{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:27:19Z","timestamp":1793042839306,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.cgh.2022.09.032","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T07:20:17Z","timestamp":1665732017000},"page":"1854-1863.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"title":["The Sequential Application of Baveno VII Criteria and VITRO Score Improves Diagnosis of Clinically Significant Portal Hypertension"],"prefix":"10.1016","volume":"21","author":[{"given":"Mathias","family":"Jachs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Simbrunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Paternostro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Scheiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Balcar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Semmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Friedrich","family":"St\u00e4ttermayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Pinter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Quehenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-0017","authenticated-orcid":false,"given":"Mattias","family":"Mandorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2022.09.032_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1055\/s-0040-1708806","article-title":"Noninvasive diagnostics for portal hypertension: a comprehensive review","volume":"40","author":"Mandorfer","year":"2020","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.cgh.2022.09.032_bib2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","author":"de Franchis","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.09.032_bib3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2009.149","article-title":"The clinical use of HVPG measurements in chronic liver disease","volume":"6","author":"Bosch","year":"2009","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2022.09.032_bib4","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII - renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.09.032_bib5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2017.02.003","article-title":"Non-invasive evaluation of portal hypertension using ultrasound elastography","volume":"67","author":"Berzigotti","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.09.032_bib6","first-page":"239","article-title":"Long-term outcome of HBV-infected patients with clinically significant portal hypertension achieving viral suppression","volume":"12","author":"Jachs","year":"2022","journal-title":"J\u00a0Pers Med"},{"key":"10.1016\/j.cgh.2022.09.032_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/hep.28264","article-title":"Development of hyperdynamic circulation and response to \u03b2-blockers in compensated cirrhosis with portal hypertension","volume":"63","author":"Villanueva","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2022.09.032_bib8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s11901-019-00469-x","article-title":"Hepatic venous pressure gradient response in non-selective beta-blocker treatment\u2014is it worth measuring?","volume":"18","author":"Mandorfer","year":"2019","journal-title":"Curr Hepatol Rep"},{"key":"10.1016\/j.cgh.2022.09.032_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cld.2021.01.003","article-title":"Prevention of first decompensation in advanced chronic liver disease","volume":"25","author":"Mandorfer","year":"2021","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.cgh.2022.09.032_bib10","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(18)31875-0","article-title":"\u03b2 blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial","volume":"393","author":"Villanueva","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.cgh.2022.09.032_bib11","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/hep.510230613","article-title":"High plasma levels of von Willebrand factor as a marker of endothelial perturbation in cirrhosis: relationship to endotoxemia","volume":"23","author":"Ferro","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2022.09.032_bib12","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/hep.25806","article-title":"von Willebrand factor as new noninvasive predictor of portal hypertension, decompensation and mortality in patients with liver cirrhosis","volume":"56","author":"Ferlitsch","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2022.09.032_bib13","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1136\/gut.2010.235689","article-title":"Von Willebrand factor levels predict clinical outcome in patients with cirrhosis and portal hypertension","volume":"60","author":"La Mura","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2022.09.032_bib14","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/apt.14522","article-title":"Vienna Hepatic Hemodynamic Lab. Von Willebrand factor indicates bacterial translocation, inflammation, and procoagulant imbalance and predicts complications independently of portal hypertension severity","volume":"47","author":"Mandorfer","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2022.09.032_bib15","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.cgh.2021.07.012","article-title":"Decreasing von Willebrand factor levels upon nonselective beta blocker therapy indicate a decreased risk of further decompensation, acute-on-chronic liver failure, and death","volume":"20","author":"Jachs","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2022.09.032_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149230","article-title":"The VITRO score (Von Willebrand Factor Antigen\/Thrombocyte Ratio) as a new marker for clinically significant portal hypertension in comparison to other non-invasive parameters of fibrosis including ELF test","volume":"11","author":"Hametner","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cgh.2022.09.032_bib17","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/hep.31462","article-title":"Noninvasive risk stratification after HCV eradication in patients with advanced chronic liver disease","volume":"73","author":"Semmler","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2022.09.032_bib18","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/hep.30885","article-title":"Changes in hepatic venous pressure gradient predict hepatic decompensation in patients who achieved sustained virologic response to interferon-free therapy","volume":"71","author":"Mandorfer","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2022.09.032_bib19","first-page":"160","article-title":"Measurement of the hepatic venous pressure gradient and transjugular liver biopsy","author":"Reiberger","year":"2020","journal-title":"J\u00a0Vis Exp"},{"key":"10.1016\/j.cgh.2022.09.032_bib20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00508-017-1262-3","article-title":"Austrian consensus guidelines on the management and treatment of portal hypertension (Billroth III)","volume":"129","author":"Reiberger","year":"2017","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.cgh.2022.09.032_bib21","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A\u00a0proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J\u00a0Am Stat Assn"},{"key":"10.1016\/j.cgh.2022.09.032_bib22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.14309\/ajg.0000000000000994","article-title":"Noninvasive diagnosis of portal hypertension in patients with compensated advanced chronic liver disease","volume":"116","author":"Pons","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2022.09.032_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/liv.14228","article-title":"A\u00a0novel spleen-dedicated stiffness measurement by FibroScan\u00ae improves the screening of high-risk oesophageal varices","volume":"40","author":"Stefanescu","year":"2020","journal-title":"Liver Int"},{"key":"10.1016\/j.cgh.2022.09.032_bib24","first-page":"160","article-title":"Measurement of the hepatic venous pressure gradient and transjugular liver biopsy","author":"Reiberger","year":"2020","journal-title":"J\u00a0Vis Exp"},{"key":"10.1016\/j.cgh.2022.09.032_bib25","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1111\/liv.12783","article-title":"Evaluation of a new balloon occlusion catheter specifically designed for measurement of hepatic venous pressure gradient","volume":"35","author":"Ferlitsch","year":"2015","journal-title":"Liver Int"},{"key":"10.1016\/j.cgh.2022.09.032_bib26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/liv.12623","article-title":"New reliability criteria for transient elastography increase the number of accurate measurements for screening of cirrhosis and portal hypertension","volume":"35","author":"Schwabl","year":"2015","journal-title":"Liver Int"},{"key":"10.1016\/j.cgh.2022.09.032_bib27","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.cgh.2021.07.012","article-title":"Decreasing VWF-levels upon NSBB-therapy indicate a decreased risk of further decompensation, ACLF, and death","volume":"20","author":"Jachs","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2022.09.032_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/apt.12564","article-title":"Von Willebrand factor as a new marker for non-invasive assessment of liver fibrosis and cirrhosis in patients with chronic hepatitis C","volume":"39","author":"Maieron","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2022.09.032_bib29","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/hep.31462","article-title":"Noninvasive risk stratification after HCV eradication in patients with advanced chronic liver disease","volume":"73","author":"Semmler","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2022.09.032_bib30","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII - Renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.09.032_bib31","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(18)31875-0","article-title":"\u03b2 blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial","volume":"393","author":"Villanueva","year":"2019","journal-title":"Lancet"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356522009570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356522009570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:40:54Z","timestamp":1761543654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356522009570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1542356522009570"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2022.09.032","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Sequential Application of Baveno VII Criteria and VITRO Score Improves Diagnosis of Clinically Significant Portal Hypertension","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2022.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the AGA Institute. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}