article-title":"Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma","volume":"22","author":"Langevin","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.cgh.2014.08.044_bib23","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/lary.21165","article-title":"Reevaluation of gastroesophageal reflux disease as a risk factor for laryngeal cancer","volume":"121","author":"Francis","year":"2011","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bpg.2013.06.009","article-title":"Approach to the patient with presumed extraoesophageal GERD","volume":"27","author":"Ates","year":"2013","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2014.08.044_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1745-9974-9-19","article-title":"A\u00a0longitudinal study of CPAP therapy for patients with chronic cough and obstructive sleep apnoea","volume":"9","author":"Sundar","year":"2013","journal-title":"Cough"},{"key":"10.1016\/j.cgh.2014.08.044_bib26","doi-asserted-by":"crossref","first-page":"669","DOI":"10.5664\/jcsm.1482","article-title":"Chronic cough and OSA: a new association?","volume":"7","author":"Sundar","year":"2011","journal-title":"J\u00a0Clin Sleep Med"},{"issue":"Suppl 1","key":"10.1016\/j.cgh.2014.08.044_bib27","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1007\/s00408-009-9176-0","article-title":"Cough and sleep","volume":"188","author":"Lee","year":"2010","journal-title":"Lung"},{"key":"10.1016\/j.cgh.2014.08.044_bib28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/MLG.0b013e318158f72d","article-title":"Hoarseness: is it really laryngopharyngeal reflux?","volume":"118","author":"Cohen","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib29","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/j.gastro.2009.03.058","article-title":"Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy","volume":"137","author":"Reimer","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2014.08.044_bib30","first-page":"636","article-title":"Assessment of patient experience with unilateral vocal fold immobility: a preliminary study","volume":"28","author":"Francis","year":"2014","journal-title":"J\u00a0Voice"},{"key":"10.1016\/j.cgh.2014.08.044_bib31","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1002\/lary.24529","article-title":"Improved voluntary cough immediately following office based vocal fold medialization injections","volume":"124","author":"Ruddy","year":"2014","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib32","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1113\/jphysiol.1972.sp009721","article-title":"Circadian rhythms in human salivary flow rate and composition","volume":"220","author":"Dawes","year":"1972","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.cgh.2014.08.044_bib33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.pupt.2004.09.005","article-title":"Post-nasal drip syndrome--a symptom to be sniffed at?","volume":"17","author":"Morice","year":"2004","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.cgh.2014.08.044_bib34","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1378\/chest.12-1788","article-title":"Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease","volume":"143","author":"Kahrilas","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.cgh.2014.08.044_bib35","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1002\/lary.21897","article-title":"Traditional reflux parameters and not impedance monitoring predict outcome after fundoplication in extraesophageal reflux","volume":"121","author":"Francis","year":"2011","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib36","first-page":"596","article-title":"Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers","volume":"25","author":"Vertigan","year":"2011","journal-title":"J\u00a0Voice"},{"key":"10.1016\/j.cgh.2014.08.044_bib37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jaci.2010.10.038","article-title":"Chronic cough and irritable larynx","volume":"127","author":"Bucca","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.cgh.2014.08.044_bib38","first-page":"447","article-title":"The irritable larynx syndrome","volume":"13","author":"Morrison","year":"1999","journal-title":"J\u00a0Voice"},{"key":"10.1016\/j.cgh.2014.08.044_bib39","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/lary.24427","article-title":"U.\u00a0S. practice variations in the treatment of chronic laryngopharyngeal neuropathy","volume":"124","author":"Depietro","year":"2014","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00408-011-9333-0","article-title":"The role of speech pathology in the management of patients with chronic refractory cough","volume":"190","author":"Vertigan","year":"2012","journal-title":"Lung"},{"key":"10.1016\/j.cgh.2014.08.044_bib41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1745-9974-6-5","article-title":"Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough","volume":"6","author":"Ryan","year":"2010","journal-title":"Cough"},{"key":"10.1016\/j.cgh.2014.08.044_bib42","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/0194599812471817","article-title":"Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review","volume":"148","author":"Cohen","year":"2013","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.cgh.2014.08.044_bib43","first-page":"274","article-title":"Validity