{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:46:20Z","timestamp":1788907580418,"version":"build-2803163510"},"reference-count":224,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32261160373"],"award-info":[{"award-number":["32261160373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571656"],"award-info":[{"award-number":["32571656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32250010"],"award-info":[{"award-number":["32250010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017133","name":"National Key Project for Synthetic Biology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["25ZR1402121"],"award-info":[{"award-number":["25ZR1402121"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23HC1410100"],"award-info":[{"award-number":["23HC1410100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22N31900300"],"award-info":[{"award-number":["22N31900300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["25J22800100"],"award-info":[{"award-number":["25J22800100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFA0923300"],"award-info":[{"award-number":["2025YFA0923300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3408700"],"award-info":[{"award-number":["2025YFC3408700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.chembiol.2026.04.007","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:51:36Z","timestamp":1778511096000},"page":"597-622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Programmable living therapeutics for cancer immunotherapy"],"prefix":"10.1016","volume":"33","author":[{"given":"Zhenqiang","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxue","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningzi","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2026.04.007_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1212476","article-title":"Cancer immunotherapies: advances and bottlenecks","volume":"14","author":"Rui","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib2","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1126\/science.aaf1490","article-title":"Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade","volume":"351","author":"McGranahan","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib3","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1056\/NEJMc1713444","article-title":"Tumor Mutational Burden and Response Rate to PD-1 Inhibition","volume":"377","author":"Yarchoan","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005568","article-title":"Cell-based therapeutics: the next pillar of medicine","volume":"5","author":"Fischbach","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib5","doi-asserted-by":"crossref","first-page":"8414","DOI":"10.1073\/pnas.0402940101","article-title":"Programmable cells: interfacing natural and engineered gene networks","volume":"101","author":"Kobayashi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cell.2017.01.016","article-title":"The Principles of Engineering Immune Cells to Treat Cancer","volume":"168","author":"Lim","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41571-024-00908-9","article-title":"Exploiting bacteria for cancer immunotherapy","volume":"21","author":"Kwon","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41392-023-01407-6","article-title":"Oncolytic virotherapy: basic principles, recent advances and future directions","volume":"8","author":"Lin","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib9","doi-asserted-by":"crossref","first-page":"7963","DOI":"10.1073\/pnas.130192197","article-title":"Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity","volume":"97","author":"Urlinger","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav8826","article-title":"A green tea-triggered genetic control system for treating diabetes in mice and monkeys","volume":"11","author":"Yin","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib11","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cels.2024.09.002","article-title":"A digital CRISPR-dCas9-based gene remodeling biocomputer programmed by dietary compounds in mammals","volume":"15","author":"Yin","year":"2024","journal-title":"Cell Syst."},{"key":"10.1016\/j.chembiol.2026.04.007_bib12","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41587-021-01036-w","article-title":"A small and highly sensitive red\/far-red optogenetic switch for applications in mammals","volume":"40","author":"Zhou","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib13","article-title":"Sonogenetics-controlled synthetic designer cells for cancer therapy in tumor mouse models","volume":"5","author":"Gao","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib14","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2016.01.012","article-title":"Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors","volume":"164","author":"Morsut","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib15","article-title":"Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors","volume":"2","author":"Kosti","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ymthe.2016.10.011","article-title":"Masked Chimeric Antigen Receptor for Tumor-Specific Activation","volume":"25","author":"Han","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad1067","article-title":"Programming gene and engineered-cell therapies with synthetic biology","volume":"359","author":"Kitada","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008226","article-title":"Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia","volume":"6","author":"Davila","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib19","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1158\/2159-8290.CD-17-0698","article-title":"Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells","volume":"7","author":"Gust","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2026.04.007_bib20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nm.3838","article-title":"4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors","volume":"21","author":"Long","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41586-019-1805-z","article-title":"c-Jun overexpression in CAR T cells induces exhaustion resistance","volume":"576","author":"Lynn","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.04.007_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41571-022-00704-3","article-title":"Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours","volume":"20","author":"Flugel","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1158\/2326-6066.CIR-17-0211","article-title":"High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model","volume":"6","author":"Richman","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.chembiol.2026.04.007_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/science.aab4077","article-title":"Remote control of therapeutic T cells through a small molecule-gated chimeric receptor","volume":"350","author":"Wu","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb6295","article-title":"Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide","volume":"13","author":"Jan","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio.2529","article-title":"Human antibody-based chemically induced dimerizers for cell therapeutic applications","volume":"14","author":"Hill","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib27","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/s41589-025-01918-z","article-title":"Repurposing salicylic acid as a versatile inducer of