{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:12:59Z","timestamp":1790172779684,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004167","name":"Medicines for Malaria Venture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.chembiol.2019.11.009","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T11:17:32Z","timestamp":1575544652000},"page":"158-171.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery"],"prefix":"10.1016","volume":"27","author":[{"given":"James M.","family":"Murithi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward S.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva S.","family":"Istvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus C.S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Ottilie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Chibale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Winzeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Llin\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Fidock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-2347","authenticated-orcid":false,"given":"Manu","family":"Vanaerschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2019.11.009_bib1","doi-asserted-by":"crossref","first-page":"E1214","DOI":"10.1073\/pnas.1112037108","article-title":"Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue","volume":"108","author":"Adjalley","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.chembiol.2019.11.009_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/978-1-4939-9236-2_19","article-title":"El-MAVEN: a fast, robust, and user-friendly mass spectrometry data processing engine for metabolomics","volume":"1978","author":"Agrawal","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.chembiol.2019.11.009_bib3","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1128\/AAC.01224-16","article-title":"Metabolomic profiling of the malaria box reveals antimalarial target pathways","volume":"60","author":"Allman","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2019.11.009_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat9446","article-title":"Open-source discovery of chemical leads for next-generation chemoprotective antimalarials","volume":"362","author":"Antonova-Koch","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2019.11.009_bib5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0166-6851(93)90069-A","article-title":"Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum","volume":"61","author":"Atamna","year":"1993","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.chembiol.2019.11.009_bib57","unstructured":"Beleites, C., and Sergo, V. (2018). Hyperspec: a package to handle hyperspectral data sets in R. R package version 0.99-20180627. http:\/\/hyperspec.r-forge.r-project.org\/."},{"key":"10.1016\/j.chembiol.2019.11.009_bib6","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1089\/ars.2011.4239","article-title":"Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study","volume":"17","author":"Blank","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.chembiol.2019.11.009_bib7","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nm.4381","article-title":"Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic","volume":"23","author":"Blasco","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2019.11.009_bib8","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.2174\/156802611796575948","article-title":"Purine and pyrimidine pathways as targets in Plasmodium falciparum","volume":"11","author":"Cassera","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.chembiol.2019.11.009_bib9","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1021\/mp800007x","article-title":"Investigation of the redox behavior of ferroquine, a new antimalarial","volume":"5","author":"Chavain","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.chembiol.2019.11.009_bib10","doi-asserted-by":"crossref","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2019.11.009_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1021\/cb300454t","article-title":"Insights into the role of heme in the mechanism of action of antimalarials","volume":"8","author":"Combrinck","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2019.11.009_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1126\/science.aan4472","article-title":"Mapping the malaria parasite druggable genome by using in\u00a0vitro evolution and chemogenomics","volume":"359","author":"Cowell","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2019.11.009_bib13","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1038\/s41467-018-05777-2","article-title":"A high throughput screen for next-generation leads targeting malaria parasite transmission","volume":"9","author":"Delves","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2019.11.009_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00303-17","article-title":"A variant PfCRT isoform can contribute to Plasmodium falciparum resistance to the first-line partner drug piperaquine","volume":"8","author":"Dhingra","year":"2017","journal-title":"MBio"},{"key":"10.1016\/j.chembiol.2019.11.009_bib15","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.3390\/molecules13112900","article-title":"Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action","volume":"13","author":"Dubar","year":"2008","journal-title":"Molecules"},{"key":"10.1016\/j.chembiol.2019.11.009_bib16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ijpddr.2017.07.001","article-title":"Plasmodium falciparum in vitro continuous culture conditions: a comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle","volume":"7","author":"Duffy","year":"2017","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.chembiol.2019.11.009_bib17","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nrmicro2239","article-title":"Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria","volume":"7","author":"Eastman","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chembiol.2019.11.009_bib18","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1096\/fj.11-187401","article-title":"Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches","volume":"25","author":"Ekland","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.chembiol.2019.11.009_bib19","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1073\/pnas.0711067105","article-title":"Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum","volume":"105","author":"Elliott","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.chembiol.2019.11.009_bib59","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2013.11.103","article-title":"SupraHex: an R\/Bioconductor package for tabular omics data analysis using a supra-hexagonal map. Biochem","volume":"443","author":"Fang","year":"2014","journal-title":"Biophys. Res. Commun."},{"key":"10.1016\/j.chembiol.2019.11.009_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature09107","article-title":"Thousands of chemical starting points for antimalarial lead identification","volume":"465","author":"Gamo","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2019.11.009_bib21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ijpddr.2018.04.007","article-title":"Functional screening of selective mitochondrial inhibitors of Plasmodium","volume":"8","author":"Gomez-Lorenzo","year":"2018","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.chembiol.2019.11.009_bib22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.pt.2016.10.002","article-title":"Is the mitochondrion a good malaria drug target?","volume":"33","author":"Goodman","year":"2017","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.chembiol.2019.11.009_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature09099","article-title":"Chemical genetics of Plasmodium falciparum","volume":"465","author":"Guiguemde","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2019.11.009_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011547","article-title":"Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria","author":"Isba","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.chembiol.2019.11.009_bib25","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.285.5433.1573","article-title":"Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs","volume":"285","author":"Jomaa","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2019.11.009_bib26","doi-asserted-by":"crossref","first-page":"9371","DOI":"10.1021\/acs.jmedchem.8b01333","article-title":"Antimalarial lead-optimization studies on a 2,6-imidazopyridine series within a constrained chemical space to circumvent atypical dose-response curves against multidrug resistant parasite strains","volume":"61","author":"Le Manach","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2019.11.009_bib27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature16936","article-title":"Structure- and function-based design of Plasmodium-selective proteasome inhibitors","volume":"530","author":"Li","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2019.11.009_bib28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s12936-015-0962-2","article-title":"Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in\u00a0vitro parasite viability fast assay","volume":"14","author":"Linares","year":"2015","journal-title":"Malar. J."