{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:14:52Z","timestamp":1793394892846,"version":"4.5.0"},"reference-count":126,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI19\/00222"],"award-info":[{"award-number":["FI19\/00222"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016391","name":"Societat Catalana de Digestologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000391","name":"Association for International Cancer Research","doi-asserted-by":"publisher","award":["16-0026"],"award-info":[{"award-number":["16-0026"]}],"id":[{"id":"10.13039\/501100000391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002704","name":"Fundaci\u00f3n Cient\u00edfica Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","doi-asserted-by":"publisher","award":["PI044031"],"award-info":[{"award-number":["PI044031"]}],"id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.cgh.2021.05.002","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T17:35:14Z","timestamp":1622223314000},"page":"283-292.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":193,"title":["Incidence of Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-analysis, and Meta-regression"],"prefix":"10.1016","volume":"20","author":[{"given":"Lorenzo A.","family":"Orci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Sanduzzi-Zamparelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Caballol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Sapena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Colucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Bruix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Reig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Toso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2021.05.002_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease: meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/17474124.2019.1549989","article-title":"Trends in hepatocellular carcinoma due to non-alcoholic fatty liver disease","volume":"13","author":"Bertot","year":"2019","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.clinre.2018.03.014","article-title":"A\u00a0changing etiologic scenario in liver transplantation for hepatocellular carcinoma in a multicenter cohort study from Latin America","volume":"42","author":"Pinero","year":"2018","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00535-015-1129-1","article-title":"Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey","volume":"51","author":"Tokushige","year":"2016","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib5","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2018.05.036","article-title":"Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030","volume":"69","author":"Estes","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib6","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.cgh.2018.05.057","article-title":"Nonalcoholic steatohepatitis is the fastest growing cause of hepatocellular carcinoma in liver transplant candidates","volume":"17","author":"Younossi","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib7","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cgh.2021.05.002_bib8","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.12.053","article-title":"AGA clinical practice update on screening and surveillance for hepatocellular carcinoma in patients with nonalcoholic fatty liver disease: expert review","author":"Loomba","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib9","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cgh.2011.01.023","article-title":"Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma","volume":"9","author":"Yasui","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib10","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/hep.25536","article-title":"Outcomes of curative treatment for hepatocellular cancer in nonalcoholic steatohepatitis versus hepatitis C and alcoholic liver disease","volume":"55","author":"Reddy","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","article-title":"Management of hepatocellular carcinoma: an update","volume":"53","author":"Bruix","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib12","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/hep.29913","article-title":"Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases","volume":"68","author":"Marrero","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL clinical practice guidelines: management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib14","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cgh.2012.10.001","article-title":"Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review","volume":"10","author":"White","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib15","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/apt.14937","article-title":"Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases","volume":"48","author":"Stine","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2021.05.002_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/TP.0000000000002361","article-title":"Should patients with NAFLD\/NASH be surveyed for HCC?","volume":"103","author":"Reig","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.cgh.2021.05.002_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.cgh.2021.05.002_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.cgh.2021.05.002_bib20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.cgh.2021.05.002_bib21","doi-asserted-by":"crossref","first-page":"820","DOI":"10.7326\/0003-4819-127-9-199711010-00008","article-title":"Quantitative synthesis in systematic reviews","volume":"127","author":"Lau","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cgh.2021.05.002_bib22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.gastro.2005.04.014","article-title":"The natural history of nonalcoholic fatty liver disease: a population-based cohort study","volume":"129","author":"Adams","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib23","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1872-034X.2011.00915.x","article-title":"Difference in malignancies of chronic liver disease due to non-alcoholic fatty liver disease or