{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:37:48Z","timestamp":1791985068759,"version":"4.4.0"},"reference-count":147,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Child and Adolescent Psychiatric Clinics of North America"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.chc.2012.05.010","type":"journal-article","created":{"date-parts":[[2012,7,15]],"date-time":"2012-07-15T05:09:34Z","timestamp":1342328974000},"page":"479-500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genetics of Pediatric Anxiety Disorders"],"prefix":"10.1016","volume":"21","author":[{"given":"Dara J.","family":"Sakolsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"McCracken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika L.","family":"Nurmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.chc.2005.06.003","article-title":"The developmental epidemiology of anxiety disorders: phenomenology, prevalence, and comorbidity","volume":"14","author":"Costello","year":"2005","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/archpsyc.55.1.56","article-title":"The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders","volume":"55","author":"Pine","year":"1998","journal-title":"Arch Gen Psychiatry"},{"issue":"11","key":"10.1016\/j.chc.2012.05.010_bib3","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/da.20623","article-title":"Genetics of anxiety disorders: the complex road from DSM to DNA","volume":"26","author":"Smoller","year":"2009","journal-title":"Depress Anxiety"},{"issue":"10","key":"10.1016\/j.chc.2012.05.010_bib4","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","article-title":"A review and meta-analysis of the genetic epidemiology of anxiety disorders","volume":"158","author":"Hettema","year":"2001","journal-title":"Am J Psychiatry"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1375\/twin.8.5.450","article-title":"Twin studies on obsessive-compulsive disorder: a review","volume":"8","author":"van Grootheest","year":"2005","journal-title":"Twin Res Hum Genet"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00787-010-0087-7","article-title":"Genetics of early-onset obsessive-compulsive disorder","volume":"19","author":"Walitza","year":"2010","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"Suppl","key":"10.1016\/j.chc.2012.05.010_bib7","first-page":"5","article-title":"The cross national epidemiology of obsessive compulsive disorder","volume":"55","author":"Weissman","year":"1994","journal-title":"J Clin Psychiatry"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib8","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1600-0447.2004.00302.x","article-title":"Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature","volume":"110","author":"Stewart","year":"2004","journal-title":"Acta Psychiatr Scand"},{"issue":"Suppl 1","key":"10.1016\/j.chc.2012.05.010_bib10","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1089\/104454603322126359","article-title":"Functional impairment in children and adolescents with obsessive-compulsive disorder","volume":"13","author":"Piacentini","year":"2003","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0193-953X(05)70181-7","article-title":"Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder","volume":"23","author":"Saxena","year":"2000","journal-title":"Psychiatr Clin North Am"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib12","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1172\/JCI37563","article-title":"Children with obsessive-compulsive disorder: are they just \u201clittle adults\u201d?","volume":"119","author":"Kalra","year":"2009","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1017\/S0033291706008816","article-title":"Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins","volume":"37","author":"Bolton","year":"2007","journal-title":"Psychol Med"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1192\/bjp.bp.108.059485","article-title":"Structure of genetic and environmental risk factors for dimensional representations of DSM-IV anxiety disorders","volume":"195","author":"Tambs","year":"2009","journal-title":"Br J Psychiatry"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.31887\/DCNS.2010.12.2\/dpauls","article-title":"The genetics of obsessive-compulsive disorder: a review","volume":"12","author":"Pauls","year":"2010","journal-title":"Dialog Clin Neurosci"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.psychres.2007.07.010","article-title":"Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories","volume":"160","author":"Pinto","year":"2008","journal-title":"Psychiatry Res"},{"issue":"11","key":"10.1016\/j.chc.2012.05.010_bib17","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1176\/ajp.2006.163.11.1986","article-title":"Familiality of obsessive-compulsive disorder in nonclinical and clinical subjects","volume":"163","author":"Grabe","year":"2006","journal-title":"Am J Psychiatry"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.biopsych.2006.05.040","article-title":"Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study","volume":"61","author":"Hasler","year":"2007","journal-title":"Biol Psychiatry"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0006-3223(00)00831-3","article-title":"The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study","volume":"48","author":"Bienvenu","year":"2000","journal-title":"Biol Psychiatry"},{"issue":"8","key":"10.1016\/j.chc.2012.05.010_bib20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0006-3223(01)01074-5","article-title":"The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study","volume":"50","author":"Grados","year":"2001","journal-title":"Biol Psychiatry"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1001\/archpsyc.1992.01820050026004","article-title":"A family study of obsessive-compulsive disorder","volume":"49","author":"Black","year":"1992","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"10.1016\/j.chc.2012.05.010_bib22","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1017\/S0033291708004753","article-title":"Obsessive-compulsive disorder: subclassification based on co-morbidity","volume":"39","author":"Nestadt","year":"2009","journal-title":"Psychol