{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:01:05Z","timestamp":1789682465346,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.cgh.2020.09.001","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T21:12:24Z","timestamp":1599081144000},"page":"2551-2558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Functional Abdominal Pain Disorders and Constipation in Children on Gluten-Free Diet"],"prefix":"10.1016","volume":"19","author":[{"given":"Fernanda","family":"Cristofori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaelena","family":"Tripaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusi","family":"Lorusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Indrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Rutigliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Piscitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Castellaneta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Bentivoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-974X","authenticated-orcid":false,"given":"Ruggiero","family":"Francavilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2020.09.001_bib1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease","volume":"54","author":"Husby","year":"2012","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.cgh.2020.09.001_bib2","first-page":"193","article-title":"The pediatric Rome IV criteria: what's new?","volume":"11","author":"Koppen","year":"2017","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.09.001_bib3","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1053\/j.gastro.2016.02.015","article-title":"Functional disorders: children and adolescents","volume":"150","author":"Hyams","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2020.09.001_bib4","doi-asserted-by":"crossref","first-page":"h701","DOI":"10.1136\/bmj.h701","article-title":"Irritable bowel syndrome in adults in primary care: summary of updated NICE guidance","volume":"350","author":"Hookway","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.cgh.2020.09.001_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/ajg.2016.466","article-title":"Screening for celiac disease in irritable bowel syndrome: an updated systematic review and meta-analysis","volume":"112","author":"Irvine","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.cgh.2012.11.033","article-title":"Prevalence of irritable bowel syndrome-type symptoms in patients with celiac disease: a meta-analysis","volume":"11","author":"Sainsbury","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.09.001_bib7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/jamapediatrics.2013.4984","article-title":"Increased prevalence of celiac disease among pediatric patients with irritable bowel syndrome: a 6-year prospective cohort study","volume":"168","author":"Cristofori","year":"2014","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.cgh.2020.09.001_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MCG.0b013e3181e04d0b","article-title":"Anorectal function and visceral hypersensitivity in celiac disease","volume":"44","author":"Mulak","year":"2010","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib9","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1046\/j.1365-2362.1997.2340781.x","article-title":"Autonomic dysfunction and upper digestive functional disorders in untreated adult coeliac disease","volume":"27","author":"Usai","year":"1997","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.cgh.2020.09.001_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0039.1993.tb01970.x","article-title":"Rapid DNA typing of class II HLA antigens using the polymerase chain reaction and\u00a0reverse dot blot hybridisation","volume":"41","author":"Buyse","year":"1993","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.cgh.2020.09.001_bib11","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/00042737-199910000-00019","article-title":"The histopathology of coeliac disease: time for a standardised report scheme for pathologists","volume":"11","author":"Oberhuber","year":"1999","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.09.001_bib12","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1017\/S0007114511007367","article-title":"A\u00a0score that verifies adherence to a gluten-free diet: a cross-sectional, multicentre validation in real clinical life","volume":"108","author":"Biagi","year":"2012","journal-title":"Br J Nutr"},{"key":"10.1016\/j.cgh.2020.09.001_bib13","series-title":"Rome IV-Pediatric Functional gastrointestinal disorders-disorders of gut brain interaction","author":"Di Lorenzo","year":"2016"},{"key":"10.1016\/j.cgh.2020.09.001_bib14","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.mpg.0000172748.64103.33","article-title":"Development and preliminary validation of the questionnaire on pediatric gastrointestinal symptoms to assess functional gastrointestinal disorders in children and adolescents","volume":"41","author":"Caplan","year":"2005","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.cgh.2020.09.001_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/01.mpg.0000172749.71726.13","article-title":"Validation of the pediatric Rome II criteria for functional gastrointestinal disorders using the questionnaire on pediatric gastrointestinal symptoms","volume":"41","author":"Caplan","year":"2005","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.cgh.2020.09.001_bib16","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MPG.0000000000000266","article-title":"Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN","volume":"58","author":"Tabbers","year":"2014","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.cgh.2020.09.001_bib17","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.cgh.2017.11.005","article-title":"Prevalence of functional gastrointestinal disorders in children and adolescents in the Mediterranean region of Europe","volume":"16","author":"Scarpato","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.09.001_bib18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1365-2036.2011.04787.x","article-title":"The association of coeliac disease in childhood with functional gastrointestinal disorders: a prospective study in patients fulfilling Rome III criteria","volume":"34","author":"Turco","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2020.09.001_bib19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jpeds.2016.11.049","article-title":"Abdominal pain-associated functional gastrointestinal disorder prevalence in children and adolescents with celiac disease on gluten-free diet: a multinational study","volume":"182","author":"Saps","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.cgh.2020.09.001_bib20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jpeds.2012.08.032","article-title":"Abdominal pain and functional gastrointestinal disorders in children with celiac disease","volume":"162","author":"Saps","year":"2013","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.cgh.2020.09.001_bib21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1572-0241.2001.03462.x","article-title":"Characteristics of adult celiac disease in the U.S.A.: results of a national survey","volume":"96","author":"Green","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib22","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jpeds.2014.12.050","article-title":"Post infectious functional gastrointestinal disorders in children: a multicenter prospective study","volume":"166","author":"Pensabene","year":"2015","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.cgh.2020.09.001_bib23","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1097\/MIB.0b013e3182802a0a","article-title":"The