hepatitis C in Japanese elderly patients","volume":"42","author":"Arase","year":"2012","journal-title":"Hepatol Res"},{"key":"10.1016\/j.cgh.2021.05.002_bib24","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/hep.23527","article-title":"The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis","volume":"51","author":"Ascha","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib25","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/hep.24491","article-title":"The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study","volume":"54","author":"Bhala","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib26","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/hep.21327","article-title":"Long-term follow-up of patients with NAFLD and elevated liver enzymes","volume":"44","author":"Ekstedt","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1440-1746.2008.05640.x","article-title":"Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C","volume":"24","author":"Yatsuji","year":"2009","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/imj.12624","article-title":"Epidemiology, disease burden and outcomes of cirrhosis in a large secondary care hospital in South Auckland, New Zealand","volume":"45","author":"Hsiang","year":"2015","journal-title":"Intern Med J"},{"key":"10.1016\/j.cgh.2021.05.002_bib29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/jhep.2003.50320","article-title":"Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C","volume":"38","author":"Hui","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib30","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1053\/j.gastro.2018.08.024","article-title":"Risk of hepatocellular cancer in patients with non-alcoholic fatty liver disease","volume":"155","author":"Kanwal","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/ajg.2011.327","article-title":"Large-scale long-term follow-up study of Japanese patients with non-alcoholic fatty liver disease for the onset of hepatocellular carcinoma","volume":"107","author":"Kawamura","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib32","first-page":"345","article-title":"Association between non-alcoholic fatty liver disease and cancer incidence rate","volume":"45","author":"Kim","year":"2017","journal-title":"J\u00a0Hepatol"},{"issue":"Suppl 1","key":"10.1016\/j.cgh.2021.05.002_bib33","first-page":"E247","article-title":"Hepatic and extrahepatic malignancies in cirrhosis caused by nonalcoholic steatohepatitis and alcoholic liver disease","volume":"37","author":"Kodama","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.cgh.2021.05.002_bib34","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/ijc.30784","article-title":"The occurrence of hepatocellular carcinoma in different risk stratifications of clinically noncirrhotic nonalcoholic fatty liver disease","volume":"141","author":"Lee","year":"2017","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cgh.2021.05.002_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186715","article-title":"Alcoholic liver disease\u00a0confers a worse prognosis than HCV infection and non-alcoholic fatty liver disease among patients with cirrhosis: an observational study","volume":"12","author":"Marot","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cgh.2021.05.002_bib36","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3109\/00365521.2014.934911","article-title":"Increased risk of cirrhosis and hepatocellular cancer during long-term follow-up of patients with biopsy-proven NAFLD","volume":"49","author":"Onnerhag","year":"2014","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12916-019-1321-x","article-title":"Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts","volume":"17","author":"Alexander","year":"2019","journal-title":"BMC Med"},{"key":"10.1016\/j.cgh.2021.05.002_bib38","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/hep.30858","article-title":"Diabetes is associated with increased risk of hepatocellular carcinoma in patients with cirrhosis from nonalcoholic fatty liver disease","volume":"71","author":"Yang","year":"2020","journal-title":"Hepatology"},{"issue":"Suppl 19","key":"10.1016\/j.cgh.2021.05.002_bib39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00535-008-2262-x","article-title":"Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis","volume":"44","author":"Hashimoto","year":"2009","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib40","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/hep.21103","article-title":"Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C","volume":"43","author":"Sanyal","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib41","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jhep.2016.08.010","article-title":"Trends in hepatocellular carcinoma among people with HBV or HCV notification in\u00a0Australia (2000-2014)","volume":"65","author":"Waziry","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib42","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jhep.2017.07.025","article-title":"Hepatocellular carcinoma risk following direct-acting antiviral HCV therapy: a systematic review, meta-analyses, and meta-regression","volume":"67","author":"Waziry","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib43","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/hep.28368","article-title":"Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: a multicenter prospective study","volume":"63","author":"Piscaglia","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib44","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/hep.22734","article-title":"Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis","volume":"49","author":"Paradis","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib45","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41698-018-0048-z","article-title":"Role of nonresolving inflammation in hepatocellular carcinoma development and progression","volume":"2","author":"Yu","year":"2018","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.cgh.2021.05.002_bib46","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrgastro.2017.72","article-title":"The gut microbiome