{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:53:03Z","timestamp":1788306783263,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:00:00Z","timestamp":1715990400000},"content-version":"vor","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["083811\/Z\/07\/Z"],"award-info":[{"award-number":["083811\/Z\/07\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104111\/Z\/14\/Z"],"award-info":[{"award-number":["104111\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107046\/Z\/15\/Z"],"award-info":[{"award-number":["107046\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["MWCS-2017-789"],"award-info":[{"award-number":["MWCS-2017-789"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013986","name":"Government of the United Kingdom","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007231","name":"Cornell University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000933","name":"Hearst Foundations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000933","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MRA-1252"],"award-info":[{"award-number":["MRA-1252"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MRA-1255"],"award-info":[{"award-number":["MRA-1255"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MRA-150"],"award-info":[{"award-number":["MRA-150"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.chembiol.2023.04.006","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T10:48:24Z","timestamp":1683283704000},"page":"457-469.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Dual-pharmacophore artezomibs hijack the Plasmodium\u00a0ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance"],"prefix":"10.1016","volume":"30","author":[{"given":"Wenhu","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubha Bevkal","family":"Subramanyaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changmei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbiao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedy","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikayla","family":"Herring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson V.","family":"Simwela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sukenick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiteng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl F.","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Kirkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2023.04.006_bib1","series-title":"World Malaria Report 2018","year":"2018"},{"key":"10.1016\/j.chembiol.2023.04.006_bib2","doi-asserted-by":"crossref","first-page":"10111","DOI":"10.1038\/ncomms10111","article-title":"Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2023.04.006_bib3","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.3390\/molecules15031705","article-title":"The molecular mechanism of action of artemisinin--the debate continues","volume":"15","author":"O'Neill","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.chembiol.2023.04.006_bib4","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1002\/anie.200604697","article-title":"Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs","volume":"46","author":"Stocks","year":"2007","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chembiol.2023.04.006_bib5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.pt.2016.05.010","article-title":"Artemisinin action and resistance in Plasmodium falciparum","volume":"32","author":"Tilley","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.chembiol.2023.04.006_bib6","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1073\/pnas.1600459113","article-title":"Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7","volume":"113","author":"Ismail","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2023.04.006_bib7","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0020-7519(02)00194-7","article-title":"Artemisinin: mechanisms of action, resistance and toxicity","volume":"32","author":"Meshnick","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.chembiol.2023.04.006_bib8","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1128\/AAC.01305-09","article-title":"Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals","volume":"54","author":"F\u00fcgi","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2023.04.006_bib9","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1021\/jm00013a001","article-title":"Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin","volume":"38","author":"Posner","year":"1995","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2023.04.006_bib10","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1038\/s41467-018-06221-1","article-title":"Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome","volume":"9","author":"Bridgford","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2023.04.006_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12936-017-1845-5","article-title":"Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia","volume":"16","author":"Mukherjee","year":"2017","journal-title":"Malar. J."