{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:27:43Z","timestamp":1792232863597,"version":"4.4.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":386,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB720600"],"award-info":[{"award-number":["2012CB720600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB720603"],"award-info":[{"award-number":["2012CB720603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB720604"],"award-info":[{"award-number":["2012CB720604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB518904"],"award-info":[{"award-number":["2012CB518904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91213302"],"award-info":[{"award-number":["91213302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21432008"],"award-info":[{"award-number":["21432008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373256"],"award-info":[{"award-number":["81373256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21372182"],"award-info":[{"award-number":["21372182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21572169"],"award-info":[{"award-number":["21572169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572003"],"award-info":[{"award-number":["81572003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Province's Outstanding Medical Academic Leader Program"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.chembiol.2016.07.019","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T12:45:56Z","timestamp":1475066756000},"page":"1113-1122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":130,"title":["Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene"],"prefix":"10.1016","volume":"23","author":[{"given":"Shao-Ru","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Yi","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Shi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Hua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 3","key":"10.1016\/j.chembiol.2016.07.019_bib1","doi-asserted-by":"crossref","first-page":"S957","DOI":"10.1093\/infdis\/jir326","article-title":"Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis","volume":"204","author":"Aleksandrowicz","year":"2011","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.chembiol.2016.07.019_bib2","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1021\/ja501500c","article-title":"Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development","volume":"136","author":"Amrane","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2016.07.019_bib3","doi-asserted-by":"crossref","first-page":"12346","DOI":"10.1128\/JVI.01297-08","article-title":"Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin","volume":"82","author":"Arias","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib4","doi-asserted-by":"crossref","first-page":"g7348","DOI":"10.1136\/bmj.g7348","article-title":"Ebola virus disease","volume":"349","author":"Beeching","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.chembiol.2016.07.019_bib5","doi-asserted-by":"crossref","first-page":"e29608","DOI":"10.1371\/journal.pone.0029608","article-title":"The organisation of Ebola virus reveals a capacity for extensive, modular polyploidy","volume":"7","author":"Beniac","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2016.07.019_bib6","doi-asserted-by":"crossref","first-page":"12368","DOI":"10.3390\/molecules181012368","article-title":"G-quadruplex structures in the human genome as novel therapeutic targets","volume":"18","author":"Bidzinska","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.chembiol.2016.07.019_bib7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nchem.1548","article-title":"Quantitative visualization of DNA G-quadruplex structures in human cells","volume":"5","author":"Biffi","year":"2013","journal-title":"Nat. Chem."},{"key":"10.1016\/j.chembiol.2016.07.019_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nchem.1805","article-title":"Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells","volume":"6","author":"Biffi","year":"2014","journal-title":"Nat. Chem."},{"key":"10.1016\/j.chembiol.2016.07.019_bib9","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1093\/nar\/gks068","article-title":"5'-UTR RNA G-quadruplexes: translation regulation and targeting","volume":"40","author":"Bugaut","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib10","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1093\/nar\/gkl655","article-title":"Quadruplex DNA: sequence, topology and structure","volume":"34","author":"Burge","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1017\/S1355838298980621","article-title":"Destabilizing effect of an rRNA stem-loop on an attenuator hairpin in the 5' exon of the Tetrahymena pre-rRNA","volume":"4","author":"Cao","year":"1998","journal-title":"RNA"},{"key":"10.1016\/j.chembiol.2016.07.019_bib12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/anie.201409211","article-title":"Spherical nucleic acid nanoparticle conjugates enhance G-quadruplex formation and increase serum protein interactions","volume":"54","author":"Chinen","year":"2015","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chembiol.2016.07.019_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.7774\/cevr.2015.4.1.11","article-title":"Progress of vaccine and drug development for Ebola preparedness","volume":"4","author":"Choi","year":"2015","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib14","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1073\/pnas.1418718112","article-title":"Structure of a left-handed DNA G-quadruplex","volume":"112","author":"Chung","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2016.07.019_bib15","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/nar\/gkl286","article-title":"G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription","volume":"34","author":"Cogoi","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib16","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: a sequence logo generator","volume":"14","author":"Crooks","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib17","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1093\/nar\/gkg316","article-title":"Biophysical and biological properties of quadruplex oligodeoxyribonucleotides","volume":"31","author":"Dapic","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib18","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1128\/JVI.03050-13","article-title":"Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay","volume":"88","author":"Elshabrawy","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib19","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1002\/anie.201300058","article-title":"Suppression of gene expression by G-quadruplexes in open reading frames depends on G-quadruplex stability","volume":"52","author":"Endoh","year":"2013","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chembiol.2016.07.019_bib20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.antiviral.2013.09.015","article-title":"Favipiravir (T-705), a novel viral RNA polymerase inhibitor","volume":"100","author":"Furuta","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib21","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1101\/gad.12.15.2293","article-title":"Switch from translation to RNA replication in a positive-stranded RNA