{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:40:32Z","timestamp":1790214032087,"version":"4.1.0"},"reference-count":185,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":385,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"The Katie Moore Fund"},{"DOI":"10.13039\/100009272","name":"Chordoma Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006315","name":"CureSearch for Children's Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P50CA101942"],"award-info":[{"award-number":["P50CA101942"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.chembiol.2017.08.002","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T20:31:38Z","timestamp":1506025898000},"page":"1075-1091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Emerging Opportunities for Target Discovery in Rare Cancers"],"prefix":"10.1016","volume":"24","author":[{"given":"Tanaz","family":"Sharifnia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrie A.","family":"Painter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse S.","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2017.08.002_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.14694\/EdBook_AM.2014.34.71","article-title":"National Cancer Institute's Precision Medicine Initiatives for the new National Clinical Trials Network","author":"Abrams","year":"2014","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"10.1016\/j.chembiol.2017.08.002_bib2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.canrad.2015.12.007","article-title":"Nasopharyngeal adenoid cystic carcinoma, a rare but highly challenging disease with unmet therapeutic needs: a case-report and review of the literature","volume":"20","author":"Afani","year":"2016","journal-title":"Cancer Radiother."},{"key":"10.1016\/j.chembiol.2017.08.002_bib3","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1158\/2159-8290.CD-16-0154","article-title":"Genomic copy number dictates a gene-independent cell response to CRISPR\/Cas9 targeting","volume":"6","author":"Aguirre","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2017.08.002_bib4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrc2852","article-title":"Cell line misidentification: the beginning of the end","volume":"10","author":"American Type Culture Collection Standards Development Organization Workgroup ASN-0002","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.5606\/ehc.2014.28","article-title":"Management and retrospective analysis of primary and metastatic sacral tumors and infections: evaluation with 73 cases","volume":"25","author":"Ar\u0131kan","year":"2014","journal-title":"Eklem Hastalik Cerrahisi"},{"key":"10.1016\/j.chembiol.2017.08.002_bib6","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.1105511","article-title":"NIH molecular libraries initiative","volume":"306","author":"Austin","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S1097-2765(03)00348-4","article-title":"Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening","volume":"12","author":"Aza-Blanc","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/ng.3500","article-title":"MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism","volume":"48","author":"Bandopadhayay","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib10","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cell.2013.08.003","article-title":"An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules","volume":"154","author":"Basu","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib11","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/onc.2009.381","article-title":"Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling","volume":"29","author":"Beck","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.chembiol.2017.08.002_bib12","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/S1470-2045(15)00388-5","article-title":"The value of research collaborations and consortia in rare cancers","volume":"17","author":"Blay","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrg3967","article-title":"An ecosystem of cancer cell line factories to support a cancer dependency map","volume":"16","author":"Boehm","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2014.12.021","article-title":"Organoid models of human and mouse ductal pancreatic cancer","volume":"160","author":"Boj","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib15","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1158\/2159-8290.CD-15-1200","article-title":"In\u00a0vivo genetic screens of patient-derived tumors revealed unexpected frailty of the transformed phenotype","volume":"6","author":"Bossi","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2017.08.002_bib16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/bjc.2016.450","article-title":"Comparative mutational landscape analysis of patient-derived tumour xenografts","volume":"116","author":"Brait","year":"2017","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng.2868","article-title":"Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas","volume":"46","author":"Brastianos","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cell.2016.08.041","article-title":"A biobank of breast cancer explants with preserved intra-tumor heterogeneity to screen anticancer compounds","volume":"167","author":"Bruna","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib19","unstructured":"Burdett T., Hall P.N., Hastings E., Hindorff L.A., Junkins H.A., Klemm A.K., MacArthur J., Manolio T.A., Morales J., Parkinson H., et\u00a0al. (2017). The NHGRI-EBI Catalog of published genome-wide association studies. www.ebi.ac.uk\/gwas."},{"key":"10.1016\/j.chembiol.2017.08.002_bib20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s12029-009-9111-x","article-title":"Evaluation of self-reported progression and correlation of imatinib dose to survival in patients with metastatic gastrointestinal stromal tumors: an open cohort study","volume":"41","author":"Call","year":"2010","journal-title":"J.\u00a0Gastrointest. Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1471-2407-12-90","article-title":"Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry","volume":"12","author":"Call","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib22","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/511518a","article-title":"Contamination hits cell work","volume":"511","author":"Callaway","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib23","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/ng.3564","article-title":"Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas","volume":"48","author":"Campbell","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature15736","article-title":"Pharmacogenomic agreement between two cancer cell line data sets","volume":"528","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib25","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature07385","article-title":"Comprehensive genomic characterization defines human glioblastoma genes and core pathways","volume":"455","author":"Cancer Genome Atlas Research Network","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib26","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature13385","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","author":"Cancer Genome Atlas Research Network","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib27","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/annonc\/mdu459","article-title":"Rare Cancers Europe (RCE) methodological recommendations for clinical studies in rare cancers: a European consensus position paper","volume":"26","author":"Casali","year":"2015","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib28","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/bju.13606","article-title":"Role of biobanking in urology: a review","volume":"118","author":"Chalfin","year":"2016","journal-title":"BJU Int."},{"key":"10.1016\/j.chembiol.2017.08.002_bib29","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/ng.2806","article-title":"Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers","volume":"45","author":"Chan-On","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib30","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1158\/1055-9965.EPI-06-0353","article-title":"The enigmatic epidemiology of nasopharyngeal carcinoma","volume":"15","author":"Chang","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.chembiol.2017.08.002_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jmoldx.2014.12.006","article-title":"Memorial Sloan Kettering-integrated mutation profiling of actionable cancer targets (MSK-IMPACT): a hybridization capture-based next-generation sequencing clinical assay for solid tumor molecular oncology","volume":"17","author":"Cheng","year":"2015","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.chembiol.2017.08.002_bib32","doi-asserted-by":"crossref","first-page":"12372","DOI":"10.1073\/pnas.1109363108","article-title":"Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer","volume":"108","author":"Cheung","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2017.08.002_bib33","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ccell.2016.02.009","article-title":"Genome-wide profiles of extra-cranial malignant rhabdoid tumors reveal heterogeneity and dysregulated developmental pathways","volume":"29","author":"Chun","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib34","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","article-title":"Modeling development and disease with organoids","volume":"165","author":"Clevers","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib35","first-page":"935","article-title":"Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia","volume":"8","author":"Cohen","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chembiol.2017.08.002_bib36","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nm.4306","article-title":"The Drug Repurposing Hub: a next-generation drug library and information resource","volume":"23","author":"Corsello","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib37","doi-asserted-by":"crossref","first-page":"140035","DOI":"10.1038\/sdata.2014.35","article-title":"Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies","volume":"1","author":"Cowley","year":"2014","journal-title":"Sci. Data"},{"key":"10.1016\/j.chembiol.2017.08.002_bib38","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1126\/science.1254721","article-title":"Patient-derived models of acquired resistance can identify effective drug combinations for cancer","volume":"346","author":"Crystal","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib39","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1093\/hmg\/ddw200","article-title":"An extended genome-wide association study identifies novel susceptibility loci for nasopharyngeal carcinoma","volume":"25","author":"Cui","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib40","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1186\/gb-2013-14-10-r110","article-title":"Modeling precision treatment of breast cancer","volume":"14","author":"Daemen","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib41","first-page":"3034","article-title":"Approval summary: imatinib mesylate in the treatment of metastatic and\/or unresectable malignant gastrointestinal stromal tumors","volume":"8","author":"Dagher","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chembiol.2017.08.002_bib42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ccr.2014.07.014","article-title":"The somatic genomic landscape of chromophobe renal cell carcinoma","volume":"26","author":"Davis","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0093-7754(01)90099-5","article-title":"Targeting c-kit mutations in solid tumors: scientific rationale and novel therapeutic options","volume":"28","author":"Demetri","year":"2001","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib44","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","article-title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia","volume":"344","author":"Druker","year":"2001","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/path.3986","article-title":"ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour","volume":"227","author":"Edris","year":"2012","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib46","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ccell.2017.01.001","article-title":"Comprehensive