},{"key":"10.1016\/j.chembiol.2023.04.006_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2023.04.006_bib13","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0140-6736(09)61857-2","article-title":"Artemisinin resistance on the Thai-Cambodian border","volume":"374","author":"M\u00fcller","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.chembiol.2023.04.006_bib14","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1038\/s41591-020-1005-2","article-title":"Emergence and clonal expansion of in\u00a0vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda","volume":"26","author":"Uwimana","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2023.04.006_bib15","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1016\/S1473-3099(20)30493-X","article-title":"Spatial and molecular mapping of Pfkelch13 gene polymorphism in Africa in the era of emerging Plasmodium falciparum resistance to artemisinin: a systematic review","volume":"21","author":"Kayiba","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chembiol.2023.04.006_bib16","first-page":"1287","article-title":"Artemisinin resistance in Africa: how urgent is the threat?","volume":"2","author":"Fidock","year":"2021","journal-title":"Med (N Y)"},{"key":"10.1016\/j.chembiol.2023.04.006_bib17","doi-asserted-by":"crossref","first-page":"e701","DOI":"10.1016\/S2666-5247(22)00155-0","article-title":"Pre-existing partner-drug resistance to artemisinin combination therapies facilitates the emergence and spread of artemisinin resistance: a consensus modelling study","volume":"3","author":"Watson","year":"2022","journal-title":"Lancet. Microbe"},{"key":"10.1016\/j.chembiol.2023.04.006_bib18","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1260867","article-title":"Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates","volume":"347","author":"Straimer","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.04.006_bib19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1260403","article-title":"Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance","volume":"347","author":"Mok","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.04.006_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1126\/science.aax4735","article-title":"A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites","volume":"367","author":"Birnbaum","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.04.006_bib21","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1016\/j.celrep.2019.10.095","article-title":"Decreased K13 abundance reduces hemoglobin catabolism and proteotoxic stress, underpinning artemisinin resistance","volume":"29","author":"Yang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2023.04.006_bib22","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1128\/AAC.00197-15","article-title":"Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes","volume":"59","author":"Hott","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2023.04.006_bib23","doi-asserted-by":"crossref","first-page":"e758","DOI":"10.1016\/S2214-109X(15)00162-X","article-title":"Optimum population-level use of artemisinin combination therapies: a modelling study","volume":"3","author":"Nguyen","year":"2015","journal-title":"Lancet. Glob. Health"},{"key":"10.1016\/j.chembiol.2023.04.006_bib24","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1021\/acs.jmedchem.9b00363","article-title":"Improvement of asparagine ethylenediamines as anti-malarial Plasmodium-selective proteasome inhibitors","volume":"62","author":"Zhan","year":"2019","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2023.04.006_bib25","doi-asserted-by":"crossref","first-page":"e1007722","DOI":"10.1371\/journal.ppat.1007722","article-title":"Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in\u00a0vitro and synergize with multiple antimalarial agents","volume":"15","author":"Stokes","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chembiol.2023.04.006_bib26","doi-asserted-by":"crossref","first-page":"11424","DOI":"10.1021\/jacs.8b06656","article-title":"Defining the determinants of specificity of Plasmodium proteasome inhibitors","volume":"140","author":"Yoo","year":"2018","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2023.04.006_bib27","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1021\/acs.jmedchem.8b01161","article-title":"Target validation and identification of novel boronate inhibitors of the Plasmodium falciparum proteasome","volume":"61","author":"Xie","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2023.04.006_bib28","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1021\/acs.jmedchem.7b00671","article-title":"Development of a potent inhibitor of the Plasmodium proteasome with reduced mammalian toxicity","volume":"60","author":"LaMonte","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2023.04.006_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature16936","article-title":"Structure- and function-based design of Plasmodium-selective proteasome inhibitors","volume":"530","author":"Li","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2023.04.006_bib30","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/cb5001263","article-title":"Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes","volume":"9","author":"Li","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.04.006_bib31","doi-asserted-by":"crossref","first-page":"13562","DOI":"10.1021\/ja507692y","article-title":"Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome","volume":"136","author":"Li","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2023.04.006_bib32","doi-asserted-by":"crossref","first-page":"E6863","DOI":"10.1073\/pnas.1806109115","article-title":"Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance","volume":"115","author":"Kirkman","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2023.04.006_bib33","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/s41467-017-01760-5","article-title":"Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes","volume":"8","author":"Santos","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2023.04.006_bib34","doi-asserted-by":"crossref","first-page":"9279","DOI":"10.1002\/anie.202015845","article-title":"Development of a highly selective Plasmodium falciparum proteasome inhibitor with anti-malaria activity in humanized mice","volume":"60","author":"Zhan","year":"2021","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.chembiol.2023.04.006_bib35","doi-asserted-by":"crossref","first-page":"e02312-20","DOI":"10.1128\/mBio.02312-20","article-title":"Plasmodium berghei K13 mutations mediate in\u00a0vivo artemisinin resistance that is reversed by proteasome inhibition","volume":"11","author":"Simwela","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.chembiol.2023.04.006_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12936-020-3139-6","article-title":"The extended recovery ring-stage survival assay provides a superior association with patient clearance half-life and increases throughput","volume":"19","author":"Davis","year":"2020","journal-title":"Malar. J."