proximity","volume":"21","author":"Wang","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fcell.2019.00233","article-title":"Doxycycline Inducible Chimeric Antigen Receptor T Cells Targeting CD147 for Hepatocellular Carcinoma Therapy","volume":"7","author":"Zhang","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib29","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2106612118","article-title":"Engineering genetic devices for in vivo control of therapeutic T cell activity triggered by the dietary molecule resveratrol","volume":"118","author":"Yang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib30","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.ccell.2022.10.019","article-title":"Let\u2019s turn the CAR-T cells ON and OFF precisely","volume":"40","author":"Zhang","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba1786","article-title":"Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling","volume":"372","author":"Weber","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib32","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.cell.2022.03.041","article-title":"Enhanced safety and efficacy of protease-regulated CAR-T cell receptors","volume":"185","author":"Labanieh","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib33","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.ccell.2022.08.008","article-title":"High-performance multiplex drug-gated CAR circuits","volume":"40","author":"Li","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib34","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41587-019-0403-9","article-title":"A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy","volume":"38","author":"Giordano-Attianese","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib35","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/acschembio.3c00521","article-title":"Designer Small-Molecule Control System Based on Minocycline-Induced Disruption of Protein-Protein Interaction","volume":"19","author":"Jha","year":"2024","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib36","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1021\/acssynbio.9b00476","article-title":"A Chemical Switch System to Modulate Chimeric Antigen Receptor T Cell Activity through Proteolysis-Targeting Chimaera Technology","volume":"9","author":"Lee","year":"2020","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib37","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1021\/acssynbio.4c00109","article-title":"Degron-Based bioPROTACs for Controlling Signaling in CAR T Cells","volume":"13","author":"Kim","year":"2024","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib38","doi-asserted-by":"crossref","first-page":"12569","DOI":"10.1002\/cam4.5907","article-title":"Therapeutic effects of anti-GM2 CAR-T cells expressing IL-7 and CCL19 for GM2-positive solid cancer in xenograft model","volume":"12","author":"Sasaki","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib39","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/mt.2015.217","article-title":"Clonal Dynamics In Vivo of Virus Integration Sites of T Cells Expressing a Safety Switch","volume":"24","author":"Chang","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib40","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/mt.2015.234","article-title":"Serial Activation of the Inducible Caspase 9 Safety Switch After Human Stem Cell Transplantation","volume":"24","author":"Zhou","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib41","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1182\/blood-2004-11-4564","article-title":"An inducible caspase 9 safety switch for T-cell therapy","volume":"105","author":"Straathof","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.chembiol.2026.04.007_bib42","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJMoa2210859","article-title":"GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma","volume":"388","author":"Del Bufalo","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib43","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1182\/blood-2011-02-337360","article-title":"A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells","volume":"118","author":"Wang","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.chembiol.2026.04.007_bib44","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1182\/blood-2014-01-545020","article-title":"A highly compact epitope-based marker\/suicide gene for easier and safer T-cell therapy","volume":"124","author":"Philip","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.chembiol.2026.04.007_bib45","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1182\/blood-2005-08-3503","article-title":"Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation","volume":"107","author":"Berger","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.chembiol.2026.04.007_bib46","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2117402119","article-title":"Switchable assembly and function of antibody complexes in vivo using a small molecule","volume":"119","author":"Martinko","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib47","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1126\/science.ade0156","article-title":"Multidimensional control of therapeutic human cell function with synthetic gene circuits","volume":"378","author":"Li","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau5907","article-title":"The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on\/off switch for CAR T cells","volume":"11","author":"Mestermann","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib49","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1182\/bloodadvances.2018028720","article-title":"Pharmacologic control of CAR-T cell function using dasatinib","volume":"3","author":"Weber","year":"2019","journal-title":"Blood Adv."},{"key":"10.1016\/j.chembiol.2026.04.007_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.108005","article-title":"Optogenetic technologies in translational cancer research","volume":"60","author":"Malogolovkin","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.chembiol.2026.04.007_bib51","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/s41592-021-01240-1","article-title":"A guide to the optogenetic regulation of endogenous molecules","volume":"18","author":"Manoilov","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2026.04.007_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay9209","article-title":"Engineering light-controllable CAR T cells for cancer immunotherapy","volume":"6","author":"Huang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.chembiol.2026.04.007_bib53","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202010091","article-title":"Quantifying persistence in the T-cell signaling network using an optically controllable antigen receptor","volume":"17","author":"Harris","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201800952","article-title":"Light-Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology","volume":"6","author":"Mansouri","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.chembiol.2026.04.007_bib55","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/s41565-021-00982-5","article-title":"Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety","volume":"16","author":"Nguyen","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54781-2","article-title":"A sensitive red\/far-red photoswitch for controllable gene therapy in mouse models of metabolic