{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:03:54Z","timestamp":1789844634588,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.cgh.2021.01.011","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T13:37:33Z","timestamp":1610458653000},"page":"e548-e563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Herbal and Dietary Supplements-Induced Liver Injury in Latin America: Experience From the LATINDILI Network"],"prefix":"10.1016","volume":"20","author":[{"given":"Fernando","family":"Bessone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Garc\u00eda-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-6658","authenticated-orcid":false,"given":"Inmaculada","family":"Medina-Caliz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelia","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymundo","family":"Parana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mendizabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Schinoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Ridruejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirta","family":"Peralta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genario","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Anders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Chiodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Tagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Montes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Arrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Isabel","family":"Lizarzabal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Alvarez-Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Caballano-Infantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Pinazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.","family":"Cabello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-4896","authenticated-orcid":false,"given":"M. Isabel","family":"Lucena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal J.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2021.01.011_bib1","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1517\/17425255.2015.1064110","article-title":"Herbal hepatotoxicity: current status, examples, and challenges","volume":"11","author":"Calitz","year":"2015","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.cgh.2021.01.011_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/hep.28813","article-title":"Liver injury from herbal\u00a0and dietary supplements","volume":"65","author":"Navarro","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.01.011_bib3","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1289\/ehp.99107773","article-title":"Medicinal herbs in the United States: research needs","volume":"107","author":"Matthews","year":"1999","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.cgh.2021.01.011_bib4","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/hep.27317","article-title":"Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network","volume":"60","author":"Navarro","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.01.011_bib5","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1053\/j.gastro.2013.02.006","article-title":"Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of iceland","volume":"144","author":"Bj\u00f6rnsson","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.01.011_bib6","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s40264-017-0547-9","article-title":"The incidence of drug- and herbal and dietary supplement-induced liver injury: preliminary findings from gastroenterologist-based surveillance in the population of the state of Delaware","volume":"40","author":"Vega","year":"2017","journal-title":"Drug Saf"},{"key":"10.1016\/j.cgh.2021.01.011_bib7","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.cgh.2017.12.051","article-title":"Herbal and dietary supplement-induced liver injuries in the Spanish DILI registry","volume":"16","author":"Medina-Caliz","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.01.011_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms17010114","article-title":"Herb-induced liver injury in the berlin case-control surveillance study","volume":"17","author":"Douros","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cgh.2021.01.011_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-0038-1623518","article-title":"Hepatic damage by natural remedies","volume":"38","author":"Andrade","year":"2018","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cgh.2021.01.011_bib10","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1038\/ajg.2010.287","article-title":"Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality","volume":"105","author":"Devarbhavi","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.01.011_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5152\/tjg.2014.4486","article-title":"Drug- and herb-induced liver injury: a case series from a single center","volume":"25","author":"Da\u01e7","year":"2014","journal-title":"Turkish J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.01.011_bib12","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/jgh.13323","article-title":"Hepatobiliary and pancreatic: comparison between Chinese herbal medicine and Western medicine-induced liver injury of 1985 patients","volume":"31","author":"Zhu","year":"2016","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.01.011_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1478-3231.2007.01461.x","article-title":"Drug-induced liver injury at\u00a0an\u00a0Asian center: a prospective study","volume":"27","author":"Wai","year":"2007","journal-title":"Liver Int"},{"key":"10.1016\/j.cgh.2021.01.011_bib14","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/ajg.2012.138","article-title":"A\u00a0prospective nationwide study of drug-induced liver injury in Korea","volume":"107","author":"Suk","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.01.011_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/ijms17030313","article-title":"The Latin American DILI Registry experience: a successful ongoing collaborative strategic initiative","volume":"17","author":"Bessone","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cgh.2021.01.011_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/cld.778","article-title":"When the creation of a consortium provides useful answers: experience of the Latin American DILI Network (LATINDILIN)","volume":"13","author":"Bessone","year":"2019","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.cgh.2021.01.011_bib18","article-title":"Profile of herbal and dietary supplements induced liver injury in Latin America: a systematic review of published reports","author":"Santos","year":"2020","journal-title":"Phyther Res"},{"key":"10.1016\/j.cgh.2021.01.011_bib19","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/clpt.2011.58","article-title":"Case definition and phenotype standardization in drug-induced liver injury","volume":"89","author":"Aithal","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.cgh.2021.01.011_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1053\/j.gastro.2014.03.050","article-title":"Use of hy\u2019s law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury","volume":"147","author":"Robles-Diaz","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.01.011_bib21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-0034-1375958","article-title":"Hepatotoxicity induced by herbal and\u00a0dietary supplements","volume":"34","author":"Navarro","year":"2014","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cgh.2021.01.011_bib22","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fphar.2015.00072","article-title":"Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps","volume":"6","author":"Teschke","year":"2015","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.cgh.2021.01.011_bib23","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jhep.2010.12.003","article-title":"Herbal medicine hepatotoxicity: a new step with development of specific biomarkers","volume":"54","author":"Larrey","year":"2011","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.01.011_bib24","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hep4.1346","article-title":"The contents of herbal and dietary supplements implicated in liver injury in the United States are frequently mislabeled","volume":"3","author":"Navarro","year":"2019","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.cgh.2021.01.011_bib25","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/hep.23588","article-title":"Drug-induced autoimmune hepatitis: clinical characteristics and prognosis","volume":"51","author":"Bj\u00f6rnsson","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.01.011_bib26","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jhep.2010.12.041","article-title":"Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis","volume":"55","author":"Lucena","year":"2011","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.01.011_bib27","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/hep.24481","article-title":"The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury","volume":"54","author":"Suzuki","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.01.011_bib28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/liv.13939","article-title":"Clinicopathological features of He Shou Wu-induced liver injury: this ancient anti-aging therapy is not liver-friendly","volume":"39","author":"Wang","year":"2019","journal-title":"Liver Int"},{"key":"10.1016\/j.cgh.2021.01.011_bib29","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/pds.2180","article-title":"Continuous reporting of new cases in Spain supports the relationship between Herbalife products and liver injury","volume":"20","author":"Manso","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.cgh.2021.01.011_bib30","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/hep.30660","article-title":"HLA-B\u221735:01 allele is a potential biomarker for predicting Polygonum multiflorum\u2013induced liver injury in humans","volume":"70","author":"Li","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.01.011_bib31","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ajg.2016.114","article-title":"Clinical features and outcomes of complementary and alternative medicine induced acute liver failure and injury","volume":"111","author":"Hillman","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.01.011_bib32","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/hep.29283","article-title":"Death and liver transplantation within 2 years of onset of drug-induced liver injury","volume":"66","author":"Hayashi","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.01.011_bib33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/hepr.13288","article-title":"Analysis of 307 cases with drug-induced liver injury between 2010 and 2018 in Japan","volume":"49","author":"Aiso","year":"2019","journal-title":"Hepatol Res"},{"key":"10.1016\/j.cgh.2021.01.011_bib34","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.3346\/jkms.2015.30.12.1815","article-title":"Clinical features of drug-induced liver injury according to etiology","volume":"30","author":"Lee","year":"2015","journal-title":"J\u00a0Korean Med Sci"},{"key":"10.1016\/j.cgh.2021.01.011_bib35","first-page":"47","article-title":"Predictors of poor outcomes in 488 patients with herb induced liver injury","volume":"30","author":"Zhu","year":"2019","journal-title":"Turkish J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.01.011_bib36","article-title":"The characteristics and clinical outcome of drug-induced liver injury in a Chinese hospital: a retrospective cohort study","volume":"95","author":"Chen","year":"2016","journal-title":"Med (United States)"},{"key":"10.1016\/j.cgh.2021.01.011_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231398","article-title":"Drug induced liver injury is associated with high mortality: a study from a tertiary care hospital in Pakistan","volume":"15","author":"Abid","year":"2020","journal-title":"PLoS One"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356521000136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356521000136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:39:48Z","timestamp":1761543588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356521000136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1542356521000136"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2021.01.011","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Herbal and Dietary Supplements-Induced Liver Injury in Latin America: Experience From the LATINDILI Network","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2021.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the AGA Institute","name":"copyright","label":"Copyright"}]}}