molecular characterization of pheochromocytoma and paraganglioma","volume":"31","author":"Fishbein","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib47","doi-asserted-by":"crossref","first-page":"201ps11","DOI":"10.1126\/scitranslmed.3006800","article-title":"Power of rare diseases: found in translation","volume":"5","author":"Fishman","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib48","unstructured":"Foundation Medicine. (2016). Foundation Medicine announces release of molecular information from FoundationCORE\u2122 to the National Cancer Institute in support of the national Cancer Moonshot and Precision Medicine Initiatives. http:\/\/investors.foundationmedicine.com\/releasedetail.cfm?releaseid=977617."},{"key":"10.1016\/j.chembiol.2017.08.002_bib49","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nrc4015","article-title":"Precision medicine for cancer with next-generation functional diagnostics","volume":"15","author":"Friedman","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib50","first-page":"e12","article-title":"Patient-driven research: rich opportunities and real risks","volume":"1","author":"Frydman","year":"2009","journal-title":"J.\u00a0Participatory Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib51","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2014.08.016","article-title":"Organoid cultures derived from patients with advanced prostate cancer","volume":"159","author":"Gao","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib52","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.3954","article-title":"High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response","volume":"21","author":"Gao","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib53","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nature11005","article-title":"Systematic identification of genomic markers of drug sensitivity in cancer cells","volume":"483","author":"Garnett","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cell.2013.03.002","article-title":"Lessons from the cancer genome","volume":"153","author":"Garraway","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib55","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.ejca.2011.08.008","article-title":"Rare cancers are not so rare: the rare cancer burden in Europe","volume":"47","author":"Gatta","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib56","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.lungcan.2009.12.005","article-title":"Lung cancer cell lines: useless artifacts or invaluable tools for medical science?","volume":"68","author":"Gazdar","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib57","unstructured":"Genome Aggregation Database. (2017). gnomAD browser beta. http:\/\/gnomad.broadinstitute.org\/."},{"key":"10.1016\/j.chembiol.2017.08.002_bib58","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.aaf6162","article-title":"GENOMICS. A federated ecosystem for sharing genomic, clinical data","volume":"352","author":"Global Alliance for Genomics and Health","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib59","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/003335491012500106","article-title":"The occurrence of rare cancers in U.S. adults, 1995-2004","volume":"125","author":"Greenlee","year":"2010","journal-title":"Public Health Rep."},{"key":"10.1016\/j.chembiol.2017.08.002_bib60","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature12831","article-title":"Inconsistency in large pharmacogenomic studies","volume":"504","author":"Haibe-Kains","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib61","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1158\/1078-0432.CCR-15-3011","article-title":"DiSCoVERing innovative therapies for rare tumors: combining genetically accurate disease models with in\u00a0silico analysis to identify novel therapeutic targets","volume":"22","author":"Hanaford","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chembiol.2017.08.002_bib62","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1126\/science.1194472","article-title":"Frequent mutation of BAP1 in metastasizing uveal melanomas","volume":"330","author":"Harbour","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib63","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2015.5689","article-title":"Multicenter feasibility study of tumor molecular profiling to inform therapeutic decisions in advanced pediatric solid tumors: the individualized cancer therapy (iCat) study","author":"Harris","year":"2016","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib64","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2147\/PPA.S20445","article-title":"Patient preferences for reducing toxicities of treatments for gastrointestinal stromal tumor (GIST)","volume":"5","author":"Hauber","year":"2011","journal-title":"Patient Prefer. Adherence"},{"key":"10.1016\/j.chembiol.2017.08.002_bib65","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature17987","article-title":"Reproducible pharmacogenomic profiling of cancer cell line panels","volume":"533","author":"Haverty","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib66","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1200\/JCO.2008.17.4284","volume":"26","author":"Heinrich","year":"2008","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib67","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nm.3480","article-title":"ARID1B is a specific vulnerability in ARID1A-mutant cancers","volume":"20","author":"Helming","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib68","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ng.2643","article-title":"The mutational landscape of adenoid cystic