{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:11:17Z","timestamp":1787796677931,"version":"build-2784847793"},"reference-count":62,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001822","name":"\u00d6sterreichischen Akademie der Wissenschaften","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001821","name":"Vienna Science and Technology Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.chembiol.2023.06.029","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T10:26:37Z","timestamp":1690539997000},"page":"953-964.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors"],"prefix":"10.1016","volume":"30","author":[{"given":"Vojtech","family":"Dvorak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Casiraghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Colas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Koren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Tomek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Offensperger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rukavina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Tin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Dobner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Frommelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Boeszoermenyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriia","family":"Bernada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Thomas","family":"Hannich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard F.","family":"Ecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg E.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kubicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Superti-Furga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2023.06.029_bib1","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1021\/acs.jmedchem.9b01237","article-title":"The Druggability of Solute Carriers","volume":"63","author":"Wang","year":"2020","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2023.06.029_bib2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrd4626","article-title":"SLC transporters as therapeutic targets: Emerging opportunities","volume":"14","author":"Lin","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chembiol.2023.06.029_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2015.07.022","article-title":"A Call for Systematic Research on Solute Carriers","author":"C\u00e9sar-Razquin","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2023.06.029_bib4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/d41573-020-00056-6","article-title":"The RESOLUTE consortium: unlocking SLC transporters for drug discovery","volume":"19","author":"Superti-Furga","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chembiol.2023.06.029_bib5","doi-asserted-by":"crossref","first-page":"722889","DOI":"10.3389\/fphar.2021.722889","article-title":"An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters","volume":"12","author":"Dvorak","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.06.029_bib6","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.278.5340.1064","article-title":"Integrating genetic approaches into the discovery of anticancer drugs","volume":"278","author":"Hartwell","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.06.029_bib7","doi-asserted-by":"crossref","first-page":"aaf1420","DOI":"10.1126\/science.aaf1420","article-title":"A global genetic interaction network maps a wiring diagram of cellular function","volume":"353","author":"Costanzo","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.06.029_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf8424","article-title":"Environmental robustness of the global yeast genetic interaction network","volume":"372","author":"Costanzo","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.06.029_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41573-019-0046-z","article-title":"Synthetic lethality as an engine for cancer drug target discovery","volume":"19","author":"Huang","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chembiol.2023.06.029_bib10","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: the ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.chembiol.2023.06.029_bib11","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cmet.2018.03.008","article-title":"The Science and Translation of Lactate Shuttle Theory","volume":"27","author":"Brooks","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.chembiol.2023.06.029_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2023.06.029_bib13","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1242\/dmm.007724","article-title":"Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments","volume":"4","author":"Draoui","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.chembiol.2023.06.029_bib14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tibs.2020.07.005","article-title":"SLC16 Family: From Atomic Structure to Human Disease","volume":"46","author":"Bosshart","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.chembiol.2023.06.029_bib15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1124\/pr.119.018762","article-title":"Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease","volume":"72","author":"Felmlee","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.chembiol.2023.06.029_bib16","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1158\/1535-7163.MCT-17-1253","article-title":"Preclinical efficacy of the novel monocarboxylate transporter 1 inhibitor BAY-8002 and associated markers of resistance","volume":"17","author":"Quanz","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.chembiol.2023.06.029_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.chembiol.2023.06.029_bib18","doi-asserted-by":"crossref","first-page":"iii9","DOI":"10.1093\/annonc\/mdy048.008","article-title":"A first-in-human first-in-class (FIC) trial of the monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with advanced solid