{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:53:30Z","timestamp":1792403610398,"version":"4.4.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["316213987"],"award-info":[{"award-number":["316213987"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["239748522"],"award-info":[{"award-number":["239748522"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1127\/3"],"award-info":[{"award-number":["SFB 1127\/3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["2019 FGR 0095"],"award-info":[{"award-number":["2019 FGR 0095"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R15GM143724"],"award-info":[{"award-number":["R15GM143724"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL107887"],"award-info":[{"award-number":["HL107887"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002584","name":"AHA","doi-asserted-by":"publisher","award":["16GRNT31000010"],"award-info":[{"award-number":["16GRNT31000010"]}],"id":[{"id":"10.13039\/100002584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.chembiol.2023.08.001","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:46:47Z","timestamp":1693306007000},"page":"1508-1524.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators"],"prefix":"10.1016","volume":"30","author":[{"given":"Lukas K.","family":"Peltner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Gluthmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedemann","family":"B\u00f6rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Hoffstetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kretzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosella","family":"Bilancia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Pollastro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Koeberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Appendino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia E.","family":"Newcomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel C.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Werz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2023.08.001_bib1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cell.2015.02.010","article-title":"Homeostasis, inflammation, and disease susceptibility","volume":"160","author":"Kotas","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2023.08.001_bib2","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.08.001_bib3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2023.08.001_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.addr.2020.06.028","article-title":"Bioactive lipids, inflammation and chronic diseases","volume":"159","author":"Leuti","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.chembiol.2023.08.001_bib5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/EBC20190083","volume":"64","author":"Calder","year":"2020","journal-title":"Essays Biochem."},{"key":"10.1016\/j.chembiol.2023.08.001_bib6","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.chembiol.2023.08.001_bib7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/EBC20200018","article-title":"Specialized pro-resolving mediator network: an update on production and actions","volume":"64","author":"Chiang","year":"2020","journal-title":"Essays Biochem."},{"key":"10.1016\/j.chembiol.2023.08.001_bib8","doi-asserted-by":"crossref","first-page":"107879","DOI":"10.1016\/j.pharmthera.2021.107879","article-title":"Resolution of inflammation: An organizing principle in biology and medicine","volume":"227","author":"Panigrahy","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.chembiol.2023.08.001_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrrheum.2016.193","article-title":"Immune resolution mechanisms in inflammatory arthritis","volume":"13","author":"Perretti","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/1-4020-5688-5_1","article-title":"Anti-inflammatory drugs in the 21st century","volume":"42","author":"Rainsford","year":"2007","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.chembiol.2023.08.001_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1126\/science.1230720","article-title":"Anti-inflammatory therapy in chronic disease: challenges and opportunities","volume":"339","author":"Tabas","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2023.08.001_bib12","doi-asserted-by":"crossref","first-page":"e2205604","DOI":"10.1002\/advs.202205604","article-title":"Allosteric Activation of 15-Lipoxygenase-1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation","volume":"10","author":"B\u00f6rner","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.chembiol.2023.08.001_bib13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41589-020-0544-7","article-title":"Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products","volume":"16","author":"Gilbert","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib14","doi-asserted-by":"crossref","first-page":"114759","DOI":"10.1016\/j.bcp.2021.114759","article-title":"Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators","volume":"193","author":"Gilbert","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib15","first-page":"367","article-title":"Macrophage proresolving mediators\u2014the when and where","author":"Dalli","year":"2017","journal-title":"Myeloid Cells Health Dis. Synth."