Med"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<669::AID-AJMG17>3.0.CO;2-N","article-title":"Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores","volume":"88","author":"Alsobrook","year":"1999","journal-title":"Am J Med Genet"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/1096-8628(20000612)96:3<384::AID-AJMG28>3.0.CO;2-P","article-title":"Complex segregation analysis of obsessive-compulsive disorder in 141 families of eating disorder probands, with and without obsessive-compulsive disorder","volume":"96","author":"Cavallini","year":"2000","journal-title":"Am J Med Genet"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib25","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1086\/316898","article-title":"Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex","volume":"67","author":"Nestadt","year":"2000","journal-title":"Am J Hum Genet"},{"issue":"8","key":"10.1016\/j.chc.2012.05.010_bib26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/sj.mp.4001847","article-title":"Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q","volume":"11","author":"Shugart","year":"2006","journal-title":"Mol Psychiatry"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/ajmg.10519","article-title":"Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands","volume":"114","author":"Hanna","year":"2002","journal-title":"Am J Med Genet"},{"issue":"8","key":"10.1016\/j.chc.2012.05.010_bib28","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.biopsych.2007.01.008","article-title":"Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder","volume":"62","author":"Hanna","year":"2007","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib29","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00439-011-1033-6","article-title":"Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD","volume":"130","author":"Ross","year":"2011","journal-title":"Hum Genet"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ajmg.b.32001","article-title":"Homeobox genes in obsessive-compulsive disorder","volume":"159B","author":"Nestadt","year":"2012","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1176\/ajp.2007.164.3.493","article-title":"Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study","volume":"164","author":"Samuels","year":"2007","journal-title":"Am J Psychiatry"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ajmg.b.30760","article-title":"Gender differences in genetic linkage and association on 11p15 in obsessive-compulsive disorder families","volume":"150B","author":"Wang","year":"2009","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib33","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1086\/423899","article-title":"Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder","volume":"75","author":"Willour","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.chc.2012.05.010_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2012.03.037","article-title":"Genomewide linkage analysis of obsessive compulsive disorder implicates chromosome 1p36","author":"Mathews","year":"2012","journal-title":"Biol Psychiatry"},{"issue":"9","key":"10.1016\/j.chc.2012.05.010_bib35","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/sj.npp.1300733","article-title":"Glutamatergic dysfunction in OCD","volume":"30","author":"Chakrabarty","year":"2005","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"10.1016\/j.chc.2012.05.010_bib36","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1097\/CHI.0b013e318185d2be","article-title":"Brain imaging in pediatric obsessive-compulsive disorder","volume":"47","author":"MacMaster","year":"2008","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.chc.2012.05.010_bib37","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jad.2009.07.009","article-title":"Serum levels of brain-derived neurotrophic factor in drug-naive obsessive-compulsive patients: a case-control study","volume":"122","author":"Maina","year":"2010","journal-title":"J Affect Disord"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pnpbp.2011.09.007","article-title":"MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder","volume":"36","author":"O'Neill","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib39","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.pbb.2011.10.007","article-title":"The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder","volume":"100","author":"Wu","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib40","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.conb.2011.04.010","article-title":"Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics","volume":"21","author":"Ting","year":"2011","journal-title":"Curr Opin Neurobiol"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib41","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00213-004-1847-1","article-title":"Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study","volume":"174","author":"Arnold","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib42","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.pscychresns.2009.02.005","article-title":"Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder","volume":"172","author":"Arnold","year":"2009","journal-title":"Psychiatry Res"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11682-008-9050-3","article-title":"Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder","volume":"3","author":"Arnold","year":"2009","journal-title":"Brain Imaging Behav"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib44","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00001756-200403220-00025","article-title":"Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder","volume":"15","author":"Delorme","year":"2004","journal-title":"NeuroReport"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1755-5949.2009.00130.x","article-title":"Association between polymorphisms in GRIK2 gene and obsessive-compulsive disorder: a family-based study","volume":"17","author":"Sampaio","year":"2011","journal-title":"CNS Neurosci