{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:11:06Z","timestamp":1792080666028,"version":"4.4.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":813,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemistry & Biology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.chembiol.2011.04.012","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T10:51:21Z","timestamp":1309171881000},"page":"777-793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"title":["Neuronal Store-Operated Calcium Entry Pathway as\u00a0a\u00a0Novel Therapeutic Target for\u00a0Huntington's\u00a0Disease Treatment"],"prefix":"10.1016","volume":"18","author":[{"given":"Jun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Pei","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Vigont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Hrdlicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Len","family":"Diggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Mahoney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Chesworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Zimina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov","family":"Glushankova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ahlijanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina\u00a0N.","family":"Mozhayeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kaznacheyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Bezprozvanny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2011.04.012_bib1","unstructured":"Al-Ramahi, I., Kim, E. Sanhueza, M., Diaz, J., and Botas, J. (2010). Screen of genes involved in Ca2+ homeostasis and signaling to identify genetic modifiers and potential therapeutic targets for Huntington's Disease treatment. Paper presented at Society for Neuroscience (San Diego, CA), November 13\u201317, 2010."},{"key":"10.1016\/j.chembiol.2011.04.012_bib2","doi-asserted-by":"crossref","first-page":"26714","DOI":"10.1074\/jbc.M601603200","article-title":"CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation","volume":"281","author":"Al-Ramahi","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ng.508","article-title":"Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C","volume":"42","author":"Auer-Grumbach","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2011.04.012_bib4","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/embor.2008.29","article-title":"Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits","volume":"9","author":"Bai","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.chembiol.2011.04.012_bib5","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1073\/pnas.0810599106","article-title":"A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice","volume":"106","author":"Becker","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2011.04.012_bib6","doi-asserted-by":"crossref","first-page":"ra67","DOI":"10.1126\/scisignal.2000522","article-title":"STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death","volume":"2","author":"Berna-Erro","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.chembiol.2011.04.012_bib7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molmed.2009.01.001","article-title":"Calcium signaling and neurodegenerative diseases","volume":"15","author":"Bezprozvanny","year":"2009","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.chembiol.2011.04.012_bib8","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1074\/jbc.M407384200","article-title":"TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells","volume":"280","author":"Bollimuntha","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib9","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1096\/fj.02-0037rev","article-title":"2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release","volume":"16","author":"Bootman","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.chembiol.2011.04.012_bib10","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1074\/jbc.M209677200","article-title":"BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice","volume":"278","author":"Burke","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pneurobio.2007.03.004","article-title":"Transcriptional signatures in Huntington's disease","volume":"83","author":"Cha","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.chembiol.2011.04.012_bib12","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1046\/j.1471-4159.1999.0721890.x","article-title":"Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin","volume":"72","author":"Chen","year":"1999","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib13","doi-asserted-by":"crossref","first-page":"12722","DOI":"10.1074\/jbc.M601018200","article-title":"Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells","volume":"281","author":"Choi","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib14","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.chembiol.2011.04.012_bib15","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1097\/nen.0b013e318156a3d7","article-title":"Location, location, location: altered transcription factor trafficking in neurodegeneration","volume":"66","author":"Chu","year":"2007","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.chembiol.2011.04.012_bib16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/35077544","article-title":"The TRP ion channel family","volume":"2","author":"Clapham","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.chembiol.2011.04.012_bib17","doi-asserted-by":"crossref","first-page":"12512","DOI":"10.1074\/jbc.M709330200","article-title":"Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T\u00a0cell activation","volume":"283","author":"Dadsetan","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng.509","article-title":"Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4","volume":"42","author":"Deng","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2011.04.012_bib19","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/hmg\/ddl135","article-title":"Biologically active molecules that reduce polyglutamine aggregation and toxicity","volume":"15","author":"Desai","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.chembiol.2011.04.012_bib20","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1523\/JNEUROSCI.4356-06.2007","article-title":"Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease","volume":"27","author":"Fan","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chembiol.2011.04.012_bib21","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2008.06310.x","article-title":"Mechanisms of neurodegeneration in Huntington's disease","volume":"27","author":"Gil","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.chembiol.2011.04.012_bib22","doi-asserted-by":"crossref","first-page":"e19285","DOI":"10.1371\/journal.pone.0019285","article-title":"Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons","volume":"6","author":"Gruszczynska-Biegala","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.chembiol.2011.04.012_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1085\/jgp.200308815","article-title":"The