{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:18:51Z","timestamp":1768681131020,"version":"3.49.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":381,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI105106"],"award-info":[{"award-number":["R01AI105106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM79465"],"award-info":[{"award-number":["R01GM79465"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["R01CA260860"],"award-info":[{"award-number":["R01CA260860"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.chembiol.2023.09.006","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T14:47:59Z","timestamp":1696949279000},"page":"1468-1477.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["In\u00a0vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin"],"prefix":"10.1016","volume":"30","author":[{"given":"Ryan L.","family":"Gonciarz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linh","family":"Tram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric L.","family":"Hugelshofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Ekpenyong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Knemeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allegra T.","family":"Aron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Flygare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Collisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1240-2846","authenticated-orcid":false,"given":"Adam R.","family":"Renslo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2023.09.006_bib1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nri3863","article-title":"Iron homeostasis in host defence and inflammation","volume":"15","author":"Ganz","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chembiol.2023.09.006_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126493","article-title":"Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis","volume":"22","author":"Nemeth","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chembiol.2023.09.006_bib3","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","article-title":"Systemic iron homeostasis","volume":"93","author":"Ganz","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.chembiol.2023.09.006_bib4","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41586-020-2668-z","article-title":"Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms","volume":"586","author":"Billesb\u00f8lle","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2023.09.006_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/nyas.13008","article-title":"Iron and cancer: recent insights","volume":"1368","author":"Manz","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.chembiol.2023.09.006_bib6","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1038\/onc.2017.11","article-title":"Iron addiction: a novel therapeutic target in ovarian cancer","volume":"36","author":"Basuli","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.chembiol.2023.09.006_bib7","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1089\/ars.2017.7023","article-title":"Effects of Ferroportin-Mediated Iron Depletion in Cells Representative of Different Histological Subtypes of Prostate Cancer","volume":"30","author":"Deng","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.chembiol.2023.09.006_bib8","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.molcel.2021.12.001","article-title":"Persister cancer cells: Iron addiction and vulnerability to ferroptosis","volume":"82","author":"Rodriguez","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2023.09.006_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.118535","article-title":"Iron homeostasis and oxidative stress: An intimate relationship","volume":"1866","author":"Galaris","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.chembiol.2023.09.006_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2023.09.006_bib11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2023.09.006_bib12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chembiol.2020.03.015","article-title":"Progress in understanding ferroptosis and challenges in its targeting for therapeutic benefit","volume":"27","author":"Zou","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.09.006_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature24297","article-title":"Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"issue":"Suppl 1","key":"10.1016\/j.chembiol.2023.09.006_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/jnc.13425","article-title":"Iron neurochemistry in Alzheimer\u2019s disease and Parkinson\u2019s disease: targets for therapeutics","volume":"139","author":"Belaidi","year":"2016","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.chembiol.2023.09.006_bib15","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/mp.2017.171","article-title":"Tau-mediated iron export prevents ferroptotic damage after ischemic stroke","volume":"22","author":"Tuo","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.chembiol.2023.09.006_bib16","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2023.09.006_bib17","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/162746a0","article-title":"Order of stability of metal complexes","volume":"162","author":"Irving","year":"1948","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2023.09.006_bib18","doi-asserted-by":"crossref","first-page":"13734","DOI":"10.1002\/anie.201909690","article-title":"Activity-Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond","volume":"59","author":"Bruemmer","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.chembiol.2023.09.006_bib19","doi-asserted-by":"crossref","first-page":"15165","DOI":"10.1021\/ja4072964","article-title":"Molecular imaging of labile iron(II) pools in living cells with a turn-on fluorescent probe","volume":"135","author":"Au-Yeung","year":"2013","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2023.09.006_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.freeradbiomed.2018.07.004","article-title":"Fluorescent probes for the detection of catalytic Fe(II) ion","volume":"133","author":"Hirayama","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.chembiol.2023.09.006_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chembiol.2021.12.006","article-title":"3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis","volume":"29","author":"Shao","year":"2022","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.09.006_bib22","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1021\/ol5028392","article-title":"Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery","volume":"16","author":"Fontaine","year":"2014","journal-title":"Org. Lett."