{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:26:25Z","timestamp":1791123985501,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019540","name":"Science Fund for Distinguished Young Scholars of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Heart and Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cghjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cgh.2024.09.033","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T02:52:31Z","timestamp":1730775151000},"page":"1623-1632.e16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dietary Antioxidant Capacity, Genetic Susceptibility and Polymorphism, and Inflammatory Bowel Disease Risk in a Prospective Cohort"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-4192","authenticated-orcid":false,"given":"Jie","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-2772","authenticated-orcid":false,"given":"Lintao","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna C.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cgh.2024.09.033_bib1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/j.cgh.2024.09.033_bib2","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3390\/ph16101374","article-title":"Antioxidant therapy in inflammatory bowel disease: a systematic review and a meta-analysis of randomized clinical trials","volume":"16","author":"Rodrigues","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.cgh.2024.09.033_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12937-016-0186-5","article-title":"The importance of antioxidants which play the role in cellular response against oxidative\/nitrosative stress: current state","volume":"15","author":"Kurutas","year":"2016","journal-title":"Nutr J"},{"key":"10.1016\/j.cgh.2024.09.033_bib4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1080\/10408398.2016.1230089","article-title":"Dietary total antioxidant capacity as a tool in health outcomes in middle-aged and older adults: a systematic review","volume":"58","author":"Nascimento-Souza","year":"2018","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.cgh.2024.09.033_bib5","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/ajcn\/87.5.1290","article-title":"Food selection based on total antioxidant capacity can modify antioxidant intake, systemic inflammation, and liver function without altering markers of oxidative stress","volume":"87","author":"Valtue\u00f1a","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cgh.2024.09.033_bib6","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/ejcn.2009.46","article-title":"Intervention study with a high or low antioxidant capacity diet: effects on circulating beta-carotene","volume":"63","author":"Del Rio","year":"2009","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.cgh.2024.09.033_bib7","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/1751-2980.12823","article-title":"Dietary total antioxidant capacity and risk of ulcerative colitis: a case-control study","volume":"20","author":"Rahmani","year":"2019","journal-title":"J Dig Dis"},{"key":"10.1016\/j.cgh.2024.09.033_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169102","article-title":"Association between polymorphisms in antioxidant genes and inflammatory bowel disease","volume":"12","author":"Costa Pereira","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cgh.2024.09.033_bib9","doi-asserted-by":"crossref","first-page":"109332","DOI":"10.18632\/oncotarget.22675","article-title":"Association between SOD1, CAT, GSHPX1 polymorphisms and the risk of inflammatory bowel disease in the Polish population","volume":"8","author":"Mrowicka","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cgh.2024.09.033_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41575-018-0022-9","article-title":"The role of diet in the aetiopathogenesis of inflammatory bowel disease","volume":"15","author":"Khalili","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.cgh.2024.09.033_bib11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/apt.16938","article-title":"Age determines the risk of familial inflammatory bowel disease-a nationwide study","volume":"56","author":"Halfvarson","year":"2022","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2024.09.033_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.cgh.2024.09.033_bib13","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1021\/jf030081t","article-title":"Anthocyanin and proanthocyanidin content in selected white and red wines. Oxygen radical absorbance capacity comparison with nontraditional wines obtained from highbush blueberry","volume":"51","author":"S\u00e1nchez-Moreno","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.cgh.2024.09.033_bib14","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1021\/jf0262256","article-title":"Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples","volume":"51","author":"Prior","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.cgh.2024.09.033_bib15","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1021\/jf049696w","article-title":"Lipophilic and hydrophilic antioxidant capacities of common foods in the United States","volume":"52","author":"Wu","year":"2004","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.cgh.2024.09.033_bib16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.14309\/ajg.0000000000002180","article-title":"The contribution of genetic risk and lifestyle factors in the development of adult-onset inflammatory bowel disease: a prospective cohort study","volume":"118","author":"Sun","year":"2023","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cgh.2024.09.033_bib17","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"International Multiple Sclerosis Genetics Consortium; International IBD Genetics Consortium. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.cgh.2024.09.033_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415881","article-title":"The genetic diversity and dysfunctionality of catalase associated with a worse outcome in Crohn\u2019s disease","volume":"23","author":"Iborra","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.cgh.2024.09.033_bib19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/pds.698","article-title":"Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease","volume":"11","author":"Lewis","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.cgh.2024.09.033_bib20","series-title":"Improving data quality in the NHS: annual report on the PbR assurance programme","year":"2010"},{"key":"10.1016\/j.cgh.2024.09.033_bib21","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrika"},{"key":"10.1016\/j.cgh.2024.09.033_bib22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/oxfordjournals.aje.a113015","article-title":"Concepts of interaction","volume":"112","author":"Rothman","year":"1980","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.cgh.2024.09.033_bib23","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/apt.17392","article-title":"Antioxidants, minerals and vitamins in relation to Crohn\u2019s disease and ulcerative colitis: a Mendelian randomization study","volume":"57","author":"Chen","year":"2023","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cgh.2024.09.033_bib24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.redox.2015.10.006","article-title":"Antioxidant therapy for treatment of inflammatory bowel disease: does it