and liver cancer: mechanisms and clinical translation","volume":"14","author":"Yu","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib47","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cgh.2019.08.011","article-title":"Association between PNPLA3 rs738409 C>G variant and liver-related outcomes in patients with nonalcoholic fatty liver disease","volume":"18","author":"Grimaudo","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib48","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jhep.2014.02.030","article-title":"Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma","volume":"61","author":"Liu","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib49","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1053\/j.gastro.2018.08.066","article-title":"Hepatocellular carcinoma surveillance: an effective but complex process","volume":"156","author":"Singal","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib50","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1053\/j.gastro.2018.09.060","article-title":"Re: no association between screening for hepatocellular carcinoma and reduced cancer-related mortality in patients with cirrhosis","volume":"156","author":"Majeed","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/RMHP.S18677","article-title":"Hepatocellular carcinoma: cost-effectiveness of screening\u2014a systematic review","volume":"5","author":"Ruggeri","year":"2012","journal-title":"Risk Manag Healthc Policy"},{"key":"10.1016\/j.cgh.2021.05.002_bib52","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/s-0037-1608775","article-title":"Overdiagnosis: an understudied issue in hepatocellular carcinoma surveillance","volume":"37","author":"Rich","year":"2017","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cgh.2021.05.002_bib53","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/hep.28895","article-title":"An assessment of benefits and harms of hepatocellular carcinoma surveillance in patients with cirrhosis","volume":"65","author":"Atiq","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib54","series-title":"Cancer control, knowledge into action, WHO guide for effective programmes: early detection","year":"2007"},{"key":"10.1016\/j.cgh.2021.05.002_bib55","article-title":"Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention","author":"Huang","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib56","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jhep.2015.11.035","article-title":"PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy","volume":"64","author":"Papatheodoridis","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib57","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00535-008-2264-8","article-title":"Etiology of non-B non-C hepatocellular carcinoma in the eastern district of Tokyo","volume":"43","author":"Abe","year":"2008","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib58","doi-asserted-by":"crossref","first-page":"159","DOI":"10.7869\/tg.120","article-title":"Risk of development of hepatocellular carcinoma in patients with NASH-related cirrhosis","volume":"34","author":"Amarapurkar","year":"2013","journal-title":"Trop Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib59","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00004836-200307000-00025","article-title":"Is hepatocellular carcinoma part of the natural history of nonalcoholic steatohepatitis?","volume":"37","author":"Anagnostopoulos","year":"2003","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib60","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1111\/liv.12767","article-title":"Risk factors for hepatocellular carcinoma in Caucasian patients with non-viral cirrhosis: the importance of prior obesity","volume":"35","author":"Archambeaud","year":"2015","journal-title":"Liver Int"},{"key":"10.1016\/j.cgh.2021.05.002_bib61","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/ijc.25362","article-title":"Risk of cancer in a large cohort of U.S. veterans with diabetes","volume":"128","author":"Atchison","year":"2017","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cgh.2021.05.002_bib62","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ijc.26338","article-title":"Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults","volume":"131","author":"Borena","year":"2012","journal-title":"Int J Cancer"},{"issue":"Suppl 1","key":"10.1016\/j.cgh.2021.05.002_bib63","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000333210","article-title":"Relative etiological role of prior hepatitis B virus infection and nonalcoholic fatty liver disease in the development of non-B non-C hepatocellular carcinoma in a hepatitis B-endemic area","volume":"84","author":"Cho","year":"2011","journal-title":"Digestion"},{"key":"10.1016\/j.cgh.2021.05.002_bib64","doi-asserted-by":"crossref","first-page":"281","DOI":"10.6061\/clinics\/2016(05)07","article-title":"Nonalcoholic steatohepatitis and hepatocellular carcinoma: Brazilian survey","volume":"71","author":"Cotrim","year":"2016","journal-title":"Clinics (Sao Paulo, Brazil)"},{"key":"10.1016\/j.cgh.2021.05.002_bib65","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s12664-017-0785-x","article-title":"Risk factors for non-alcoholic fatty liver disease are common in patients with non-B non-C hepatocellular carcinoma in India","volume":"36","author":"David","year":"2017","journal-title":"Indian Journal of Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib66","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2013.08.011","article-title":"Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team","volume":"60","author":"Dyson","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib67","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1002\/ijc.25797","article-title":"Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis","volume":"128","author":"Ertle","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cgh.2021.05.002_bib68","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/bjc.2017.296","article-title":"The association between fasting blood glucose and the risk of primary liver cancer in Chinese males: a population-based prospective