{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:25:09Z","timestamp":1793118309711,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AI137168"],"award-info":[{"award-number":["R01 AI137168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AI163170"],"award-info":[{"award-number":["R01 AI163170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 CA266478"],"award-info":[{"award-number":["R01 CA266478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015127","name":"Commonwealth Foundation for Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009784","name":"Starr Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.chembiol.2024.06.004","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T10:39:55Z","timestamp":1720607995000},"page":"1699-1713.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation"],"prefix":"10.1016","volume":"31","author":[{"given":"Lydia P.","family":"Tsamouri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Geeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Che","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika R.","family":"Nambiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley J.","family":"Chui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Bachovchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2024.06.004_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/imr.12884","article-title":"The NLRP1 and CARD8 inflammasomes","volume":"297","author":"Taabazuing","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.chembiol.2024.06.004_bib2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027396","article-title":"CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain","volume":"6","author":"D'Osualdo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2024.06.004_bib4","doi-asserted-by":"crossref","first-page":"25030","DOI":"10.1074\/jbc.M112.378323","article-title":"Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity","volume":"287","author":"Finger","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2024.06.004_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002659","article-title":"Proteolytic processing of Nlrp1b is required for inflammasome activity","volume":"8","author":"Frew","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chembiol.2024.06.004_bib6","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/s41591-018-0082-y","article-title":"DPP8\/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia","volume":"24","author":"Johnson","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2024.06.004_bib7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.aau1208","article-title":"N-terminal degradation activates the NLRP1B inflammasome","volume":"364","author":"Chui","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2024.06.004_bib8","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.immuni.2021.04.024","article-title":"Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment","volume":"54","author":"Sharif","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.chembiol.2024.06.004_bib9","doi-asserted-by":"crossref","first-page":"18864","DOI":"10.1074\/jbc.RA118.004350","article-title":"Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding","volume":"293","author":"Zhong","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2024.06.004_bib10","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1021\/acschembio.9b00462","article-title":"DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation","volume":"14","author":"Griswold","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41467-020-20320-y","article-title":"Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes","volume":"12","author":"Robert Hollingsworth","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2024.06.004_bib12","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000664","article-title":"Caspase-1 interdomain linker cleavage is required for pyroptosis","volume":"3","author":"Ball","year":"2020","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.chembiol.2024.06.004_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108264","article-title":"Activation of the CARD8 Inflammasome Requires a Disordered Region","volume":"33","author":"Chui","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2024.06.004_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102032","article-title":"A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome","volume":"298","author":"Hsiao","year":"2022","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2024.06.004_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111965","article-title":"Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation","volume":"42","author":"Orth-He","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2024.06.004_bib16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.1079293","article-title":"Endoproteolytic activity of the proteasome","volume":"299","author":"Liu","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2024.06.004_bib17","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jmb.2008.12.081","article-title":"Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination","volume":"386","author":"Baugh","year":"2009","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib18","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41586-021-03350-4","article-title":"DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation","volume":"592","author":"Hollingsworth","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2024.06.004_bib19","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41586-021-03320-w","article-title":"Structural and biochemical mechanisms of NLRP1 inhibition by DPP9","volume":"592","author":"Huang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2024.06.004_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nchembio.2229","article-title":"DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis","volume":"13","author":"Okondo","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib21","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.chembiol.2017.12.013","article-title":"Inhibition of Dpp8\/9 Activates the Nlrp1b Inflammasome","volume":"25","author":"Okondo","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abm7200","article-title":"Oxidized thioredoxin-1 restrains the NLRP1 inflammasome","volume":"7","author":"Ball","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib23","article-title":"The NLRP1 and CARD8 inflammasomes detect reductive stress","volume":"42","author":"Wang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2024.06.004_bib24","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41589-021-00751-4","article-title":"A compendium of kinetic modulatory profiles identifies ferroptosis