diseases","volume":"15","author":"Qiao","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib57","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1038\/s41467-021-24212-7","article-title":"Single-component near-infrared optogenetic systems for gene transcription regulation","volume":"12","author":"Kaberniuk","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib58","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1038\/s41587-022-01351-w","article-title":"A red light-responsive photoswitch for deep tissue optogenetics","volume":"40","author":"Kuwasaki","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib59","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41592-022-01517-z","article-title":"A general approach for engineering RTKs optically controlled with far-red light","volume":"19","author":"Leopold","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2026.04.007_bib60","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nmeth.3864","article-title":"A bacterial phytochrome-based optogenetic system controllable with near-infrared light","volume":"13","author":"Kaberniuk","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2026.04.007_bib61","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1021\/acs.biochem.7b00443","article-title":"Going Deeper: Biomolecular Tools for Acoustic and Magnetic Imaging and Control of Cellular Function","volume":"56","author":"Piraner","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.chembiol.2026.04.007_bib62","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev-chembioeng-060817-084034","article-title":"Biomolecular Ultrasound and Sonogenetics","volume":"9","author":"Maresca","year":"2018","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"10.1016\/j.chembiol.2026.04.007_bib63","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/s41592-021-01229-w","article-title":"Ultrasensitive ultrasound imaging of gene expression with signal unmixing","volume":"18","author":"Sawyer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2026.04.007_bib64","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.aax4804","article-title":"Ultrasound imaging of gene expression in mammalian cells","volume":"365","author":"Farhadi","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib65","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal3128","article-title":"In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs","volume":"9","author":"Bez","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/srep20477","article-title":"Direct and sustained intracellular delivery of exogenous molecules using acoustic-transfection with high frequency ultrasound","volume":"6","author":"Yoon","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chembiol.2026.04.007_bib67","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1073\/pnas.1714900115","article-title":"Mechanogenetics for the remote and noninvasive control of cancer immunotherapy","volume":"115","author":"Pan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib68","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/s41551-021-00779-w","article-title":"Control of the activity of CAR-T cells within tumours via focused ultrasound","volume":"5","author":"Wu","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.chembiol.2026.04.007_bib69","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1016\/j.cell.2025.02.035","article-title":"Engineering sonogenetic EchoBack-CAR T cells","volume":"188","author":"Liu","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib70","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11912-019-0752-z","article-title":"HIF Inhibitors: Status of Current Clinical Development","volume":"21","author":"Fallah","year":"2019","journal-title":"Curr. Oncol. Rep."},{"key":"10.1016\/j.chembiol.2026.04.007_bib71","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1124\/mol.106.027029","article-title":"Hypoxia-inducible factor-1 (HIF-1)","volume":"70","author":"Ke","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib72","doi-asserted-by":"crossref","DOI":"10.1038\/srep39833","article-title":"An oxygen sensitive self-decision making engineered CAR T-cell","volume":"7","author":"Juillerat","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chembiol.2026.04.007_bib73","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3389\/fimmu.2020.00326","article-title":"Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review","volume":"11","author":"Brandt","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib74","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib75","doi-asserted-by":"crossref","first-page":"PO074","DOI":"10.1158\/2326-6074.TUMIMM20-PO074","article-title":"Abstract PO074: Logic-gating HER2 CAR-T to the tumor microenvironment mitigates on-target, off-tumor toxicity without compromising cytotoxicity against HER2-over-expressing tumors","volume":"9","author":"Zhang","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.chembiol.2026.04.007_bib76","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1016\/j.ymthe.2025.04.037","article-title":"Engineering TME-gated inducible CAR-T cell therapy for solid tumors","volume":"33","author":"Nguyen","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib77","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nchembio.2565","article-title":"Rewiring T-cell responses to soluble factors with chimeric antigen receptors","volume":"14","author":"Chang","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib78","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41586-024-08366-0","article-title":"Engineered receptors for soluble cellular communication and disease sensing","volume":"638","author":"Piraner","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.04.007_bib79","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1038\/s41589-025-01986-1","article-title":"Conversion of natural cytokine receptors into orthogonal synthetic biosensors","volume":"21","author":"Edelstein","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib80","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41586-025-09212-7","article-title":"Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery","volume":"644","author":"Chen","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.04.007_bib81","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/mt.2010.24","article-title":"Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2","volume":"18","author":"Morgan","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib82","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12943-019-1057-4","article-title":"Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity","volume":"18","author":"Yu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.chembiol.2026.04.007_bib83","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cell.2016.01.011","article-title":"Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits","volume":"164","author":"Roybal","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib84","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd8836","article-title":"SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models","volume":"13","author":"Hyrenius-Wittsten","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib85","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads3403","article-title":"Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity","volume":"11","author":"Vogt","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.chembiol.2026.04.007_bib86","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1126\/science.abc1855","article-title":"T cell circuits that sense antigen density with