Ther"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib46","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/ajmg.b.30897","article-title":"Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study","volume":"150B","author":"Bienvenu","year":"2009","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib47","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ajmg.b.31184","article-title":"Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder","volume":"156B","author":"Samuels","year":"2011","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib48","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/archgenpsychiatry.2009.6","article-title":"A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder","volume":"66","author":"Wendland","year":"2009","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib49","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/ajmg.b.30914","article-title":"A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families","volume":"150B","author":"Shugart","year":"2009","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"8","key":"10.1016\/j.chc.2012.05.010_bib50","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/ajmg.b.30533","article-title":"Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder","volume":"144B","author":"Stewart","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"7","key":"10.1016\/j.chc.2012.05.010_bib51","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1001\/archpsyc.63.7.778","article-title":"Association testing of the positional and functional candidate gene SLC1A1\/EAAC1 in early-onset obsessive-compulsive disorder","volume":"63","author":"Dickel","year":"2006","journal-title":"Arch Gen Psychiatry"},{"issue":"7","key":"10.1016\/j.chc.2012.05.010_bib52","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/archpsyc.63.7.769","article-title":"Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder","volume":"63","author":"Arnold","year":"2006","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib53","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.biopsych.2007.06.020","article-title":"Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessive-compulsive disorder","volume":"63","author":"Alonso","year":"2008","journal-title":"Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib54","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1086\/377003","article-title":"Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder","volume":"73","author":"Hall","year":"2003","journal-title":"Am J Hum Genet"},{"issue":"12","key":"10.1016\/j.chc.2012.05.010_bib55","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/sj.npp.1301394","article-title":"A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder","volume":"32","author":"Wendland","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"1\u20132","key":"10.1016\/j.chc.2012.05.010_bib56","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jad.2011.04.002","article-title":"Brain-derived neurotrophic factor (BDNF) plasma levels in drug-naive OCD patients are lower than those in healthy people, but are not lower than those in drug-treated OCD patients","volume":"133","author":"Wang","year":"2011","journal-title":"J Affect Disord"},{"key":"10.1016\/j.chc.2012.05.010_bib57","doi-asserted-by":"crossref","DOI":"10.1017\/S1092852912000363","article-title":"Symptom dimensional approach and BDNF in unmedicated obsessive-compulsive patients: an exploratory study","author":"Dos Santos","year":"2011","journal-title":"CNS Spectr"},{"issue":"7","key":"10.1016\/j.chc.2012.05.010_bib58","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.biopsych.2009.05.017","article-title":"A brain-derived neurotrophic factor haplotype is associated with therapeutic response in obsessive-compulsive disorder","volume":"66","author":"Real","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.chc.2012.05.010_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/da.21890","article-title":"White matter abnormalities in children and adolescents with obsessive-compulsive disorder: a diffusion tensor imaging study","author":"Jayarajan","year":"2012","journal-title":"Depress Anxiety"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib60","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pscychresns.2009.08.005","article-title":"Orbital frontal cortex in treatment-naive pediatric obsessive-compulsive disorder","volume":"181","author":"Macmaster","year":"2010","journal-title":"Psychiatry Res"},{"issue":"Pt 4","key":"10.1016\/j.chc.2012.05.010_bib61","first-page":"853","article-title":"The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems","volume":"132","author":"van den Heuvel","year":"2009","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.chc.2012.05.010_bib62","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/archpsyc.62.7.782","article-title":"White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study","volume":"62","author":"Szeszko","year":"2005","journal-title":"Arch Gen Psychiatry"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib63","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.pnpbp.2007.12.026","article-title":"Obsessive-compulsive disorder and immunology: a review","volume":"32","author":"da Rocha","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib64","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/archpsyc.64.2.209","article-title":"A genetic family-based association study of OLIG2 in obsessive-compulsive disorder","volume":"64","author":"Stewart","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib65","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/ajmg.b.30077","article-title":"Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder","volume":"129B","author":"Zai","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib66","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jad.2010.03.027","article-title":"The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive-compulsive disorder","volume":"124","author":"Atmaca","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1016\/j.chc.2012.05.010_bib67","unstructured":"Stewart SE, Yu D, Scharf J, et al. IOCDF Genome-wide association study of obsessive-compulsive disorder. Paper presented at International Congress of Human Genetics 2011; Montreal, Canada."