{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:17:32Z","timestamp":1792793852191,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"am","delay-in-days":335,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.cgh.2021.07.043","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T23:24:09Z","timestamp":1627687449000},"page":"1251-1258.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical and Psychological Factors Predict Outcome in Patients With Functional Dyspepsia: A Prospective Study"],"prefix":"10.1016","volume":"20","author":[{"given":"Prashant","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ballou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Rangan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Katon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafla","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Iturrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Lembo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9437-4163","authenticated-orcid":false,"given":"Judy","family":"Nee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2021.07.043_bib1","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1056\/NEJMra1501505","article-title":"Functional dyspepsia","volume":"373","author":"Talley","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cgh.2021.07.043_bib2","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","article-title":"Gastroduodenal disorders","volume":"150","author":"Stanghellini","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.043_bib3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S2468-1253(18)30003-7","article-title":"Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: a cross-sectional population-based study","volume":"3","author":"Aziz","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.07.043_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation global study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.043_bib5","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cgh.2010.03.003","article-title":"Functional dyspepsia impacts absenteeism and direct and indirect costs","volume":"8","author":"Brook","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.07.043_bib6","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/apt.12355","article-title":"Functional dyspepsia: the economic impact to patients","volume":"38","author":"Lacy","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2021.07.043_bib7","doi-asserted-by":"crossref","first-page":"17081","DOI":"10.1038\/nrdp.2017.81","article-title":"Functional dyspepsia","volume":"3","author":"Enck","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.cgh.2021.07.043_bib8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1053\/j.gastro.2007.06.010","article-title":"Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study","volume":"133","author":"Halder","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.043_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.dld.2011.10.009","article-title":"Natural history of functional gastrointestinal disorders: comparison of two longitudinal population-based studies","volume":"44","author":"Olafsdottir","year":"2012","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.cgh.2021.07.043_bib10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/ajg.2010.406","article-title":"Longitudinal and cross-sectional factors associated with long-term clinical course in functional dyspepsia: a 5-year follow-up study","volume":"106","author":"Kindt","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.07.043_bib11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4166\/kjg.2018.72.6.286","article-title":"Female gender is a poor predictive factor of functional dyspepsia resolution after Helicobacter pylori eradication: a prospective, multi-center Korean trial","volume":"72","author":"Kim","year":"2018","journal-title":"Korean J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.07.043_bib12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.gastro.2015.04.020","article-title":"Effect of amitriptyline and escitalopram on functional dyspepsia: a multicenter, randomized controlled study","volume":"149","author":"Talley","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.043_bib13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/j.gastro.2009.03.039","article-title":"Anxiety is associated with uninvestigated and functional dyspepsia (Rome III criteria) in a Swedish population-based study","volume":"137","author":"Aro","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.043_bib14","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1053\/j.gastro.2015.01.039","article-title":"Anxiety is linked to new-onset dyspepsia in the Swedish population: a 10-year follow-up study","volume":"148","author":"Aro","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.043_bib15","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/apt.12036","article-title":"Dyspepsia is strongly associated with major depression and generalised anxiety disorder - a community study","volume":"36","author":"Mak","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2021.07.043_bib16","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/j.1572-0241.2000.02009.x","article-title":"Sleep disturbances in clinic patients with functional bowel disorders","volume":"95","author":"Fass","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.07.043_bib17","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.cgh.2011.02.010","article-title":"Functional dyspepsia is associated with sleep disorders","volume":"9","author":"Lacy","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.07.043_bib18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12888-018-1720-0","article-title":"Sleep disturbance and psychological distress are associated with functional dyspepsia based on Rome III criteria","volume":"18","author":"Li","year":"2018","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.cgh.2021.07.043_bib19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cgh.2017.10.021","article-title":"Effects of amitriptyline and escitalopram on sleep and mood in patients with functional dyspepsia","volume":"16","author":"Herrick","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.07.043_bib20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.cgh.2015.09.043","article-title":"Efficacy of mirtazapine in patients with functional dyspepsia and weight loss","volume":"14","author":"Tack","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.07.043_bib21","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel disorders","volume":"150","author":"Lacy","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.043_bib22","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s11136-004-9567-x","article-title":"Development and psychometric evaluation of the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) in patients with upper gastrointestinal disorders","volume":"13","author":"Rentz","year":"2004","journal-title":"Qual Life Res"},{"key":"10.1016\/j.cgh.2021.07.043_bib23","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3758\/BRM.40.3.879","article-title":"Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models","volume":"40","author":"Preacher","year":"2008","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.cgh.2021.07.043_bib24","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1053\/j.gastro.2005.08.020","article-title":"Influence of experimentally induced anxiety on gastric sensorimotor function in humans","volume":"129","author":"Geeraerts","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.043_bib25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/PSY.0b013e3180600a4a","article-title":"Relationship between anxiety and gastric sensorimotor function in functional dyspepsia","volume":"69","author":"Van Oudenhove","year":"2007","journal-title":"Psychosom Med"},{"key":"10.1016\/j.cgh.2021.07.043_bib26","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1136\/gutjnl-2011-300474","article-title":"The brain--gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study","volume":"61","author":"Koloski","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2021.07.043_bib27","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/apt.13738","article-title":"Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study","volume":"44","author":"Koloski","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2021.07.043_bib28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5056\/jnm.2014.20.1.104","article-title":"Impact of sleep disorders, quality of life and gastric emptying in distinct subtypes of functional dyspepsia in Japan","volume":"20","author":"Yamawaki","year":"2014","journal-title":"J\u00a0Neurogastroenterol Motil"},{"key":"10.1016\/j.cgh.2021.07.043_bib29","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/jgh.12236","article-title":"Impact of sleep disorders in Japanese patients with functional dyspepsia (FD): nizatidine improves clinical symptoms, gastric emptying and sleep disorders in FD patients","volume":"28","author":"Futagami","year":"2013","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.07.043_bib30","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/ajg.2009.13","article-title":"Adequate relief in a treatment trial with IBS patients: a prospective assessment","volume":"104","author":"Passos","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.07.043_bib31","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.cgh.2018.04.009","article-title":"Factors associated with response to placebo in patients with irritable bowel syndrome and constipation","volume":"16","author":"Ballou","year":"2018","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356521008259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356521008259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:39:32Z","timestamp":1761543572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356521008259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S1542356521008259"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2021.07.043","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and Psychological Factors Predict Outcome in Patients With Functional Dyspepsia: A Prospective Study","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2021.07.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the AGA Institute","name":"copyright","label":"Copyright"}]}}