{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:15:30Z","timestamp":1791191730834,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":716,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemistry & Biology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.chembiol.2011.06.007","type":"journal-article","created":{"date-parts":[[2011,8,27]],"date-time":"2011-08-27T07:41:35Z","timestamp":1314430895000},"page":"988-999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["XPF-Dependent DNA Breaks and RNA Polymerase II Arrest Induced by Antitumor DNA Interstrand Crosslinking-Mimetic Alkaloids"],"prefix":"10.1016","volume":"18","author":[{"given":"Sascha","family":"Feuerhahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Giraudon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mart\u00ednez-D\u00edez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan\u00a0A.","family":"Bueren-Calabuig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos\u00a0M.","family":"Galmarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Gago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Egly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2011.06.007_bib1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0092-8674(95)90289-9","article-title":"Mammalian DNA nucleotide excision repair reconstituted with purified protein components","volume":"80","author":"Aboussekhra","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2011.06.007_bib2","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.molcel.2009.08.014","article-title":"Checkpoint signaling from a single DNA interstrand crosslink","volume":"35","author":"Ben-Yehoyada","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2011.06.007_bib3","doi-asserted-by":"crossref","unstructured":"Bustamante, C., Cheng, W., and Mejia, Y.X. (2011). Revisiting the central dogma one molecule at a time. Cell 144, 480\u2013497. Erratum: (2011). Cell 145, 160.","DOI":"10.1016\/j.cell.2011.01.033"},{"key":"10.1016\/j.chembiol.2011.06.007_bib4","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1158\/1535-7163.MCT-07-2432","article-title":"Relevance of the Fanconi anemia pathway in the response of human cells to trabectedin","volume":"7","author":"Casado","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.chembiol.2011.06.007_bib5","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/sj.emboj.7601403","article-title":"RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors","volume":"25","author":"Charlet-Berguerand","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.chembiol.2011.06.007_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/mutage\/gem051","article-title":"The comet assay: topical issues","volume":"23","author":"Collins","year":"2008","journal-title":"Mutagenesis"},{"key":"10.1016\/j.chembiol.2011.06.007_bib7","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.gde.2004.01.003","article-title":"RNA polymerase II structure: from core to functional complexes","volume":"14","author":"Cramer","year":"2004","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.chembiol.2011.06.007_bib8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1039\/b808331m","article-title":"Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem","volume":"26","author":"Cuevas","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.chembiol.2011.06.007_bib9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/ijc.1221","article-title":"Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways","volume":"92","author":"Damia","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.chembiol.2011.06.007_bib10","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1074\/jbc.273.14.7835","article-title":"DNA structural elements required for ERCC1-XPF endonuclease activity","volume":"273","author":"de Laat","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.06.007_bib11","doi-asserted-by":"crossref","first-page":"7980","DOI":"10.1128\/MCB.20.21.7980-7990.2000","article-title":"Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells","volume":"20","author":"De Silva","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chembiol.2011.06.007_bib12","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1158\/1535-7163.MCT-10-0263","article-title":"A review of trabectedin (ET-743): a unique mechanism of action","volume":"9","author":"D'Incalci","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.chembiol.2011.06.007_bib13","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1517\/13543784.12.11.1843","article-title":"Preclinical and clinical results with the natural marine product ET-743","volume":"12","author":"D'Incalci","year":"2003","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.chembiol.2011.06.007_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(83)90210-6","article-title":"The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter","volume":"35","author":"Dynan","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2011.06.007_bib15","first-page":"3377","article-title":"Ecteinascidin-743 inhibits activated but not constitutive transcription","volume":"62","author":"Friedman","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.chembiol.2011.06.007_bib16","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S1097-2765(02)00732-3","article-title":"Transcriptional activators stimulate DNA repair","volume":"10","author":"Frit","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2011.06.007_bib17","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1021\/jm000322d","article-title":"Increased DNA binding specificity for antitumor ecteinascidin 743 through protein-DNA interactions?","volume":"43","author":"Garc\u00eda-Nieto","year":"2000","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2011.06.007_bib18","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1091\/mbc.e08-02-0215","article-title":"Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex","volume":"19","author":"Guirouilh-Barbat","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.chembiol.2011.06.007_bib19","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1158\/1535-7163.MCT-09-0336","article-title":"Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C\u00a0ring of trabectedin for transcription-coupled repair inhibition","volume":"8","author":"Guirouilh-Barbat","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.chembiol.2011.06.007_bib20","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1126\/science.270.5243.1842","article-title":"Solution structure of a cisplatin-induced DNA interstrand cross-link","volume":"270","author":"Huang","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2011.06.007_bib21","doi-asserted-by":"crossref","first-page":"6775","DOI":"10.1073\/pnas.97.12.6775","article-title":"Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation","volume":"97","author":"Jin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2011.06.007_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nprot.2009.2","article-title":"Protein structure prediction on the Web: a case study using the Phyre server","volume":"4","author":"Kelley","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chembiol.2011.06.007_bib23","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1158\/1078-0432.CCR-04-0442","article-title":"Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells","volume":"10","author":"Koeppel","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chembiol.2011.06.007_bib24","doi-asserted-by":"crossref","first-page":"26632","DOI":"10.1074\/jbc.C000337200","article-title":"Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair\/recombination nuclease","volume":"275","author":"Kuraoka","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2011.06.007_bib25","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bcp.2009.04.003","article-title":"Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines","volume":"78","author":"Leal","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chembiol.2011.06.007_bib26","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/290310a0","article-title":"The