},{"key":"10.1016\/j.chc.2012.05.010_bib68","series-title":"Paper presented at International OCD Foundation","article-title":"OCD Genetics: Progress Report from the OCD Collaborative Genetics Association (OCGAS) Study","author":"Nestadt","year":"2011"},{"issue":"10","key":"10.1016\/j.chc.2012.05.010_bib69","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jaac.2010.05.017","article-title":"Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication\u2014Adolescent Supplement (NCS-A)","volume":"49","author":"Merikangas","year":"2010","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib70","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1176\/appi.ajp.157.4.493","article-title":"Neuroanatomical hypothesis of panic disorder, revised","volume":"157","author":"Gorman","year":"2000","journal-title":"Am J Psychiatry"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib71","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1600-0447.1994.tb01608.x","article-title":"A family study of anxiety disorders: familial transmission and relationship to mood disorder and psychoactive substance use disorder","volume":"90","author":"Skre","year":"1994","journal-title":"Acta Psychiatr Scand"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib72","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1001\/archpsyc.1997.01830150097014","article-title":"Familial aggregation and phenomenology of \u2018early'-onset (at or before age 20 years) panic disorder","volume":"54","author":"Goldstein","year":"1997","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib73","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.biopsych.2006.04.018","article-title":"A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci","volume":"60","author":"Fyer","year":"2006","journal-title":"Biol Psychiatry"},{"issue":"7","key":"10.1016\/j.chc.2012.05.010_bib74","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/mp.2009.145","article-title":"Advances in molecular genetics of panic disorder","volume":"15","author":"Maron","year":"2010","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.chc.2012.05.010_bib75","doi-asserted-by":"crossref","unstructured":"Gratacos M, Sahun I, Gallego X, et al. Candidate genes for panic disorder: insight from human and mouse genetic studies. Genes Brain Behav 6(Suppl 1):2\u201323.","DOI":"10.1111\/j.1601-183X.2007.00318.x"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib76","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S146114570400416X","article-title":"Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women","volume":"7","author":"Domschke","year":"2004","journal-title":"Int J Neuropsychopharmacol"},{"issue":"10","key":"10.1016\/j.chc.2012.05.010_bib77","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1038\/sj.npp.1301048","article-title":"Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder","volume":"31","author":"Rothe","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib78","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/YPG.0b013e3280d6472e","article-title":"Is 472G\/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?","volume":"17","author":"Zintzaras","year":"2007","journal-title":"Psychiatr Genet"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib79","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/ajmg.b.30494","article-title":"Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity","volume":"144B","author":"Domschke","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"34","key":"10.1016\/j.chc.2012.05.010_bib80","doi-asserted-by":"crossref","first-page":"24704","DOI":"10.1074\/jbc.M603691200","article-title":"Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I","volume":"281","author":"Bernier","year":"2006","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.chc.2012.05.010_bib81","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.pnpbp.2007.06.026","article-title":"Gender-specific association of a functional coding polymorphism in the neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit\/hyperactivity disorder","volume":"31","author":"Okamura","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"9","key":"10.1016\/j.chc.2012.05.010_bib82","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/mp.2010.81","article-title":"Neuropeptide S receptor gene\u2014converging evidence for a role in panic disorder","volume":"16","author":"Domschke","year":"2011","journal-title":"Mol Psychiatry"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib83","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/mp.2010.41","article-title":"TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies","volume":"16","author":"Erhardt","year":"2011","journal-title":"Mol Psychiatry"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib84","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/jhg.2008.17","article-title":"Genome-wide association study of panic disorder in the Japanese population","volume":"54","author":"Otowa","year":"2009","journal-title":"J Hum Genet"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib85","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/jhg.2009.127","article-title":"Replication of a genome-wide association study of panic disorder in a Japanese population","volume":"55","author":"Otowa","year":"2010","journal-title":"J Hum Genet"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib86","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cpr.2009.10.002","article-title":"The role of genes and environment on trauma exposure and posttraumatic stress disorder symptoms: a review of twin studies","volume":"30","author":"Afifi","year":"2010","journal-title":"Clin Psychol Rev"},{"issue":"10","key":"10.1016\/j.chc.2012.05.010_bib87","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1176\/appi.ajp.159.10.1675","article-title":"Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study","volume":"159","author":"Stein","year":"2002","journal-title":"Am J Psychiatry"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib88","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ajmg.1320480107","article-title":"Do