and reliability of the reflux symptom index (RSI)","volume":"16","author":"Belafsky","year":"2002","journal-title":"J\u00a0Voice"},{"key":"10.1016\/j.cgh.2014.08.044_bib44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/0003489414525021","article-title":"Symptom overlap between laryngopharyngeal reflux and glottic insufficiency in vocal fold atrophy patients","volume":"123","author":"Patel","year":"2014","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.cgh.2014.08.044_bib45","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/000348940211100509","article-title":"Extraesophageal reflux in patients with contact granuloma: a prospective controlled study","volume":"111","author":"Ylitalo","year":"2002","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.cgh.2014.08.044_bib46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/00005537-199903000-00017","article-title":"A\u00a0retrospective study of contact granuloma","volume":"109","author":"Ylitalo","year":"1999","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib47","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1177\/000348941011900509","article-title":"Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas: a series of 67 granulomas","volume":"119","author":"Hillel","year":"2010","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.cgh.2014.08.044_bib48","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.oraloncology.2004.11.002","article-title":"Vocal process granuloma of the larynx-recognition, differential diagnosis and treatment","volume":"41","author":"Devaney","year":"2005","journal-title":"Oral Oncol"},{"key":"10.1016\/j.cgh.2014.08.044_bib49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.amjoto.2004.08.010","article-title":"Effects of voice therapy on vocal process granuloma: a phonoscopic approach","volume":"26","author":"Leonard","year":"2005","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.cgh.2014.08.044_bib50","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/lary.20656","article-title":"Vocal process granuloma and glottal insufficiency: an overlooked etiology?","volume":"120","author":"Carroll","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib51","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1017\/S0022215100126337","article-title":"Vocal process granulomata","volume":"108","author":"McFerran","year":"1994","journal-title":"J\u00a0Laryngol Otol"},{"key":"10.1016\/j.cgh.2014.08.044_bib52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF00179894","article-title":"Contact granulomas of the larynx","volume":"251","author":"Shin","year":"1994","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.cgh.2014.08.044_bib53","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.oraloncology.2009.01.008","article-title":"Vocal process granuloma - a result of long-term observation in 53 patients","volume":"45","author":"Wang","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.cgh.2014.08.044_bib54","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/lary.22426","article-title":"Prevalence and causes of dysphonia in a large treatment-seeking population","volume":"122","author":"Cohen","year":"2012","journal-title":"Laryngoscope"},{"key":"10.1016\/j.cgh.2014.08.044_bib55","first-page":"261","article-title":"Current and emerging concepts in muscle tension dysphonia: a 30-month review","volume":"19","author":"Altman","year":"2005","journal-title":"J\u00a0Voice"},{"key":"10.1016\/j.cgh.2014.08.044_bib56","first-page":"CD006373","article-title":"Interventions for treating functional dysphonia in adults","volume":"3","author":"Ruotsalainen","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.cgh.2014.08.044_bib57","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/0194599811422014","article-title":"Combination of voice therapy and antireflux therapy rapidly recovers voice-related symptoms in laryngopharyngeal reflux patients","volume":"146","author":"Park","year":"2012","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.cgh.2014.08.044_bib58","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/ajg.2013.80","article-title":"Diagnostic testing in extraesophageal GERD: another case of \u201cfuror medicus\u201d?","volume":"108","author":"Spiegel","year":"2013","journal-title":"Am J Gastroenterol"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235651401386X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235651401386X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:18:08Z","timestamp":1761542288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154235651401386X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S154235651401386X"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2014.08.044","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Should the Reflex Be Reflux? Throat Symptoms and Alternative Explanations","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2014.08.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 AGA Institute. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}