{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:04:51Z","timestamp":1773929091555,"version":"3.50.1"},"reference-count":76,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010178","name":"Indiana University Bloomington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010178","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.chembiol.2025.11.008","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T16:09:34Z","timestamp":1765469374000},"page":"1517-1531.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bugs delivering drugs: Listeria monocytogenes-mediated cytotoxin delivery enhances anti-tumor activity in colorectal cancer"],"prefix":"10.1016","volume":"32","author":[{"given":"Wyatt","family":"Paulishak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianen","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6093-5949","authenticated-orcid":false,"given":"Michael S.","family":"VanNieuwenhze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence M.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2025.11.008_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrc1529","article-title":"Chemotherapy and the war on cancer","volume":"5","author":"Chabner","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2025.11.008_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphar.2018.00245","article-title":"Editorial: Adverse effects of cancer chemotherapy: Anything new to improve tolerance and reduce sequelae?","volume":"9","author":"Nurgali","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib3","doi-asserted-by":"crossref","first-page":"e0184360","DOI":"10.1371\/journal.pone.0184360","article-title":"Incidence and severity of self-reported chemotherapy side effects in routine care: A prospective cohort study","volume":"12","author":"Pearce","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2025.11.008_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/cncr.10630","article-title":"Changing patient perceptions of the side effects of cancer chemotherapy","volume":"95","author":"Carelle","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.chembiol.2025.11.008_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0447.1994.tb05859.x","article-title":"Compliance with antipsychotic drug treatment: influence of side effects","volume":"89","author":"WW","year":"1994","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.chembiol.2025.11.008_bib6","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s11906-001-0011-0","article-title":"Adverse events, compliance, and changes in therapy","volume":"3","author":"D\u00fcsing","year":"2001","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.chembiol.2025.11.008_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/bjc.1983.4","article-title":"Localisation and toxicity study of a vindesine-anti-CEA conjugate in patients with advanced cancer","volume":"47","author":"Ford","year":"1983","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.chembiol.2025.11.008_bib8","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1002\/jcp.27419","article-title":"Antibody\u2013drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes","volume":"234","author":"Abdollahpour-Alitappeh","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib9","first-page":"751","article-title":"Pharmacological-toxicological expert report Caelyx (Stealth liposomal doxorubicin-HCl)","volume":"15","author":"Working","year":"1996","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrc.2016.108","article-title":"Cancer nanomedicine: Progress, challenges and opportunities","volume":"17","author":"Shi","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2025.11.008_bib11","first-page":"3","article-title":"Antibody-Drug Conjugates: Possibilities and Challenges","volume":"11","author":"Nejadmoghaddam","year":"2019","journal-title":"Avicenna J. Med. Biotechnol. (AJMB)"},{"key":"10.1016\/j.chembiol.2025.11.008_bib12","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1021\/acs.bioconjchem.6b00437","article-title":"Nano-drug delivery: Is the enhanced permeability and retention (EPR) effect sufficient for curing cancer?","volume":"27","author":"Nakamura","year":"2016","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.chembiol.2025.11.008_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010195","article-title":"Surface functionalization and targeting strategies of liposomes in solid tumor therapy: A review","volume":"19","author":"Riaz","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.chembiol.2025.11.008_bib14","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1039\/c3ob41721b","article-title":"Liposome Surface Functionalization Based on Different Anchoring Lipids via Staudinger Ligation","volume":"12","author":"Vabbilisetty","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.chembiol.2025.11.008_bib15","first-page":"2964","article-title":"Liposome-induced immunosuppression and tumor growth is mediated by macrophages and mitigated by liposomeencapsulated alendronate","volume":"72","author":"Robin","year":"2018","journal-title":"Rev. del Col. Am. Cardiol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00000658-189112000-00015","article-title":"Contribution To the Knowledge of Sarcoma","volume":"14","author":"Coley","year":"1891","journal-title":"Ann. Surg."},{"key":"10.1016\/j.chembiol.2025.11.008_bib17","first-page":"154","article-title":"The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas","volume":"26","author":"McCarthy","year":"2006","journal-title":"Iowa Orthop. J."