carcinoma","volume":"45","author":"Ho","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib69","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1249484","article-title":"Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma","volume":"343","author":"Honeyman","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib70","doi-asserted-by":"crossref","first-page":"11987","DOI":"10.1038\/ncomms11987","article-title":"Integrated genetic and pharmacologic interrogation of rare cancers","volume":"7","author":"Hong","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2017.08.002_bib71","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/pbc.21078","article-title":"The pediatric preclinical testing program: description of models and early testing results","volume":"49","author":"Houghton","year":"2007","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib72","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1101\/sqb.2016.81.031070","article-title":"Functional genomic characterization of cancer genomes","volume":"81","author":"Howard","year":"2016","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib73","doi-asserted-by":"crossref","first-page":"80ps16","DOI":"10.1126\/scitranslmed.3001862","article-title":"The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics","volume":"3","author":"Huang","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib74","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.cell.2016.12.015","article-title":"Implementing genome-driven oncology","volume":"168","author":"Hyman","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib75","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1038\/ncomms8419","article-title":"Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours","volume":"6","author":"Ince","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2017.08.002_bib76","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature09298","article-title":"Integrating common and rare genetic variation in diverse human populations","volume":"467","author":"Altshuler","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib77","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.cell.2016.06.017","article-title":"A landscape of pharmacogenomic interactions in cancer","volume":"166","author":"Iorio","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib78","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/bio.2012.1022","article-title":"2012 best practices for repositories collection, storage, retrieval, and distribution of biological materials for research international society for biological and environmental repositories","volume":"10","author":"ISBER","year":"2012","journal-title":"Biopreserv. Biobank."},{"key":"10.1016\/j.chembiol.2017.08.002_bib79","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/cpt.354","article-title":"Patient-derived xenografts as tools in pharmaceutical development","volume":"99","author":"Izumchenko","year":"2016","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.chembiol.2017.08.002_bib80","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/314067a0","article-title":"Hypervariable 'minisatellite' regions in human DNA","volume":"314","author":"Jeffreys","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib81","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ng.2813","article-title":"Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas","volume":"45","author":"Jiao","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib82","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature11284","article-title":"Dissecting the genomic complexity underlying medulloblastoma","volume":"488","author":"Jones","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib83","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrc1691","article-title":"The concept of synthetic lethality in the context of anticancer therapy","volume":"5","author":"Kaelin","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib84","doi-asserted-by":"crossref","first-page":"289","DOI":"10.14639\/0392-100X-807","article-title":"Malignant salivary gland tumours of the larynx: a single institution review","volume":"36","author":"Karatayli-Ozgursoy","year":"2016","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"10.1016\/j.chembiol.2017.08.002_bib85","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/jamaoncol.2015.3960","article-title":"Disease-specific Hashtags for online communication about cancer care","volume":"2","author":"Katz","year":"2016","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib86","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1200\/JCO.2014.56.2728","article-title":"Olaparib monotherapy in patients with advanced cancer and a germline BRCA1\/2 mutation","volume":"33","author":"Kaufman","year":"2015","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib87","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ng0298-184","article-title":"A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma","volume":"18","author":"Knezevich","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib88","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.aad5214","article-title":"MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells","volume":"351","author":"Kryukov","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib89","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature12213","article-title":"Mutational heterogeneity in cancer and the search for new cancer-associated genes","volume":"499","author":"Lawrence","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib90","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1172\/JCI64400","article-title":"A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers","volume":"122","author":"Lee","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chembiol.2017.08.002_bib91","unstructured":"Leiomyosarcoma Direct Research Foundation. (2016). Paraffin tissue block donation. http:\/\/lmsdr.org\/paraffin-tissue-block-donation\/."