{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:13:14Z","timestamp":1790784794701,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T00:00:00Z","timestamp":1469232000000},"content-version":"vor","delay-in-days":388,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.chembiol.2015.06.007","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T16:12:08Z","timestamp":1436026328000},"page":"829-837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Metal Ion-Mediated Nucleobase Recognition by the ZTP Riboswitch"],"prefix":"10.1016","volume":"22","author":[{"given":"Jeremiah\u00a0J.","family":"Trausch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan\u00a0G.","family":"Marcano-Vel\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal\u00a0M.","family":"Matyjasik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert\u00a0T.","family":"Batey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2015.06.007_bib1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tibs.2014.02.004","article-title":"Serine and glycine metabolism in cancer","volume":"39","author":"Amelio","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.chembiol.2015.06.007_bib2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.chembiol.2010.05.020","article-title":"A eubacterial riboswitch class that senses the coenzyme tetrahydrofolate","volume":"17","author":"Ames","year":"2010","journal-title":"Chem. Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib3","first-page":"1","article-title":"Metal ion binding to RNA","volume":"9","author":"Auffinger","year":"2011","journal-title":"Met. Ions Life Sci."},{"key":"10.1016\/j.chembiol.2015.06.007_bib4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/wrna.63","article-title":"Recognition of S-adenosylmethionine by riboswitches","volume":"2","author":"Batey","year":"2011","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.chembiol.2015.06.007_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1017\/S0033583512000078","article-title":"Structure and mechanism of purine-binding riboswitches","volume":"45","author":"Batey","year":"2012","journal-title":"Q.\u00a0Rev. Biophys."},{"key":"10.1016\/j.chembiol.2015.06.007_bib6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1107\/S0907444910048675","article-title":"iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM","volume":"67","author":"Battye","year":"2011","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chembiol.2015.06.007_bib7","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0092-8674(82)90455-X","article-title":"ZTP (5-amino 4-imidazole carboxamide riboside 5\u2032-triphosphate): a proposed alarmone for 10-formyl-tetrahydrofolate deficiency","volume":"29","author":"Bochner","year":"1982","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2015.06.007_bib8","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1126\/science.273.5282.1678","article-title":"Crystal structure of a group I ribozyme domain: principles of RNA packing","volume":"273","author":"Cate","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2015.06.007_bib9","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1021\/ar0000509","article-title":"Inhibitors of de novo nucleotide biosynthesis as drugs","volume":"35","author":"Christopherson","year":"2002","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.chembiol.2015.06.007_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chembiol.2006.12.005","article-title":"Structural investigation of the GlmS ribozyme bound to its catalytic cofactor","volume":"14","author":"Cochrane","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib11","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3201\/eid0912.020646","article-title":"Actinomyces odontolyticus bacteremia","volume":"9","author":"Cone","year":"2003","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.chembiol.2015.06.007_bib12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nmeth.1603","article-title":"Sequence-based identification of 3D structural modules in RNA with RMDetect","volume":"8","author":"Cruz","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2015.06.007_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jmb.2005.05.069","article-title":"RNA helical packing in solution: NMR structure of a 30\u00a0kDa GAAA tetraloop-receptor complex","volume":"351","author":"Davis","year":"2005","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib14","first-page":"628","article-title":"Solution structure of an ATP-binding RNA aptamer reveals a novel fold","volume":"2","author":"Dieckmann","year":"1996","journal-title":"RNA"},{"key":"10.1016\/j.chembiol.2015.06.007_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.molcel.2015.01.012","article-title":"ZMP: a master regulator of one-carbon metabolism","volume":"57","author":"Ducker","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2015.06.007_bib16","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.str.2006.07.008","article-title":"Crystal structures of the thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition","volume":"14","author":"Edwards","year":"2006","journal-title":"Structure"},{"key":"10.1016\/j.chembiol.2015.06.007_bib17","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chembiol.2015.06.007_bib18","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003533","article-title":"Riboswitches: structures and mechanisms","volume":"3","author":"Garst","year":"2011","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jmbi.1994.1552","article-title":"A major family of motifs involving G.A mismatches in ribosomal RNA","volume":"242","author":"Gautheret","year":"1994","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-59745-558-9_8","article-title":"Monitoring RNA-ligand interactions using isothermal titration