},{"key":"10.1016\/j.chembiol.2025.11.008_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13027-018-0180-y","article-title":"The role of bacteria in cancer therapy \u2013 enemies in the past, but allies at present","volume":"13","author":"Song","year":"2018","journal-title":"Infect. Agent. Cancer"},{"key":"10.1016\/j.chembiol.2025.11.008_bib19","doi-asserted-by":"crossref","first-page":"1026248","DOI":"10.3389\/fbioe.2022.1026248","article-title":"Recent advances in bacteria-mediated cancer therapy","volume":"10","author":"Liang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/cas.12075","article-title":"Bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer: Current understanding and perspectives on engineered BCG vaccine","volume":"104","author":"Kawai","year":"2013","journal-title":"Cancer Sci."},{"key":"10.1016\/j.chembiol.2025.11.008_bib21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41585-018-0055-4","article-title":"Mechanisms of BCG immunotherapy and its outlook for bladder cancer","volume":"15","author":"Pettenati","year":"2018","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib22","doi-asserted-by":"crossref","first-page":"642316","DOI":"10.3389\/fimmu.2021.642316","article-title":"Clinical Experience and Recent Advances in the Development of Listeria-Based Tumor Immunotherapies","volume":"12","author":"Oladejo","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fcimb.2014.00051","article-title":"Attenuated Listeria monocytogenes: a powerful and versatile vector for the future of tumor immunotherapy","volume":"4","author":"Wood","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib24","doi-asserted-by":"crossref","first-page":"S597","DOI":"10.1245\/s10434-011-2037-0","article-title":"Tumor-associated antigen expressing listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases","volume":"19","author":"Olino","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib25","doi-asserted-by":"crossref","first-page":"8668","DOI":"10.1073\/pnas.1211287110","article-title":"Nontoxic radioactive Listeriaat is a highly effective therapy against metastatic pancreatic cancer","volume":"110","author":"Quispe-Tintaya","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2025.11.008_bib26","doi-asserted-by":"crossref","first-page":"20729","DOI":"10.18632\/oncotarget.15117","article-title":"32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect","volume":"8","author":"Chandra","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.chembiol.2025.11.008_bib27","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1158\/0008-5472.CAN-08-4855","article-title":"High efficacy of a Listeria-based vaccine against metastatic breast cancer reveals a dual mode of action","volume":"69","author":"Kim","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.chembiol.2025.11.008_bib28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nbt0298-181","article-title":"Delivery of antigen-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide Listeria monocytogenes","volume":"16","author":"Dietrich","year":"1998","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib29","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jconrel.2017.10.041","article-title":"Doxorubicin-conjugated Escherichia coli Nissle 1917 swimmers to achieve tumor targeting and responsive drug release","volume":"268","author":"Xie","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.chembiol.2025.11.008_bib30","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1021\/acschembio.4c00250","article-title":"Enhancing the anticancer activity of attenuated Listeria monocytogenes by cell wall functionalization with \u201cclickable\u201d doxorubicin","volume":"19","author":"Lepori","year":"2024","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib31","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1128\/JB.184.15.4177-4186.2002","article-title":"Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors","volume":"184","author":"Lauer","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib32","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.4049\/jimmunol.167.11.6471","article-title":"Two Listeria monocytogenes Vaccine Vectors That Express Different Molecular Forms of Human Papilloma Virus-16 (HPV-16) E7 Induce Qualitatively Different T Cell Immunity That Correlates with Their Ability to Induce Regression of Established Tumors Immorta","volume":"167","author":"Gunn","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib70","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00262-011-1129-9","article-title":"The ubiquitin-like protein, ISG15, is a novel tumor-associated antigen for cancer immunotherapy","volume":"61","author":"Wood","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.chembiol.2025.11.008_bib33","doi-asserted-by":"crossref","first-page":"13832","DOI":"10.1073\/pnas.0406035101","article-title":"Listeria-based cancer vaccines that segregate immunogenicity from toxicity","volume":"101","author":"Brockstedt","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2025.11.008_bib34","doi-asserted-by":"crossref","first-page":"183604","DOI":"10.1016\/j.bbamem.2021.183604","article-title":"The molecular mechanisms of listeriolysin O-induced lipid membrane damage","volume":"1863","author":"Petri\u0161i\u010d","year":"2021","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.chembiol.2025.11.008_bib35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/vco.12642","article-title":"Safety evaluation of the canine osteosarcoma vaccine, live Listeria vector","volume":"19","author":"Musser","year":"2021","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib36","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/mmi.14836","article-title":"Role of internalin proteins in the pathogenesis of Listeria monocytogenes","volume":"116","author":"Ireton","year":"2021","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib37","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1093\/annonc\/mdf337","article-title":"Irinotecan: Mechanisms of tumor resistance