},{"key":"10.1016\/j.chembiol.2023.08.001_bib16","doi-asserted-by":"crossref","first-page":"115210","DOI":"10.1016\/j.bcp.2022.115210","article-title":"Formation of eicosanoids and other oxylipins in human macrophages","volume":"204","author":"Radmark","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.smim.2015.07.002","article-title":"Macrophage development and polarization in chronic inflammation","volume":"27","author":"Motwani","year":"2015","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib18","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1182\/blood-2012-04-423525","article-title":"Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators","volume":"120","author":"Dalli","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.chembiol.2023.08.001_bib19","doi-asserted-by":"crossref","first-page":"108247","DOI":"10.1016\/j.celrep.2020.108247","article-title":"Staphylococcus aureus-derived \u03b1-hemolysin evokes generation of specialized pro-resolving mediators promoting inflammation resolution","volume":"33","author":"Jordan","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2023.08.001_bib20","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1096\/fj.201802509R","article-title":"Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome","volume":"33","author":"Werner","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.chembiol.2023.08.001_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41467-017-02538-5","article-title":"Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity","volume":"9","author":"Werz","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2023.08.001_bib22","doi-asserted-by":"crossref","first-page":"105556","DOI":"10.1016\/j.phrs.2021.105556","article-title":"Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators","volume":"167","author":"Pace","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.chembiol.2023.08.001_bib23","doi-asserted-by":"crossref","first-page":"114825","DOI":"10.1016\/j.bcp.2021.114825","article-title":"Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages","volume":"195","author":"Kretzer","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib24","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.apsb.2021.04.011","article-title":"From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution","volume":"11","author":"Van Anh","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.chembiol.2023.08.001_bib25","doi-asserted-by":"crossref","first-page":"908198","DOI":"10.3389\/fphar.2022.908198","article-title":"Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action","volume":"13","author":"Anil","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib26","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.bmc.2015.01.059","article-title":"Cannabidiol (CBD) and its analogs: a review of their effects on inflammation","volume":"23","author":"Burstein","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.chembiol.2023.08.001_bib27","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S1474-4422(19)30032-8","article-title":"Safety, efficacy, and mechanisms of action of cannabinoids in neurological disorders","volume":"18","author":"Friedman","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/glia.23738","article-title":"Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS\/NF-\u03baB-dependent signaling and glucose consumption","volume":"68","author":"dos-Santos-Pereira","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.chembiol.2023.08.001_bib29","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/ph14030220","article-title":"Cannabidiol (CBD) alters the functionality of neutrophils (PMN). Implications in the refractory epilepsy treatment","volume":"14","author":"G\u00f3mez","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.chembiol.2023.08.001_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.taap.2019.02.011","article-title":"DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A2A receptor","volume":"368","author":"Silva","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib31","doi-asserted-by":"crossref","first-page":"114713","DOI":"10.1016\/j.taap.2019.114713","article-title":"Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts","volume":"382","author":"Muthumalage","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1089\/can.2020.0105","article-title":"The effects of cannabinoids on pro-and anti-inflammatory cytokines: a systematic review of in\u00a0vivo studies","volume":"6","author":"Henshaw","year":"2021","journal-title":"Cannabis Cannabinoid Res."},{"key":"10.1016\/j.chembiol.2023.08.001_bib33","doi-asserted-by":"crossref","first-page":"e00682","DOI":"10.1002\/prp2.682","article-title":"Diversity of molecular targets and signaling pathways for CBD","volume":"8","author":"de Almeida","year":"2020","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.chembiol.2023.08.001_bib34","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/sj.bjp.0704327","article-title":"Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide","volume":"134","author":"Bisogno","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib35","doi-asserted-by":"crossref","first-page":"110367","DOI":"10.1016\/j.pnpbp.2021.110367","article-title":"PPAR\u03b3 receptors are involved in the effects of cannabidiol on orofacial dyskinesia and cognitive dysfunction induced by typical antipsychotic in mice","volume":"111","author":"Sonego","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.chembiol.2023.08.001_bib36","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1021\/acs.jnatprod.6b01126","article-title":"The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains","volume":"80","author":"Allegrone","year":"2017","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.chembiol.2023.08.001_bib37","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1021\/np8002673","article-title":"Antibacterial cannabinoids from Cannabis sativa: a structure-activity study","volume":"71","author":"Appendino","year":"2008","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.chembiol.2023.08.001_bib38","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0006-2952(02)01387-4","article-title":"Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase","volume":"64","author":"Albert","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib39","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1124\/jpet.108.139444","article-title":"Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1","volume":"326","author":"Koeberle","year":"2008","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.chembiol.2023.08.001_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fj.02-0815fje","article-title":"Phosphorylation-and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors","volume":"17","author":"Fischer","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.chembiol.2023.08.001_bib41","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.bbalip.2018.07.002","article-title":"Selectivity of phospholipid hydrolysis by phospholipase A2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization","volume":"1864","author":"Astudillo","year":"2019","journal-title":"Biochim. Biophys. Acta. Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.chembiol.2023.08.001_bib42","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1042\/bj3630727","article-title":"Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone","volume":"363","author":"Ono","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.chembiol.2023.08.001_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.07.073","article-title":"Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)","volume":"573","author":"Ivanov","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.chembiol.2023.08.001_bib44","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbalip.2014.08.012","article-title":"5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease","volume":"1851","author":"R\u00e5dmark","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chembiol.2023.08.001_bib45","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1083\/jcb.145.6.1219","article-title":"Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2","volume":"145","author":"Gij\u00f3n","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib46","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00210-004-0871-3","article-title":"Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw","volume":"369","author":"Costa","year":"2004","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejphar.2006.11.006","article-title":"The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain","volume":"556","author":"Costa","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib48","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1021\/acs.jnatprod.5b00949","article-title":"Evolution of the cannabinoid and terpene content during the growth of Cannabis sativa plants from different chemotypes","volume":"79","author":"Aizpurua-Olaizola","year":"2016","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.chembiol.2023.08.001_bib49","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejphar.2018.11.029","article-title":"Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma","volume":"843","author":"Vuolo","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib50","doi-asserted-by":"crossref","first-page":"989717","DOI":"10.3389\/fphar.2022.989717","article-title":"Cannabidiol for neurodegenerative disorders: A comprehensive review","volume":"13","author":"Bhunia","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib51","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1124\/mol.111.071290","article-title":"Cannabidiol and other cannabinoids reduce microglial activation in\u00a0vitro and in\u00a0vivo: relevance to Alzheimer's disease","volume":"79","author":"Mart\u00edn-Moreno","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuroscience.2022.11.001","article-title":"Resolvins Lipid Mediators: Potential Therapeutic Targets in Alzheimer and Parkinson Disease","volume":"507","author":"Anand","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.chembiol.2023.08.001_bib53","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.msard.2017.06.015","article-title":"Sativex in the management of multiple sclerosis-related spasticity: An overview of the last decade of clinical evaluation","volume":"17","author":"Giacoppo","year":"2017","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.chembiol.2023.08.001_bib54","doi-asserted-by":"crossref","first-page":"E755","DOI":"10.36076\/ppj.20.5.E755","article-title":"Efficacy of cannabis-based medicines for pain management: a systematic review and meta-analysis of randomized controlled trials","volume":"20","author":"Aviram","year":"2017","journal-title":"Pain Physician"},{"key":"10.1016\/j.chembiol.2023.08.001_bib55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/17474124.2020.1740590","article-title":"An overview of cannabis based treatment in Crohn's disease","volume":"14","author":"Naftali","year":"2020","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib56","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.3390\/nu14102101","article-title":"Cannabidiol (CBD) Dosing: Plasma Pharmacokinetics and Effects on Accumulation in Skeletal Muscle, Liver and Adipose Tissue","volume":"14","author":"Child","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.chembiol.2023.08.001_bib57","doi-asserted-by":"crossref","first-page":"862391","DOI":"10.1155\/2015\/862391","article-title":"Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation","volume":"2015","author":"Styrczewska","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.chembiol.2023.08.001_bib58","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.4049\/jimmunol.1003865","article-title":"Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing","volume":"186","author":"Norling","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib59","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.bjp.0707442","article-title":"The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: \u03949-tetrahydrocannabinol, cannabidiol and \u03949-tetrahydrocannabivarin","volume":"153","author":"Pertwee","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib60","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1476-5381.2010.01063.x","article-title":"Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action","volume":"162","author":"Maione","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib61","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-2999(02)02624-9","article-title":"(\u2212)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens","volume":"456","author":"Pertwee","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib62","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/j.1471-4159.2007.05073.x","article-title":"5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid","volume":"104","author":"Massi","year":"2008","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.chembiol.2023.08.001_bib63","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3390\/nu13051603","article-title":"Attenuation of oxidative stress and inflammatory response by chronic cannabidiol administration is associated with improved n-6\/n-3 PUFA ratio in the white and red skeletal muscle in a rat model of high-fat diet-induced obesity","volume":"13","author":"Bielawiec","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.chembiol.2023.08.001_bib64","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/cpt.980","article-title":"Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation","volume":"104","author":"Motwani","year":"2018","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.chembiol.2023.08.001_bib65","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1089\/can.2022.0220","article-title":"Molecular Mechanisms Through Which Cannabidiol May Affect Skeletal Muscle Metabolism, Inflammation, Tissue Regeneration, and Anabolism: A Narrative Review","volume":"7","author":"Schouten","year":"2022","journal-title":"Cannabis Cannabinoid Res."},{"key":"10.1016\/j.chembiol.2023.08.001_bib66","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/9550","article-title":"Inducible cyclooxygenase may have anti-inflammatory properties","volume":"5","author":"Gilroy","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2023.08.001_bib67","doi-asserted-by":"crossref","first-page":"12023","DOI":"10.1073\/pnas.1004982107","article-title":"A pro-resolution mediator, prostaglandin D(2), is specifically up-regulated in individuals in long-term remission from ulcerative colitis","volume":"107","author":"Vong","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2023.08.001_bib68","doi-asserted-by":"crossref","first-page":"7360","DOI":"10.1096\/fj.201902055R","article-title":"Prostaglandin E2 confers protection against diabetic coronary atherosclerosis by stimulating M2 macrophage polarization via the activation of the CREB\/BDNF\/TrkB signaling pathway","volume":"34","author":"Bi","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.chembiol.2023.08.001_bib69","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11882-022-01049-8","article-title":"Urinary Leukotriene E4 as a Biomarker in NSAID-Exacerbated Respiratory Disease (N-ERD): a Systematic Review and Meta-analysis","volume":"22","author":"Marquette","year":"2022","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.chembiol.2023.08.001_bib70","doi-asserted-by":"crossref","first-page":"704163","DOI":"10.3389\/fimmu.2021.704163","article-title":"Safety and preliminary efficacy of a novel host-modulatory therapy for reducing gingival inflammation","volume":"12","author":"Hasturk","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chembiol.2023.08.001_bib71","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1124\/dmd.109.026930","article-title":"Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor","volume":"37","author":"Takeda","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.chembiol.2023.08.001_bib72","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/biom11050746","article-title":"Beneficial modulation of lipid mediator biosynthesis in innate immune cells by antirheumatic Tripterygium wilfordii glycosides","volume":"11","author":"Zhang","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.chembiol.2023.08.001_bib73","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1016\/j.bbagen.2014.05.016","article-title":"An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis","volume":"1840","author":"Gerstmeier","year":"2014","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.chembiol.2023.08.001_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2014.05.011","article-title":"In\u00a0vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis","volume":"87","author":"Rossi","year":"2014","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.chembiol.2023.08.001_bib75","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.chembiol.2023.08.001_bib76","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1107\/S0907444909029436","article-title":"electronic Ligand Builder and Optimization Workbench (eLBOW): a tool for ligand coordinate and restraint generation","volume":"65","author":"Moriarty","year":"2009","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chembiol.2023.08.001_bib77","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.chembiol.2023.08.001_bib78","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2023.08.001_bib79","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucl. Acids Res."}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945623002490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945623002490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T23:51:52Z","timestamp":1778889112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945623002490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":79,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S2451945623002490"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2023.08.001","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2023.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}