calorimetry","volume":"540","author":"Gilbert","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.drup.2012.07.002","article-title":"Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance","volume":"15","author":"Gonen","year":"2012","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.chembiol.2015.06.007_bib22","doi-asserted-by":"crossref","first-page":"D121","DOI":"10.1093\/nar\/gki081","article-title":"Rfam: annotating non-coding RNAs in complete genomes","volume":"33","author":"Griffiths-Jones","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2015.06.007_bib23","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1093\/nar\/gkg539","article-title":"PSEUDOVIEWER2: visualization of RNA pseudoknots of any type","volume":"31","author":"Han","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2015.06.007_bib24","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1107\/S0907444999005442","article-title":"Macromolecular crystal annealing: evaluation of techniques and variables","volume":"55","author":"Harp","year":"1999","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chembiol.2015.06.007_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1126\/science.1712983","article-title":"Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops","volume":"253","author":"Heus","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2015.06.007_bib26","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1107\/S0907444904003804","article-title":"Structures of two RNA octamers containing tandem GA base pairs","volume":"60","author":"Jang","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chembiol.2015.06.007_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/382183a0","article-title":"Structural basis of RNA folding and recognition in an AMP-RNA aptamer complex","volume":"382","author":"Jiang","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2015.06.007_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nature11607","article-title":"B12 cofactors directly stabilize an mRNA regulatory switch","volume":"492","author":"Johnson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2015.06.007_bib29","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1017\/S1355838299991033","article-title":"A simple and efficient method to reduce nontemplated nucleotide addition at the 3 terminus of RNAs transcribed by T7 RNA polymerase","volume":"5","author":"Kao","year":"1999","journal-title":"RNA"},{"key":"10.1016\/j.chembiol.2015.06.007_bib30","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.str.2007.06.003","article-title":"A general strategy to solve the phase problem in RNA crystallography","volume":"15","author":"Keel","year":"2007","journal-title":"Structure"},{"key":"10.1016\/j.chembiol.2015.06.007_bib31","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1073\/pnas.1419328112","article-title":"GEMM-I riboswitches from Geobacter sense the bacterial second messenger cyclic AMP-GMP","volume":"112","author":"Kellenberger","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2015.06.007_bib32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.molcel.2015.01.001","article-title":"An ancient riboswitch class in bacteria regulates purine biosynthesis and one-carbon metabolism","volume":"57","author":"Kim","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2015.06.007_bib33","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1126\/science.1129666","article-title":"Structural basis of glmS ribozyme activation by glucosamine-6-phosphate","volume":"313","author":"Klein","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2015.06.007_bib34","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1016\/j.bmc.2005.12.060","article-title":"The purines: potent and versatile small molecule inhibitors and modulators of key biological targets","volume":"14","author":"Legraverend","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.chembiol.2015.06.007_bib35","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1093\/nar\/gkf481","article-title":"The non-Watson-Crick base pairs and their associated isostericity matrices","volume":"30","author":"Leontis","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2015.06.007_bib36","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrc3557","article-title":"Serine, glycine and one-carbon units: cancer metabolism in full circle","volume":"13","author":"Locasale","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2015.06.007_bib37","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.chembiol.2015.06.007_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4161\/rna.8.1.13865","article-title":"Challenges of ligand identification for riboswitch candidates","volume":"8","author":"Meyer","year":"2011","journal-title":"RNA Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib39","doi-asserted-by":"crossref","first-page":"D130","DOI":"10.1093\/nar\/gku1063","article-title":"Rfam 12.0: updates to the RNA families database","volume":"43","author":"Nawrocki","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2015.06.007_bib40","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1073\/pnas.081082398","article-title":"RNA tertiary interactions in the large ribosomal subunit: the A-minor motif","volume":"98","author":"Nissen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2015.06.007_bib41","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1126\/science.1218298","article-title":"Fluorescence imaging of cellular metabolites with RNA","volume":"335","author":"Paige","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2015.06.007_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature06684","article-title":"The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data","volume":"452","author":"Parisien","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2015.06.007_bib43","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.bbagrm.2014.02.012","article-title":"Themes and variations in riboswitch structure and function","volume":"1839","author":"Peselis","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chembiol.2015.06.007_bib44","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1126\/science.1133281","article-title":"Structural basis for ribosome recruitment and manipulation by a viral IRES RNA","volume":"314","author":"Pfingsten","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2015.06.007_bib45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/372111a0","article-title":"Model for an RNA tertiary interaction from the structure of an intermolecular complex between a GAAA tetraloop and an RNA helix","volume":"372","author":"Pley","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2015.06.007_bib46","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/protein\/5.8.827","article-title":"Recursive PCR: a novel technique for total gene synthesis","volume":"5","author":"Prodromou","year":"1992","journal-title":"Protein Eng."