{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:43:58Z","timestamp":1772120638507,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.cgh.2015.01.014","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T10:17:06Z","timestamp":1422267426000},"page":"1249-1255.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers"],"prefix":"10.1016","volume":"13","author":[{"given":"Takashi","family":"Kondo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadayuki","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Watari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2015.01.014_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cgh.2006.09.016","article-title":"Time trends of gastroesophageal reflux disease: a systematic review","volume":"5","author":"El-Serag","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2015.01.014_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.gtc.2008.09.009","article-title":"The pathophysiologic basis for epidemiologic trends in gastroesophageal reflux disease","volume":"37","author":"Pandolfino","year":"2008","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.cgh.2015.01.014_bib3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00535-009-0047-5","article-title":"Epidemiology and clinical characteristics of GERD in the Japanese population","volume":"44","author":"Fujiwara","year":"2009","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2015.01.014_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/j.gastro.2010.05.016","article-title":"Persistent reflux symptoms in the proton pump inhibitor era: the changing face of gastroesophageal reflux disease","volume":"139","author":"Dellon","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2015.01.014_bib5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cgh.2009.03.006","article-title":"What makes individuals with gastroesophageal reflux disease dissatisfied with their treatment?","volume":"7","author":"Bytzer","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2015.01.014_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2036.2007.03350.x","article-title":"Efficacy of rabeprazole on heartburn symptom resolution in patients with non-erosive and erosive gastro-oesophageal reflux disease: a multicenter study from Japan","volume":"26","author":"Miwa","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2015.01.014_bib7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S1542-3565(04)00288-5","article-title":"Effectiveness of proton pump inhibitors in nonerosive reflux disease","volume":"2","author":"Dean","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2015.01.014_bib8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ncpgasthep1160","article-title":"Mechanisms of heartburn","volume":"5","author":"Ang","year":"2008","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2015.01.014_bib9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrgastro.2013.50","article-title":"NERD: an umbrella term including heterogeneous subpopulations","volume":"10","author":"Savarino","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2015.01.014_bib10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1096\/fj.11-0302ufm","article-title":"Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years","volume":"25","author":"Narumiya","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.cgh.2015.01.014_bib11","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tips.2012.02.004","article-title":"Prostaglandins and chronic inflammation","volume":"33","author":"Aoki","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.cgh.2015.01.014_bib12","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.pain.2011.02.019","article-title":"ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis","volume":"152","author":"Miki","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.cgh.2015.01.014_bib13","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1046\/j.1460-9568.1999.00602.x","article-title":"Involvement of primary afferent C-fibres in touch-evoked pain (allodynia) induced by prostaglandin E2","volume":"11","author":"Minami","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.cgh.2015.01.014_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00000539-200101000-00045","article-title":"The effects of peripheral administration of a novel selective antagonist for prostaglandin E receptor subtype EP(1), ONO-8711, in a rat model of postoperative pain","volume":"92","author":"Omote","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1016\/j.cgh.2015.01.014_bib15","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1097\/00000539-200110000-00043","article-title":"A\u00a0prostaglandin E2 receptor subtype EP1 receptor antagonist (ONO-8711) reduces hyperalgesia, allodynia, and c-fos gene expression in rats with chronic nerve constriction","volume":"93","author":"Kawahara","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1016\/j.cgh.2015.01.014_bib16","doi-asserted-by":"crossref","first-page":"G568","DOI":"10.1152\/ajpgi.00276.2012","article-title":"Prostaglandin E(2) mediates acid-induced heartburn in healthy volunteers","volume":"304","author":"Kondo","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.cgh.2015.01.014_bib17","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s00535-004-1417-7","article-title":"Development and evaluation of FSSG: frequency scale for the symptoms of GERD","volume":"39","author":"Kusano","year":"2004","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2015.01.014_bib18","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0016-5085(98)70014-9","article-title":"Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans","volume":"115","author":"Fass","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2015.01.014_bib19","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1023\/A:1018850824287","article-title":"Increased esophageal chemoreceptor sensitivity to acid in patients after successful reversal of Barrett's esophagus","volume":"42","author":"Fass","year":"1997","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.cgh.2015.01.014_bib20","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0140-6736(00)02758-6","article-title":"Contribution of central sensitisation to the development of non-cardiac chest