{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:25:07Z","timestamp":1792153507728,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.cgh.2020.03.034","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T03:13:33Z","timestamp":1584760413000},"page":"2998-3007.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Deep Convolutional Neural Network-Aided Detection of Portal Hypertension in Patients With Cirrhosis"],"prefix":"10.1016","volume":"18","author":[{"given":"Yanna","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyuan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necati","family":"\u00d6rmeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangfu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8716-4926","authenticated-orcid":false,"given":"Huiguo","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzeng","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3071-494X","authenticated-orcid":false,"given":"Jitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seray","family":"Ak\u00e7alar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrecan","family":"\u00c7elebio\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evren","family":"\u00dcst\u00fcner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sad\u0131k","family":"Bilgi\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Ellik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcn \u00d6mer","family":"Asiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaojun","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaolong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0498-0432","authenticated-orcid":false,"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghong","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-5855","authenticated-orcid":false,"given":"Xiaolong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2020.03.034_bib1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(18)31875-0","article-title":"\u03b2 blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial","volume":"393","author":"Villanueva","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.cgh.2020.03.034_bib2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jhep.2017.10.020","article-title":"Clinical states of cirrhosis and competing risks","volume":"68","author":"D'Amico","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2020.03.034_bib3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/hep.28906","article-title":"Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases","volume":"65","author":"Garcia-Tsao","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2020.03.034_bib4","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S2468-1253(18)30232-2","article-title":"Emerging non-invasive approaches for diagnosis and monitoring of portal hypertension","volume":"3","author":"Qi","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.03.034_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cgh.2017.06.050","article-title":"Diagnosing liver fibrosis and cirrhosis: serum, imaging or tissue?","volume":"16","author":"Tana","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.03.034_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ultrasmedbio.2016.07.025","article-title":"A\u00a0meta-analysis for the diagnostic performance of transient elastography for clinically significant portal hypertension","volume":"43","author":"You","year":"2017","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.cgh.2020.03.034_bib7","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/hep.28824","article-title":"Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: the \u201cAnticipate\u201d study","volume":"64","author":"Abraldes","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2020.03.034_bib8","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1148\/rg.2017170077","article-title":"Deep learning: a primer for radiologists","volume":"37","author":"Chartrand","year":"2017","journal-title":"Radiographics"},{"key":"10.1016\/j.cgh.2020.03.034_bib9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature14539","article-title":"Deep learning","volume":"521","author":"LeCun","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cgh.2020.03.034_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1470-2045(18)30762-9","article-title":"Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study","volume":"20","author":"Li","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.cgh.2020.03.034_bib11","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1001\/jama.2017.14585","article-title":"Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer","volume":"318","author":"Bejnordi","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.cgh.2020.03.034_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.media.2016.05.004","article-title":"Brain tumor segmentation with deep neural networks","volume":"35","author":"Havaei","year":"2017","journal-title":"Med Image Anal"},{"key":"10.1016\/j.cgh.2020.03.034_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmpb.2016.10.007","article-title":"Classification of CT brain images based on deep learning networks","volume":"138","author":"Gao","year":"2017","journal-title":"Comput Meth Prog Bio"},{"key":"10.1016\/j.cgh.2020.03.034_bib14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/gutjnl-2018-316204","article-title":"Deep learning radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study","volume":"68","author":"Wang","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2020.03.034_bib15","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1148\/radiol.2018180425","article-title":"Virtual hepatic venous pressure gradient with CT angiography (CHESS 1601): a prospective multicenter study for the noninvasive diagnosis of portal hypertension","volume":"290","author":"Qi","year":"2019","journal-title":"Radiology"},{"key":"10.1016\/j.cgh.2020.03.034_bib16","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jhep.2013.12.015","article-title":"Accurate computed tomography-based portal pressure assessment in patients with hepatocellular carcinoma","volume":"60","author":"Iranmanesh","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2020.03.034_bib17","first-page":"1302","article-title":"Utility of a discriminant score for diagnosing advanced fibrosis or cirrhosis in patients with chronic hepatitis C virus infection","volume":"92","author":"Bonacini","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2020.03.034_bib18","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","article-title":"A\u00a0simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C","volume":"38","author":"Wai","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2020.03.034_bib19","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/j.1572-0241.2008.01826.x","article-title":"Noninvasive prediction of clinically significant portal hypertension and esophageal varices in patients with compensated liver cirrhosis","volume":"103","author":"Berzigotti","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2020.03.034_bib20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/hep.21669","article-title":"FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection comparison with liver biopsy and Fibrotest","volume":"46","author":"Vallet-Pichard","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2020.03.034_bib21","first-page":"77","article-title":"Simple surrogate index of the fibrosis stage in chronic hepatitis C patients using platelet count and serum albumin level","volume":"60","author":"Ohta","year":"2006","journal-title":"Acta Med Okayama"},{"key":"10.1016\/j.cgh.2020.03.034_bib22","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1136\/gutjnl-2015-309260","article-title":"The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa","volume":"65","author":"Lemoine","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2020.03.034_bib23","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/MEG.0b013e32830dfcb3","article-title":"King's score: an accurate marker of cirrhosis in chronic hepatitis C","volume":"21","author":"Cross","year":"2009","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.03.034_bib24","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/hep.20772","article-title":"Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT-C cohort","volume":"42","author":"Lok","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2020.03.034_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/17474124.2017.1374852","article-title":"Elastography methods for the non-invasive assessment of portal hypertension","volume":"12","author":"Roccarina","year":"2018","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.03.034_bib26","first-page":"4368","article-title":"Spleen ultrasound elastography: state of the art and future directions - a systematic review","volume":"23","author":"Gibiino","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.cgh.2020.03.034_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ebiom.2018.09.023","article-title":"Development and validation of a radiomics signature for clinically significant portal hypertension in cirrhosis (CHESS1701): a prospective multicenter study","volume":"36","author":"Liu","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cgh.2020.03.034_bib28","article-title":"Diagnostic and prognostic values of noninvasive predictors of portal hypertension in patients with alcoholic cirrhosis","volume":"10","author":"Cho","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cgh.2020.03.034_bib29","article-title":"Diagnostic efficacy of noninvasive liver fibrosis indexes in predicting portal hypertension in patients with cirrhosis","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cgh.2020.03.034_bib30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/MEG.0000000000001381","article-title":"Diagnostic accuracy of \u03b3-glutamyl transpeptidase-to-platelet ratio for predicting hepatitis B-related fibrosis: a meta-analysis","volume":"31","author":"Lian","year":"2019","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.03.034_bib31","article-title":"Very Deep Convolutional Networks for Large-Scale Image Recognition","author":"Simonyan","year":"2014","journal-title":"arXiv technical report"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356520303463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356520303463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:33:25Z","timestamp":1761543205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356520303463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":31,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S1542356520303463"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2020.03.034","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep Convolutional Neural Network-Aided Detection of Portal Hypertension in Patients With Cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2020.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the AGA Institute","name":"copyright","label":"Copyright"}]}}