},{"key":"10.1016\/j.chembiol.2017.08.002_bib92","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Lek","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib93","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/modpathol.3800755","article-title":"Differentiating Ewing's sarcoma from other round blue cell tumors using a RT-PCR translocation panel on formalin-fixed paraffin-embedded tissues","volume":"20","author":"Lewis","year":"2007","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib94","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nature07485","article-title":"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome","volume":"456","author":"Ley","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib95","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ajpath.2011.10.036","article-title":"ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells","volume":"180","author":"Liu","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib96","doi-asserted-by":"crossref","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","article-title":"The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)","volume":"45","author":"MacArthur","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2017.08.002_bib97","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1158\/2159-8290.CD-11-0224","article-title":"Essential gene profiles in breast, pancreatic, and ovarian cancer cells","volume":"2","author":"Marcotte","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2017.08.002_bib98","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cell.2015.11.062","article-title":"Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance","volume":"164","author":"Marcotte","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib99","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/path.4573","article-title":"Genomic landscape of adenoid cystic carcinoma of the breast","volume":"237","author":"Martelotto","year":"2015","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35043102","article-title":"Human cancer cell lines: fact and fantasy","volume":"1","author":"Masters","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib101","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/annonc\/mdw133","article-title":"Olaparib monotherapy in patients with advanced relapsed ovarian cancer and a germline BRCA1\/2 mutation: a multistudy analysis of response rates and safety","volume":"27","author":"Matulonis","year":"2016","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib102","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.aad5944","article-title":"Disordered methionine metabolism in MTAP\/CDKN2A-deleted cancers leads to dependence on PRMT5","volume":"351","author":"Mavrakis","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1008947301735","article-title":"Chordoma: incidence and survival patterns in the United States, 1973-1995","volume":"12","author":"McMaster","year":"2001","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.chembiol.2017.08.002_bib104","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrg2841","article-title":"Advances in understanding cancer genomes through second-generation sequencing","volume":"11","author":"Meyerson","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib105","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1158\/2159-8290.CD-15-0125","article-title":"A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma","volume":"5","author":"Mirabello","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2017.08.002_bib106","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/jama.2015.10080","article-title":"Integrative clinical sequencing in the management of refractory or relapsed cancer in youth","volume":"314","author":"Mody","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.chembiol.2017.08.002_bib107","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.cell.2006.01.040","article-title":"A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen","volume":"124","author":"Moffat","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib108","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1200\/JCO.2011.36.9678","article-title":"Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft","volume":"30","author":"Morelli","year":"2012","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib109","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature11331","article-title":"Passenger deletions generate therapeutic vulnerabilities in cancer","volume":"488","author":"Muller","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib110","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1053\/j.seminhematol.2013.10.001","article-title":"Genomic characterization of childhood acute lymphoblastic leukemia","volume":"50","author":"Mullighan","year":"2013","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib111","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1056\/NEJMoa0808253","article-title":"Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia","volume":"360","author":"Mullighan","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib112","unstructured":"Multiple Myeloma Research Foundation. (2015). The multiple myeloma research foundation releases latest interim analysis from the CoMMpass Study\u2122 to researchers and clinicians on its researcher gateway. https:\/\/www.themmrf.org\/the-multiple-myeloma-research-foundation-releases-latest-interim-analysis-from-the-commpass-study-to-researchers-and-clinicians-on-its-researcher-gateway\/."},{"key":"10.1016\/j.chembiol.2017.08.002_bib113","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1158\/2159-8290.CD-16-0178","article-title":"CRISPR screens provide a comprehensive assessment of cancer vulnerabilities but generate false-positive hits for highly amplified genomic regions","volume":"6","author":"Munoz","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2017.08.002_bib114","unstructured":"National Cancer Institute. (2007). Synergizing epidemiologic research on rare cancers. https:\/\/epi.grants.cancer.gov\/events\/rare-cancers\/."},{"key":"10.1016\/j.chembiol.2017.08.002_bib115","unstructured":"National Cancer Institute. (2016a). NCI collaborates with Multiple Myeloma Research Foundation. https:\/\/www.cancer.gov\/news-events\/press-releases\/2016\/gdc-data-expansion-mmrf."