genes influence exposure to trauma?","volume":"48","author":"Lyons","year":"1993","journal-title":"Am J Med Genet"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib89","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-3956(01)00032-2","article-title":"Relationship of parental trauma exposure and PTSD to PTSD, depressive and anxiety disorders in offspring","volume":"35","author":"Yehuda","year":"2001","journal-title":"J Psychiatr Res"},{"issue":"9","key":"10.1016\/j.chc.2012.05.010_bib90","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1097\/00004583-199509000-00013","article-title":"Posttraumatic stress disorder across two generations of Cambodian refugees","volume":"34","author":"Sack","year":"1995","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib91","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/sj.mp.4001905","article-title":"Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder","volume":"12","author":"Zieker","year":"2007","journal-title":"Mol Psychiatry"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib92","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/jts.20205","article-title":"Genetics of posttraumatic stress disorder: review and recommendations for future studies","volume":"20","author":"Koenen","year":"2007","journal-title":"J Trauma Stress"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib93","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1375\/twin.10.4.564","article-title":"Trauma exposure and stress response: exploration of mechanisms of cause and effect","volume":"10","author":"Jang","year":"2007","journal-title":"Twin Res Hum Genet"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib94","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.neuropharm.2011.11.007","article-title":"Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy","volume":"62","author":"Hauger","year":"2012","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib95","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/sj.mp.4001676","article-title":"Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors","volume":"10","author":"Segman","year":"2005","journal-title":"Mol Psychiatry"},{"issue":"7","key":"10.1016\/j.chc.2012.05.010_bib96","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.biopsych.2009.02.034","article-title":"Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks","volume":"66","author":"Yehuda","year":"2009","journal-title":"Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib97","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuropharm.2011.02.013","article-title":"PTSD and gene variants: new pathways and new thinking","volume":"62","author":"Skelton","year":"2012","journal-title":"Neuropharmacology"},{"issue":"9","key":"10.1016\/j.chc.2012.05.010_bib98","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/archgenpsychiatry.2011.50","article-title":"Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies","volume":"68","author":"Mehta","year":"2011","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib99","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1460-9568.2008.06332.x","article-title":"Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls","volume":"28","author":"Ising","year":"2008","journal-title":"Eur J Neurosci"},{"issue":"12","key":"10.1016\/j.chc.2012.05.010_bib100","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/sj.mp.4001727","article-title":"Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children","volume":"10","author":"Koenen","year":"2005","journal-title":"Mol Psychiatry"},{"issue":"11","key":"10.1016\/j.chc.2012.05.010_bib101","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1001\/jama.299.11.1291","article-title":"Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults","volume":"299","author":"Binder","year":"2008","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.chc.2012.05.010_bib102","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/npp.2010.37","article-title":"Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder","volume":"35","author":"Xie","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"2\u20133","key":"10.1016\/j.chc.2012.05.010_bib103","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1155\/2011\/328054","article-title":"Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks","volume":"30","author":"Sarapas","year":"2011","journal-title":"Dis Markers"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib104","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.biopsych.2011.10.026","article-title":"Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study","volume":"71","author":"van Zuiden","year":"2012","journal-title":"Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib105","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0896-6273(00)80775-8","article-title":"Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala","volume":"23","author":"Fanselow","year":"1999","journal-title":"Neuron"},{"issue":"32","key":"10.1016\/j.chc.2012.05.010_bib106","doi-asserted-by":"crossref","first-page":"7429","DOI":"10.1523\/JNEUROSCI.2314-05.2005","article-title":"Prefrontal control of the amygdala","volume":"25","author":"Likhtik","year":"2005","journal-title":"J Neurosci"},{"issue":"6499","key":"10.1016\/j.chc.2012.05.010_bib107","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/371702a0","article-title":"Beta-adrenergic activation and memory for emotional events","volume":"371","author":"Cahill","year":"1994","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib108","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1523\/JNEUROSCI.5231-11.2012","article-title":"Redundant catecholamine signaling consolidates fear memory via phospholipase C","volume":"32","author":"Ouyang","year":"2012","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib109","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nn1463","article-title":"5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression","volume":"8","author":"Pezawas","year":"2005","journal-title":"Nat Neurosci"},{"issue":"8","key":"10.1016\/j.chc.2012.05.010_bib110","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.cpr.2009.09.001","article-title":"Emerging