},{"key":"10.1016\/j.chembiol.2023.09.006_bib23","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/nchembio.2116","article-title":"A reactivity-based probe of the intracellular labile ferrous iron pool","volume":"12","author":"Spangler","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.09.006_bib24","doi-asserted-by":"crossref","first-page":"14338","DOI":"10.1021\/jacs.6b08016","article-title":"An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells","volume":"138","author":"Aron","year":"2016","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2023.09.006_bib25","doi-asserted-by":"crossref","first-page":"12669","DOI":"10.1073\/pnas.1708747114","article-title":"In\u00a0vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection","volume":"114","author":"Aron","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2023.09.006_bib26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1021\/acscentsci.9b00240","article-title":"Measuring Dynamic Changes in the Labile Iron Pool in\u00a0Vivo with a Reactivity-Based Probe for Positron Emission Tomography","volume":"5","author":"Muir","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.chembiol.2023.09.006_bib27","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2967\/jnumed.120.252460","article-title":"Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies","volume":"62","author":"Zhao","year":"2021","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.chembiol.2023.09.006_bib28","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.chembiol.2020.07.022","article-title":"Seeing (and using) the light: recent developments in bioluminescence technology","volume":"27","author":"Love","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.09.006_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113111","article-title":"Recent achievements of bioluminescence imaging based on firefly luciferin-luciferase system","volume":"211","author":"Li","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.chembiol.2023.09.006_bib30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.copbio.2019.05.002","article-title":"Caged luciferins for bioluminescent activity-based sensing","volume":"60","author":"Su","year":"2019","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.chembiol.2023.09.006_bib31","doi-asserted-by":"crossref","first-page":"21316","DOI":"10.1073\/pnas.1012864107","article-title":"In\u00a0vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter","volume":"107","author":"Van de Bittner","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2023.09.006_bib32","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1021\/acs.analchem.7b01103","article-title":"Bioluminescent Turn-On Probe for Sensing Hypochlorite in\u00a0Vitro and in Tumors","volume":"89","author":"Chen","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chembiol.2023.09.006_bib33","doi-asserted-by":"crossref","first-page":"8684","DOI":"10.1021\/jacs.5b04357","article-title":"Luciferin amides enable in\u00a0vivo bioluminescence detection of endogenous fatty acid amide hydrolase activity","volume":"137","author":"Mofford","year":"2015","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2023.09.006_bib34","doi-asserted-by":"crossref","first-page":"8656","DOI":"10.1021\/jacs.5b02774","article-title":"A \u201cCaged\u201d Luciferin for Imaging Cell-Cell Contacts","volume":"137","author":"Porterfield","year":"2015","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2023.09.006_bib35","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/acssensors.0c00393","article-title":"Noncovalently Caged Firefly Luciferins Enable Amplifiable Bioluminescence Sensing of Hyaluronidase-1 Activity in\u00a0Vivo","volume":"5","author":"Luo","year":"2020","journal-title":"ACS Sens."},{"key":"10.1016\/j.chembiol.2023.09.006_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.talanta.2019.05.017","article-title":"In\u00a0vivo bioluminescence imaging of labile iron pools in a murine model of sepsis with a highly selective probe","volume":"203","author":"Feng","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.chembiol.2023.09.006_bib37","doi-asserted-by":"crossref","first-page":"13277","DOI":"10.1021\/ja505795s","article-title":"Aminoluciferins extend firefly luciferase bioluminescence into the near-infrared and can be preferred substrates over D-luciferin","volume":"136","author":"Mofford","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2023.09.006_bib38","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1021\/acs.bioconjchem.6b00099","article-title":"Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker","volume":"27","author":"Zhang","year":"2016","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.chembiol.2023.09.006_bib39","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1002\/chem.201500158","article-title":"Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers","volume":"21","author":"Dal Corso","year":"2015","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.chembiol.2023.09.006_bib40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejmech.2017.03.040","article-title":"Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38","volume":"132","author":"Jin","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.chembiol.2023.09.006_bib41","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/anie.201710727","article-title":"Near-Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid","volume":"57","author":"Miao","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.chembiol.2023.09.006_bib42","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1021\/mp500781a","article-title":"Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985","volume":"12","author":"Elgersma","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.chembiol.2023.09.006_bib43","first-page":"2021","article-title":"Byondis announces positive topline results of pivotal phase III TULIP\u00ae study in patientswith HER2-positive unresectable locally advanced or metastatic breast cancer. News release","volume":"8","author":"BioSpace","year":"2021","journal-title":"Byondis B.V"},{"key":"10.1016\/j.chembiol.2023.09.006_bib44","doi-asserted-by":"crossref","first-page":"14740","DOI":"10.1002\/chem.201903127","article-title":"Innovative Linker Strategies for Tumor-Targeted Drug Conjugates","volume":"25","author":"Dal Corso","year":"2019","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.chembiol.2023.09.006_bib45","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1016\/j.bmcl.2014.04.022","article-title":"Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action","volume":"24","author":"Kisin-Finfer","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.chembiol.2023.09.006_bib46","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.1002\/anie.201916394","article-title":"Fast Cyclization of a Proline-Derived Self-Immolative Spacer Improves the Efficacy of Carbamate Prodrugs","volume":"59","author":"Dal Corso","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.chembiol.2023.09.006_bib47","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1021\/jacs.9b11245","article-title":"Learning from Artemisinin: Bioinspired Design of a Reaction-Based Fluorescent Probe for the Selective Sensing of Labile Heme in Complex Biosystems","volume":"142","author":"Xu","year":"2020","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2023.09.006_bib48","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.bbamcr.2012.01.003","article-title":"Cellular and mitochondrial iron homeostasis in vertebrates","volume":"1823","author":"Chen","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chembiol.2023.09.006_bib49","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bbamcr.2012.01.014","article-title":"Hepcidin and iron homeostasis","volume":"1823","author":"Ganz","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.chembiol.2023.09.006_bib50","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/sj.gt.3300947","article-title":"Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA","volume":"6","author":"Liu","year":"1999","journal-title":"Gene Ther."