},{"key":"10.1016\/j.chembiol.2017.08.002_bib116","unstructured":"National Cancer Institute. (2016b). SEER Cancer Statistics Review (CSR) 1975-2013. http:\/\/seer.cancer.gov\/csr\/1975_2013\/."},{"key":"10.1016\/j.chembiol.2017.08.002_bib117","unstructured":"NCCN Guidelines. (2017a). Bone Cancer Version 2.2017 - November 7, 2016. www.nccn.org."},{"key":"10.1016\/j.chembiol.2017.08.002_bib118","unstructured":"NCCN Guidelines. (2017b). Breast Cancer Version 2.2017 - April 6, 2017. www.nccn.org."},{"key":"10.1016\/j.chembiol.2017.08.002_bib119","unstructured":"NCCN Guidelines. (2017c). Prostate Cancer Version 2.2017 - February 21, 2017. www.nccn.org."},{"key":"10.1016\/j.chembiol.2017.08.002_bib120","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.cell.2012.07.023","article-title":"Cancer vulnerabilities unveiled by genomic loss","volume":"150","author":"Nijhawan","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib121","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jcb.240630504","article-title":"Cell culture methods for the establishment of the NCI series of lung cancer cell lines","volume":"24","author":"Oie","year":"1996","journal-title":"J.\u00a0Cell. Biochem. Suppl."},{"key":"10.1016\/j.chembiol.2017.08.002_bib122","doi-asserted-by":"crossref","first-page":"8070","DOI":"10.1038\/ncomms9070","article-title":"Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells","volume":"6","author":"Oikawa","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2017.08.002_bib123","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/ng.2273","article-title":"Exome sequencing of liver fluke-associated cholangiocarcinoma","volume":"44","author":"Ong","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib124","unstructured":"Orphanet. (2016). Prevalence and incidence of rare diseases: bibliographic data. http:\/\/www.orpha.net\/orphacom\/cahiers\/docs\/GB\/Prevalence_of_rare_diseases_by_alphabetical_list.pdf."},{"key":"10.1016\/j.chembiol.2017.08.002_bib125","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1586\/17512433.2015.1088382","article-title":"Clinical trial design for rare cancers: why a less conventional route may be required","volume":"8","author":"Panageas","year":"2015","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib126","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2016-217695","article-title":"Invasive thymoma presenting as classic superior vena cava syndrome: a case of venous spread metastasis","volume":"2016","author":"Panda","year":"2016","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.chembiol.2017.08.002_bib127","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2015.5699","article-title":"Diagnostic yield of clinical tumor and germline whole-exome sequencing for children with solid tumors","author":"Parsons","year":"2016","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib128","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/nprot.2014.108","article-title":"Establishing a human renal cell carcinoma tumorgraft platform for preclinical drug testing","volume":"9","author":"Pavia-Jimenez","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.chembiol.2017.08.002_bib129","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/humu.22858","article-title":"The Matchmaker Exchange: a platform for rare disease gene discovery","volume":"36","author":"Philippakis","year":"2015","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.chembiol.2017.08.002_bib130","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/ng.2419","article-title":"A common single-nucleotide variant in T is strongly associated with chordoma","volume":"44","author":"Pillay","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib131","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1073\/pnas.0611373104","article-title":"Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas","volume":"104","author":"Price","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2017.08.002_bib132","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa1603144","article-title":"Inherited DNA-repair gene mutations in men with metastatic prostate cancer","volume":"375","author":"Pritchard","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib133","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ng.2529","article-title":"The genetic landscape of high-risk neuroblastoma","volume":"45","author":"Pugh","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2017.08.002_bib134","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/cytob.21192","article-title":"Stable phenotype of B-cell subsets following cryopreservation and thawing of normal human lymphocytes stored in a tissue biobank","volume":"88","author":"Rasmussen","year":"2015","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.chembiol.2017.08.002_bib135","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nmeth924","article-title":"Genome-scale loss-of-function screening with a lentiviral RNAi library","volume":"3","author":"Root","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2017.08.002_bib136","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/PAS.0000000000000102","article-title":"Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies","volume":"38","author":"Ross","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib137","doi-asserted-by":"crossref","first-page":"111ra121","DOI":"10.1126\/scitranslmed.3003161","article-title":"Personalized oncology through integrative high-throughput sequencing: a pilot study","volume":"3","author":"Roychowdhury","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib138","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1699-0463.1969.tb04520.x","article-title":"Heterotransplantation of a human malignant tumour to \u201cNude\u201d mice","volume":"77","author":"Rygaard","year":"1969","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"10.1016\/j.chembiol.2017.08.002_bib139","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in\u00a0vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib140","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1084\/jem.97.5.695","article-title":"Studies on the propagation