an ultrasensitive threshold","volume":"371","author":"Hernandez-Lopez","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib87","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41586-023-05778-2","article-title":"Co-opting signalling molecules enables logic-gated control of CAR T cells","volume":"615","author":"Tousley","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.04.007_bib88","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1126\/science.abc6270","article-title":"Precise T cell recognition programs designed by transcriptionally linking multiple receptors","volume":"370","author":"Williams","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib89","doi-asserted-by":"crossref","first-page":"9543","DOI":"10.1128\/MCB.25.21.9543-9553.2005","article-title":"CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms","volume":"25","author":"Parry","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib90","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006597","article-title":"PD-1- and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses","volume":"5","author":"Fedorov","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib91","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2312374120","article-title":"Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy","volume":"120","author":"Bangayan","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib92","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00003086-199101000-00002","article-title":"The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893","author":"Coley","year":"1991","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.chembiol.2026.04.007_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114085","article-title":"Bacteria and bacterial derivatives as delivery carriers for immunotherapy","volume":"181","author":"Kang","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.chembiol.2026.04.007_bib94","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrc2934","article-title":"Engineering the perfect (bacterial) cancer therapy","volume":"10","author":"Forbes","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2026.04.007_bib95","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1038\/s41467-023-39224-8","article-title":"Bioengineering of bacteria for cancer immunotherapy","volume":"14","author":"Nguyen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib96","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa3519","article-title":"Programmable probiotics for detection of cancer in urine","volume":"7","author":"Danino","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib97","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/s41587-022-01244-y","article-title":"A programmable encapsulation system improves delivery of therapeutic bacteria in mice","volume":"40","author":"Harimoto","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib98","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1128\/jb.177.14.4121-4130.1995","article-title":"Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter","volume":"177","author":"Guzman","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib99","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1158\/0008-5472.CAN-09-3453","article-title":"Genetically engineered Salmonella typhimurium as an imageable therapeutic probe for cancer","volume":"70","author":"Nguyen","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.chembiol.2026.04.007_bib100","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aak9537","article-title":"Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin","volume":"9","author":"Zheng","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib101","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.canlet.2018.06.031","article-title":"Genetically-engineered Salmonella typhimurium expressing TIMP-2 as a therapeutic intervention in an orthotopic glioma mouse model","volume":"433","author":"Wen","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.chembiol.2026.04.007_bib102","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/mt.2013.183","article-title":"Engineering of bacteria for the visualization of targeted delivery of a cytolytic anticancer agent","volume":"21","author":"Jiang","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib103","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1161\/CIRCULATIONAHA.110.963843","article-title":"Aspirin: a historical and contemporary therapeutic overview","volume":"123","author":"Fuster","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.chembiol.2026.04.007_bib104","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nmeth1107","article-title":"In vivo gene regulation in Salmonella spp. by a salicylate-dependent control circuit","volume":"4","author":"Royo","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2026.04.007_bib105","doi-asserted-by":"crossref","first-page":"46351","DOI":"10.1021\/acsami.2c14633","article-title":"Upconversion Optogenetic Engineered Bacteria System for Time-Resolved Imaging Diagnosis and Light-Controlled Cancer Therapy","volume":"14","author":"Zhang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.chembiol.2026.04.007_bib106","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41377-024-01547-6","article-title":"Lanthanide ion-doped upconversion nanoparticles for low-energy super-resolution applications","volume":"13","author":"Lamon","year":"2024","journal-title":"Light Sci. Appl."},{"key":"10.1016\/j.chembiol.2026.04.007_bib107","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwad031","article-title":"Programming the lifestyles of engineered bacteria for cancer therapy","volume":"10","author":"Fu","year":"2023","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.chembiol.2026.04.007_bib108","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s43018-025-00932-3","article-title":"Engineered bacteria for near-infrared light-inducible expression of cancer therapeutics","volume":"6","author":"Qiao","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.chembiol.2026.04.007_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.107915","article-title":"Biofilm control by interfering with c-di-GMP metabolism and signaling","volume":"56","author":"Liu","year":"2022","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.chembiol.2026.04.007_bib110","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.tim.2021.02.003","article-title":"High-specificity local and global c-di-GMP signaling","volume":"29","author":"Hengge","year":"2021","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib111","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1021\/acssynbio.5c00044","article-title":"A Robust and Orthogonal Far-Red Light Sensor for Gene Expression Control in Escherichia coli","volume":"14","author":"Sun","year":"2025","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib112","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1021\/acscentsci.5c01848","article-title":"Red-Light-Only Control of Protein-Protein Interactions Using a Cyanobacteriochrome (UNICYCL)","volume":"12","author":"Le","year":"2026","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.chembiol.2026.04.007_bib113","article-title":"An ultra-low background far-red light-responsive optogenetic tool based on an engineered biliverdin-binding domain","author":"Le","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.chembiol.2026.04.007_bib114","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1021\/acssynbio.4c00388","article-title":"Red Light Responsive