and novel strategies for modulating its activity","volume":"13","author":"Xu","year":"2002","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.pa.34.040194.001203","article-title":"DNA Topoisomerases: Essential Enzymes and Lethal Targets","volume":"34","author":"Chen","year":"1994","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2000.tb07020.x","article-title":"Mechanism of action of camptothecin","volume":"922","author":"Liu","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.chembiol.2025.11.008_bib40","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s13361-014-1071-0","article-title":"Quantitative determination of irinotecan and the metabolite SN-38 by nanoflow liquid chromatography-tandem mass spectrometry in different regions of multicellular tumor spheroids","volume":"26","author":"Liu","year":"2015","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.chembiol.2025.11.008_bib41","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s11095-008-9572-9","article-title":"Potential Oral Delivery of 7-Ethyl-10-Hydroxy-Camptothecin (SN-38) using Poly (amidoamine) Dendrimers","volume":"25","author":"Kolhatkar","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.chembiol.2025.11.008_bib42","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.2147\/IJN.S133816","article-title":"In vitro and in vivo evaluation of SN-38 nanocrystals with different particle sizes","volume":"12","author":"Chen","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.chembiol.2025.11.008_bib43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jcp.28967","article-title":"Potential drugs used in the antibody\u2013drug conjugate (ADC) architecture for cancer therapy","volume":"235","author":"Yaghoubi","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib44","doi-asserted-by":"crossref","first-page":"13761","DOI":"10.1021\/bi00250a029","article-title":"Transport Studies of Doxorubicin in Model Membranes Indicate a Difference in Passive Diffusion across and Binding at the Outer and Inner Leaflet of the Plasma Membrane","volume":"33","author":"Speelmans","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.chembiol.2025.11.008_bib45","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/FPC.0b013e32833ffb56","article-title":"Doxorubicin pathways: pharmacodynamics and adverse effects","volume":"21","author":"Thorn","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.chembiol.2025.11.008_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14020396","article-title":"Linkers: An Assurance for Controlled Delivery of Antibody-Drug Conjugate","volume":"14","author":"Sheyi","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.chembiol.2025.11.008_bib47","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1016\/j.apsb.2021.03.042","article-title":"Antibody\u2013drug conjugates: Recent advances in linker chemistry","volume":"11","author":"Su","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.chembiol.2025.11.008_bib48","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1007\/s11095-015-1657-7","article-title":"Current ADC Linker Chemistry","volume":"32","author":"Jain","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.chembiol.2025.11.008_bib49","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00280-001-0416-0","article-title":"Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines","volume":"49","author":"Pavillard","year":"2002","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib50","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jchromb.2017.11.038","article-title":"A novel adenine-releasing assay for ribosome-inactivating proteins","volume":"1072","author":"Weng","year":"2018","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.chembiol.2025.11.008_bib51","first-page":"60","article-title":"Ricin Toxicity: Clinical and Molecular Aspects","volume":"4","author":"Moshiri","year":"2016","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib52","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3390\/toxins5101698","article-title":"Saporin-S6: A useful tool in cancer therapy","volume":"5","author":"Polito","year":"2013","journal-title":"Toxins"},{"key":"10.1016\/j.chembiol.2025.11.008_bib53","doi-asserted-by":"crossref","first-page":"12133","DOI":"10.1021\/acs.chemrev.7b00013","article-title":"Ligand-Targeted Drug Delivery","volume":"117","author":"Srinivasarao","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.chembiol.2025.11.008_bib76","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1128\/AEM.03235-14","article-title":"Listeria phage and phage tail induction triggered by components of bacterial growth media (photphate , LiCl, nalidixic acid, and acriflavine)","volume":"81","author":"Lema\u00eetre","year":"2015","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.chembiol.2025.11.008_bib54","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ymthe.2018.11.010","article-title":"Modulating the Tumor Microenvironment via Oncolytic Viruses and CSF-1R Inhibition Synergistically Enhances Anti-PD-1 Immunotherapy","volume":"27","author":"Shi","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2025.11.008_bib55","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1073\/pnas.1801910115","article-title":"Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment","volume":"115","author":"Deng","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2025.11.008_bib56","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1038\/s41388-019-0681-1","article-title":"Antitumoral effects of attenuated Listeria monocytogenes in a genetically engineered mouse model of