{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:10:01Z","timestamp":1762251001953,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3211,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.chembiol.2004.07.008","type":"journal-article","created":{"date-parts":[[2004,10,19]],"date-time":"2004-10-19T12:23:43Z","timestamp":1098188623000},"page":"1339-1350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Molecular Dynamics Simulation Links Conformation of a Pore-Flanking Region to Hyperekplexia-Related Dysfunction of the Inhibitory Glycine Receptor"],"prefix":"10.1016","volume":"11","author":[{"given":"Hans-Georg","family":"Breitinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Lanig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Vohwinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Grewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Breitinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cord-Michael","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2004.07.008_BIB1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1749-6632.1999.tb11343.x","article-title":"Structure and functions of inhibitory and excitatory glycine receptors","volume":"868","author":"Betz","year":"1999","journal-title":"Ann. N Y Acad. Sci"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/138161280404221010152919","article-title":"The inhibitory glycine receptor","volume":"4","author":"Breitinger","year":"1998","journal-title":"Curr. Pharm. Des"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB3","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/1521-3773(20010903)40:17<3100::AID-ANIE3100>3.0.CO;2-A","article-title":"Ligand-gated ion channels","volume":"40","author":"Hucho","year":"2001","journal-title":"Angew. Chem. Int. Ed. Engl"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/0470868759.ch2","article-title":"Structure of the acetylcholine-gated channel","volume":"245","author":"Unwin","year":"2002","journal-title":"Novartis Found. Symp"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB5","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/1439-7633(20021104)3:11<1042::AID-CBIC1042>3.0.CO;2-7","article-title":"The inhibitory glycine receptor-simple views of a complicated channel","volume":"3","author":"Breitinger","year":"2002","journal-title":"Chembiochem"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/35077011","article-title":"Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors","volume":"411","author":"Brejc","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB7","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1074\/jbc.M303811200","article-title":"Conserved high affinity ligand binding and membrane association in the native and refolded extracellular domain of the human glycine receptor alpha1-subunit","volume":"279","author":"Breitinger","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB8","doi-asserted-by":"crossref","first-page":"19383","DOI":"10.1074\/jbc.R300035200","article-title":"Structure and function of the glycine receptor and related nicotinicoid receptors","volume":"279","author":"Cascio","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB9","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature01748","article-title":"Structure and gating mechanism of the acetylcholine receptor pore","volume":"424","author":"Miyazawa","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB10","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/7610","article-title":"Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy","volume":"6","author":"Opella","year":"1999","journal-title":"Nat. Struct. Biol"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB11","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1021\/bi026767g","article-title":"NMR structure and backbone dynamics of the extended second transmembrane domain of the human neuronal glycine receptor alpha1 subunit","volume":"42","author":"Yushmanov","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB12","series-title":"Channelopathies","article-title":"The inhibitory glycine receptor as a model of hereditary channelopathies","author":"Becker","year":"2000"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB13","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1523\/JNEUROSCI.19-03-00869.1999","article-title":"Novel GLRA1 missense mutation (P250T) in dominant hyperekplexia defines an intracellular determinant of glycine receptor channel gating","volume":"19","author":"Saul","year":"1999","journal-title":"J. Neurosci"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB14","first-page":"215","article-title":"Molecular basis of the charge selectivity of nicotinic acetylcholine receptor and related ligand-gated ion channels","volume":"225","author":"Corringer","year":"1999","journal-title":"Novartis Found. Symp"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB15","doi-asserted-by":"crossref","first-page":"29657","DOI":"10.1074\/jbc.M100446200","article-title":"Opposing effects of molecular volume and charge at the hyperekplexia site alpha 1(P250) govern glycine receptor activation and desensitization","volume":"276","author":"Breitinger","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB16","doi-asserted-by":"crossref","first-page":"7718","DOI":"10.1021\/bi00190a027","article-title":"Mechanism for the channel-opening reaction of strychnine-sensitive glycine receptors on cultured embryonic mouse spinal cord cells","volume":"33","author":"Walstrom","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB17","doi-asserted-by":"crossref","first-page":"8419","DOI":"10.1021\/bi0106890","article-title":"Inhibition of the 5\u2013HT3 serotonin receptor by nicotine, cocaine and fluoxetine investigated by rapid chemical kinetic