virus","volume":"12","author":"Gamarnik","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.chembiol.2016.07.019_bib22","first-page":"565","article-title":"The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in\u00a0vivo","volume":"1","author":"Grand","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.chembiol.2016.07.019_bib23","doi-asserted-by":"crossref","first-page":"W70","DOI":"10.1093\/nar\/gkn188","article-title":"The Vienna RNA website","volume":"36","author":"Gruber","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1021\/cb200447r","article-title":"Recent advances in developing small molecules targeting RNA","volume":"7","author":"Guan","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature13124","article-title":"C9orf72 nucleotide repeat structures initiate molecular cascades of disease","volume":"507","author":"Haeusler","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2016.07.019_bib26","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/nar\/27.2.537","article-title":"A DNA polymerase stop assay for G-quadruplex-interactive compounds","volume":"27","author":"Han","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib27","doi-asserted-by":"crossref","first-page":"e1004562","DOI":"10.1371\/journal.ppat.1004562","article-title":"G-quadruplexes in pathogens: a common route to virulence control?","volume":"11","author":"Harris","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chembiol.2016.07.019_bib28","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/nprot.2007.132","article-title":"Gene splicing and mutagenesis by PCR-driven overlap extension","volume":"2","author":"Heckman","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chembiol.2016.07.019_bib29","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1093\/nar\/gkv063","article-title":"Telomeric repeat-containing RNA\/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in\u00a0vivo","volume":"43","author":"Hirashima","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib30","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nature15542","article-title":"Selective small-molecule inhibition of an RNA structural element","volume":"526","author":"Howe","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2016.07.019_bib31","doi-asserted-by":"crossref","first-page":"13399","DOI":"10.1021\/ja904007p","article-title":"A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics","volume":"131","author":"Hsu","year":"2009","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2016.07.019_bib32","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/nar\/gki609","article-title":"Prevalence of quadruplexes in the human genome","volume":"33","author":"Huppert","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nrc749","article-title":"DNA and its associated processes as targets for cancer therapy","volume":"2","author":"Hurley","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2016.07.019_bib34","doi-asserted-by":"crossref","first-page":"12052","DOI":"10.1002\/anie.201305366","article-title":"Fluorescent-ligand-mediated screening of G-quadruplex structures using a DNA microarray","volume":"52","author":"Iida","year":"2013","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chembiol.2016.07.019_bib35","doi-asserted-by":"crossref","first-page":"190ra179","DOI":"10.1126\/scitranslmed.3005471","article-title":"FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection","volume":"5","author":"Johansen","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2016.07.019_bib36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nchembio864","article-title":"An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation","volume":"3","author":"Kumari","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib37","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1002\/anie.201500891","article-title":"Targeted detection of G-quadruplexes in cellular RNAs","volume":"54","author":"Kwok","year":"2015","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chembiol.2016.07.019_bib38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.micinf.2014.11.012","article-title":"Development of therapeutics for treatment of Ebola virus infection","volume":"17","author":"Li","year":"2015","journal-title":"Microbes Infect."},{"key":"10.1016\/j.chembiol.2016.07.019_bib39","doi-asserted-by":"crossref","first-page":"14581","DOI":"10.1073\/pnas.1516925112","article-title":"Guanine-vacancy-bearing G-quadruplexes responsive to guanine derivatives","volume":"112","author":"Li","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2016.07.019_bib40","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1056\/NEJMoa1409838","article-title":"Clinical care of two patients with Ebola virus disease in the United States","volume":"371","author":"Lyon","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2016.07.019_bib41","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/wrna.1113","article-title":"G-quadruplexes in RNA biology","volume":"3","author":"Millevoi","year":"2012","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.chembiol.2016.07.019_bib42","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1021\/ja310251r","article-title":"Bulges in G-quadruplexes: broadening the definition of G-quadruplex-forming sequences","volume":"135","author":"Mukundan","year":"2013","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2016.07.019_bib43","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/nchem.842","article-title":"Small-molecule-mediated G-quadruplex isolation from human cells","volume":"2","author":"Muller","year":"2010","journal-title":"Nat. Chem."},{"key":"10.1016\/j.chembiol.2016.07.019_bib44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.gde.2013.10.012","article-title":"Existence and consequences of G-quadruplex structures in DNA","volume":"25","author":"Murat","year":"2014","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.chembiol.2016.07.019_bib45","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nchembio.1479","article-title":"G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation","volume":"10","author":"Murat","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7774\/cevr.2015.4.1.17","article-title":"Ebola outbreak in Western Africa 2014: what is going on with Ebola virus?","volume":"4","author":"Na","year":"2015","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib47","doi-asserted-by":"crossref","first-page":"e1001121","DOI":"10.1371\/journal.ppat.1001121","article-title":"Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner","volume":"6","author":"Nanbo","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chembiol.2016.07.019_bib48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.antiviral.2014.02.014","article-title":"Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model","volume":"105","author":"Oestereich","year":"2014","journal-title":"Antiviral Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib49","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1006\/jmbi.1998.1901","article-title":"Folding intermediates of a self-splicing RNA: mispairing of the catalytic core","volume":"280","author":"Pan","year":"1998","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib50","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nature755","article-title":"Crystal structure of parallel quadruplexes from human telomeric DNA","volume":"417","author":"Parkinson","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2016.07.019_bib51","doi-asserted-by":"crossref","first-page":"e73121","DOI":"10.1371\/journal.pone.0073121","article-title":"Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity","volume":"8","author":"Perrone","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2016.07.019_bib52","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1742-4658.2009.07464.x","article-title":"Human telomeric G-quadruplex: structures of DNA and RNA sequences","volume":"277","author":"Phan","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.chembiol.2016.07.019_bib53","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1093\/nar\/gkm538","article-title":"Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4","volume":"35","author":"Qin","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12985-014-0205-0","article-title":"Plant-based vaccines against viruses","volume":"11","author":"Rybicki","year":"2014","journal-title":"Virol. J."