tumours","volume":"29","author":"Plummer","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.chembiol.2023.06.029_bib19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cmet.2020.12.003","article-title":"The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure","volume":"33","author":"Cluntun","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.chembiol.2023.06.029_bib20","doi-asserted-by":"crossref","first-page":"11904","DOI":"10.1021\/acs.jmedchem.1c00448","article-title":"Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in\u00a0Vivo Useable Chemical Probe to Dissect MCT4 Biology","volume":"64","author":"Heinrich","year":"2021","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2023.06.029_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112393","article-title":"Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights","volume":"199","author":"Puri","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.chembiol.2023.06.029_bib22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1021\/acs.jmedchem.2c01342","article-title":"Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology","volume":"66","author":"Goldberg","year":"2023","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2023.06.029_bib23","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1021\/acschembio.2c00666","article-title":"Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit","volume":"18","author":"Kawatkar","year":"2023","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.06.029_bib24","article-title":"A systematic genetic interaction map of human solute carriers assigns a role to SLC25A51\/MCART1 in mitochondrial NAD uptake","author":"Girardi","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.chembiol.2023.06.029_bib25","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.aac7557","article-title":"Gene essentiality and synthetic lethality in haploid human cells","volume":"350","author":"Blomen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.06.029_bib26","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nmeth.2609","article-title":"A reversible gene trap collection empowers haploid genetics in human cells","volume":"10","author":"B\u00fcrckst\u00fcmmer","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2023.06.029_bib27","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1101\/gr.177220.114","article-title":"Megabase-scale deletion using CRISPR\/Cas9 to generate a fully haploid human cell line","volume":"24","author":"Essletzbichler","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.chembiol.2023.06.029_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1158\/0008-5472.CAN-14-2260","article-title":"Genetic disruption of lactate\/H+ symporters (MCTs) and their subunit CD147\/BASIGIN sensitizes glycolytic tumor cells to phenformin","volume":"75","author":"Marchiq","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.chembiol.2023.06.029_bib29","doi-asserted-by":"crossref","first-page":"69219","DOI":"10.18632\/oncotarget.18215","article-title":"Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt\u2019s lymphoma anti-tumor activity","volume":"8","author":"Curtis","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.chembiol.2023.06.029_bib30","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1016\/j.celrep.2018.11.043","article-title":"Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells","volume":"25","author":"Benjamin","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2023.06.029_bib31","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1038\/s41467-021-27329-x","article-title":"Metabolic drug survey highlights cancer cell dependencies and vulnerabilities","volume":"12","author":"Pemovska","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2023.06.029_bib32","doi-asserted-by":"crossref","first-page":"e67690","DOI":"10.1371\/journal.pone.0067690","article-title":"Crucial Residue Involved in L-Lactate Recognition by Human Monocarboxylate Transporter 4 (hMCT4)","volume":"8","author":"Sasaki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2023.06.029_bib33","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1056\/NEJMoa1407778","article-title":"Monocarboxylate Transporter 1 Deficiency and Ketone Utilization","volume":"371","author":"van Hasselt","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.chembiol.2023.06.029_bib34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.cell.2020.11.043","article-title":"Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2023.06.029_bib35","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1038\/s41467-020-16334-1","article-title":"Cooperative transport mechanism of human monocarboxylate transporter 2","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2023.06.029_bib36","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1038\/s41467-019-10566-6","article-title":"Mechanistic basis of L-lactate transport in the SLC16 solute carrier family","volume":"10","author":"Bosshart","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2023.06.029_bib37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2020.01.025","article-title":"Click Chemistry in Proteomic Investigations","volume":"180","author":"Parker","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2023.06.029_bib38","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1146\/annurev-biochem-011420-092302","article-title":"Quantifying Target Occupancy of Small Molecules within Living Cells","volume":"89","author":"Robers","year":"2020","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.chembiol.2023.06.029_bib39","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.bbrc.2017.10.025","article-title":"Identification of a selective inhibitor of human monocarboxylate transporter 4","volume":"495","author":"Futagi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.chembiol.2023.06.029_bib40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.celrep.2019.08.068","article-title":"Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy","volume":"29","author":"Renner","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2023.06.029_bib41","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.18632\/oncotarget.26760","article-title":"Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors","volume":"10","author":"Jonnalagadda","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.chembiol.2023.06.029_bib42","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nchembio.1867","article-title":"The