techniques","volume":"40","author":"Breitinger","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB18","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1002\/j.1460-2075.1993.tb06050.x","article-title":"Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers","volume":"12","author":"Bormann","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB19","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0006-3495(99)76927-4","article-title":"Investigation of the \u03b1(1)-glycine receptor channel-opening kinetics in the submillisecond time domain","volume":"77","author":"Grewer","year":"1999","journal-title":"Biophys. J"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0076-6879(98)91028-X","article-title":"Development and application of caged ligands for neurotransmitter receptors in transient kinetic and neuronal circuit mapping studies","volume":"291","author":"Hess","year":"1998","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB21","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1021\/bi9919652","article-title":"A new photolabile precursor of glycine with improved properties","volume":"39","author":"Grewer","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB22","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/sj.bjp.0702164","article-title":"Binding, gating, affinity and efficacy","volume":"125","author":"Colquhoun","year":"1998","journal-title":"Br. J. Pharmacol"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/107385840100700204","article-title":"Fast kinetic analysis of ligand-gated ion channels","volume":"7","author":"Breitinger","year":"2001","journal-title":"Neuroscientist"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1469-7793.1998.025bu.x","article-title":"Properties of human glycine receptors containing the hyperekplexia mutation \u03b11(K276E), expressed in Xenopus oocytes","volume":"507","author":"Lewis","year":"1998","journal-title":"J. Physiol"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1113\/jphysiol.2002.032045","article-title":"Mutations at the GABA receptor selectivity filter","volume":"548","author":"Wotring","year":"2003","journal-title":"J. Physiol"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neulet.2003.08.005","article-title":"The contribution of proline 250 (P-2\u2032) to pore diameter and ion selectivity in the human glycine receptor channel","volume":"351","author":"Lee","year":"2003","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB27","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0028-3908(01)00132-0","article-title":"Mutation of the 9\u2032 leucine in the GABA(A) receptor \u03b32L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states","volume":"41","author":"Bianchi","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.2002.020255","article-title":"Slow phases of GABA(A) receptor desensitization","volume":"544","author":"Bianchi","year":"2002","journal-title":"J. Physiol"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB29","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1110\/ps.8.6.1166","article-title":"Polymer principles and protein folding","volume":"8","author":"Dill","year":"1999","journal-title":"Protein Sci"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB30","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1110\/ps.0220003","article-title":"The topomer search model","volume":"12","author":"Makarov","year":"2003","journal-title":"Protein Sci"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1749-6632.1995.tb17462.x","article-title":"Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods","volume":"757","author":"Hess","year":"1995","journal-title":"Ann. N Y Acad. Sci"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB32","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1021\/bi00139a012","article-title":"How fast does an acetylcholine receptor channel open? Laser-pulse photolysis of an inactive precursor of carbamoylcholine in the microsecond time region with BC3H1 cells","volume":"31","author":"Matsubara","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0079-6107(72)90005-3","article-title":"Protein volume in solution","volume":"24","author":"Zamyatnin","year":"1972","journal-title":"Prog. Biophys. Mol. Biol"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.bb.15.060186.001541","article-title":"Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins","volume":"15","author":"Engelman","year":"1986","journal-title":"Annu. Rev. Biophys. Biophys. Chem"},{"key":"10.1016\/j.chembiol.2004.07.008_BIB35","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1021\/ja00124a002","article-title":"A second generation force field for the simulation of proteins, nucleic acids, and organic molecules","volume":"117","author":"Cornell","year":"1995","journal-title":"J. Am. Chem. Soc"}],"container-title":["Chemistry &amp; Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552104002145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552104002145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:03:32Z","timestamp":1761030212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074552104002145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S1074552104002145"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2004.07.008","relation":{},"ISSN":["1074-5521"],"issn-type":[{"type":"print","value":"1074-5521"}],"subject":[],"published":{"date-parts":[[2004,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Dynamics Simulation Links Conformation of a Pore-Flanking Region to Hyperekplexia-Related Dysfunction of the Inhibitory Glycine Receptor","name":"articletitle","label":"Article Title"},{"value":"Chemistry & Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2004.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}