{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:08:14Z","timestamp":1790474894014,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008321","name":"Pennsylvania State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203134\/Z\/16\/Z"],"award-info":[{"award-number":["203134\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004167","name":"Medicines for Malaria Venture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013996","name":"Global Health Innovative Technology Fund","doi-asserted-by":"publisher","award":["G2018-202"],"award-info":[{"award-number":["G2018-202"]}],"id":[{"id":"10.13039\/501100013996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1032548"],"award-info":[{"award-number":["OPP1032548"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1054480"],"award-info":[{"award-number":["OPP1054480"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1162467"],"award-info":[{"award-number":["OPP1162467"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U2C-DK119886"],"award-info":[{"award-number":["U2C-DK119886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.chembiol.2021.07.010","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T11:20:04Z","timestamp":1627989604000},"page":"191-201.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"title":["Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0840-1784","authenticated-orcid":false,"given":"Robert L.","family":"Summers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-3680","authenticated-orcid":false,"given":"Charisse Flerida A.","family":"Pasaje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-7354","authenticated-orcid":false,"given":"Joao P.","family":"Pisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefine","family":"Striepen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline R.","family":"Luth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krittikorn","family":"Kumpornsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1911-6842","authenticated-orcid":false,"given":"Emma F.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3309-558X","authenticated-orcid":false,"given":"Justin T.","family":"Munro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Plater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash S.","family":"Punekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-2347","authenticated-orcid":false,"given":"Manu","family":"Vanaerschot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Murithi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4149-4030","authenticated-orcid":false,"given":"Kelly","family":"Rubiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"Akidil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Ottilie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimisha","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Hazel","family":"Dilmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalyn","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.K.","family":"Mandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8451-4070","authenticated-orcid":false,"given":"Kerry","family":"McGowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Walpole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Llin\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-0915","authenticated-orcid":false,"given":"Marcus C.S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Winzeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Fidock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8604-4455","authenticated-orcid":false,"given":"Dyann F.","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquin C.","family":"Niles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Baraga\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-7643","authenticated-orcid":false,"given":"Amanda K.","family":"Lukens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2021.07.010_bib1","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1128\/AAC.01224-16","article-title":"Metabolomic profiling of the malaria box reveals antimalarial target pathways","volume":"60","author":"Allman","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2021.07.010_bib2","doi-asserted-by":"crossref","first-page":"e31847","DOI":"10.1371\/journal.pone.0031847","article-title":"Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors","volume":"7","author":"Andrews","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2021.07.010_bib3","doi-asserted-by":"crossref","first-page":"eaat9446","DOI":"10.1126\/science.aat9446","article-title":"Open-source discovery of chemical leads for next-generation chemoprotective antimalarials","volume":"362","author":"Antonova-Koch","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2021.07.010_bib4","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1093\/nar\/gki709","article-title":"Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains","volume":"33","author":"Balaji","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2021.07.010_bib5","doi-asserted-by":"crossref","first-page":"e9569","DOI":"10.15252\/msb.20209569","article-title":"Exploring the virulence gene interactome with CRISPR\/dCas9 in the human malaria parasite","volume":"16","author":"Bryant","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.chembiol.2021.07.010_bib6","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.celrep.2016.12.055","article-title":"Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation","volume":"18","author":"Bulusu","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2021.07.010_bib7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cell.2017.06.030","article-title":"Functional profiling of a Plasmodium genome reveals an abundance of essential genes","volume":"170","author":"Bushell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2021.07.010_bib8","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1093\/bioinformatics\/bty528","article-title":"MetaboAnalystR: an R package for flexible and reproducible analysis of metabolomics data","volume":"34","author":"Chong","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.chembiol.2021.07.010_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/metabo9030057","article-title":"MetaboAnalystR 