regulators","volume":"17","author":"Conlon","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib25","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2024.06.004_bib26","doi-asserted-by":"crossref","first-page":"111965","DOI":"10.1016\/j.celrep.2022.111965","article-title":"Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation","volume":"42","author":"Orth-He","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2024.06.004_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ab.2007.04.007","article-title":"A homogeneous assay to measure live and dead cells in the same sample by detecting different protease markers","volume":"366","author":"Niles","year":"2007","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.chembiol.2024.06.004_bib28","doi-asserted-by":"crossref","first-page":"4551","DOI":"10.1021\/ja411006a","article-title":"Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models","volume":"136","author":"Skouta","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2024.06.004_bib29","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.electacta.2016.11.046","article-title":"Electrochemical behavior of 2-aminodiphenylamine and efficient factors on the site-selectivity of sulfonylation reaction: Experimental and theoretical studies","volume":"222","author":"Sharafi-Kolkeshvandi","year":"2016","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.chembiol.2024.06.004_bib30","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1021\/acschembio.8b00199","article-title":"Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis","volume":"13","author":"Gaschler","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41573-018-0008-x","article-title":"Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases","volume":"18","author":"Cuadrado","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chembiol.2024.06.004_bib32","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1128\/MCB.23.22.8137-8151.2003","article-title":"Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress","volume":"23","author":"Zhang","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5906189","article-title":"Andrographolide Activates Keap1\/Nrf2\/ARE\/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A\u03b242 through Nrf2-Related Inflammatory Response","volume":"2017","author":"Seo","year":"2017","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.chembiol.2024.06.004_bib34","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1021\/jm2002348","article-title":"Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells","volume":"54","author":"Kumar","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.chembiol.2024.06.004_bib35","article-title":"The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond","author":"Geeson","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.chembiol.2024.06.004_bib36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41586-023-06532-4","article-title":"Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome","volume":"622","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2024.06.004_bib37","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41419-020-02865-4","article-title":"DPP8\/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes","volume":"11","author":"Johnson","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.chembiol.2024.06.004_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105071","article-title":"CARD8 inflammasome activation triggers pyroptosis in human T\u00a0cells","volume":"39","author":"Linder","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.chembiol.2024.06.004_bib39","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2024.01.048","article-title":"The CARD8 inflammasome dictates HIV\/SIV pathogenesis and disease progression","volume":"187","author":"Wang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2024.06.004_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/science.1242454","article-title":"Fueling immunity: insights into metabolism and lymphocyte function","volume":"342","author":"Pearce","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2024.06.004_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg2379","article-title":"Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life","volume":"9","author":"Yumimoto","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.chembiol.2024.06.004_bib42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nmeth.1212","article-title":"Real-time imaging of the intracellular glutathione redox potential","volume":"5","author":"Gutscher","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2024.06.004_bib43","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/nchembio.2417","article-title":"Monitoring thioredoxin redox with a genetically encoded red fluorescent biosensor","volume":"13","author":"Fan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib44","doi-asserted-by":"crossref","first-page":"22284","DOI":"10.1074\/jbc.M312847200","article-title":"Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators","volume":"279","author":"Dooley","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.chembiol.2024.06.004_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe1707","article-title":"CARD8 is an inflammasome sensor for HIV-1 protease activity","volume":"371","author":"Wang","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2024.06.004_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002144","article-title":"Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome","volume":"21","author":"Tsu","year":"2023","journal-title":"PLoS Biol."},{"key":"10.1016\/j.chembiol.2024.06.004_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.84108","article-title":"A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection","volume":"12","author":"Kulsuptrakul","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.chembiol.2024.06.004_bib48","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.molcel.2021.01.001","article-title":"NLRP1: a jack of all trades, or a master of one?","volume":"81","author":"Bachovchin","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2024.06.004_bib49","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2024.06.004_bib50","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1021\/ol101801u","article-title":"Total synthesis and biological evaluation of tyroscherin","volume":"12","author":"Tae","year":"2010","journal-title":"Org. Lett."}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245194562400223X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245194562400223X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T02:03:17Z","timestamp":1758679397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245194562400223X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S245194562400223X"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2024.06.004","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2024.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2024.08.012","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}