Cre Recombinase for Bacterial Optogenetics","volume":"13","author":"Jafarbeglou","year":"2024","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib115","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1021\/acssynbio.5c00142","article-title":"Digitizing the Blue Light-Activated T7 RNA Polymerase System with a tet-Controlled Riboregulator","volume":"14","author":"Baldanta","year":"2025","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib116","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1038\/s41467-022-31932-x","article-title":"Spatiotemporal control of engineered bacteria to express interferon-\u03b3 by focused ultrasound for tumor immunotherapy","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib117","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1038\/s41467-022-29065-2","article-title":"Ultrasound-controllable engineered bacteria for cancer immunotherapy","volume":"13","author":"Abedi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib118","article-title":"An Oral Nanovaccine Secreted by Genetically Engineered and Ultrasound-Responsive Bacteria for Colon Cancer Immunotherapy","volume":"35","author":"Li","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.chembiol.2026.04.007_bib119","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41579-019-0186-5","article-title":"Bacterial quorum sensing in complex and dynamically changing environments","volume":"17","author":"Mukherjee","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib120","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature18930","article-title":"Synchronized cycles of bacterial lysis for in vivo delivery","volume":"536","author":"Din","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.04.007_bib121","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1073\/pnas.1414558112","article-title":"Quorum-sensing Salmonella selectively trigger protein expression within tumors","volume":"112","author":"Swofford","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib122","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41467-024-44776-4","article-title":"Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia","volume":"15","author":"Gurbatri","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib123","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax0876","article-title":"Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies","volume":"12","author":"Gurbatri","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib124","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adn9879","article-title":"Programmable bacteria synergize with PD-1 blockade to overcome cancer cell-intrinsic immune resistance mechanisms","volume":"9","author":"Li","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib125","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ado8395","article-title":"Synthetic biology-driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer","volume":"17","author":"Mi","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib126","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s41591-019-0498-z","article-title":"Programmable bacteria induce durable tumor regression and systemic antitumor immunity","volume":"25","author":"Chowdhury","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib127","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.add7034","article-title":"Probiotic-guided CAR-T cells for solid tumor targeting","volume":"382","author":"Vincent","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib128","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1093\/nar\/gkr1041","article-title":"Identification of tumor-specific Salmonella Typhimurium promoters and their regulatory logic","volume":"40","author":"Leschner","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.chembiol.2026.04.007_bib129","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1038\/s41467-020-16602-0","article-title":"Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity","volume":"11","author":"Leventhal","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib130","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/gt.2008.188","article-title":"Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors","volume":"16","author":"Ryan","year":"2009","journal-title":"Gene Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib131","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13036-021-00269-2","article-title":"Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo","volume":"15","author":"Samadi","year":"2021","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.chembiol.2026.04.007_bib132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omto.2016.12.003","article-title":"Bacterial Carriers for Glioblastoma Therapy","volume":"4","author":"Mehta","year":"2017","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.chembiol.2026.04.007_bib133","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/srep00436","article-title":"Explicit hypoxia targeting with tumor suppression by creating an \u201cobligate\u201d anaerobic Salmonella Typhimurium strain","volume":"2","author":"Yu","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chembiol.2026.04.007_bib134","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1158\/2159-8290.CD-11-0201","article-title":"A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy","volume":"2","author":"Flentie","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2026.04.007_bib135","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202105086","article-title":"Bacteria-Elicited Specific Thrombosis Utilizing Acid-Induced Cytolysin A Expression to Enable Potent Tumor Therapy","volume":"9","author":"Qin","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.chembiol.2026.04.007_bib136","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41551-021-00772-3","article-title":"Enhancing the tropism of bacteria via genetically programmed biosensors","volume":"6","author":"Chien","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.chembiol.2026.04.007_bib137","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1021\/acssynbio.1c00456","article-title":"Engineered l-Lactate Responding Promoter System Operating in Glucose-Rich and Anoxic Environments","volume":"10","author":"Z\u00fa\u00f1iga","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib138","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202406486","article-title":"Self-Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery","volume":"12","author":"Zou","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.chembiol.2026.04.007_bib139","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41522-024-00479-8","article-title":"Enhancing tumor-specific recognition of programmable synthetic bacterial consortium for precision therapy of colorectal cancer","volume":"10","author":"Zhou","year":"2024","journal-title":"npj Biofilms Microbiomes"},{"key":"10.1016\/j.chembiol.2026.04.007_bib140","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nrd4663","article-title":"Oncolytic viruses: a new class of immunotherapy drugs","volume":"14","author":"Kaufman","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.chembiol.2026.04.007_bib141","doi-asserted-by":"crossref","DOI":"10.3390\/v15081645","article-title":"Oncolytic Virus Engineering and Utilizations: Cancer Immunotherapy Perspective","volume":"15","author":"Muthukutty","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.chembiol.2026.04.007_bib142","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13040588","article-title":"Oncolytic