in\u00a0vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix","volume":"97","author":"Scherer","year":"1953","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib141","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1073\/pnas.1103205108","article-title":"Organic synthesis toward small-molecule probes and drugs","volume":"108","author":"Schreiber","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2017.08.002_bib142","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.cell.2015.05.023","article-title":"Advancing biological understanding and therapeutics discovery with small-molecule probes","volume":"161","author":"Schreiber","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib143","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1158\/2159-8290.CD-15-0235","article-title":"Harnessing connectivity in a large-scale small-molecule sensitivity dataset","volume":"5","author":"Seashore-Ludlow","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2017.08.002_bib144","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11764-014-0348-4","article-title":"Social networking site usage among childhood cancer survivors\u2013a potential tool for research recruitment?","volume":"8","author":"Seltzer","year":"2014","journal-title":"J.\u00a0Cancer Surviv."},{"key":"10.1016\/j.chembiol.2017.08.002_bib145","doi-asserted-by":"crossref","first-page":"18661","DOI":"10.1073\/pnas.1412228112","article-title":"Genetic modifiers of EGFR dependence in non-small cell lung cancer","volume":"111","author":"Sharifnia","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2017.08.002_bib146","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrc1951","article-title":"The NCI60 human tumour cell line anticancer drug screen","volume":"6","author":"Shoemaker","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2017.08.002_bib147","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.chembiol.2017.08.002_bib148","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s10072-016-2640-8","article-title":"A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma","volume":"37","author":"Simonetti","year":"2016","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.chembiol.2017.08.002_bib149","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-3-319-20579-3_2","article-title":"The future of biobanking: a conceptual look at how biobanks can respond to the growing human biospecimen needs of researchers","volume":"864","author":"Somiari","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib150","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/523149a","article-title":"Data analysis: create a cloud commons","volume":"523","author":"Stein","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib151","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1172\/JCI67201","article-title":"Whole exome sequencing of adenoid cystic carcinoma","volume":"123","author":"Stephens","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chembiol.2017.08.002_bib152","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1038\/ncomms5846","article-title":"The landscape of kinase fusions in cancer","volume":"5","author":"Stransky","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2017.08.002_bib153","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/bmj.327.7405.47","article-title":"Strategy for randomised clinical trials in rare cancers","volume":"327","author":"Tan","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.chembiol.2017.08.002_bib154","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nature21350","article-title":"Scaling single-cell genomics from phenomenology to mechanism","volume":"541","author":"Tanay","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib155","unstructured":"The Cancer Genome Atlas. (2005). NIH launches comprehensive effort to\u00a0explore cancer genomics. https:\/\/cancergenome.nih.gov\/newsevents\/newsannouncements\/news_12_13_2005."},{"key":"10.1016\/j.chembiol.2017.08.002_bib156","unstructured":"The Life Raft Group. (2000). Battling the dragon. https:\/\/liferaftgroup.org\/wp-content\/uploads\/2012\/09\/Dec2000newsletter.pdf."},{"key":"10.1016\/j.chembiol.2017.08.002_bib157","unstructured":"The New York Times. (2001). Powerful anti-cancer drug emerges from basic biology. http:\/\/www.nytimes.com\/2001\/05\/08\/science\/powerful-anti-cancer-drug-emerges-from-basic-biology.html."},{"key":"10.1016\/j.chembiol.2017.08.002_bib158","unstructured":"The New York Times. (2009). Reseacher behind the drug Gleevec. http:\/\/www.nytimes.com\/2009\/11\/03\/science\/03conv.html?pagewanted=all."},{"key":"10.1016\/j.chembiol.2017.08.002_bib159","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJMoa1014209","article-title":"BRAF mutations in hairy-cell leukemia","volume":"364","author":"Tiacci","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib160","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq","volume":"352","author":"Tirosh","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib161","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature20123","article-title":"Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma","volume":"539","author":"Tirosh","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib162","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/RUQ.0000000000000274","article-title":"Primary Angiosarcoma of the breast: a case report and review of the literature","volume":"33","author":"Tomich","year":"2017","journal-title":"Ultrasound Q."},{"key":"10.1016\/j.chembiol.2017.08.002_bib163","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccell.2016.06.008","article-title":"The\u00a0public repository of xenografts enables discovery and randomized phase\u00a0II-like trials in mice","volume":"30","author":"Townsend","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib164","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1038\/sj.onc.1204704","article-title":"STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications","volume":"20","author":"Tuveson","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.chembiol.2017.08.002_bib165","unstructured":"US Food & Drug Administration. (2017). FDA approves first cancer treatment for any solid tumor with a specific genetic feature. https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm560167.htm."