{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:04:07Z","timestamp":1790114647418,"version":"4.0.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.cgh.2021.02.006","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T11:45:59Z","timestamp":1612525559000},"page":"e964-e973","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Primary Sclerosing Cholangitis\u2013Associated Pouchitis: A Distinct Clinical Phenotype"],"prefix":"10.1016","volume":"20","author":[{"given":"Kevin P.","family":"Quinn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri A.","family":"Urquhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens P.","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Lennon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor G.","family":"Chedid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5267-2592","authenticated-orcid":false,"given":"Laura E.","family":"Raffals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2021.02.006_bib1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJM199504063321406","article-title":"Primary sclerosing cholangitis","volume":"332","author":"Lee","year":"1995","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cgh.2021.02.006_bib2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.23294","article-title":"Diagnosis and management of primary sclerosing cholangitis","volume":"51","author":"Chapman","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.02.006_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5009\/gnl16510","article-title":"Inflammatory bowel disease and primary sclerosing cholangitis: a review of the phenotype and associated specific features","volume":"12","author":"Palmela","year":"2018","journal-title":"Gut Liver"},{"key":"10.1016\/j.cgh.2021.02.006_bib4","first-page":"124","article-title":"Primary sclerosing cholangitis and inflammatory bowel disease comorbidity: an update of the evidence","volume":"32","author":"Mertz","year":"2019","journal-title":"Ann Gastroenterol"},{"key":"10.1016\/j.cgh.2021.02.006_bib5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00384-011-1140-9","article-title":"The clinical impact of primary sclerosing cholangitis in patients with an ileal pouch-anal anastomosis for ulcerative colitis","volume":"26","author":"Rahman","year":"2011","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.cgh.2021.02.006_bib6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/ibd\/izy267","article-title":"A\u00a0comprehensive approach to pouch disorders","volume":"25","author":"Quinn","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.cgh.2021.02.006_bib7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.surg.2005.07.014","article-title":"Surgical outcome in patients with primary sclerosing cholangitis undergoing ileal pouch-anal anastomosis: a case-control study","volume":"138","author":"Gorgun","year":"2005","journal-title":"Surgery"},{"key":"10.1016\/j.cgh.2021.02.006_bib8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.crohns.2013.12.007","article-title":"Outcomes after ileal pouch anal anastomosis in patients with primary sclerosing cholangitis","volume":"8","author":"Pavlides","year":"2014","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.cgh.2021.02.006_bib9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/gut.38.2.234","article-title":"Pouchitis after ileal pouch-anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis","volume":"38","author":"Penna","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2021.02.006_bib10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/00000658-199304000-00002","article-title":"Complications and risk-factors after ileal pouch-anal anastomosis for ulcerative-colitis associated with primary sclerosing cholangitis","volume":"217","author":"Kartheuser","year":"1993","journal-title":"Ann Surg"},{"key":"10.1016\/j.cgh.2021.02.006_bib11","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/ibd.21594","article-title":"Primary sclerosing cholangitis is associated with endoscopic and histologic inflammation of the distal afferent limb in patients with ileal pouch-anal anastomosis","volume":"17","author":"Shen","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.cgh.2021.02.006_bib12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J\u00a0Biomed Inform"},{"key":"10.1016\/j.cgh.2021.02.006_bib13","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J\u00a0Biomed Inform"},{"key":"10.1016\/j.cgh.2021.02.006_bib14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/SLA.0b013e31827d99a2","article-title":"Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients","volume":"257","author":"Fazio","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.cgh.2021.02.006_bib15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/bjs.6210","article-title":"Ileal pouch-anal anastomosis and liver transplantation for ulcerative colitis complicated by primary sclerosing cholangitis","volume":"95","author":"Mathis","year":"2008","journal-title":"Br J Surg"},{"key":"10.1016\/j.cgh.2021.02.006_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/00000658-199508000-00003","article-title":"Ileal pouch-anal anastomoses complications and function in 1005 patients","volume":"222","author":"Fazio","year":"1995","journal-title":"Ann Surg"},{"key":"10.1016\/j.cgh.2021.02.006_bib17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/00365529850170883","article-title":"Chronic inflammatory changes in the pouch mucosa are associated with cholangitis found on preoperative liver biopsy specimens at restorative proctocolectomy for ulcerative colitis","volume":"33","author":"Aitola","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.02.006_bib18","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s10350-008-9194-7","article-title":"Predictors of pouchitis after ileal pouch-anal anastomosis: a retrospective review","volume":"51","author":"Hoda","year":"2008","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.cgh.2021.02.006_bib19","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1053\/j.gastro.2019.10.001","article-title":"Predominantly antibiotic-resistant intestinal microbiome persists in patients with pouchitis who respond to antibiotic therapy","volume":"158","author":"Dubinsky","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.02.006_bib20","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.cgh.2013.03.033","article-title":"Pouchitis: what every gastroenterologist needs to know","volume":"11","author":"Shen","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.02.006_bib21","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/ibd.21911","article-title":"Etiology of pouchitis","volume":"18","author":"Landy","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.cgh.2021.02.006_bib22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/2050640617708953","article-title":"The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease","volume":"6","author":"Torres","year":"2018","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.cgh.2021.02.006_bib23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1136\/gutjnl-2016-311915","article-title":"The gut-adherent microbiota of PSC-IBD is distinct to that of IBD","volume":"66","author":"Quraishi","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2021.02.006_bib24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/gutjnl-2015-310500","article-title":"The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls","volume":"66","author":"Kummen","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2021.02.006_bib25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/gutjnl-2012-302578","article-title":"Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases","volume":"62","author":"Duboc","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2021.02.006_bib26","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/ibd.21594","article-title":"Primary sclerosing cholangitis is associated with endoscopic and histologic inflammation of the distal afferent limb in patients with ileal pouch-anal anastomosis","volume":"17","author":"Shen","year":"2011","journal-title":"Inflamm Bowel Dis"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356521001075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356521001075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:36:23Z","timestamp":1761543383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356521001075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1542356521001075"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2021.02.006","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary Sclerosing Cholangitis\u2013Associated Pouchitis: A Distinct Clinical Phenotype","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2021.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the AGA Institute","name":"copyright","label":"Copyright"}]}}