treatments for PTSD","volume":"29","author":"Cukor","year":"2009","journal-title":"Clin Psychol Rev"},{"issue":"11","key":"10.1016\/j.chc.2012.05.010_bib111","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1176\/appi.ajp.2007.06122007","article-title":"The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults","volume":"164","author":"Kilpatrick","year":"2007","journal-title":"Am J Psychiatry"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib112","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/aje\/kwn397","article-title":"Modification of the association between serotonin transporter genotype and risk of posttraumatic stress disorder in adults by county-level social environment","volume":"169","author":"Koenen","year":"2009","journal-title":"Am J Epidemiol"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib113","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4088\/JCP.08m04787blu","article-title":"Association study of trauma load and SLC6A4 promoter polymorphism in posttraumatic stress disorder: evidence from survivors of the Rwandan genocide","volume":"71","author":"Kolassa","year":"2010","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib114","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/archgenpsychiatry.2011.109","article-title":"Acute and posttraumatic stress symptoms in a prospective gene \u00d7 environment study of a university campus shooting","volume":"69","author":"Mercer","year":"2012","journal-title":"Arch Gen Psychiatry"},{"issue":"11","key":"10.1016\/j.chc.2012.05.010_bib115","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.biopsych.2011.06.012","article-title":"Catechol-O-methyltransferase Val158Met polymorphism moderates anterior cingulate volume in posttraumatic stress disorder","volume":"70","author":"Schulz-Heik","year":"2011","journal-title":"Biol Psychiatry"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib116","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.biopsych.2009.10.009","article-title":"The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-O-methyltransferase Val(158)Met polymorphism","volume":"67","author":"Kolassa","year":"2010","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib117","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3928\/00485713-20090526-01","article-title":"Genetics of PTSD: fear conditioning as a model for future research","volume":"39","author":"Amstadter","year":"2009","journal-title":"Psychiatr Ann"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib118","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.psychres.2010.04.043","article-title":"PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake","volume":"178","author":"Bailey","year":"2010","journal-title":"Psychiatry Res"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib119","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nn.2499","article-title":"Synaptic correlates of fear extinction in the amygdala","volume":"13","author":"Amano","year":"2010","journal-title":"Nat Neurosci"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib120","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/mp.2008.81","article-title":"Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults","volume":"14","author":"Nelson","year":"2009","journal-title":"Mol Psychiatry"},{"issue":"25","key":"10.1016\/j.chc.2012.05.010_bib121","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1523\/JNEUROSCI.0153-06.2006","article-title":"Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes","volume":"26","author":"Kamprath","year":"2006","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib122","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/npp.2010.196","article-title":"Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala","volume":"36","author":"Kamprath","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"10.1016\/j.chc.2012.05.010_bib123","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/ajmg.b.30693","article-title":"Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder","volume":"147B","author":"Lu","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib124","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.janxdis.2008.12.005","article-title":"Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure","volume":"23","author":"Amstadter","year":"2009","journal-title":"J Anxiety Disord"},{"issue":"5","key":"10.1016\/j.chc.2012.05.010_bib125","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jts.20448","article-title":"The relevance of epigenetics to PTSD: implications for the DSM-V","volume":"22","author":"Yehuda","year":"2009","journal-title":"J Trauma Stress"},{"issue":"8","key":"10.1016\/j.chc.2012.05.010_bib126","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nn1276","article-title":"Epigenetic programming by maternal behavior","volume":"7","author":"Weaver","year":"2004","journal-title":"Nat Neurosci"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib127","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nn.2270","article-title":"Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse","volume":"12","author":"McGowan","year":"2009","journal-title":"Nat Neurosci"},{"issue":"7335","key":"10.1016\/j.chc.2012.05.010_bib128","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature09856","article-title":"Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor","volume":"470","author":"Ressler","year":"2011","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.chc.2012.05.010_bib129","doi-asserted-by":"crossref","first-page":"9470","DOI":"10.1073\/pnas.0910794107","article-title":"Epigenetic and immune function profiles associated with posttraumatic stress disorder","volume":"107","author":"Uddin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib130","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2217\/epi.11.116","article-title":"DNA methylation in repetitive elements and post-traumatic stress disorder: a case-control study of US military service