},{"key":"10.1016\/j.chembiol.2023.09.006_bib51","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3390\/pharmaceutics7030213","article-title":"Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions","volume":"7","author":"Kamimura","year":"2015","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.chembiol.2023.09.006_bib52","article-title":"Dual-LuciferaseTM Reporter Assay: An Advanced Co-Reporter Technology Integrating Firefly and Renilla Luciferase Assays","volume":"57","author":"Sherf","year":"1996","journal-title":"Promega Notes Magazine"},{"key":"10.1016\/j.chembiol.2023.09.006_bib53","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1073\/pnas.012611099","article-title":"Optical imaging of Renilla luciferase reporter gene expression in living mice","volume":"99","author":"Bhaumik","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2023.09.006_bib54","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1172\/JCI57693","article-title":"Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload","volume":"121","author":"Preza","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"issue":"Suppl 1","key":"10.1016\/j.chembiol.2023.09.006_bib55","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1517\/14740338.2011.589834","article-title":"Anthracycline cardiotoxicity","volume":"11","author":"Menna","year":"2012","journal-title":"Expet Opin. Drug Saf."},{"key":"10.1016\/j.chembiol.2023.09.006_bib56","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mam.2007.09.016","article-title":"4-Hydroxynonenal-protein adducts: A reliable biomarker of lipid oxidation in liver diseases","volume":"29","author":"Poli","year":"2008","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.chembiol.2023.09.006_bib57","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/hep.31328","article-title":"Iron chaperone poly rc binding protein 1 protects mouse liver from lipid peroxidation and steatosis","volume":"73","author":"Protchenko","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.chembiol.2023.09.006_bib58","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","article-title":"The multifaceted role of ferroptosis in liver disease","volume":"29","author":"Chen","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.chembiol.2023.09.006_bib59","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210739","article-title":"Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors","volume":"219","author":"Jiang","year":"2022","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.chembiol.2023.09.006_bib60","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1158\/0008-5472.CAN-20-3477","article-title":"Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer","volume":"81","author":"Ghoochani","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.chembiol.2023.09.006_bib61","doi-asserted-by":"crossref","first-page":"19085","DOI":"10.1021\/jacs.0c06709","article-title":"Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis","volume":"142","author":"Chen","year":"2020","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2023.09.006_bib62","article-title":"Modulation of ferroptosis sensitivity by TXNRD1 in pancreatic cancer cells","author":"Cai","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.chembiol.2023.09.006_bib63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40170-020-00217-6","article-title":"Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer","volume":"8","author":"Tousignant","year":"2020","journal-title":"Cancer Metabol."},{"key":"10.1016\/j.chembiol.2023.09.006_bib64","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41418-019-0352-3","article-title":"Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis","volume":"27","author":"Chen","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.chembiol.2023.09.006_bib65","doi-asserted-by":"crossref","first-page":"517","DOI":"10.18632\/oncoscience.160","article-title":"Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells","volume":"2","author":"Eling","year":"2015","journal-title":"Oncoscience"},{"key":"10.1016\/j.chembiol.2023.09.006_bib66","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1021\/acschembio.5b00900","article-title":"Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells","volume":"11","author":"Abrams","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2023.09.006_bib67","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.tips.2020.11.003","article-title":"Ferrous Iron-Dependent Pharmacology","volume":"42","author":"Gonciarz","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.chembiol.2023.09.006_bib68","doi-asserted-by":"crossref","first-page":"11161","DOI":"10.1021\/acs.jmedchem.6b01470","article-title":"A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models","volume":"59","author":"Spangler","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2023.09.006_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115110","article-title":"Elevated labile iron in castration-resistant prostate cancer is targetable with ferrous iron-activatable antiandrogen therapy","volume":"249","author":"Gonciarz","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.chembiol.2023.09.006_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096801","article-title":"IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples","volume":"9","author":"Varghese","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2023.09.006_bib71","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2023.09.006_bib72","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1021\/acsinfecdis.0c00064","article-title":"Antimalarial Trioxolanes with Superior Drug-Like Properties and In\u00a0Vivo Efficacy","volume":"6","author":"Blank","year":"2020","journal-title":"ACS Infect. Dis."}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945623003252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945623003252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T05:11:05Z","timestamp":1749273065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945623003252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":72,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2451945623003252"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2023.09.006","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2023.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}