store-operated calcium entry pathways in human carcinoma A431 cells: functional properties and activation mechanisms","volume":"122","author":"Gusev","year":"2003","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.chembiol.2011.04.012_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fncir.2010.00010","article-title":"The enigma of store-operated ca-entry in neurons: answers from the Drosophila flight circuit","volume":"4","author":"Hasan","year":"2010","journal-title":"Front Neural Circuits"},{"key":"10.1016\/j.chembiol.2011.04.012_bib25","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1074\/jbc.M206769200","article-title":"Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein","volume":"278","author":"Herms","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib26","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2011.04.012_bib27","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1212\/01.wnl.0000198586.85250.13","article-title":"Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial","volume":"66","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.chembiol.2011.04.012_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20071619","article-title":"Huntington's disease: from pathology and genetics to potential therapies","volume":"412","author":"Imarisio","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.chembiol.2011.04.012_bib29","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1523\/JNEUROSCI.2675-04.2004","article-title":"Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity","volume":"24","author":"Khoshnan","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chembiol.2011.04.012_bib30","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng.512","article-title":"Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C","volume":"42","author":"Landoure","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2011.04.012_bib31","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1083\/jcb.149.4.793","article-title":"Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice","volume":"149","author":"Leissring","year":"2000","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chembiol.2011.04.012_bib32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1042\/bj20031345","article-title":"Modification of phospholipase C-gamma-induced Ca2+ signal generation by 2-aminoethoxydiphenyl borate","volume":"376","author":"Ma","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.chembiol.2011.04.012_bib33","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1074\/jbc.R800065200","article-title":"Animal models of polyglutamine diseases and therapeutic approaches","volume":"284","author":"Marsh","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib34","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1113\/jphysiol.2007.142448","article-title":"Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load","volume":"585","author":"Milnerwood","year":"2007","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.chembiol.2011.04.012_bib35","doi-asserted-by":"crossref","first-page":"re3","DOI":"10.1126\/stke.2722005re3","article-title":"The TRP superfamily of cation channels","volume":"2005","author":"Montell","year":"2005","journal-title":"Sci. STKE"},{"key":"10.1016\/j.chembiol.2011.04.012_bib36","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1046\/j.1471-4159.2000.740647.x","article-title":"Kainic acid-induced apoptosis in rat striatum is associated with nuclear factor-kappaB activation","volume":"74","author":"Nakai","year":"2000","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neulet.2008.09.034","article-title":"Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death","volume":"446","author":"Narayanan","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.chembiol.2011.04.012_bib38","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chembiol.2011.04.012_bib39","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/07853890410031948","article-title":"Mechanism of neurodegenerative disease: role of the ubiquitin proteasome system","volume":"36","author":"Petrucelli","year":"2004","journal-title":"Ann. Med."},{"key":"10.1016\/j.chembiol.2011.04.012_bib40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0143-4160(03)00143-X","article-title":"Capacitative calcium entry in the nervous system","volume":"34","author":"Putney","year":"2003","journal-title":"Cell Calcium"},{"key":"10.1016\/j.chembiol.2011.04.012_bib41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0022-3565(24)29513-6","article-title":"Prostaglandin A(1) protects striatal neurons against excitotoxic injury in rat striatum","volume":"297","author":"Qin","year":"2001","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.chembiol.2011.04.012_bib42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1124\/mol.53.1.33","article-title":"Nuclear factor-kappa B contributes to excitotoxin-induced apoptosis in rat striatum","volume":"53","author":"Qin","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.chembiol.2011.04.012_bib43","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng1362","article-title":"Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease","volume":"36","author":"Ravikumar","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2011.04.012_bib44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0169-328X(02)00527-2","article-title":"mRNA distribution analysis of human TRPC family in CNS and peripheral tissues","volume":"109","author":"Riccio","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.chembiol.2011.04.012_bib45","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/WCO.0b013e328304b692","article-title":"Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments","volume":"21","author":"Roze","year":"2008","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.chembiol.2011.04.012_bib46","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/187152710790966650","article-title":"TRPC channels and their implication in neurological diseases","volume":"9","author":"Selvaraj","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.chembiol.2011.04.012_bib47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ceca.2009.07.008","article-title":"TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP\/MPP(+)","volume":"46","author":"Selvaraj","year":"2009","journal-title":"Cell Calcium"},{"key":"10.1016\/j.chembiol.2011.04.012_bib48","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2174\/1566524023362276","article-title":"The molecular basis of mucolipidosis type