members","volume":"4","author":"Rusiecki","year":"2012","journal-title":"Epigenomics"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib131","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11920-010-0126-6","article-title":"Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies","volume":"12","author":"Cornelis","year":"2010","journal-title":"Curr Psychiatry Rep"},{"issue":"3","key":"10.1016\/j.chc.2012.05.010_bib132","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10567-007-0022-8","article-title":"Genetic influences on anxiety in children: what we've learned and where we're heading","volume":"10","author":"Gregory","year":"2007","journal-title":"Clin Child Fam Psychol Rev"},{"issue":"6","key":"10.1016\/j.chc.2012.05.010_bib133","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10802-008-9216-x","article-title":"A multivariate genetic analysis of specific phobia, separation anxiety and social phobia in early childhood","volume":"36","author":"Eley","year":"2008","journal-title":"J Abnorm Child Psychol"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib134","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.janxdis.2010.02.008","article-title":"The role of genes and environment in shaping co-occurrence of DSM-IV defined anxiety dimensions among Italian twins aged 8\u201317","volume":"24","author":"Ogliari","year":"2010","journal-title":"J Anxiety Disord"},{"issue":"12","key":"10.1016\/j.chc.2012.05.010_bib135","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1017\/S0033291708002936","article-title":"The development of fears from early adolesence to young adulthood: a multivariate study","volume":"38","author":"Kendler","year":"2008","journal-title":"Psychol Med"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib136","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1176\/appi.ajp.161.1.59","article-title":"Genome-wide linkage scan for loci predisposing to social phobia: evidence for a chromosome 16 risk locus","volume":"161","author":"Gelernter","year":"2004","journal-title":"Am J Psychiatry"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib137","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/sj.mp.4001224","article-title":"A chromosome 14 risk locus for simple phobia: results from a genomewide linkage scan","volume":"8","author":"Gelernter","year":"2003","journal-title":"Mol Psychiatry"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib138","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1086\/501072","article-title":"Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus","volume":"78","author":"Kaabi","year":"2006","journal-title":"Am J Hum Genet"},{"issue":"4","key":"10.1016\/j.chc.2012.05.010_bib139","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1176\/appi.ajp.160.4.671","article-title":"Relation of shyness in grade school children to the genotype for the long form of the serotonin transporter promoter region polymorphism","volume":"160","author":"Arbelle","year":"2003","journal-title":"Am J Psychiatry"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archpsyc.62.1.85","article-title":"Influence of the serotonin transporter promoter gene and shyness on children's cerebral responses to facial expressions","volume":"62","author":"Battaglia","year":"2005","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"10.1016\/j.chc.2012.05.010_bib141","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0191-8869(01)00147-7","article-title":"Molecular genetics of shyness and aggression in preschoolers","volume":"33","author":"Schmidt","year":"2002","journal-title":"Pers Individ Dif"},{"issue":"12","key":"10.1016\/j.chc.2012.05.010_bib142","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1467-9280.2005.01637.x","article-title":"Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood","volume":"16","author":"Fox","year":"2005","journal-title":"Psychol Sci"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib143","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.mcn.2004.01.006","article-title":"Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning","volume":"26","author":"Koponen","year":"2004","journal-title":"Mol Cell Neurosci"},{"issue":"10","key":"10.1016\/j.chc.2012.05.010_bib144","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/S0006-3223(03)00418-9","article-title":"Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than \u201cdepressive.\u201d","volume":"54","author":"Zorner","year":"2003","journal-title":"Biol Psychiatry"},{"issue":"9","key":"10.1016\/j.chc.2012.05.010_bib145","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.biopsych.2010.11.008","article-title":"A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits","volume":"69","author":"Stein","year":"2011","journal-title":"Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.chc.2012.05.010_bib146","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajhg.2007.09.005","article-title":"Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene","volume":"82","author":"Alarcon","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"9","key":"10.1016\/j.chc.2012.05.010_bib147","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.biopsych.2011.07.012","article-title":"Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders","volume":"70","author":"Hettema","year":"2011","journal-title":"Biol Psychiatry"}],"container-title":["Child and Adolescent Psychiatric Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056499312000454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1056499312000454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T22:42:14Z","timestamp":1761000134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1056499312000454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":147,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S1056499312000454"],"URL":"https:\/\/doi.org\/10.1016\/j.chc.2012.05.010","relation":{},"ISSN":["1056-4993"],"issn-type":[{"value":"1056-4993","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetics of Pediatric Anxiety Disorders","name":"articletitle","label":"Article Title"},{"value":"Child and Adolescent Psychiatric Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chc.2012.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}