SV40 early region TATA box is required for accurate in\u00a0vitro initiation of transcription","volume":"290","author":"Mathis","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2011.06.007_bib27","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1470-2045(01)00454-5","article-title":"Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance","volume":"2","author":"McHugh","year":"2001","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.chembiol.2011.06.007_bib28","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.1073\/pnas.97.12.6780","article-title":"Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743","volume":"97","author":"Minuzzo","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2011.06.007_bib29","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1038\/sj.emboj.7601730","article-title":"The human DNA repair factor XPC-HR23B distinguishes stereoisomeric benzo[a]pyrenyl-DNA lesions","volume":"26","author":"Mocquet","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.chembiol.2011.06.007_bib30","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1128\/MCB.20.7.2446-2454.2000","article-title":"DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts","volume":"20","author":"Mu","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chembiol.2011.06.007_bib31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/10409230903501819","article-title":"DNA interstrand crosslink repair in mammalian cells: step by step","volume":"45","author":"Muniandy","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.chembiol.2011.06.007_bib32","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/sj.emboj.7600581","article-title":"Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition","volume":"24","author":"Newman","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.chembiol.2011.06.007_bib33","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1128\/MCB.24.13.5776-5787.2004","article-title":"The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks","volume":"24","author":"Niedernhofer","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chembiol.2011.06.007_bib34","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1182\/blood-2008-09-177774","article-title":"Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks","volume":"113","author":"Ocio","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.chembiol.2011.06.007_bib35","doi-asserted-by":"crossref","unstructured":"Oku, N., Matsunaga, S., van Soest, R.W., and Fusetani, N. (2003). Renieramycin J, a highly cytotoxic tetrahydroisoquinoline alkaloid, from a marine sponge Neopetrosia sp. J. Nat. Prod. 66, 1136\u20131139. Erratum: (2004). J. Nat. Prod. 67, 526.","DOI":"10.1021\/np030092g"},{"key":"10.1016\/j.chembiol.2011.06.007_bib36","first-page":"2817","article-title":"Marked activity of irofulven toward human carcinoma cells: comparison with cisplatin and ecteinascidin","volume":"9","author":"Poindessous","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chembiol.2011.06.007_bib37","doi-asserted-by":"crossref","first-page":"13303","DOI":"10.1021\/bi960306b","article-title":"DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata","volume":"35","author":"Pommier","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.chembiol.2011.06.007_bib38","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/em.20583","article-title":"Multiple roles of ERCC1-XPF in mammalian interstrand crosslink repair","volume":"51","author":"Rahn","year":"2010","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.chembiol.2011.06.007_bib39","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1093\/emboj\/cdg489","article-title":"The comings and goings of nucleotide excision repair factors on damaged DNA","volume":"22","author":"Riedl","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.chembiol.2011.06.007_bib40","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1021\/np50070a001","article-title":"Bioactive compounds from aquatic and terrestrial sources","volume":"53","author":"Rinehart","year":"1990","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.chembiol.2011.06.007_bib41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0092-8674(85)90021-2","article-title":"Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region","volume":"43","author":"Sawadogo","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2011.06.007_bib42","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.1093\/nar\/gkg771","article-title":"Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences","volume":"31","author":"Schinecker","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2011.06.007_bib43","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1021\/cr010212u","article-title":"Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics","volume":"102","author":"Scott","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.chembiol.2011.06.007_bib44","doi-asserted-by":"crossref","first-page":"13062","DOI":"10.1073\/pnas.0609877104","article-title":"Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743","volume":"104","author":"Soares","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2011.06.007_bib45","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1093\/nar\/gkf405","article-title":"DNA bending and unwinding due to the major 1,2-GG intrastrand cross-link formed by antitumor cis-diamminedichloroplatinum(II) are flanking-base independent","volume":"30","author":"Stehlikova","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2011.06.007_bib46","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.molcel.2009.06.002","article-title":"Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA","volume":"34","author":"Sydow","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2011.06.007_bib47","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/91008","article-title":"Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair","volume":"7","author":"Takebayashi","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2011.06.007_bib48","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ejca.2008.01.003","article-title":"Role of homologous recombination in trabectedin-induced DNA damage","volume":"44","author":"Tavecchio","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.chembiol.2011.06.007_bib49","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1101\/gad.9.12.1479","article-title":"Recycling of the general transcription factors during RNA polymerase II transcription","volume":"9","author":"Zawel","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.chembiol.2011.06.007_bib50","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1021\/jm990241l","article-title":"Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove","volume":"42","author":"Zewail-Foote","year":"1999","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2011.06.007_bib51","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1074-5521(01)00071-0","article-title":"The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent","volume":"8","author":"Zewail-Foote","year":"2001","journal-title":"Chem. Biol."}],"container-title":["Chemistry & Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552111002274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552111002274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:16:34Z","timestamp":1761030994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074552111002274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S1074552111002274"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2011.06.007","relation":{},"ISSN":["1074-5521"],"issn-type":[{"value":"1074-5521","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"XPF-Dependent DNA Breaks and RNA Polymerase II Arrest Induced by Antitumor DNA Interstrand Crosslinking-Mimetic Alkaloids","name":"articletitle","label":"Article Title"},{"value":"Chemistry & Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2011.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}