},{"key":"10.1016\/j.chembiol.2023.04.006_bib37","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.chembiol.2006.09.013","article-title":"A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in\u00a0vitro and in\u00a0vivo","volume":"13","author":"Verdoes","year":"2006","journal-title":"Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.04.006_bib38","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1021\/acsinfecdis.0c00900","article-title":"A proteasome mutation sensitizes P. falciparum Cam3.II K13(C580Y) parasites to DHA and OZ439","volume":"7","author":"Rosenthal","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.chembiol.2023.04.006_bib39","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107213118","article-title":"Design of proteasome inhibitors with oral efficacy in\u00a0vivo against Plasmodium falciparum and selectivity over the human proteasome","volume":"118","author":"Xie","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2023.04.006_bib40","doi-asserted-by":"crossref","first-page":"e0081722","DOI":"10.1128\/aac.00817-22","article-title":"Susceptibilities of Ugandan Plasmodium falciparum isolates to proteasome inhibitors","volume":"66","author":"Garg","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.chembiol.2023.04.006_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.15252\/emmm.201607295","article-title":"How to tackle antimalarial resistance?","volume":"9","author":"Leroy","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.chembiol.2023.04.006_bib42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12936-016-1675-x","article-title":"New developments in anti-malarial target candidate and product profiles","volume":"16","author":"Burrows","year":"2017","journal-title":"Malar. J."},{"key":"10.1016\/j.chembiol.2023.04.006_bib43","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1084\/jem.20170637","article-title":"Kunkel lecture: fundamental immunodeficiency and its correction","volume":"214","author":"Nathan","year":"2017","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chembiol.2023.04.006_bib44","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature08357","article-title":"Inhibitors selective for mycobacterial versus human proteasomes","volume":"461","author":"Lin","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2023.04.006_bib45","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/S0140-6736(10)61963-0","article-title":"Artemisinin resistance--the clock is ticking","volume":"376","author":"White","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.chembiol.2023.04.006_bib46","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S1473-3099(12)70226-8","article-title":"Resistance to artemisinin-based combination therapy","volume":"12","author":"Breman","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chembiol.2023.04.006_bib47","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0140-6736(12)60484-X","article-title":"Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study","volume":"379","author":"Phyo","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.chembiol.2023.04.006_bib48","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/S0140-6736(12)60488-7","article-title":"Loss of malarial susceptibility to artemisinin in Thailand","volume":"379","author":"Uhlemann","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.chembiol.2023.04.006_bib49","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/S0140-6736(12)61820-0","article-title":"Artemisinin-resistant malaria in the Asia-Pacific region","volume":"381","author":"Tulloch","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.chembiol.2023.04.006_bib50","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/S0140-6736(14)60700-5","article-title":"Time to contain artemisinin resistance","volume":"383","author":"The","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.chembiol.2023.04.006_bib51","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/S1473-3099(19)30391-3","article-title":"Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study","volume":"19","author":"van der Pluijm","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.chembiol.2023.04.006_bib52","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(20)30552-3","article-title":"Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial","volume":"395","author":"van der Pluijm","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.chembiol.2023.04.006_bib53","doi-asserted-by":"crossref","first-page":"11468","DOI":"10.1073\/pnas.0503386102","article-title":"Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration","volume":"102","author":"Franke-Fayard","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945623000922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945623000922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:51:45Z","timestamp":1778889105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945623000922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S2451945623000922"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2023.04.006","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-pharmacophore artezomibs hijack the Plasmodium\u00a0ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2023.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}