study","volume":"117","author":"Feng","year":"2017","journal-title":"Br J Cancer"},{"key":"10.1016\/j.cgh.2021.05.002_bib69","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.5858\/132.11.1761","article-title":"Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis?","volume":"132","author":"Guzman","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.cgh.2021.05.002_bib70","doi-asserted-by":"crossref","first-page":"164s","DOI":"10.1111\/j.1530-0277.2004.tb03237.x","article-title":"Comparison of hepatocellular carcinoma patients with alcoholic liver disease and nonalcoholic steatohepatitis","volume":"28","author":"Hashimoto","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.cgh.2021.05.002_bib71","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/MEG.0b013e3282748ef2","article-title":"Primary liver cancers with nonalcoholic steatohepatitis","volume":"19","author":"Hashizume","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib72","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00508-011-0033-9","article-title":"Clinical characteristics of patients with hepatocellular carcinoma in Austria: is there a need for a structured screening program?","volume":"123","author":"Hucke","year":"2011","journal-title":"Wiener Klinische Wochenschrift"},{"key":"10.1016\/j.cgh.2021.05.002_bib73","first-page":"129","article-title":"Clinicopathological characteristics of patients with non-B non-C hepatocellular carcinoma: a special reference to metabolic syndrome","volume":"61","author":"Imura","year":"2014","journal-title":"Hepato-gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib74","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/MEG.0b013e3283534b40","article-title":"Hepatocellular carcinoma in nonalcoholic fatty liver cirrhosis and alcoholic cirrhosis: risk factor analysis in liver transplant recipients","volume":"24","author":"Jain","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib75","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/MCG.0000000000000689","article-title":"Increased prevalence of metabolic risk factors in Asian Americans with hepatocellular carcinoma","volume":"51","author":"Kutsenko","year":"2017","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib76","first-page":"76","article-title":"Hepatocellular carcinoma can occur in non-alcoholic fatty liver disease without cirrhosis","volume":"28","author":"Leung","year":"2013","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib77","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3748\/wjg.v21.i4.1189","article-title":"Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease","volume":"21","author":"Leung","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib78","doi-asserted-by":"crossref","first-page":"S516","DOI":"10.1016\/S0168-8278(13)61276-3","article-title":"Carriage of PNPLA3 I148M is associated with an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma","volume":"58","author":"Liu","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib79","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.cgh.2012.08.011","article-title":"Incidence of hepatocellular carcinoma among US patients with cirrhosis of viral or nonviral etiologies","volume":"10","author":"Mair","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib80","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1002\/hep.1840360609","article-title":"NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States","volume":"36","author":"Marrero","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib81","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12072-016-9731-8","article-title":"NAFLD as a risk factor for HCC: new rules of engagement?","volume":"10","author":"Masuzaki","year":"2016","journal-title":"Hepatol Int"},{"key":"10.1016\/j.cgh.2021.05.002_bib82","doi-asserted-by":"crossref","first-page":"S991","DOI":"10.1016\/S0016-5085(14)63604-0","article-title":"Surveillance and outcomes in non-alcoholic fatty liver disease related hepatocellular carcinoma in veteran affairs (VA) population","volume":"146","author":"Mittal","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib83","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.cgh.2014.08.013","article-title":"Temporal trends of nonalcoholic fatty liver disease-related hepatocellular carcinoma in the veteran affairs population","volume":"13","author":"Mittal","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib84","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s12072-015-9679-0","article-title":"Characterization of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients without cirrhosis","volume":"10","author":"Mohamad","year":"2016","journal-title":"Hepatol Int"},{"key":"10.1016\/j.cgh.2021.05.002_bib85","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.3748\/wjg.v23.i15.2763","article-title":"Patients with non-viral liver disease have a greater tumor burden and less curative treatment options when diagnosed with hepatocellular carcinoma","volume":"23","author":"Mohsen","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187033","article-title":"Etiology and mode of presentation of chronic liver diseases in India: a multi centric study","volume":"12","author":"Mukherjee","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.cgh.2021.05.002_bib87","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/ijc.30818","article-title":"The association between individual metabolic syndrome components, primary liver cancer and cirrhosis: a study in the Swedish AMORIS cohort","volume":"141","author":"Nderitu","year":"2017","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cgh.2021.05.002_bib88","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1007\/s10620-015-3821-7","article-title":"Hepatocellular carcinoma in the setting of non-cirrhotic nonalcoholic fatty liver disease and the metabolic syndrome: US experience","volume":"60","author":"Perumpail","year":"2015","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.cgh.2021.05.002_bib89","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.canep.2016.04.009","article-title":"Obesity, diabetes, serum glucose, and risk of primary liver cancer by birth