2.0: from raw spectra to biological insights","volume":"9","author":"Chong","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.chembiol.2021.07.010_bib10","doi-asserted-by":"crossref","first-page":"36338","DOI":"10.1074\/jbc.M113.503557","article-title":"Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum","volume":"288","author":"Cobbold","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2021.07.010_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2144\/000112517","article-title":"ImageJ for microscopy","volume":"43","author":"Collins","year":"2007","journal-title":"Biotechniques"},{"key":"10.1016\/j.chembiol.2021.07.010_bib12","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2014.11.020","article-title":"Acetate dependence of tumors","volume":"159","author":"Comerford","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2021.07.010_bib13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1126\/science.aan4472","article-title":"Mapping the malaria parasite druggable genome by using in\u00a0vitro evolution and chemogenomics","volume":"359","author":"Cowell","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2021.07.010_bib14","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1128\/AAC.01226-16","article-title":"Metabolomics-based screening of the malaria box reveals both novel and established mechanisms of action","volume":"60","author":"Creek","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2021.07.010_bib15","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/nar\/29.3.850","article-title":"Transformation of malaria parasites by the spontaneous uptake and expression of DNA from human erythrocytes","volume":"29","author":"Deitsch","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2021.07.010_bib16","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1038\/s41467-018-05777-2","article-title":"A high throughput screen for next-generation leads targeting malaria parasite transmission","volume":"9","author":"Delves","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2021.07.010_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature09107","article-title":"Thousands of chemical starting points for antimalarial lead identification","volume":"465","author":"Gamo","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2021.07.010_bib53","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00379-17","article-title":"Screening the medicines for malaria venture pathogen box across multiple pathogens reclassifies starting points for open-source drug discovery","volume":"61","author":"Duffy","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.chembiol.2021.07.010_bib18","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nchembio.2434","article-title":"Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis","volume":"13","author":"Gahloth","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2021.07.010_bib19","doi-asserted-by":"crossref","first-page":"10727","DOI":"10.1038\/ncomms10727","article-title":"Synthetic RNA-protein modules integrated with native translation mechanisms to control gene expression in malaria parasites","volume":"7","author":"Ganesan","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2021.07.010_bib20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature09099","article-title":"Chemical genetics of Plasmodium falciparum","volume":"465","author":"Guiguemde","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2021.07.010_bib21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13072-017-0147-z","article-title":"Histone 4 lysine 8 acetylation regulates proliferation and host-pathogen interaction in Plasmodium falciparum","volume":"10","author":"Gupta","year":"2017","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.chembiol.2021.07.010_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tig.2020.09.003","article-title":"Dynamic chromatin structure and epigenetics control the fate of malaria parasites","volume":"37","author":"Hollin","year":"2020","journal-title":"Trends Genet."},{"key":"10.1016\/j.chembiol.2021.07.010_bib23","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1128\/AAC.01607-06","article-title":"Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening","volume":"51","author":"Johnson","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2021.07.010_bib24","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","article-title":"Synchronization of Plasmodium falciparum erythrocytic stages in culture","volume":"65","author":"Lambros","year":"1979","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.chembiol.2021.07.010_bib25","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1080\/15548627.2017.1349581","article-title":"Local histone acetylation by ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy","volume":"13","author":"Li","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.chembiol.2021.07.010_bib26","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.molcel.2017.04.026","article-title":"Nucleus-translocated ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy","volume":"66","author":"Li","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2021.07.010_bib27","doi-asserted-by":"crossref","first-page":"16166","DOI":"10.1038\/nmicrobiol.2016.166","article-title":"UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes","volume":"1","author":"Lim","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.chembiol.2021.07.010_bib28","doi-asserted-by":"crossref","first-page":"26458","DOI":"10.1074\/jbc.M004160200","article-title":"Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins","volume":"275","author":"Luong","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2021.07.010_bib29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/acsinfecdis.7b00276","article-title":"Using in\u00a0vitro evolution and whole genome analysis to discover next generation targets for antimalarial drug discovery","volume":"4","author":"Luth","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.chembiol.2021.07.010_bib30","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.cell.2014.11.025","article-title":"Acetate