},{"key":"10.1016\/j.chembiol.2015.06.007_bib47","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0076-6879(09)69006-6","article-title":"Strategies in RNA crystallography","volume":"469","author":"Reyes","year":"2009","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib48","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ymeth.2010.06.011","article-title":"Solving novel RNA structures using only secondary structural fragments","volume":"52","author":"Robertson","year":"2010","journal-title":"Methods"},{"key":"10.1016\/j.chembiol.2015.06.007_bib49","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.biochem.78.070507.135656","article-title":"The structural and functional diversity of metabolite-binding riboswitches","volume":"78","author":"Roth","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.chembiol.2015.06.007_bib50","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/364550a0","article-title":"An RNA motif that binds ATP","volume":"364","author":"Sassanfar","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2015.06.007_bib51","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/nature04740","article-title":"Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch","volume":"441","author":"Serganov","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2015.06.007_bib52","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature07642","article-title":"Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch","volume":"458","author":"Serganov","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2015.06.007_bib53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/138955713804484749","article-title":"Recent advances in medicinal chemistry of sulfonamides. Rational design as anti-tumoral, anti-bacterial and anti-inflammatory agents","volume":"13","author":"Shah","year":"2013","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.chembiol.2015.06.007_bib54","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1128451","article-title":"Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand","volume":"312","author":"Thore","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2015.06.007_bib55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.chembiol.2013.11.012","article-title":"A disconnect between high-affinity binding and efficient regulation by antifolates and purines in the tetrahydrofolate riboswitch","volume":"21","author":"Trausch","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib56","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.str.2011.06.019","article-title":"The structure of a tetrahydrofolate-sensing riboswitch reveals two ligand binding sites in a single aptamer","volume":"19","author":"Trausch","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.chembiol.2015.06.007_bib57","doi-asserted-by":"crossref","first-page":"14859","DOI":"10.1021\/ja036166s","article-title":"On the value of c: can low affinity systems be studied by isothermal titration calorimetry?","volume":"125","author":"Turnbull","year":"2003","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2015.06.007_bib58","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/gb-2010-11-3-r31","article-title":"Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea, and their metagenomes","volume":"11","author":"Weinberg","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib59","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nsb1101-968","article-title":"Crystal structures of restrictocin-inhibitor complexes with implications for RNA recognition and base flipping","volume":"8","author":"Yang","year":"2001","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.chembiol.2015.06.007_bib60","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1107\/S0907444998004697","article-title":"A flash-annealing technique to improve diffraction limits and lower mosaicity in crystals of glycerol kinase","volume":"54","author":"Yeh","year":"1998","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chembiol.2015.06.007_bib61","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1007\/s00018-008-8295-8","article-title":"Structural biology of the purine biosynthetic pathway","volume":"65","author":"Zhang","year":"2008","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Chemistry &amp; Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552115002331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074552115002331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:25:10Z","timestamp":1761031510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074552115002331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1074552115002331"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2015.06.007","relation":{},"ISSN":["1074-5521"],"issn-type":[{"value":"1074-5521","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metal Ion-Mediated Nucleobase Recognition by the ZTP Riboswitch","name":"articletitle","label":"Article Title"},{"value":"Chemistry & Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2015.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}