{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:02:48Z","timestamp":1773428568439,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014690","name":"Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.chembiol.2020.08.001","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T11:09:52Z","timestamp":1597748992000},"page":"1434-1440.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Controlled Inhibition of Apoptosis by Photoactivatable Caspase Inhibitors"],"prefix":"10.1016","volume":"27","author":[{"given":"Suravi","family":"Chakrabarty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven H.L.","family":"Verhelst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2020.08.001_bib1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.molcel.2006.06.021","article-title":"Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes","volume":"23","author":"Berger","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2020.08.001_bib2","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1016\/j.bmc.2017.06.011","article-title":"Azobenzene-containing photoswitchable proteasome inhibitors with selective activity and cellular toxicity","volume":"25","author":"Blanco","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.chembiol.2020.08.001_bib3","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1021\/cr010183n","article-title":"Caspases: keys in the ignition of cell death","volume":"102","author":"Denault","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.chembiol.2020.08.001_bib4","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nrd3053","article-title":"Emerging principles in protease-based drug discovery","volume":"9","author":"Drag","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chembiol.2020.08.001_bib5","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1073\/pnas.96.4.1193","article-title":"Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis","volume":"96","author":"Furuta","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.chembiol.2020.08.001_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0076-6879(98)91004-7","article-title":"New photoprotecting groups: desyl and p-hydroxyphenacyl phosphate and carboxylate esters","volume":"291","author":"Givens","year":"1998","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.chembiol.2020.08.001_bib7","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1002\/cbic.201402237","article-title":"Proteasome inhibitors with photocontrolled activity","volume":"15","author":"Hansen","year":"2014","journal-title":"Chembiochem"},{"key":"10.1016\/j.chembiol.2020.08.001_bib8","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1016\/j.bmcl.2015.09.001","article-title":"Development of 4-methoxy-7-nitroindolinyl (MNI)-caged auxins which are extremely stable in planta","volume":"25","author":"Hayashi","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.chembiol.2020.08.001_bib9","doi-asserted-by":"crossref","first-page":"10710","DOI":"10.1021\/acs.chemrev.8b00037","article-title":"In\u00a0vivo photopharmacology","volume":"118","author":"Hull","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.chembiol.2020.08.001_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nchembio707","article-title":"Activity-based probes that target diverse cysteine protease families","volume":"1","author":"Kato","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2020.08.001_bib12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/cr300177k","article-title":"Photoremovable protecting groups in chemistry and biology: reaction mechanisms and efficacy","volume":"113","author":"Klan","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.chembiol.2020.08.001_bib13","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1002\/anie.201601931","article-title":"Emerging targets in photopharmacology","volume":"55","author":"Lerch","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.chembiol.2020.08.001_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0092-8674(00)80085-9","article-title":"Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2020.08.001_bib15","doi-asserted-by":"crossref","first-page":"e0163937","DOI":"10.1371\/journal.pone.0163937","article-title":"Ncm, a photolabile group for preparation of caged molecules: synthesis and biological application","volume":"11","author":"Muralidharan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2020.08.001_bib16","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.immuni.2019.05.020","article-title":"Caspases in cell death, inflammation, and disease","volume":"50","author":"Van Opdenbosch","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.chembiol.2020.08.001_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1074-5521(97)90258-1","article-title":"A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)","volume":"4","author":"Rano","year":"1997","journal-title":"Chem. Biol."},{"key":"10.1016\/j.chembiol.2020.08.001_bib18","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/cmdc.201400081","article-title":"Inhibition of cathepsin activity in a cell-based assay by a light-activated ruthenium compound","volume":"9","author":"Respondek","year":"2014","journal-title":"ChemMedChem"},{"key":"10.1016\/j.chembiol.2020.08.001_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-291X(67)80055-X","article-title":"On the size of the active site in proteases. I. Papain","volume":"27","author":"Schechter","year":"1967","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.chembiol.2020.08.001_bib31","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.chembiol.2020.08.001_bib20","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1021\/acschembio.9b00564","article-title":"Selective and rapid cell-permeable inhibitor of human caspase-3","volume":"14","author":"Solania","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2020.08.001_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/meth.1999.0745","article-title":"Caspases: preparation and characterization","volume":"17","author":"Stennicke","year":"1999","journal-title":"Methods"},{"key":"10.1016\/j.chembiol.2020.08.001_bib22","doi-asserted-by":"crossref","first-page":"8682","DOI":"10.1002\/anie.201402665","article-title":"Photocaging of carboxylic acids: a modular approach","volume":"53","author":"Szymanski","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.chembiol.2020.08.001_bib23","doi-asserted-by":"crossref","first-page":"17907","DOI":"10.1074\/jbc.272.29.17907","article-title":"A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis","volume":"272","author":"Thornberry","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2020.08.001_bib24","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1021\/acschembio.9b00711","article-title":"BODIPY-caged photoactivated inhibitors of cathepsin B flip the light switch on cancer cell apoptosis","volume":"14","author":"Toupin","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2020.08.001_bib25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrd2092","article-title":"Targeting proteases: successes, failures and future prospects","volume":"5","author":"Turk","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chembiol.2020.08.001_bib26","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1080\/00397910902883645","article-title":"Efficient preparation of photolabile agent MNI-glu by regioselective nitration of 4-methoxyindoline derivative","volume":"39","author":"Wang","year":"2009","journal-title":"Synth. Commun."},{"key":"10.1016\/j.chembiol.2020.08.001_bib27","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1021\/cc034008r","article-title":"Synthesis of a diverse library of mechanism-based cysteine protease inhibitors","volume":"5","author":"Wood","year":"2003","journal-title":"J.\u00a0Comb. Chem."},{"key":"10.1016\/j.chembiol.2020.08.001_bib28","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1039\/B616410M","article-title":"Photochemical control of biological processes","volume":"5","author":"Young","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.chembiol.2020.08.001_bib29","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/sj.cdd.4400593","article-title":"Caspase knockouts: matters of life and death","volume":"6","author":"Zheng","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.chembiol.2020.08.001_bib30","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1074\/jbc.272.12.7797","article-title":"Target protease specificity of the viral serpin CrmA. Analysis of five caspases","volume":"272","author":"Zhou","year":"1997","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945620302981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945620302981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:37:18Z","timestamp":1762526238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945620302981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2451945620302981"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2020.08.001","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Controlled Inhibition of Apoptosis by Photoactivatable Caspase Inhibitors","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2020.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}