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Chem."},{"key":"10.1016\/j.chembiol.2012.08.019_bib91","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cmet.2008.11.008","article-title":"The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor","volume":"9","author":"McBride","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.chembiol.2012.08.019_bib92","first-page":"E1107","article-title":"AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle","volume":"273","author":"Merrill","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.chembiol.2012.08.019_bib93","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. 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J."},{"key":"10.1016\/j.chembiol.2012.08.019_bib100","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nature07536","article-title":"Caenorhabditis elegans dauers need LKB1\/AMPK to ration lipid reserves and ensure long-term survival","volume":"457","author":"Narbonne","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2012.08.019_bib101","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1128\/MCB.23.11.3909-3917.2003","article-title":"Yeast Pak1 kinase associates with and activates Snf1","volume":"23","author":"Nath","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chembiol.2012.08.019_bib102","doi-asserted-by":"crossref","first-page":"19237","DOI":"10.1073\/pnas.1009705107","article-title":"\u03b2-Subunit myristoylation is the gatekeeper for\u00a0initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)","volume":"107","author":"Oakhill","year":"2010","journal-title":"Proc. Natl. Acad. Sci. 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Cardiol."},{"key":"10.1016\/j.chembiol.2012.08.019_bib108","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1096\/fj.11-198168","article-title":"Overexpression of AMP-metabolizing enzymes controls adenine nucleotide levels and AMPK activation\u00a0in HEK293T cells","volume":"26","author":"Plaideau","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.chembiol.2012.08.019_bib109","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0960-9822(03)00292-6","article-title":"AMPK\u00a0\u03b2 subunit targets metabolic stress sensing to glycogen","volume":"13","author":"Polekhina","year":"2003","journal-title":"Curr. 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Biol. Chem."},{"key":"10.1016\/j.chembiol.2012.08.019_bib113","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1124\/mol.106.029421","article-title":"Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver","volume":"70","author":"Rencurel","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.chembiol.2012.08.019_bib114","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S1369-5266(98)80264-1","article-title":"Jasmonate and salicylate as global signals for defense gene expression","volume":"1","author":"Reymond","year":"1998","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.chembiol.2012.08.019_bib115","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1021\/jf000745o","article-title":"Method for the quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the\u00a0stilbene content","volume":"49","author":"Romero-P\u00e9rez","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.chembiol.2012.08.019_bib116","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1074\/jbc.M110.189779","article-title":"Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase","volume":"286","author":"Ross","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2012.08.019_bib117","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/S0140-6736(11)61720-0","article-title":"Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials","volume":"379","author":"Rothwell","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.chembiol.2012.08.019_bib118","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(12)60209-8","article-title":"Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials","volume":"379","author":"Rothwell","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.chembiol.2012.08.019_bib119","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1073\/pnas.1102758108","article-title":"Roles of two protein phosphatases, Reg1-Glc7 and Sit4, and glycogen synthesis in regulation of SNF1 protein kinase","volume":"108","author":"Ruiz","year":"2011","journal-title":"Proc. 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Neurochem."},{"key":"10.1016\/j.chembiol.2012.08.019_bib124","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/bj3340177","article-title":"AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the \u03b12 isoform","volume":"334","author":"Salt","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.chembiol.2012.08.019_bib125","doi-asserted-by":"crossref","first-page":"32539","DOI":"10.1074\/jbc.M706543200","article-title":"Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family","volume":"282","author":"Sanders","year":"2007","journal-title":"J. Biol. 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Biol."},{"key":"10.1016\/j.chembiol.2012.08.019_bib128","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI19874","article-title":"CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations","volume":"113","author":"Scott","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.chembiol.2012.08.019_bib129","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.chembiol.2008.10.005","article-title":"Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes","volume":"15","author":"Scott","year":"2008","journal-title":"Chem. 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