Virotherapy in Solid Tumors: The Challenges and Achievements","volume":"13","author":"Jin","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.chembiol.2026.04.007_bib143","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/imm.12509","article-title":"Combined cytotoxic activity of an infectious, but non-replicative herpes simplex virus type 1 and plasmacytoid dendritic cells against tumour cells","volume":"146","author":"Thomann","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.chembiol.2026.04.007_bib144","doi-asserted-by":"crossref","DOI":"10.3390\/ph16050709","article-title":"Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy","volume":"16","author":"Martin","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.chembiol.2026.04.007_bib145","article-title":"Oncolytic cytomegaloviruses expressing EGFR-retargeted fusogenic glycoprotein complex and drug-controllable interleukin 12","volume":"6","author":"Jiang","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib146","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1038\/s41467-023-38651-x","article-title":"Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies","volume":"14","author":"Azad","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib147","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/s41467-021-21630-5","article-title":"Chemogenetic ON and OFF switches for RNA virus replication","volume":"12","author":"Heilmann","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib148","doi-asserted-by":"crossref","first-page":"11587","DOI":"10.1073\/pnas.1906531116","article-title":"Photocontrollable mononegaviruses","volume":"116","author":"Tahara","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib149","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41419-020-02782-6","article-title":"Photoactivatable oncolytic adenovirus for optogenetic cancer therapy","volume":"11","author":"Hagihara","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.chembiol.2026.04.007_bib150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/cgt.2011.67","article-title":"Gene-viro-therapy targeting liver cancer by a dual-regulated oncolytic adenoviral vector harboring IL-24 and TRAIL","volume":"19","author":"Liu","year":"2012","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib151","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/aps.2017.91","article-title":"GOLPH2-regulated oncolytic adenovirus, GD55, exerts strong killing effect on human prostate cancer stem-like cells in vitro and in vivo","volume":"39","author":"Ying","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.chembiol.2026.04.007_bib152","first-page":"1319","article-title":"Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma","volume":"29","author":"Zhu","year":"2006","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib153","doi-asserted-by":"crossref","first-page":"13431","DOI":"10.1111\/jcmm.15966","article-title":"Doxorubicin hydrochloride enhanced antitumour effect of CEA-regulated oncolytic virotherapy in live cancer cells and a mouse model","volume":"24","author":"Xiao","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib154","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.omto.2020.05.015","article-title":"Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression","volume":"18","author":"Tanimoto","year":"2020","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.chembiol.2026.04.007_bib155","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/s41598-018-19300-6","article-title":"A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma","volume":"8","author":"Oh","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.chembiol.2026.04.007_bib156","doi-asserted-by":"crossref","first-page":"6872","DOI":"10.1158\/0008-5472.CAN-06-3244","article-title":"Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4","volume":"67","author":"Post","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.chembiol.2026.04.007_bib157","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12071852","article-title":"A Comprehensive Review of Cancer MicroRNA Therapeutic Delivery Strategies","volume":"12","author":"Forterre","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.chembiol.2026.04.007_bib158","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1158\/1535-7163.MCT-12-0157","article-title":"MicroRNA regulation of oncolytic adenovirus 6 for selective treatment of castration-resistant prostate cancer","volume":"11","author":"Zhang","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib159","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073964","article-title":"Anti-tumor activity of a miR-199-dependent oncolytic adenovirus","volume":"8","author":"Callegari","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2026.04.007_bib160","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/mt.2011.36","article-title":"MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy","volume":"19","author":"Hikichi","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib161","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1158\/1078-0432.CCR-09-0051","article-title":"MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells","volume":"15","author":"Lee","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chembiol.2026.04.007_bib162","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1038\/s41467-019-12794-2","article-title":"Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy","volume":"10","author":"Huang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib163","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ymthe.2006.05.008","article-title":"Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF","volume":"14","author":"Kim","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib164","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.surge.2014.01.001","article-title":"Viral warfare! Front-line defence and arming the immune system against cancer using oncolytic vaccinia and other viruses","volume":"12","author":"Dave","year":"2014","journal-title":"Surgeon"},{"key":"10.1016\/j.chembiol.2026.04.007_bib165","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/mt.2010.26","article-title":"Transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1 for targeting prostate tumors","volume":"18","author":"Lee","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib166","doi-asserted-by":"crossref","first-page":"E4504","DOI":"10.1073\/pnas.1408759111","article-title":"Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers","volume":"111","author":"Lin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib167","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2018.03.035","article-title":"Oncogenic Signaling Pathways in The Cancer Genome Atlas","volume":"173","author":"Sanchez-Vega","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib168","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jbo.2016.12.001","article-title":"Oncolytic adenoviruses as a therapeutic approach for osteosarcoma: A new hope","volume":"9","author":"Garcia-Moure","year":"2017","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib169","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1073\/pnas.89.8.3266","article-title":"The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells","volume":"89","author":"Chou","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib170","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.ymthe.2006.02.007","article-title":"A mutant type 2 herpes simplex virus deleted for the