cohort, race\/ethnicity, and sex: multiphasic health checkup study","volume":"42","author":"Petrick","year":"2016","journal-title":"Cancer Epidemiol"},{"key":"10.1016\/j.cgh.2021.05.002_bib90","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/hep.28368","article-title":"Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: a multicenter prospective study","volume":"63","author":"Piscaglia","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib91","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1053\/jhep.2002.33324","article-title":"Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis","volume":"35","author":"Ratziu","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib92","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/hep.25536","article-title":"Outcomes of curative treatment for hepatocellular cancer in nonalcoholic steatohepatitis versus hepatitis C and alcoholic liver disease","volume":"55","author":"Reddy","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib93","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.medcli.2016.12.048","article-title":"Clinical characteristics of hepatocellular carcinoma in Spain: comparison with the 2008-2009 period and analysis of the causes of diagnosis out of screening programs\u2014analysis of 686 cases in 73 centers","volume":"149","author":"Rodr\u00edguez de Lope","year":"2017","journal-title":"Medicina Clinica"},{"key":"10.1016\/j.cgh.2021.05.002_bib94","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000346743","article-title":"Clinical characteristics and time trends in etiology of hepatocellular cancer in Germany","volume":"87","author":"Schutte","year":"2013","journal-title":"Digestion"},{"key":"10.1016\/j.cgh.2021.05.002_bib95","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1471-230X-14-117","article-title":"Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver","volume":"14","author":"Schutte","year":"2014","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib96","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/hepr.12840","article-title":"Development of hepatocellular carcinoma in Japanese patients with biopsy-proven non-alcoholic fatty liver disease: association between PNPLA3 genotype and hepatocarcinogenesis\/fibrosis progression","volume":"47","author":"Seko","year":"2017","journal-title":"Hepatology Research"},{"key":"10.1016\/j.cgh.2021.05.002_bib97","first-page":"S438","article-title":"Progression and HCC in Japanese patients with NAFLD","volume":"10","author":"Seko","year":"2016","journal-title":"Hepatology International"},{"key":"10.1016\/j.cgh.2021.05.002_bib98","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1007\/s10620-013-2743-5","article-title":"Predictors of all-cause mortality and liver-related mortality in patients with non-alcoholic fatty liver disease (NAFLD)","volume":"58","author":"Stepanova","year":"2013","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.cgh.2021.05.002_bib99","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002080","article-title":"Nonalcoholic cirrhosis increased risk of digestive tract malignancies: a population-based cohort study","volume":"94","author":"Sun","year":"2015","journal-title":"Medicine"},{"key":"10.1016\/j.cgh.2021.05.002_bib100","first-page":"609","article-title":"Influence of risk factors for metabolic syndrome and non-alcoholic fatty liver disease on the progression and prognosis of hepatocellular carcinoma","volume":"55","author":"Takamatsu","year":"2008","journal-title":"Hepato-gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib101","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3748\/wjg.v16.i12.1436","article-title":"Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: our case series and literature review","volume":"16","author":"Takuma","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib102","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s00535-014-0973-8","article-title":"Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort study","volume":"50","author":"Tateishi","year":"2015","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib103","first-page":"73","article-title":"Comparing clinical presentations, treatments and outcomes of hepatocellular carcinoma due to hepatitis C and non-alcoholic fatty liver disease","volume":"110","author":"Than","year":"2017","journal-title":"QJM"},{"key":"10.1016\/j.cgh.2021.05.002_bib104","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1007\/s00535-011-0431-9","article-title":"Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease, alcoholic liver disease, and chronic liver disease of unknown etiology: report of the nationwide survey","volume":"46","author":"Tokushige","year":"2011","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib105","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1007\/s00535-010-0237-1","article-title":"Prospective study of hepatocellular carcinoma in nonalcoholic steatohepatitis in comparison with hepatocellular carcinoma caused by chronic hepatitis C","volume":"45","author":"Tokushige","year":"2010","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib106","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/bjc.2012.492","article-title":"Metabolic syndrome and hepatocellular carcinoma risk","volume":"108","author":"Turati","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.cgh.2021.05.002_bib107","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/MEG.0000000000000527","article-title":"Hepatocellular carcinoma in cirrhotic versus noncirrhotic livers: results from a large cohort in the Netherlands","volume":"28","author":"van Meer","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib108","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/MEG.0000000000000641","article-title":"Hepatocellular carcinoma in noncirrhotic livers is associated with steatosis rather than steatohepatitis: potential implications for pathogenesis","volume":"28","author":"van Meer","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib109","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-015-1197-x","article-title":"Treatment and survival of non-alcoholic steatohepatitis associated