pain","volume":"356","author":"Sarkar","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.cgh.2015.01.014_bib21","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1053\/j.gastro.2003.11.047","article-title":"The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor","volume":"126","author":"Willert","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2015.01.014_bib22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1053\/gast.2003.50022","article-title":"The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans","volume":"124","author":"Sarkar","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2015.01.014_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(78)90020-9","article-title":"Ratio scales of sensory and affective verbal pain descriptors","volume":"5","author":"Gracely","year":"1978","journal-title":"Pain"},{"key":"10.1016\/j.cgh.2015.01.014_bib24","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s00535-012-0665-1","article-title":"Effect of age and correlation between esophageal visceral chemosensitivity and mechanosensitivity in healthy Japanese subjects","volume":"48","author":"Yamasaki","year":"2013","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2015.01.014_bib25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1053\/j.gastro.2007.12.010","article-title":"The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease","volume":"134","author":"Fass","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2015.01.014_bib26","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1053\/gast.1996.v111.pm8898633","article-title":"Dilated intercellular spaces: a morphological feature of acid reflux\u2013damaged human esophageal epithelium","volume":"111","author":"Tobey","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2015.01.014_bib27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11894-009-0030-6","article-title":"Dilated intercellular spaces as a marker of GERD","volume":"11","author":"Orlando","year":"2009","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.cgh.2015.01.014_bib28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/MCG.0b013e318299f181","article-title":"Esophageal mucosal integrity in nonerosive reflux disease","volume":"48","author":"Woodland","year":"2014","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2015.01.014_bib29","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1136\/gut.2007.127886","article-title":"Visceral hypersensitivity in non-erosive reflux disease","volume":"57","author":"Knowles","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2015.01.014_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pain.2008.12.011","article-title":"Basic and clinical aspects of gastrointestinal pain","volume":"141","author":"Knowles","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.cgh.2015.01.014_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00535-011-0476-9","article-title":"Comparisons of symptoms reported by elderly and non-elderly patients with GERD","volume":"47","author":"Furuta","year":"2012","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2015.01.014_bib32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1056\/NEJM200108093450607","article-title":"The coxibs, selective inhibitors of cyclooxygenase-2","volume":"345","author":"FitzGerald","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cgh.2015.01.014_bib33","first-page":"8","article-title":"NSAID induced gastrointestinal complications: the ARAMIS perspective\u20131997. Arthritis, Rheumatism, and Aging Medical Information System","volume":"51","author":"Singh","year":"1998","journal-title":"J\u00a0Rheumatol Suppl"},{"key":"10.1016\/j.cgh.2015.01.014_bib34","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJM199906173402407","article-title":"Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs","volume":"340","author":"Wolfe","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cgh.2015.01.014_bib35","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1023\/A:1018834301901","article-title":"Effect of one-month treatment with nonsteroidal antiinflammatory drugs (NSAIDs) on gastric pH of rheumatoid arthritis patients","volume":"43","author":"Savarino","year":"1998","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.cgh.2015.01.014_bib36","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1023\/A:1005560104847","article-title":"Interaction between NSAIDs and steroid in rat stomach: safety of nimesulide as a preferential COX-2 inhibitor in the stomach","volume":"45","author":"Kataoka","year":"2000","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.cgh.2015.01.014_bib37","first-page":"407","article-title":"Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach","volume":"58","author":"Nishio","year":"2007","journal-title":"J\u00a0Physiol Pharmacol"},{"key":"10.1016\/j.cgh.2015.01.014_bib38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1172\/JCI6749","article-title":"The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure","volume":"107","author":"Stock","year":"2001","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.cgh.2015.01.014_bib39","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1016\/S0016-5085(13)60486-2","article-title":"746 ONO-8539, a novel prostanoid EP1 receptor antagonist, suppresses acid-induced primary and secondary esophageal hypersensitivity in monkeys","volume":"144","author":"Konemura","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2015.01.014_bib40","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1248\/bpb.34.1170","article-title":"Prostaglandin E2 and pain\u2013an update","volume":"34","author":"Kawabata","year":"2011","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.cgh.2015.01.014_bib41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2036.2007.03367.x","article-title":"Generation of dyspeptic symptoms by direct acid infusion into the stomach of healthy Japanese subjects","volume":"26","author":"Miwa","year":"2007","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356515001007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356515001007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:17:28Z","timestamp":1761542248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356515001007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1542356515001007"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2015.01.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725332894.793509819","asserted-by":"object"}]},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2015.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 AGA Institute. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}