},{"key":"10.1016\/j.chembiol.2016.07.019_bib55","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1039\/C4SC03853C","article-title":"G-quadruplex DNA and ligand interaction in living cells using NMR spectroscopy","volume":"6","author":"Salgado","year":"2015","journal-title":"Chem. Sci."},{"key":"10.1016\/j.chembiol.2016.07.019_bib56","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1158\/1535-7163.MCT-09-0586","article-title":"Disabling c-Myc in childhood medulloblastoma and atypical teratoid\/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD","volume":"9","author":"Shalaby","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.chembiol.2016.07.019_bib57","doi-asserted-by":"crossref","first-page":"11593","DOI":"10.1073\/pnas.182256799","article-title":"Direct evidence for a G-quadruplex in a promoter region and its targeting with a small\u00a0molecule to repress c-MYC transcription","volume":"99","author":"Siddiqui-Jain","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2016.07.019_bib58","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1021\/acschembio.5b00566","article-title":"G-quadruplex DNA- and RNA-specific-binding proteins engineered from the RGG domain of TLS\/FUS","volume":"10","author":"Takahama","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib59","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: molecular evolutionary genetics analysis version 6.0","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib60","doi-asserted-by":"crossref","first-page":"8884","DOI":"10.1093\/nar\/gkv897","article-title":"Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription","volume":"43","author":"Tosoni","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib61","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.virol.2004.10.048","article-title":"Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening","volume":"332","author":"Towner","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.chembiol.2016.07.019_bib62","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.antiviral.2014.03.018","article-title":"High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola viruses","volume":"106","author":"Uebelhoer","year":"2014","journal-title":"Antiviral Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib63","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nchembio.1452","article-title":"Sequence-based design of bioactive small molecules that target precursor microRNAs","volume":"10","author":"Velagapudi","year":"2014","journal-title":"Nat. Chem. Biol."},{"issue":"Pt 2","key":"10.1016\/j.chembiol.2016.07.019_bib64","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1099\/0022-1317-80-2-355","article-title":"Characterization of the L gene and 5' trailer region of Ebola virus","volume":"80","author":"Volchkov","year":"1999","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib65","doi-asserted-by":"crossref","first-page":"e1501535","DOI":"10.1126\/sciadv.1501535","article-title":"A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C\u00a0target","volume":"2","author":"Wang","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.chembiol.2016.07.019_bib66","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1073\/pnas.1006026107","article-title":"G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation","volume":"107","author":"Wanrooij","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2016.07.019_bib67","doi-asserted-by":"crossref","first-page":"10334","DOI":"10.1093\/nar\/gks802","article-title":"A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop","volume":"40","author":"Wanrooij","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2016.07.019_bib68","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature13027","article-title":"Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430","volume":"508","author":"Warren","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2016.07.019_bib69","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1128\/JVI.80.8.3743-3751.2006","article-title":"Functional mapping of the nucleoprotein of Ebola virus","volume":"80","author":"Watanabe","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib70","doi-asserted-by":"crossref","first-page":"10511","DOI":"10.1128\/JVI.01272-14","article-title":"A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity","volume":"88","author":"Watt","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.chembiol.2016.07.019_bib71","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1056\/NEJMoa1411100","article-title":"Ebola virus disease in West Africa\u2013the first 9\u00a0months of the epidemic and forward projections","volume":"371","author":"WHO Ebola Response Team","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2016.07.019_bib72","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature13485","article-title":"RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer","volume":"513","author":"Wolfe","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2016.07.019_bib73","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1111\/j.1742-4658.2010.07760.x","article-title":"G-quadruplex nucleic acids and human disease","volume":"277","author":"Wu","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.chembiol.2016.07.019_bib74","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1021\/ja511680u","article-title":"Stability and kinetics of c-MYC promoter G-quadruplexes studied by single-molecule manipulation","volume":"137","author":"You","year":"2015","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2016.07.019_bib75","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1128\/JVI.01565-13","article-title":"An amino acid of human parainfluenza virus type 3 nucleoprotein is critical for template function and cytoplasmic inclusion body formation","volume":"87","author":"Zhang","year":"2013","journal-title":"J.\u00a0Virol."}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945616302859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945616302859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T21:45:21Z","timestamp":1749591921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945616302859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":75,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S2451945616302859"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2016.07.019","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2016.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}