hepatocellular carcinoma","volume":"15","author":"Weinmann","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cgh.2021.05.002_bib110","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/MCG.0b013e3182a8a793","article-title":"Trends in epidemiology, treatment, and survival of hepatocellular carcinoma patients between 1998 and 2009: an analysis of 1066 cases of a German HCC Registry","volume":"48","author":"Weinmann","year":"2014","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib111","first-page":"71","article-title":"Metabolic syndrome increases the risk of primary liver cancer in the United States","author":"Welzel","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.cgh.2021.05.002_bib112","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/MCG.0000000000000810","article-title":"Recent trends in the epidemiology of hepatocellular carcinoma in Olmsted County, Minnesota: a US population-based study","volume":"51","author":"Yang","year":"2017","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib113","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cgh.2011.03.027","article-title":"Factors that affect risk for hepatocellular carcinoma and effects of surveillance","volume":"9","author":"Yang","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib114","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mayocp.2011.07.001","article-title":"Hepatocellular carcinoma in olmsted county, Minnesota, 1976-2008","volume":"87","author":"Yang","year":"2012","journal-title":"Mayo Clinic Proc"},{"key":"10.1016\/j.cgh.2021.05.002_bib115","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cgh.2011.01.023","article-title":"Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma","volume":"9","author":"Yasui","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib116","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s00535-004-1475-x","article-title":"Nonalcoholic steatohepatitis: cirrhosis, hepatocellular carcinoma, and burnt-out NASH","volume":"39","author":"Yoshioka","year":"2004","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib117","doi-asserted-by":"crossref","first-page":"S209","DOI":"10.1016\/S0168-8278(15)30049-0","article-title":"Increasing association of non-alcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma in the United States: data from surveillance, epidemiology and end results (SEER)-medicare registries (2004-2009)","volume":"62","author":"Younossi","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2021.05.002_bib118","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1053\/j.gastro.2017.07.001","article-title":"Influence of metabolic risk factors on risk of hepatocellular carcinoma and liver-related death in men with chronic hepatitis B: a large cohort study","volume":"153","author":"Yu","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib119","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1440-1827.2001.01174.x","article-title":"Hepatocellular carcinoma arising in non-alcoholic steatohepatitis","volume":"51","author":"Zen","year":"2001","journal-title":"Pathol Int"},{"key":"10.1016\/j.cgh.2021.05.002_bib120","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/cncr.32789","article-title":"Global incidence trends in primary liver cancer by age at diagnosis, sex, region, and etiology, 1990-2017","volume":"126","author":"Liu","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.cgh.2021.05.002_bib121","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1158\/1055-9965.EPI-19-0560","article-title":"Disparities in hepatocellular carcinoma incidence in California: an update","volume":"29","author":"Sangaramoorthy","year":"2020","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.cgh.2021.05.002_bib122","article-title":"The characteristics and risk factors of hepatocellular carcinoma in non-alcoholic fatty liver disease without cirrhosis","volume":"70","author":"Tobari","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib123","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/gast.2002.34168","article-title":"Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma","volume":"123","author":"Bugianesi","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib124","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/hep.22734","article-title":"Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: a pathological analysis","volume":"49","author":"Paradis","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2021.05.002_bib125","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3748\/wjg.v21.i3.913","article-title":"Association of nonalcoholic fatty liver disease and liver cancer","volume":"21","author":"Schulz","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.05.002_bib126","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1053\/j.gastro.2015.07.056","article-title":"Trends in burden of cirrhosis and hepatocellular carcinoma by underlying liver disease in US veterans, 2001-2013","volume":"149","author":"Beste","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.05.002_bib127","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.3748\/wjg.v18.i31.4145","article-title":"A\u00a0comparison of survival and pathologic features of non-alcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma","volume":"18","author":"Hernandez-Alejandro","year":"2012","journal-title":"World J Gastroenterol"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235652100505X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235652100505X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:39:28Z","timestamp":1761543568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154235652100505X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":126,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S154235652100505X"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2021.05.002","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence of Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-analysis, and Meta-regression","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2021.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 AGA Institute. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}