is a bioenergetic substrate for human glioblastoma and brain metastases","volume":"159","author":"Mashimo","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2021.07.010_bib31","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.chembiol.2021.07.010_bib32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature22405","article-title":"Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory","volume":"546","author":"Mews","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2021.07.010_bib33","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41598-020-77644-4","article-title":"An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum","volume":"11","author":"Nasamu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chembiol.2021.07.010_bib34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.abb.2014.04.004","article-title":"Acetylation of acetyl-CoA synthetase from Mycobacterium tuberculosis leads to specific inactivation of the adenylation reaction","volume":"550-551","author":"Noy","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.chembiol.2021.07.010_bib35","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2015.05.014","article-title":"Acetyl coenzyme A: a central metabolite and second messenger","volume":"21","author":"Pietrocola","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.chembiol.2021.07.010_bib36","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1073\/pnas.0802982105","article-title":"In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen","volume":"105","author":"Plouffe","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.chembiol.2021.07.010_bib37","doi-asserted-by":"crossref","first-page":"6536","DOI":"10.1021\/bi6026506","article-title":"Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase","volume":"46","author":"Reger","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.chembiol.2021.07.010_bib38","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1126\/science.7015505","article-title":"Cloning of naturally occurring mixed infections of malaria parasites","volume":"212","author":"Rosario","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2021.07.010_bib39","doi-asserted-by":"crossref","first-page":"eaas9917","DOI":"10.1126\/scitranslmed.aas9917","article-title":"Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum","volume":"11","author":"Schalkwijk","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2021.07.010_bib40","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1110\/ps.072918107","article-title":"The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum","volume":"16","author":"Shonhai","year":"2007","journal-title":"Protein Sci."},{"key":"10.1016\/j.chembiol.2021.07.010_bib41","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1128\/AAC.48.5.1803-1806.2004","article-title":"Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening","volume":"48","author":"Smilkstein","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2021.07.010_bib42","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1007\/s00018-004-3448-x","article-title":"Acetyl-coenzyme A synthetase (AMP forming)","volume":"61","author":"Starai","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.chembiol.2021.07.010_bib43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.molcel.2006.05.040","article-title":"Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription","volume":"23","author":"Takahashi","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2021.07.010_bib44","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1101\/gr.2615304","article-title":"Comparative analysis of apicomplexa and genomic diversity in eukaryotes","volume":"14","author":"Templeton","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.chembiol.2021.07.010_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molbiopara.2004.05.009","article-title":"Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method","volume":"137","author":"Tonkin","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.chembiol.2021.07.010_bib46","doi-asserted-by":"crossref","first-page":"e1005763","DOI":"10.1371\/journal.ppat.1005763","article-title":"Open source drug discovery with the malaria box compound collection for neglected diseases and beyond","volume":"12","author":"Van Voorhis","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chembiol.2021.07.010_bib47","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1073\/pnas.89.11.4884","article-title":"A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems","volume":"89","author":"Webb","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.chembiol.2021.07.010_bib48","series-title":"World Malaria Report 2019, Geneva","year":"2019"},{"key":"10.1016\/j.chembiol.2021.07.010_bib49","doi-asserted-by":"crossref","first-page":"W174","DOI":"10.1093\/nar\/gkv342","article-title":"I-TASSER server: new development for protein structure and function predictions","volume":"43","author":"Yang","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2021.07.010_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx366","article-title":"COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information","volume":"45","author":"Zhang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2021.07.010_bib51","doi-asserted-by":"crossref","first-page":"eaap7847","DOI":"10.1126\/science.aap7847","article-title":"Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis","volume":"360","author":"Zhang","year":"2018","journal-title":"Science"}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945621003500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945621003500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:40:21Z","timestamp":1762526421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945621003500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S2451945621003500"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2021.07.010","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2021.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}