IV","volume":"2","author":"Slaugenhaupt","year":"2002","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.chembiol.2011.04.012_bib49","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.chembiol.2011.04.012_bib50","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/35099568","article-title":"Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila","volume":"413","author":"Steffan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2011.04.012_bib51","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1074\/jbc.M310226200","article-title":"Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis","volume":"279","author":"Sugars","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib52","doi-asserted-by":"crossref","first-page":"24713","DOI":"10.1074\/jbc.M103501200","article-title":"Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95","volume":"276","author":"Sun","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib53","doi-asserted-by":"crossref","first-page":"38440","DOI":"10.1074\/jbc.M606736200","article-title":"Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice","volume":"281","author":"Supnet","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib54","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0896-6273(03)00366-0","article-title":"Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1","volume":"39","author":"Tang","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.chembiol.2011.04.012_bib55","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1073\/pnas.0409402102","article-title":"Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease","volume":"102","author":"Tang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2011.04.012_bib56","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1523\/JNEUROSCI.4411-08.2009","article-title":"Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model","volume":"29","author":"Tang","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.chembiol.2011.04.012_bib57","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.200909067","article-title":"IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome","volume":"187","author":"Thompson","year":"2009","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chembiol.2011.04.012_bib58","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0968-0896(02)00440-6","article-title":"Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation","volume":"11","author":"Tobe","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib59","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1016\/S0968-0896(03)00438-3","article-title":"A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives","volume":"11","author":"Tobe","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.chembiol.2011.04.012_bib60","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cell.2008.09.041","article-title":"Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells","volume":"135","author":"Venkatachalam","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2011.04.012_bib61","doi-asserted-by":"crossref","first-page":"10326","DOI":"10.1073\/pnas.0902982106","article-title":"Intracellular Ca2+ signaling and store-operated Ca2+ entry are required in Drosophila neurons for flight","volume":"106","author":"Venkiteswaran","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2011.04.012_bib62","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.chembiol.2011.04.012_bib63","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.bbamcr.2010.12.022","article-title":"TRP expression pattern and the functional importance of TRPC3 in primary human T-cells","volume":"1813","author":"Wenning","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chembiol.2011.04.012_bib64","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neulet.2006.08.036","article-title":"Evaluation of clinically relevant glutamate pathway inhibitors in in\u00a0vitro model of Huntington's disease","volume":"407","author":"Wu","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.chembiol.2011.04.012_bib65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1750-1326-3-15","article-title":"Evaluation of Dimebon in cellular model of Huntington's disease","volume":"3","author":"Wu","year":"2008","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.chembiol.2011.04.012_bib66","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/jnr.22017","article-title":"Ginsenosides protect striatal neurons in a cellular model of Huntington's disease","volume":"87","author":"Wu","year":"2009","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.chembiol.2011.04.012_bib67","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbadis.2007.03.006","article-title":"Transient receptor potential channels in Alzheimer's disease","volume":"1772","author":"Yamamoto","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chembiol.2011.04.012_bib68","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.bbrc.2005.03.221","article-title":"Arachidonic acid inhibits capacitative Ca2+ entry and activates non-capacitative Ca2+ entry in cultured astrocytes","volume":"331","author":"Yang","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.chembiol.2011.04.012_bib69","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0896-6273(00)00066-0","article-title":"Presenilin-mediated modulation of capacitative calcium entry","volume":"27","author":"Yoo","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.chembiol.2011.04.012_bib70","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(02)00615-3","article-title":"Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease","volume":"33","author":"Zeron","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.chembiol.2011.04.012_bib71","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1038\/sj.emboj.7601445","article-title":"Huntingtin inhibits caspase-3 activation","volume":"25","author":"Zhang","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.chembiol.2011.04.012_bib72","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2008.03.010","article-title":"Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease","volume":"31","author":"Zhang","year":"2008","journal-title":"Neurobiol. Dis."}],"container-title":["Chemistry & Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552111001621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552111001621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:17:02Z","timestamp":1761031022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074552111001621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":72,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S1074552111001621"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2011.04.012","relation":{},"ISSN":["1074-5521"],"issn-type":[{"value":"1074-5521","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuronal Store-Operated Calcium Entry Pathway as\u00a0a\u00a0Novel Therapeutic Target for\u00a0Huntington's\u00a0Disease Treatment","name":"articletitle","label":"Article Title"},{"value":"Chemistry & Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2011.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}