{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:46:02Z","timestamp":1793781962025,"version":"4.6.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004321","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004914","name":"Ferring Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.cgh.2021.07.053","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:27:54Z","timestamp":1628641674000},"page":"1306-1314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Higher Anti-tumor Necrosis Factor-\u03b1 Levels Correlate With Improved Radiologic Outcomes in Crohn\u2019s Perianal Fistulas"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9325-9876","authenticated-orcid":false,"given":"Michael","family":"De Gregorio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krupa","family":"Krishnaprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Amos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Kyo","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Bastian-Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Begun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nira","family":"Borok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dougal J.M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wa","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gerstenmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gilmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonita","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Numan","family":"Kutaiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Mahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Thin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Welman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric X.Z.","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"De Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"van Langenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles P.","family":"Sparrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nik S.","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2021.07.053_bib1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1053\/gast.2002.32362","article-title":"The natural history of fistulizing Crohn\u2019s disease in Olmsted County, Minnesota","volume":"122","author":"Schwartz","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.053_bib2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0016-5085(98)70420-2","article-title":"Clinical course of colorectal Crohn\u2019s disease: a 35-year follow-up study of 507 patients","volume":"114","author":"Lapidus","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2021.07.053_bib3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/gut.21.6.525","article-title":"Occurrence and outcome after primary treatment of anal fistulae in Crohn\u2019s disease","volume":"21","author":"Hellers","year":"1980","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2021.07.053_bib4","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-2036.2009.04088.x","article-title":"Prospective assessment of the effect on quality of life of anti-tumour necrosis factor therapy for perineal Crohn\u2019s fistulas","volume":"30","author":"Ng","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2021.07.053_bib5","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1111\/j.1572-0241.2002.05842.x","article-title":"Psychological disorder and severity of inflammatory bowel disease predict health-related quality of life in ulcerative colitis and Crohn\u2019s disease","volume":"97","author":"Guthrie","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.07.053_bib6","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1046\/j.1365-2036.2002.01323.x","article-title":"The quality of life in patients with Crohn\u2019s disease","volume":"16","author":"Cohen","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2021.07.053_bib7","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1097\/MIB.0000000000000148","article-title":"Disappointing durable remission rates in complex Crohn\u2019s disease fistula","volume":"20","author":"Molendijk","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.cgh.2021.07.053_bib8","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJMoa030815","article-title":"Infliximab maintenance therapy for fistulizing Crohn\u2019s disease","volume":"350","author":"Sands","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cgh.2021.07.053_bib9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.gastro.2006.11.041","article-title":"Adalimumab for maintenance of clinical response and remission in patients with Crohn\u2019s disease: the CHARM trial","volume":"132","author":"Colombel","year":"2007","journal-title":"Gastroenterology"},{"issue":"Suppl 1","key":"10.1016\/j.cgh.2021.07.053_bib10","doi-asserted-by":"crossref","first-page":"S053","DOI":"10.1093\/ecco-jcc\/jjy222.079","article-title":"Adequate infliximab exposure during the induction phase is associated with early complete fistula response in patients with fistulizing Crohn\u2019s disease: a post-hoc analysis of the ACCENT-2 trial","volume":"13","author":"Vande Casteele","year":"2019","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.cgh.2021.07.053_bib11","first-page":"549","article-title":"Association of induction infliximab levels with clinical response in perianal Crohn\u2019s disease","volume":"11","author":"Davidov","year":"2017","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.cgh.2021.07.053_bib12","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/apt.13970","article-title":"Higher infliximab trough levels are associated with perianal fistula healing in patients with Crohn's disease","volume":"45","author":"Yarur","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2021.07.053_bib13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/00365521.2019.1600014","article-title":"Higher anti-TNF serum levels are associated with perianal fistula closure in Crohn\u2019s disease patients","volume":"54","author":"Strik","year":"2019","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.07.053_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/MEG.0000000000001561","article-title":"Higher anti-tumor necrosis factor levels are associated with perianal fistula healing and fistula closure in Crohn\u2019s disease","volume":"32","author":"Plevris","year":"2020","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2021.07.053_bib15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/gut.36.3.407","article-title":"Pelvic and perineal complications of Crohn\u2019s disease: assessment using magnetic resonance imaging","volume":"36","author":"Haggett","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2021.07.053_bib16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0002-9270(02)05909-9","article-title":"Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn\u2019s disease","volume":"98","author":"Van Assche","year":"2003","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 1","key":"10.1016\/j.cgh.2021.07.053_bib17","doi-asserted-by":"crossref","first-page":"S278","DOI":"10.1093\/ecco-jcc\/jjy222.475","article-title":"P351 MRI outcomes in perianal fistulising Crohn\u2019s disease following anti-TNF-\u03b1 therapy: a systematic review and meta-analysis","volume":"13","author":"Lee","year":"2019","journal-title":"J\u00a0Crohns Colitis"},{"issue":"Supp1","key":"10.1016\/j.cgh.2021.07.053_bib18","doi-asserted-by":"crossref","first-page":"S434","DOI":"10.14309\/00000434-200609001-01109","article-title":"Higher remission and maintenance of response rates with subcutaneous monthly certolizumab pegol in patients with recent-onset Crohn\u2019s disease: data from PRECiSE 2","volume":"101","author":"Sandborn","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2021.07.053_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.crohns.2012.05.015","article-title":"Subgroup analysis of the placebo-controlled CHARM trial: increased remission rates through 3 years for adalimumab-treated patients with early Crohn\u2019s disease","volume":"7","author":"Schreiber","year":"2013","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.cgh.2021.07.053_bib20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10151-017-1647-3","article-title":"Prognostic factors affecting outcomes in fistulating perianal Crohn\u2019s disease: a systematic review","volume":"21","author":"Braithwaite","year":"2017","journal-title":"Tech Coloproctol"},{"key":"10.1016\/j.cgh.2021.07.053_bib21","first-page":"1","article-title":"ECCO-ESCP consensus on surgery for Crohn\u2019s disease","volume":"12","author":"Bemelman","year":"2018","journal-title":"J\u00a0Crohns Colitis"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235652100865X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154235652100865X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:37:07Z","timestamp":1761543427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154235652100865X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S154235652100865X"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2021.07.053","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Higher Anti-tumor Necrosis Factor-\u03b1 Levels Correlate With Improved Radiologic Outcomes in Crohn\u2019s Perianal Fistulas","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2021.07.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the AGA Institute","name":"copyright","label":"Copyright"}]}}