{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:48:22Z","timestamp":1790430502930,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3272,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemistry & Biology"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.chembiol.2004.05.020","type":"journal-article","created":{"date-parts":[[2004,8,21]],"date-time":"2004-08-21T09:11:59Z","timestamp":1093079519000},"page":"1139-1146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Discovery of a Small Molecule that Inhibits the Interaction of Anthrax Edema Factor with Its Cellular Activator, Calmodulin"],"prefix":"10.1016","volume":"11","author":[{"given":"Young-Sam","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Bergson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Song","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Mrksich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2004.05.020_BIB1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1126\/science.1083653","article-title":"Assembly of cell regulatory systems through protein interaction domains","volume":"300","author":"Pawson","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2004.05.020_BIB2","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1021\/jm010468s","article-title":"Inhibition of protein-protein association by small molecules","volume":"45","author":"Toogood","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB3","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S1074-5521(02)00246-6","article-title":"Inhibitors of cell migration that inhibit intracellular paxillin\/alpha4 binding","volume":"9","author":"Ambroise","year":"2002","journal-title":"Chem. Biol."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB4","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1073\/pnas.062036999","article-title":"Small-molecule antagonists of Myc\/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts","volume":"99","author":"Berg","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2004.05.020_BIB5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1092472","article-title":"In vivo activation of p53 pathway by small-molecule antagonists of MDM2","volume":"303","author":"Vassilev","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2004.05.020_BIB6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1158\/1535-7163.261.3.3","article-title":"Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity","volume":"3","author":"Turkson","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.19.111301.140655","article-title":"Anthrax toxin","volume":"19","author":"Collier","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB8","doi-asserted-by":"crossref","first-page":"16396","DOI":"10.1016\/S0021-9258(18)42016-9","article-title":"Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen","volume":"267","author":"Molloy","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/415396a","article-title":"Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin","volume":"415","author":"Drum","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2004.05.020_BIB10","doi-asserted-by":"crossref","first-page":"36334","DOI":"10.1074\/jbc.M004778200","article-title":"An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis","volume":"275","author":"Drum","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB11","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0092-8674(02)00682-7","article-title":"Calmodulin in action","volume":"108","author":"Hoeflich","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2004.05.020_BIB12","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0076-6879(79)58173-7","article-title":"Adrenocortical Y1 cells","volume":"58","author":"Schimmer","year":"1979","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB13","doi-asserted-by":"crossref","first-page":"29211","DOI":"10.1074\/jbc.271.46.29211","article-title":"Regulation of cytoskeleton organization and paxillin dephosphorylation by cAMP","volume":"271","author":"Han","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB14","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1093\/emboj\/cdf681","article-title":"Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins","volume":"21","author":"Shen","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB15","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1073\/pnas.072685299","article-title":"Selective immobilization of proteins to self-assembled monolayers presenting active site-directed capture ligands","volume":"99","author":"Hodneland","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2004.05.020_BIB16","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/jm010533y","article-title":"A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening","volume":"45","author":"McGovern","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB17","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/S1471-1931(02)00200-8","article-title":"Protein chips","volume":"20","author":"Lee","year":"2002","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB18","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S1367-5931(02)00362-9","article-title":"What can surface chemistry do for cell biology","volume":"6","author":"Mrksich","year":"2002","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB19","series-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"1999"},{"key":"10.1016\/j.chembiol.2004.05.020_BIB20","doi-asserted-by":"crossref","first-page":"13367","DOI":"10.1074\/jbc.273.22.13367","article-title":"Regulation of the calmodulin-stimulated protein phosphatase, calcineurin","volume":"273","author":"Klee","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB21","doi-asserted-by":"crossref","first-page":"8595","DOI":"10.1016\/S0021-9258(18)93016-4","article-title":"Expression and characterization of calmodulin-activated (type I) adenylyl cyclase","volume":"266","author":"Tang","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0966-842X(99)01468-7","article-title":"Bordatella pertussis adenylate cyclase","volume":"7","author":"Ladant","year":"1999","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB23","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1023\/A:1026493310144","article-title":"The yeast two-hybrid system and its pharmaceutical significance","volume":"17","author":"Topcu","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0076-6879(83)02019-4","article-title":"Transmembrane Ca2+ signaling and a new class of inhibitors","volume":"102","author":"Hidaka","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB25","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1016\/S0021-9258(19)39565-1","article-title":"KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific inhibitor of Ca2+\/calmodulin-dependent protein kinase II","volume":"265","author":"Tokumitsu","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB26","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1073\/pnas.0306552101","article-title":"Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection","volume":"101","author":"Shen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2004.05.020_BIB27","doi-asserted-by":"crossref","first-page":"25990","DOI":"10.1074\/jbc.M301232200","article-title":"Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough","volume":"278","author":"Soelaiman","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB28","doi-asserted-by":"crossref","first-page":"7573","DOI":"10.1074\/jbc.270.13.7573","article-title":"Identification of functional domains of adenylyl cyclase using in vivo chimeras","volume":"270","author":"Levin","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2004.05.020_BIB29","first-page":"705","article-title":"Synthesis of some sulfonamide derivatives","volume":"54","author":"Shingare","year":"1977","journal-title":"J. Indian Chem. Soc."}],"container-title":["Chemistry & Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552104001899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552104001899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:03:19Z","timestamp":1761030199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074552104001899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S1074552104001899"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2004.05.020","relation":{},"ISSN":["1074-5521"],"issn-type":[{"value":"1074-5521","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of a Small Molecule that Inhibits the Interaction of Anthrax Edema Factor with Its Cellular Activator, Calmodulin","name":"articletitle","label":"Article Title"},{"value":"Chemistry & Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2004.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}