{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:34:34Z","timestamp":1792607674474,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.cgh.2022.11.033","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T20:45:22Z","timestamp":1670273122000},"page":"2308-2317.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"title":["Alcohol Abstinence Improves Prognosis Across All Stages of Portal Hypertension in Alcohol-Related Cirrhosis"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-3372","authenticated-orcid":false,"given":"Benedikt Silvester","family":"Hofer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Simbrunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Jachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Josef Maria","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Balcar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Paternostro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schwabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Semmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Scheiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Friedrich","family":"Staettermayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Mandorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-3583","authenticated-orcid":false,"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2022.11.033_bib1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jhep.2012.12.005","article-title":"The burden of liver disease in Europe: a review of available epidemiological data","volume":"58","author":"Blachier","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2013.03.007","article-title":"Global burden of alcoholic liver diseases","volume":"59","author":"Rehm","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib3","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/hep.23500","article-title":"Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study","volume":"51","author":"Jepsen","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cgh.2022.11.033_bib4","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jhep.2016.11.011","article-title":"Histological parameters and alcohol abstinence determine long-term prognosis in patients with alcoholic liver disease","volume":"66","author":"Lackner","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib5","article-title":"Portal hypertension in cirrhosis: pathophysiological mechanisms and therapy","volume":"3","author":"Iwakiri","year":"2021","journal-title":"JHEP Rep"},{"key":"10.1016\/j.cgh.2022.11.033_bib6","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/S0016-5085(97)70142-2","article-title":"Effects of ethanol consumption on hepatic hemodynamics in patients with alcoholic cirrhosis","volume":"112","author":"Luca","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2022.11.033_bib7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII - renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1053\/j.gastro.2007.05.024","article-title":"Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis","volume":"133","author":"Ripoll","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2022.11.033_bib9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jhep.2007.10.008","article-title":"Hepatic venous pressure gradient and prognosis in patients with acute variceal bleeding treated with pharmacologic and endoscopic therapy","volume":"48","author":"Abraldes","year":"2008","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib10","doi-asserted-by":"crossref","first-page":"17941","DOI":"10.3748\/wjg.v20.i47.17941","article-title":"Risk factors for early rebleeding and mortality in acute variceal hemorrhage","volume":"20","author":"Zhao","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cgh.2022.11.033_bib11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jhep.2016.11.001","article-title":"Beta adrenergic blockade and decompensated cirrhosis","volume":"66","author":"Reiberger","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib12","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1136\/gutjnl-2020-322712","article-title":"Amelioration of systemic inflammation in advanced chronic liver disease upon beta-blocker therapy translates into improved clinical outcomes","volume":"70","author":"Jachs","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2022.11.033_bib13","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1136\/gutjnl-2012-304038","article-title":"Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol","volume":"62","author":"Reiberger","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.cgh.2022.11.033_bib14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jhep.2016.05.027","article-title":"Sustained virologic response to interferon-free therapies ameliorates HCV-induced portal hypertension","volume":"65","author":"Mandorfer","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jhep.2018.03.018","article-title":"EASL Clinical Practice Guidelines: management of alcohol-related liver disease","volume":"69","author":"Thursz","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib16","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/hep4.1776","article-title":"Associations between alcohol use and liver-related outcomes in a large national cohort of patients with cirrhosis","volume":"5","author":"Pearson","year":"2021","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.cgh.2022.11.033_bib17","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1080\/00365520410006350","article-title":"Long-term prognosis of patients with alcoholic liver cirrhosis: a 15-year follow-up study of 100 Norwegian patients admitted to one unit","volume":"39","author":"Bell","year":"2004","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cgh.2022.11.033_bib18","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/MCG.0b013e3182284e13","article-title":"Long-term clinical course of decompensated alcoholic cirrhosis: a prospective study of 165 patients","volume":"45","author":"Alvarez","year":"2011","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.cgh.2022.11.033_bib19","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jhep.2021.05.037","article-title":"Prognostic performance of 7 biomarkers compared with liver biopsy in early alcohol-related liver disease","volume":"75","author":"Rasmussen","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib20","article-title":"Measurement of the hepatic venous pressure gradient and transjugular liver biopsy","volume":"160","author":"Reiberger","year":"2020","journal-title":"J\u00a0Vis Exp"},{"key":"10.1016\/j.cgh.2022.11.033_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","article-title":"Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies","volume":"44","author":"D\u2019Amico","year":"2006","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.cgh.2022.11.033_bib22","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.3748\/wjg.v25.i39.5897","article-title":"Gut-liver axis signaling in portal hypertension","volume":"25","author":"Simbrunner","year":"2019","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cgh.2022.11.033_bib23","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1053\/gast.1996.v111.pm8780575","article-title":"Prognostic value of hepatic venous pressure gradient measurements in alcoholic cirrhosis: a 10-year prospective study","volume":"111","author":"Vorobioff","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cgh.2022.11.033_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jsat.2018.05.003","article-title":"Misconceptions, preferences and barriers to alcohol use disorder treatment in alcohol-related cirrhosis","volume":"91","author":"Mellinger","year":"2018","journal-title":"J\u00a0Subst Abuse Treat"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356522011132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356522011132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:44:36Z","timestamp":1761543876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356522011132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S1542356522011132"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2022.11.033","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alcohol Abstinence Improves Prognosis Across All Stages of Portal Hypertension in Alcohol-Related Cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2022.11.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2022.10.032","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the AGA Institute. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}