{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:06:31Z","timestamp":1791093991398,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":716,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI074658"],"award-info":[{"award-number":["AI074658"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemistry & Biology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.chembiol.2011.05.014","type":"journal-article","created":{"date-parts":[[2011,8,27]],"date-time":"2011-08-27T07:40:44Z","timestamp":1314430844000},"page":"1032-1041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus"],"prefix":"10.1016","volume":"18","author":[{"given":"Fei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Chuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoonsik","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Xiao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hao","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeok","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zigang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2011.05.014_bib1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/90429","article-title":"The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution","volume":"8","author":"Alekshun","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1086\/520289","article-title":"Staphylococcus aureus: a well-armed pathogen","volume":"26","author":"Archer","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.chembiol.2011.05.014_bib3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.280.5362.438","article-title":"Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus","volume":"280","author":"Balaban","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2011.05.014_bib4","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1126\/science.154.3754.1288","article-title":"Circular dichroism of biological macromolecules","volume":"154","author":"Beychok","year":"1966","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2011.05.014_bib5","doi-asserted-by":"crossref","first-page":"8255","DOI":"10.1128\/AEM.00499-10","article-title":"Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in Pseudomonas aeruginosa by high-throughput screening","volume":"76","author":"Borlee","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib6","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0960-894X(02)00017-3","article-title":"Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation","volume":"12","author":"Cameron","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.chembiol.2011.05.014_bib7","first-page":"197","article-title":"Invasive methicillin-resistant Staphylococcus aureus infections among dialysis patients\u2014United States, 2005","volume":"56","year":"2007","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.chembiol.2011.05.014_bib8","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1056\/NEJMoa025025","article-title":"Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene","volume":"348","author":"Chang","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2011.05.014_bib9","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1158\/0008-5472.CAN-04-4453","article-title":"Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors","volume":"65","author":"Chau","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.chembiol.2011.05.014_bib10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nchembio820","article-title":"An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus","volume":"2","author":"Chen","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nchembio.2007.24","article-title":"Targeting virulence: a new paradigm for antimicrobial therapy","volume":"3","author":"Clatworthy","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib12","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nrc906","article-title":"Transcription factors as targets for cancer therapy","volume":"2","author":"Darnell","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2011.05.014_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0022-3565(25)26029-3","article-title":"On the metabolism and toxicity of methyl salicylate","volume":"132","author":"Davison","year":"1961","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.chembiol.2011.05.014_bib14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/1568011054222346","article-title":"Programmable DNA binding oligomers for control of transcription","volume":"5","author":"Dervan","year":"2005","journal-title":"Curr. Med. Chem. Anticancer Agents"},{"key":"10.1016\/j.chembiol.2011.05.014_bib15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1574-6968.2010.01930.x","article-title":"Phosphorylation of the virulence regulator SarA modulates its ability to bind DNA in Staphylococcus aureus","volume":"306","author":"Didier","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.chembiol.2011.05.014_bib16","series-title":"Pharmacology","author":"Finkel","year":"2009"},{"key":"10.1016\/j.chembiol.2011.05.014_bib17","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa043252","article-title":"Methicillin-resistant Staphylococcus aureus disease in three communities","volume":"352","author":"Fridkin","year":"2005","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2011.05.014_bib18","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1128\/AAC.49.10.4101-4109.2005","article-title":"Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli","volume":"49","author":"Gauthier","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2011.05.014_bib19","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1038\/nprot.2006.202","article-title":"Using circular dichroism spectra to estimate protein secondary structure","volume":"1","author":"Greenfield","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chembiol.2011.05.014_bib20","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.4049\/jimmunol.164.7.3713","article-title":"Survival of Staphylococcus aureus inside neutrophils contributes to infection","volume":"164","author":"Gresham","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1081\/SCC-200046532","article-title":"A simple and effective method for chemoselective esterification of phenolic acids","volume":"36","author":"Guo","year":"2005","journal-title":"Synth. Commun."},{"key":"10.1016\/j.chembiol.2011.05.014_bib22","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1128\/AAC.43.4.990","article-title":"Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus","volume":"43","author":"Gustafson","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2011.05.014_bib23","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1126\/science.1116739","article-title":"Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization","volume":"310","author":"Hung","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2011.05.014_bib24","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1128\/IAI.73.3.1423-1431.2005","article-title":"Rat\/MgrA, a regulator of autolysis, is a regulator of virulence genes in Staphylococcus aureus","volume":"73","author":"Ingavale","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chembiol.2011.05.014_bib25","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1046\/j.1365-2958.2003.03503.x","article-title":"Characterization of RAT, an autolysis regulator in Staphylococcus aureus","volume":"48","author":"Ingavale","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib26","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1126\/science.276.5321.2027","article-title":"Bacterial interference caused by autoinducing peptide variants","volume":"276","author":"Ji","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2011.05.014_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/AAC.49.1.161-169.2005","article-title":"Effect of promoter region mutations and mgrA overexpression on transcription of norA, which encodes a Staphylococcus aureus multidrug efflux transporter","volume":"49","author":"Kaatz","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2011.05.014_bib28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/cmdc.200600294","article-title":"Selective inhibition of c-Myc\/Max dimerization by a