},{"key":"10.1016\/j.chembiol.2017.08.002_bib166","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2015.03.053","article-title":"Prospective derivation of a living organoid biobank of colorectal cancer patients","volume":"161","author":"van de Wetering","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib167","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature07586","article-title":"Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi","volume":"457","author":"Van Raamsdonk","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib168","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/bio.2010.0003","article-title":"A review of international biobanks and networks: success factors and key benchmarks","volume":"7","author":"Vaught","year":"2009","journal-title":"Biopreserv. Biobank."},{"key":"10.1016\/j.chembiol.2017.08.002_bib169","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1158\/2159-8290.CD-11-0184","article-title":"High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing","volume":"2","author":"Wagle","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2017.08.002_bib170","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature09609","article-title":"Integrative genomics identifies LMO1 as a neuroblastoma oncogene","volume":"469","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib171","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1126\/science.aac7041","article-title":"Identification and characterization of essential genes in the human genome","volume":"350","author":"Wang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib172","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.cell.2017.01.013","article-title":"Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic Ras","volume":"168","author":"Wang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2017.08.002_bib173","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3322\/caac.21219","article-title":"Childhood and adolescent cancer statistics, 2014","volume":"64","author":"Ward","year":"2014","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.chembiol.2017.08.002_bib174","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1126\/science.1073096","article-title":"Cancer. Addiction to oncogenes\u2013the Achilles heal of cancer","volume":"297","author":"Weinstein","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib175","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1158\/1078-0432.CCR-13-2611","article-title":"Tumorgrafts as in\u00a0vivo surrogates for women with ovarian cancer","volume":"20","author":"Weroha","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chembiol.2017.08.002_bib176","unstructured":"Wetterstrand K.A. (2016). DNA sequencing costs: data from the NHGRI Genome Sequencing Program (GSP). www.genome.gov\/sequencingcostsdata."},{"key":"10.1016\/j.chembiol.2017.08.002_bib177","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1128\/MCB.01372-13","article-title":"Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation","volume":"34","author":"Wilson","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib178","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/jso.23904","article-title":"Leiomyosarcoma: one disease or distinct biologic entities based on site of origin?","volume":"111","author":"Worhunsky","year":"2015","journal-title":"J.\u00a0Surg. Oncol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib179","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1056\/NEJMoa0808710","article-title":"IDH1 and IDH2 mutations in gliomas","volume":"360","author":"Yan","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib180","doi-asserted-by":"crossref","first-page":"D955","DOI":"10.1093\/nar\/gks1111","article-title":"Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells","volume":"41","author":"Yang","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2017.08.002_bib181","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.1253533","article-title":"Cancer therapy. Ex\u00a0vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility","volume":"345","author":"Yu","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2017.08.002_bib182","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature14397","article-title":"A resource for cell line authentication, annotation and quality control","volume":"520","author":"Yu","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2017.08.002_bib183","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nbt.3460","article-title":"High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines","volume":"34","author":"Yu","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2017.08.002_bib184","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1056\/NEJMoa1203055","article-title":"Use of reprogrammed cells\u00a0to identify therapy for respiratory papillomatosis","volume":"367","author":"Yuan","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2017.08.002_bib185","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ccell.2016.07.013","article-title":"Comprehensive Pan-Genomic characterization of adrenocortical carcinoma","volume":"30","author":"Zheng","year":"2016","journal-title":"Cancer Cell"}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945617302763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945617302763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T21:18:42Z","timestamp":1750886322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945617302763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":185,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S2451945617302763"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2017.08.002","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging Opportunities for Target Discovery in Rare Cancers","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2017.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}