work?","volume":"6","author":"Moura","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/j.cgh.2024.09.033_bib25","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1001\/archinte.167.15.1610","article-title":"A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women\u2019s Antioxidant Cardiovascular Study","volume":"167","author":"Cook","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cgh.2024.09.033_bib26","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1001\/jama.2008.600","article-title":"Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians\u2019 Health Study II randomized controlled trial","volume":"300","author":"Sesso","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.cgh.2024.09.033_bib27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/01.fpc.0000199498.08725.9c","article-title":"Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans","volume":"16","author":"Bastaki","year":"2006","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.cgh.2024.09.033_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/17562848231207305","article-title":"Associations of sugar-sweetened beverages, artificially sweetened beverages, and natural juices with cardiovascular disease and all-cause mortality in individuals with inflammatory bowel disease in a prospective cohort study","volume":"16","author":"Dan","year":"2023","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.cgh.2024.09.033_bib29","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1017\/S1368980011000942","article-title":"Development and evaluation of the Oxford WebQ, a low-cost, web-based method for assessment of previous 24 h dietary intakes in large-scale prospective studies","volume":"14","author":"Liu","year":"2011","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.cgh.2024.09.033_bib30","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1093\/aje\/kwz165","article-title":"Validation of the Oxford WebQ online 24-hour dietary questionnaire using biomarkers","volume":"188","author":"Greenwood","year":"2019","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.cgh.2024.09.033_bib31","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1021\/jf0262256","article-title":"Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples","volume":"51","author":"Prior","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.cgh.2024.09.033_bib32","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1021\/jf049696w","article-title":"Lipophilic and hydrophilic antioxidant capacities of common foods in the United States","volume":"52","author":"Wu","year":"2004","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.cgh.2024.09.033_bib33","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1021\/jf030081t","article-title":"Anthocyanin and proanthocyanidin content in selected white and red wines. Oxygen radical absorbance capacity comparison with nontraditional wines obtained from highbush blueberry","volume":"51","author":"S\u00e1nchez-Moreno","year":"2003","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.cgh.2024.09.033_bib34","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00990-2019","article-title":"Dietary antioxidant intake in school age and lung function development up to adolescence","volume":"55","author":"Sdona","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cgh.2024.09.033_bib35","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1183\/09031936.00109513","article-title":"Processed meat consumption and lung function: modification by antioxidants and smoking","volume":"43","author":"Okubo","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cgh.2024.09.033_bib36","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/mds.27120","article-title":"Dietary antioxidants and risk of Parkinson\u2019s disease in two population-based cohorts","volume":"32","author":"Yang","year":"2017","journal-title":"Mov Disord"},{"key":"10.1016\/j.cgh.2024.09.033_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1096288","article-title":"Antioxidant potential of the diet in Italian children with food allergies","volume":"10","author":"Pendezza","year":"2023","journal-title":"Front Nutr"},{"key":"10.1016\/j.cgh.2024.09.033_bib38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.numecd.2021.09.012","article-title":"Evaluation of protein and amino acid intake estimates from the EPIC dietary questionnaires and 24-h dietary recalls using different food composition databases","volume":"32","author":"Iguacel","year":"2022","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.cgh.2024.09.033_bib39","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/sj.ejcn.1602679","article-title":"The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study","volume":"61","author":"Slimani","year":"2007","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.cgh.2024.09.033_bib40","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1021\/jf025768c","article-title":"Coffee drinking influences plasma antioxidant capacity in humans","volume":"50","author":"Natella","year":"2002","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.cgh.2024.09.033_bib41","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2307\/590279","article-title":"Health and deprivation: inequality and the north","volume":"40","author":"Blane","year":"1987","journal-title":"Br J Sociol"},{"key":"10.1016\/j.cgh.2024.09.033_bib43","author":"Sjostrom"},{"key":"10.1016\/j.cgh.2024.09.033_bib44","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"International Multiple Sclerosis Genetics Consortium; International IBD Genetics Consortium;. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.cgh.2024.09.033_bib45","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/gepi.20630","article-title":"Transethnic meta-analysis of genomewide association studies","volume":"35","author":"Morris","year":"2011","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.cgh.2024.09.033_bib46","series-title":"Improving data quality in the NHS: annual report on the PbR assurance programme","year":"2010"},{"key":"10.1016\/j.cgh.2024.09.033_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/pds.698","article-title":"Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease","volume":"11","author":"Lewis","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.cgh.2024.09.033_bib48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12876-021-01716-6","article-title":"The incidence and prevalence of inflammatory bowel disease in UK primary care: a retrospective cohort study of the IQVIA Medical Research Database","volume":"21","author":"Freeman","year":"2021","journal-title":"BMC Gastroenterol"}],"container-title":["Clinical Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356524009807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1542356524009807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T08:32:07Z","timestamp":1753259527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1542356524009807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1542356524009807"],"URL":"https:\/\/doi.org\/10.1016\/j.cgh.2024.09.033","relation":{},"ISSN":["1542-3565"],"issn-type":[{"value":"1542-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary Antioxidant Capacity, Genetic Susceptibility and Polymorphism, and Inflammatory Bowel Disease Risk in a Prospective Cohort","name":"articletitle","label":"Article Title"},{"value":"Clinical Gastroenterology and Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cgh.2024.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}