protein kinase domain of the ICP10 gene is a potent oncolytic virus","volume":"13","author":"Fu","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib171","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5662\/wjm.v6.i1.25","article-title":"Clinical development of reovirus for cancer therapy: An oncolytic virus with immune-mediated antitumor activity","volume":"6","author":"Gong","year":"2016","journal-title":"World J. Methodol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib172","article-title":"Rewiring oncogenic signaling to RNA vector replication for the treatment of metastatic cancer","author":"Zou","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.chembiol.2026.04.007_bib173","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/rmv.430","article-title":"Measles virus receptors: SLAM and CD46","volume":"14","author":"Dhiman","year":"2004","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib174","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/cas.13324","article-title":"CD155, an onco-immunologic molecule in human tumors","volume":"108","author":"Gao","year":"2017","journal-title":"Cancer Sci."},{"key":"10.1016\/j.chembiol.2026.04.007_bib175","doi-asserted-by":"crossref","first-page":"10455","DOI":"10.1021\/ac4025522","article-title":"Analysis of compounds that interfere with herpes simplex virus-host receptor interactions using surface plasmon resonance","volume":"85","author":"Gopinath","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.chembiol.2026.04.007_bib176","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/sj.cgt.7700198","article-title":"Targeting of adenoviral vectors through a bispecific single-chain antibody","volume":"7","author":"Haisma","year":"2000","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib177","doi-asserted-by":"crossref","first-page":"E869","DOI":"10.1073\/pnas.1213653110","article-title":"Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters","volume":"110","author":"Dreier","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.04.007_bib178","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41467-017-02707-6","article-title":"Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control","volume":"9","author":"Schmid","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib179","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007209","article-title":"A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors","volume":"14","author":"Leoni","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chembiol.2026.04.007_bib180","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/gt.2010.150","article-title":"CD20-targeted measles virus shows high oncolytic specificity in clinical samples from lymphoma patients independent of prior rituximab therapy","volume":"18","author":"Yaiw","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib181","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41551-025-01476-8","article-title":"Engineered bacteria launch and control an oncolytic virus","volume":"10","author":"Singer","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.chembiol.2026.04.007_bib182","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn2231","article-title":"Oncolytic virus-mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice","volume":"14","author":"Evgin","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib183","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.ccell.2022.08.001","article-title":"Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance","volume":"40","author":"Zheng","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib184","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/s41587-023-02118-7","article-title":"An oncolytic virus-T cell chimera for cancer immunotherapy","volume":"42","author":"Chen","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib185","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1038\/s41467-019-10912-8","article-title":"A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)","volume":"10","author":"Wu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib186","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1038\/s41467-020-19314-7","article-title":"Synthesizing AND gate minigene circuits based on CRISPReader for identification of bladder cancer cells","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib187","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1038\/ncomms6393","article-title":"Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells","volume":"5","author":"Liu","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib188","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.cell.2017.09.049","article-title":"Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy","volume":"171","author":"Nissim","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib189","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1038\/s41467-018-07181-2","article-title":"Synthetic RNA-based logic computation in mammalian cells","volume":"9","author":"Matsuura","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib190","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1038\/s41467-025-60392-2","article-title":"Split RNA switch orchestrates pre- and post-translational control to enable cell type-specific gene expression","volume":"16","author":"Abe","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib191","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41587-022-01534-5","article-title":"Programmable eukaryotic protein synthesis with RNA sensors by harnessing ADAR","volume":"41","author":"Jiang","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib192","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41587-022-01493-x","article-title":"Modular, programmable RNA sensing using ADAR editing in living cells","volume":"41","author":"Kaseniit","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib193","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41586-022-05280-1","article-title":"Programmable RNA sensing for cell monitoring and manipulation","volume":"610","author":"Qian","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.04.007_bib194","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/s41587-022-01224-2","article-title":"Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells","volume":"40","author":"North","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib195","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1021\/acssynbio.0c00612","article-title":"Engineering L7Ae for RNA-Only Delivery Kill Switch Targeting CMS2 Type Colorectal Cancer Cells","volume":"10","author":"Yang","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib196","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1038\/s41467-018-06825-7","article-title":"Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells","volume":"9","author":"Cella","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib197","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.omto.2020.03.008","article-title":"Programmable Synthetic Protein Circuits for the Identification and Suppression of Hepatocellular Carcinoma","volume":"17","author":"Han","year":"2020","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.chembiol.2026.04.007_bib198","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1038\/s41467-018-03984-5","article-title":"Engineering modular intracellular protein sensor-actuator devices","volume":"9","author":"Siciliano","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib199","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1126\/science.aat5062","article-title":"Programmable