melanoma","volume":"38","author":"Vitiello","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.chembiol.2025.11.008_bib57","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1073\/pnas.1614315114","article-title":"Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors","volume":"114","author":"Xin","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2025.11.008_bib58","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1158\/1078-0432.CCR-19-3642","article-title":"Intratumoral immunotherapy for early-stage solid tumors","volume":"26","author":"Hong","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chembiol.2025.11.008_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216798","article-title":"Intratumoral injection of interferon gamma promotes the efficacy anti-PD1 treatment in colorectal cancer","volume":"588","author":"Tang","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.chembiol.2025.11.008_bib60","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.200205009","article-title":"The cell biology of Listeria monocytogenes infection: The intersection of bacterial pathogenesis and cell-mediated immunity","volume":"158","author":"Portnoy","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib61","doi-asserted-by":"crossref","first-page":"e0019","DOI":"10.1097\/MD.0000000000010019","article-title":"The significance of microsatellite instability in colorectal cancer after controlling for clinicopathological factors","volume":"97","author":"Kang","year":"2018","journal-title":"Medicine"},{"key":"10.1016\/j.chembiol.2025.11.008_bib62","first-page":"1","article-title":"Immunotherapy for Microsatellite Stable Colorectal Cancers: Challenges and Novel Therapeutic Avenues","volume":"42","author":"Sahin","year":"2022","journal-title":"Am. Soc. Clin. Oncol. Educ. Book."},{"key":"10.1016\/j.chembiol.2025.11.008_bib63","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3747\/co.19.1037","article-title":"Disappearing breast cancers","volume":"19","author":"Narod","year":"2012","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib64","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/s41388-019-1072-3","article-title":"Listeria-based hepatocellular carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage polarization","volume":"39","author":"Xu","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.chembiol.2025.11.008_bib65","doi-asserted-by":"crossref","first-page":"e28926","DOI":"10.4161\/onci.28926","article-title":"Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis","volume":"3","author":"Lizotte","year":"2014","journal-title":"OncoImmunology"},{"key":"10.1016\/j.chembiol.2025.11.008_bib66","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3390\/cancers11030394","article-title":"Acquired resistance to antibody-drug conjugates","volume":"11","author":"Collins","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.chembiol.2025.11.008_bib67","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1128\/IAI.01274-08","article-title":"Impact of preexisting vector-specific immunity on vaccine potency: Characterization of Listeria monocytogenes-specific humoral and cellular immunity in humans and modeling studies using recombinant vaccines in mice","volume":"77","author":"Leong","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chembiol.2025.11.008_bib68","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1039\/c2ib00091a","article-title":"Motility is Critical for Effective Distribution and Accumulation of Bacteria in Tumor Tissue","volume":"4","author":"Bhushan","year":"2012","journal-title":"Integr. Biol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib69","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1128\/iai.62.12.5608-5613.1994","article-title":"Characterization of Listeria monocytogenes Pathogenesis in a Strain Expressing Perfringolysin 0 in Place of Listeriolysin 0","volume":"62","author":"Jones","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.chembiol.2025.11.008_bib71","series-title":"Listeria Monocytogenes: Methods and Protocols","author":"Jordan","year":"2014"},{"key":"10.1016\/j.chembiol.2025.11.008_bib72","first-page":"e3292","article-title":"Gentamicin Protection Assay to Determine the Number of Intracellular Bacteria during Infection of Human TC7 Intestinal Epithelial Cells by Shigella flexneri","volume":"9","author":"Sharma","year":"2019","journal-title":"Bio. Protoc."},{"key":"10.1016\/j.chembiol.2025.11.008_bib73","doi-asserted-by":"crossref","first-page":"e00160-18","DOI":"10.1128\/mBio.00160-18","article-title":"Invasion of the Brain by Listeria monocytogenes Is Mediated by InIF and host cell vimentin","volume":"9","author":"Vimentin","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.chembiol.2025.11.008_bib74","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nbt1172","article-title":"Engineering and characterization of a superfolder green fluorescent protein","volume":"24","author":"P\u00e9delacq","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2025.11.008_bib75","doi-asserted-by":"crossref","first-page":"11052","DOI":"10.1073\/pnas.1704937114","article-title":"Mechanically switching single-molecule fluorescence of GFP by unfolding and refolding","volume":"114","author":"Ganim","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945625003885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945625003885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:52:20Z","timestamp":1773917540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945625003885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":76,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2451945625003885"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2025.11.008","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bugs delivering drugs: Listeria monocytogenes-mediated cytotoxin delivery enhances anti-tumor activity in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2025.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}