pyrazolo[1,5-a]pyrimidine","volume":"2","author":"Kiessling","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.chembiol.2011.05.014_bib29","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1128\/JB.00928-09","article-title":"Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus","volume":"192","author":"Lan","year":"2010","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib30","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.0609699104","article-title":"Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists","volume":"104","author":"Lauth","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2011.05.014_bib31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ab.2004.04.031","article-title":"Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery","volume":"332","author":"Lo","year":"2004","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.chembiol.2011.05.014_bib32","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2011.05.014_bib33","doi-asserted-by":"crossref","first-page":"29689","DOI":"10.1074\/jbc.M504895200","article-title":"Unraveling the mechanism of a potent transcriptional activator","volume":"280","author":"Lu","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.05.014_bib34","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1128\/JB.188.5.1899-1910.2006","article-title":"Transcription profiling of the mgrA regulon in Staphylococcus aureus","volume":"188","author":"Luong","year":"2006","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib35","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1128\/JB.186.16.5267-5280.2004","article-title":"Identification of sarV (SA2062), a new transcriptional regulator, is repressed by SarA and MgrA (SA0641) and involved in the regulation of autolysis in Staphylococcus aureus","volume":"186","author":"Manna","year":"2004","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib36","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1073\/pnas.92.12.5456","article-title":"Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences","volume":"92","author":"Martin","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2011.05.014_bib37","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.chembiol.2007.08.013","article-title":"Infection control by antibody disruption of bacterial quorum sensing signaling","volume":"14","author":"Park","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/jmcb\/mjq021","article-title":"Molecular mechanisms of ligand-mediated attenuation of DNA binding by MarR family transcriptional regulators","volume":"2","author":"Perera","year":"2010","journal-title":"J.\u00a0Mol. Cell. Biol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0924-8579(02)00162-0","article-title":"The multidrug efflux pump NorA is not required for salicylate-induced reduction in drug accumulation by Staphylococcus aureus","volume":"20","author":"Price","year":"2002","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.chembiol.2011.05.014_bib40","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrmicro977","article-title":"Antitoxins: novel strategies to target agents of bioterrorism","volume":"2","author":"Rainey","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib41","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1128\/JB.01149-06","article-title":"Response of Staphylococcus aureus to salicylate challenge","volume":"189","author":"Riordan","year":"2007","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib42","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ab.2005.02.012","article-title":"A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors","volume":"340","author":"Rishi","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.chembiol.2011.05.014_bib43","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1073\/pnas.0611643104","article-title":"Virstatin inhibits dimerization of the transcriptional activator ToxT","volume":"104","author":"Shakhnovich","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2011.05.014_bib44","doi-asserted-by":"crossref","first-page":"e10000949","DOI":"10.1371\/journal.ppat.1000949","article-title":"The battle for iron between bacterial pathogens and their vertebrate hosts","volume":"6","author":"Skaar","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chembiol.2011.05.014_bib45","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1021\/jo101075a","article-title":"Construction of peptoids with all trans-amide backbones and peptoid reverse turns via the tactical incorporation of N-aryl side chains capable of hydrogen bonding","volume":"75","author":"Stringer","year":"2010","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.chembiol.2011.05.014_bib46","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/cbic.200900557","article-title":"Wall teichoic acid function, biosynthesis, and inhibition","volume":"11","author":"Swoboda","year":"2010","journal-title":"ChemBioChem"},{"key":"10.1016\/j.chembiol.2011.05.014_bib47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1086\/595740","article-title":"Role of mgrA and sarA in methicillin-resistant Staphylococcus aureus autolysis and resistance to cell wall-active antibiotics","volume":"199","author":"Trotonda","year":"2009","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chembiol.2011.05.014_bib48","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.1128\/JB.01068-08","article-title":"Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus","volume":"190","author":"Truong-Bolduc","year":"2008","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib49","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1128\/JB.187.7.2395-2405.2005","article-title":"MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus","volume":"187","author":"Truong-Bolduc","year":"2005","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib50","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1128\/JB.01819-06","article-title":"The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus","volume":"189","author":"Truong-Bolduc","year":"2007","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib51","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1128\/JB.00018-10","article-title":"Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus","volume":"192","author":"Truong-Bolduc","year":"2010","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib52","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1128\/AAC.50.3.1104-1107.2006","article-title":"NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus","volume":"50","author":"Truong-Bolduc","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2011.05.014_bib53","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1092472","article-title":"In\u00a0vivo activation of the p53 pathway by small-molecule antagonists of MDM2","volume":"303","author":"Vassilev","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2011.05.014_bib54","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1126\/science.8392747","article-title":"Vancomycin resistance: decoding the molecular logic","volume":"261","author":"Walsh","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2011.05.014_bib55","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1126\/science.1090956","article-title":"Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus","volume":"302","author":"Weigel","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2011.05.014_bib56","first-page":"51","article-title":"Ligand-responsive transcriptional regulation by members of the MarR family of winged helix proteins","volume":"8","author":"Wilkinson","year":"2006","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.chembiol.2011.05.014_bib57","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1073\/pnas.0407661102","article-title":"Transient interference with staphylococcal quorum sensing blocks abscess formation","volume":"102","author":"Wright","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Chemistry & Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552111002055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552111002055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:16:10Z","timestamp":1761030970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074552111002055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S1074552111002055"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2011.05.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13143956.14473054","asserted-by":"object"}]},"ISSN":["1074-5521"],"issn-type":[{"value":"1074-5521","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Chemistry & Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2011.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}