overlap of functional abdominal pain in pediatric Crohn\u2019s disease","volume":"19","author":"Zimmerman","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.cgh.2020.09.001_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/apt.13636","article-title":"The prevalence of irritable bowel syndrome-type symptoms in paediatric inflammatory bowel disease, and the relationship with bio-chemical markers of disease activity","volume":"44","author":"Diederen","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2020.09.001_bib25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/MPG.0000000000001479","article-title":"The prevalence and impact of functional abdominal pain disorders in children with inflammatory bowel diseases (IBD-FAPD)","volume":"65","author":"Watson","year":"2017","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.cgh.2020.09.001_bib26","first-page":"268","article-title":"Overlap between functional abdominal pain disorders and organic diseases in children","volume":"83","author":"Langshaw","year":"2018","journal-title":"Rev Gastroenterol Mex"},{"key":"10.1016\/j.cgh.2020.09.001_bib27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/j.1572-0241.2002.05690.x","article-title":"Celiac disease and irritable bowel-type symptoms","volume":"97","author":"O\u2019Leary","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib28","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1038\/ajg.2009.188","article-title":"Between celiac disease and irritable bowel syndrome: the \"no man's land\" of gluten sensitivity","volume":"104","author":"Verdu","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib29","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1111\/j.1572-0241.2003.07631.x","article-title":"Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture","volume":"98","author":"Kakar","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib30","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/ajg.2010.10","article-title":"Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet","volume":"105","author":"Rubio-Tapia","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib31","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1053\/j.gastro.2009.02.074","article-title":"Postinfectious irritable bowel syndrome","volume":"136","author":"Spiller","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2020.09.001_bib32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/1756283X11422264","article-title":"A\u00a0review of rifaximin and bacterial overgrowth in poorly responsive celiac disease","volume":"5","author":"Chang","year":"2012","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/MCG.0b013e3181557e67","article-title":"Prevalence of small intestine bacterial overgrowth diagnosed by quantitative culture of intestinal aspirate in celiac disease","volume":"43","author":"Rubio-Tapia","year":"2009","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1572-0241.2003.07379.x","article-title":"High prevalence of small intestinal bacterial overgrowth in celiac patients with persistence of gastrointestinal symptoms after gluten withdrawal","volume":"98","author":"Tursi","year":"2003","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 2","key":"10.1016\/j.cgh.2020.09.001_bib35","first-page":"28","article-title":"Microbiome and gluten","volume":"67","author":"Sanz","year":"2015","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.cgh.2020.09.001_bib36","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2016.02.028","article-title":"The intestinal microenvironment and functional gastrointestinal disorders","author":"Barbara","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2020.09.001_bib37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s12325-018-0673-5","article-title":"A\u00a0review of microbiota and irritable bowel syndrome: future in therapies","volume":"35","author":"Rodi\u00f1o-Janeiro","year":"2018","journal-title":"Adv Ther"},{"key":"10.1016\/j.cgh.2020.09.001_bib38","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1038\/ajg.2014.355","article-title":"Altered duodenal microbiota composition in celiac disease patients suffering from persistent symptoms on a long-term gluten-free diet","volume":"109","author":"Wacklin","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ejcn.2015.114","article-title":"A\u00a0comparison of the nutritional status between adult celiac patients on a long-term, strictly gluten-free diet and healthy subjects","volume":"70","author":"Barone","year":"2016","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.cgh.2020.09.001_bib40","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1017\/S0007114509371767","article-title":"Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects","volume":"102","author":"De Palma","year":"2009","journal-title":"Br J Nutr"},{"key":"10.1016\/j.cgh.2020.09.001_bib41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijfoodmicro.2016.07.025","article-title":"Salivary and fecal microbiota and metabolome of celiac children under gluten-free diet","volume":"239","author":"De Angelis","year":"2016","journal-title":"Int J Food Microbiol"},{"key":"10.1016\/j.cgh.2020.09.001_bib42","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1128\/AEM.02793-08","article-title":"Different fecal microbiotas and volatile organic compounds in treated and untreated children with celiac disease","volume":"75","author":"Di Cagno","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.cgh.2020.09.001_bib43","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/MCG.0000000000000218","article-title":"Dietary supplement use in patients with celiac disease in the United States","volume":"49","author":"Nazareth","year":"2015","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2020.09.001_bib44","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/MEG.0b013e328342a547","article-title":"Reflux and irritable bowel syndrome are negative predictors of quality of life in coeliac disease and inflammatory bowel disease","volume":"23","author":"Barratt","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2020.09.001_bib45","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1007\/s10620-010-1342-y","article-title":"Psychosocial factors are more important than disease activity in determining gastrointestinal symptoms and health status in adults at a celiac disease referral center","volume":"55","author":"Dorn","year":"2010","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.cgh.2020.09.001_bib46","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.dld.2007.05.017","article-title":"Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on health-related quality of life in adult coeliac patients","volume":"39","author":"Usai","year":"2007","journal-title":"Dig Liver Dis"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356520312295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356520312295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:37:32Z","timestamp":1761543452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356520312295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1542356520312295"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2020.09.001","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional Abdominal Pain Disorders and Constipation in Children on Gluten-Free Diet","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2020.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the AGA Institute","name":"copyright","label":"Copyright"}]}}