promise and peril of chemical probes","volume":"11","author":"Arrowsmith","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.06.029_bib43","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.chembiol.2015.11.011","article-title":"The Impact of Chemical Probes in Drug Discovery: A Pharmaceutical Industry Perspective","volume":"23","author":"Garbaccio","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.06.029_bib44","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/path.4562","article-title":"Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival","volume":"237","author":"Baenke","year":"2015","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.chembiol.2023.06.029_bib45","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/path.4006","article-title":"Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target","volume":"227","author":"Gerlinger","year":"2012","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.chembiol.2023.06.029_bib46","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.celrep.2014.11.025","article-title":"MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies","volume":"9","author":"Baek","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2023.06.029_bib47","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1158\/1535-7163.MCT-18-0107","article-title":"Selective inhibition of the lactate transporter MCT4 reduces growth of invasive bladder cancer","volume":"17","author":"Todenh\u00f6fer","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.chembiol.2023.06.029_bib48","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.celrep.2016.04.028","article-title":"Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy","volume":"15","author":"Pisarsky","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2023.06.029_bib49","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1002\/art.39270","article-title":"Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis","volume":"67","author":"Fujii","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.chembiol.2023.06.029_bib50","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-021-03828-1","article-title":"Highly accurate protein structure prediction for the human proteome","volume":"596","author":"Tunyasuvunakool","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2023.06.029_bib51","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1038\/s41467-022-30126-9","article-title":"Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS","volume":"13","author":"Shi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2023.06.029_bib52","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1158\/2159-8290.CD-20-1849","article-title":"SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia","volume":"12","author":"Wei","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2023.06.029_bib53","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s43018-022-00360-7","article-title":"Phosphate dysregulation via the XPR1\u2013KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer","volume":"3","author":"Bondeson","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.chembiol.2023.06.029_bib54","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1126\/science.aap8210","article-title":"LZTR1 is a regulator of RAS ubiquitination and signaling","volume":"362","author":"Bigenzahn","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.06.029_bib55","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1002\/cpbi.108","article-title":"Protein Sequence Analysis Using the MPI Bioinformatics Toolkit","volume":"72","author":"Gabler","year":"2020","journal-title":"Curr. Protoc. Bioinforma."},{"key":"10.1016\/j.chembiol.2023.06.029_bib56","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1093\/nar\/gkn072","article-title":"PROMALS3D: A tool for multiple protein sequence and structure alignments","volume":"36","author":"Pei","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2023.06.029_bib57","first-page":"1","article-title":"Comparative Protein Structure Modeling Using Modeller Modeling Structure from Sequence 5.6.1","author":"Eswar","year":"2006","journal-title":"Curr. Protoc. Bioinforma."},{"key":"10.1016\/j.chembiol.2023.06.029_bib58","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1110\/ps.062416606","article-title":"Statistical potential for assessment and prediction of protein structures","volume":"15","author":"Shen","year":"2006","journal-title":"Protein Sci."},{"key":"10.1016\/j.chembiol.2023.06.029_bib59","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00228148","article-title":"AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR","volume":"8","author":"Laskowski","year":"1996","journal-title":"J.\u00a0Biomol. NMR"},{"key":"10.1016\/j.chembiol.2023.06.029_bib60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1747-0285.2005.00327.x","article-title":"Use of an induced fit receptor structure in virtual screening","volume":"67","author":"Sherman","year":"2006","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.chembiol.2023.06.029_bib61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: Parameters, protocols, and influence on virtual screening enrichments","volume":"27","author":"Sastry","year":"2013","journal-title":"J.\u00a0Comput. Aided Mol. Des."},{"key":"10.1016\/j.chembiol.2023.06.029_bib62","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945623002040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945623002040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:44:43Z","timestamp":1762526683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945623002040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2451945623002040"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2023.06.029","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2023.06.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences GmbH. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}