},{"key":"10.1016\/j.chembiol.2019.11.009_bib29","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S1473-3099(18)30309-8","article-title":"Antimalarial activity of single-dose DSM265, a novel Plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study","volume":"18","author":"Llanos-Cuentas","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chembiol.2019.11.009_bib30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature12782","article-title":"Targeting Plasmodium PI(4)K to eliminate malaria","volume":"504","author":"McNamara","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2019.11.009_bib31","doi-asserted-by":"crossref","first-page":"a025619","DOI":"10.1101\/cshperspect.a025619","article-title":"Antimalarial drug resistance: a threat to malaria elimination","volume":"7","author":"Menard","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.chembiol.2019.11.009_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/415673a","article-title":"The pathogenic basis of malaria","volume":"415","author":"Miller","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2019.11.009_bib33","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/molbev\/msm087","article-title":"Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment","volume":"24","author":"Musset","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.chembiol.2019.11.009_bib34","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1021\/acs.accounts.6b00631","article-title":"Insights into integrated lead generation and target identification in malaria and tuberculosis drug discovery","volume":"50","author":"Okombo","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.chembiol.2019.11.009_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2011.03.003","article-title":"Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine","volume":"178","author":"Paguio","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.chembiol.2019.11.009_bib37","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1038\/s41467-018-04966-3","article-title":"Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development","volume":"9","author":"Painter","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2019.11.009_bib36","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1128\/AAC.00937-10","article-title":"Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum","volume":"54","author":"Painter","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2019.11.009_bib38","doi-asserted-by":"crossref","first-page":"296ra111","DOI":"10.1126\/scitranslmed.aaa6645","article-title":"A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria","volume":"7","author":"Phillips","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2019.11.009_bib39","doi-asserted-by":"crossref","first-page":"17050","DOI":"10.1038\/nrdp.2017.50","article-title":"Malaria","volume":"3","author":"Phillips","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.chembiol.2019.11.009_bib40","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1073\/pnas.0802982105","article-title":"In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen","volume":"105","author":"Plouffe","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.chembiol.2019.11.009_bib41","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1128\/AAC.02110-15","article-title":"Discovery of dual-stage malaria inhibitors with new targets","volume":"60","author":"Raphemot","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2019.11.009_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.chom.2019.06.001","article-title":"Elucidating mechanisms of drug-resistant Plasmodium falciparum","volume":"26","author":"Ross","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chembiol.2019.11.009_bib43","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1038\/s41467-018-05652-0","article-title":"Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine","volume":"9","author":"Ross","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2019.11.009_bib58","unstructured":"RStudio Team (2015). RStudio: integrated development for R. RStudio, Inc., Boston, MA. http:\/\/www.rstudio.com\/."},{"key":"10.1016\/j.chembiol.2019.11.009_bib44","doi-asserted-by":"crossref","first-page":"e30949","DOI":"10.1371\/journal.pone.0030949","article-title":"P.\u00a0falciparum in\u00a0vitro killing rates allow to discriminate between different antimalarial mode-of-action","volume":"7","author":"Sanz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2019.11.009_bib45","article-title":"Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum","volume":"11","author":"Schalwijk","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2019.11.009_bib46","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/mmi.13626","article-title":"A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay","volume":"104","author":"Siciliano","year":"2017","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chembiol.2019.11.009_bib47","doi-asserted-by":"crossref","first-page":"e1007722","DOI":"10.1371\/journal.ppat.1007722","article-title":"Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in\u00a0vitro and synergize with multiple antimalarial agents","volume":"15","author":"Stokes","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chembiol.2019.11.009_bib48","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4269\/ajtmh.16-0731","article-title":"Phase 2a, open-label, 4-escalating-dose, randomized multicenter study evaluating the safety and activity of ferroquine (SSR97193) plus artesunate, versus amodiaquine plus artesunate, in African adult men with uncomplicated Plasmodium falciparum malaria","volume":"97","author":"Supan","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.chembiol.2019.11.009_bib49","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41564-017-0007-4","article-title":"Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity","volume":"2","author":"Vanaerschot","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chembiol.2019.11.009_bib50","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1038\/ncomms11553","article-title":"Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies","volume":"7","author":"Veiga","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2019.11.009_bib51","series-title":"World Malaria Report 2018","year":"2018"},{"key":"10.1016\/j.chembiol.2019.11.009_bib52","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1128\/AAC.01881-12","article-title":"Defining the timing of action of antimalarial drugs against Plasmodium falciparum","volume":"57","author":"Wilson","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2019.11.009_bib53","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/AAC.03342-14","article-title":"A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis","volume":"59","author":"Wu","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2019.11.009_bib54","first-page":"406","article-title":"Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins","volume":"129","author":"Xie","year":"2016","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.chembiol.2019.11.009_bib55","doi-asserted-by":"crossref","first-page":"11424","DOI":"10.1021\/jacs.8b06656","article-title":"Defining the determinants of specificity of Plasmodium proteasome inhibitors","volume":"140","author":"Yoo","year":"2018","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2019.11.009_bib56","doi-asserted-by":"crossref","first-page":"830","DOI":"10.2307\/3281830","article-title":"Stage-dependent inhibition of chloroquine on Plasmodium falciparum in vitro","volume":"72","author":"Zhang","year":"1986","journal-title":"J.\u00a0Parasitol."}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945619303915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945619303915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:34:25Z","timestamp":1762526065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945619303915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S2451945619303915"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2019.11.009","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2019.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}