protein circuits in living cells","volume":"361","author":"Gao","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.04.007_bib200","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1016\/j.cell.2024.03.031","article-title":"Synthetic protein circuits for programmable control of mammalian cell death","volume":"187","author":"Xia","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib201","article-title":"Engineered protein circuits for cancer therapy","author":"Lu","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.chembiol.2026.04.007_bib202","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1158\/2159-8290.CD-20-1808","article-title":"Therapeutic Targeting of the Tumor Microenvironment","volume":"11","author":"Bejarano","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2026.04.007_bib203","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s13205-025-04366-7","article-title":"Advances in viral vector-based delivery systems for gene therapy: a comprehensive review","volume":"15","author":"Singh","year":"2025","journal-title":"3 Biotech"},{"key":"10.1016\/j.chembiol.2026.04.007_bib204","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1080\/21645515.2015.1037058","article-title":"Oncolytic viruses: From bench to bedside with a focus on safety","volume":"11","author":"Buijs","year":"2015","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.chembiol.2026.04.007_bib205","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2022.198924","article-title":"Homologous recombination risk in baculovirus expression vector system","volume":"321","author":"Huang","year":"2022","journal-title":"Virus Res."},{"key":"10.1016\/j.chembiol.2026.04.007_bib206","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/mt.2011.55","article-title":"MicroRNA-sensitive oncolytic measles viruses for cancer-specific vector tropism","volume":"19","author":"Leber","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib207","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3390\/microorganisms13030599","article-title":"Engineering Useful Microbial Species for Pharmaceutical Applications","volume":"13","author":"Sadanov","year":"2025","journal-title":"Microorganisms"},{"key":"10.1016\/j.chembiol.2026.04.007_bib208","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41467-022-28163-5","article-title":"Genetically stable CRISPR-based kill switches for engineered microbes","volume":"13","author":"Rottinghaus","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib209","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ymben.2025.06.009","article-title":"A multilayered biocontainment system for laboratory and probiotic yeast","volume":"91","author":"Maneira","year":"2025","journal-title":"Metab. Eng."},{"key":"10.1016\/j.chembiol.2026.04.007_bib210","doi-asserted-by":"crossref","first-page":"6317","DOI":"10.1016\/j.cell.2025.07.046","article-title":"Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy","volume":"188","author":"Wu","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib211","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41590-023-01687-8","article-title":"A second-generation M1-polarized CAR macrophage with antitumor efficacy","volume":"25","author":"Lei","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib212","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.stem.2024.10.004","article-title":"Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a\/GLP","volume":"32","author":"Jing","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.chembiol.2026.04.007_bib213","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41587-020-0462-y","article-title":"Human chimeric antigen receptor macrophages for cancer immunotherapy","volume":"38","author":"Klichinsky","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib214","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/s43018-025-00940-3","article-title":"Safety and feasibility of 4-1BB co-stimulated CD19-specific CAR-NK cell therapy in refractory\/relapsed large B cell lymphoma: a phase 1 trial","volume":"6","author":"Lei","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.chembiol.2026.04.007_bib215","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/s41556-022-01024-5","article-title":"IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer","volume":"24","author":"Bae","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib216","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41392-024-02028-3","article-title":"Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors","volume":"9","author":"Zhu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.chembiol.2026.04.007_bib217","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz1863","article-title":"Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors","volume":"12","author":"Park","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.chembiol.2026.04.007_bib218","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/s41587-024-02418-6","article-title":"Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responses","volume":"43","author":"Yang","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib219","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1021\/acs.nanolett.2c00699","article-title":"Boarding Oncolytic Viruses onto Tumor-Homing Bacterium-Vessels for Augmented Cancer Immunotherapy","volume":"22","author":"Sun","year":"2022","journal-title":"Nano Lett."},{"key":"10.1016\/j.chembiol.2026.04.007_bib220","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41579-019-0255-9","article-title":"Common principles and best practices for engineering microbiomes","volume":"17","author":"Lawson","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib221","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1038\/s41467-025-65281-2","article-title":"LDBT instead of DBTL: combining machine learning and rapid cell-free testing","volume":"16","author":"Clark-ElSayed","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.04.007_bib222","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1021\/acssynbio.8b00165","article-title":"Predicting Transcriptional Output of Synthetic Multi-input Promoters","volume":"7","author":"Zong","year":"2018","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.chembiol.2026.04.007_bib223","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41588-025-02441-6","article-title":"Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion","volume":"58","author":"DaSilva","year":"2026","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2026.04.007_bib224","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1126\/science.abq0225","article-title":"Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning","volume":"378","author":"Daniels","year":"2022","journal-title":"Science"}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245194562600142X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245194562600142X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:42:20Z","timestamp":1783132940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245194562600142X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":224,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S245194562600142X"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2026.04.007","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Programmable living therapeutics for cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2026.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}