{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:10:50Z","timestamp":1789755050200,"version":"4.0.1"},"reference-count":141,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["project number: 493624519"],"award-info":[{"award-number":["project number: 493624519"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["project number: 523862973"],"award-info":[{"award-number":["project number: 523862973"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 5705"],"award-info":[{"award-number":["FOR 5705"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1648\/1 2024"],"award-info":[{"award-number":["SFB 1648\/1 2024"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["project number: 511556502"],"award-info":[{"award-number":["project number: 511556502"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["project number: 512741711"],"award-info":[{"award-number":["project number: 512741711"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008384","name":"Association of German Science Foundations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008384","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003493","name":"Gemeinn\u00fctzige Hertie-Stiftung","doi-asserted-by":"publisher","award":["project number: P1260014"],"award-info":[{"award-number":["project number: P1260014"]}],"id":[{"id":"10.13039\/501100003493","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.chembiol.2026.08.011","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:06:26Z","timestamp":1789398386000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuronal translational control in physiology, infection, and inflammation"],"prefix":"10.1016","author":[{"given":"Felix","family":"Fischbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike K.","family":"Grosshans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Binkle-Ladisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-2420","authenticated-orcid":false,"given":"Manuel A.","family":"Friese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2026.08.011_bib1","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/s41418-021-00814-y","article-title":"Molecular mechanisms of cell death in neurological diseases","volume":"28","author":"Moujalled","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.chembiol.2026.08.011_bib2","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113929118","article-title":"The translatome of neuronal cell bodies, dendrites, and axons","volume":"118","author":"Glock","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.08.011_bib3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41594-019-0263-5","article-title":"Local translation in neurons: visualization and function","volume":"26","author":"Holt","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cell.2006.09.014","article-title":"Dendritic Protein Synthesis, Synaptic Plasticity, and Memory","volume":"127","author":"Sutton","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib5","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.neuron.2013.10.036","article-title":"The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons","volume":"80","author":"Holt","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.chembiol.2026.08.011_bib6","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41593-024-01615-5","article-title":"Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding","volume":"27","author":"Hacisuleyman","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chembiol.2026.08.011_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41586-023-06812-z","article-title":"A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain","volume":"624","author":"Yao","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.08.011_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/science.add3067","article-title":"Spatially resolved single-cell translatomics at molecular resolution","volume":"380","author":"Zeng","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib9","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1126\/science.abb5317","article-title":"Structural basis of transcription-translation coupling","volume":"369","author":"Wang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1126\/science.aal3059","article-title":"Architecture of a transcribing-translating expressome","volume":"356","author":"Kohler","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanh\u00e4usser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.08.011_bib12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the Dependency of Cellular Protein Levels on mRNA Abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib13","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1126\/science.aad9868","article-title":"Translational control by 5\u2032-untranslated regions of eukaryotic mRNAs","volume":"352","author":"Hinnebusch","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.molcel.2005.09.008","article-title":"Pi Release from eIF2, Not GTP Hydrolysis, Is the Step Controlled by Start-Site Selection during Eukaryotic Translation Initiation","volume":"20","author":"Algire","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1126\/science.aaw4104","article-title":"Structural basis for eIF2B inhibition in integrated stress response","volume":"364","author":"Kashiwagi","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46976","article-title":"HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis","volume":"8","author":"Zhang","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.chembiol.2026.08.011_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: From mechanism to disease","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib18","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.biochi.2007.03.001","article-title":"The dsRNA protein kinase PKR: Virus and cell control","volume":"89","author":"Garc\u00eda","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.chembiol.2026.08.011_bib19","doi-asserted-by":"crossref","first-page":"6365","DOI":"10.1111\/febs.15691","article-title":"A tale of two proteins: PACT and PKR and their roles in inflammation","volume":"288","author":"Chukwurah","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.chembiol.2026.08.011_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.08.011_bib21","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1073\/pnas.1217611110","article-title":"Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains","volume":"110","author":"Volmer","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.08.011_bib22","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14295","article-title":"Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation","volume":"5","author":"Ishimura","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.chembiol.2026.08.011_bib23","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib24","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1074\/jbc.M110.216093","article-title":"Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation","volume":"286","author":"Palam","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.08.011_bib25","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.1074\/jbc.M806735200","article-title":"An Upstream Open Reading Frame Regulates Translation of GADD34 during Cellular Stresses That Induce eIF2\u03b1 Phosphorylation","volume":"284","author":"Lee","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.08.011_bib26","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1083\/jcb.200308075","article-title":"Inhibition of a constitutive translation initiation factor 2\u03b1 phosphatase, CReP , promotes survival of stressed cells","volume":"163","author":"Jousse","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib27","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1083\/jcb.153.5.1011","article-title":"Feedback Inhibition of the Unfolded Protein Response by GADD34 -Mediated Dephosphorylation of eIF2\u03b1","volume":"153","author":"Novoa","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib28","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1038\/s41467-019-10167-3","article-title":"The structural basis of translational control by eIF2 phosphorylation","volume":"10","author":"Adomavicius","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.08.011_bib29","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S1097-2765(01)00265-9","article-title":"Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis","volume":"7","author":"Scheuner","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib30","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1073\/pnas.0809632106","article-title":"Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2\u03b1) dephosphorylation in mammalian development","volume":"106","author":"Harding","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.08.011_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ng764","article-title":"Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter","volume":"29","author":"Leegwater","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chembiol.2026.08.011_bib32","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/acn3.50826","article-title":"Vanishing white matter: deregulated integrated stress response as therapy target","volume":"6","author":"Abbink","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib33","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1212\/WNL.48.4.845","article-title":"A new leukoencephalopathy with vanishing white matter","volume":"48","author":"Van Der Knaap","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.chembiol.2026.08.011_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42940","article-title":"eIF2B activator prevents neurological defects caused by a chronic integrated stress response","volume":"8","author":"Wong","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.chembiol.2026.08.011_bib35","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/bies.201600052","article-title":"Peripheral neuropathy via mutant tRNA synthetases: Inhibition of protein translation provides a possible explanation","volume":"38","author":"Storkebaum","year":"2016","journal-title":"Bioessays"},{"key":"10.1016\/j.chembiol.2026.08.011_bib36","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.abb3414","article-title":"The integrated stress response contributes to tRNA synthetase\u2013associated peripheral neuropathy","volume":"373","author":"Spaulding","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib37","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.abb3356","article-title":"tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase","volume":"373","author":"Zuko","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib38","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1111\/bph.70154","article-title":"GCN2 regulates paclitaxel-induced neuropathic pain","volume":"182","author":"Mikesell","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib39","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1097\/j.pain.0000000000003761","article-title":"Translational control by general control nonderepressible 2 kinase regulates methylglyoxal-induced pain in mice","volume":"166","author":"Meyer","year":"2025","journal-title":"Pain"},{"key":"10.1016\/j.chembiol.2026.08.011_bib40","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.molcel.2024.11.023","article-title":"eEF2K regulates pain through translational control of BDNF","volume":"85","author":"Smith","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib41","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/s41593-022-01164-9","article-title":"Developmental dynamics of RNA translation in the human brain","volume":"25","author":"Duffy","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chembiol.2026.08.011_bib42","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1038\/s41467-024-49198-w","article-title":"Protein translation rate determines neocortical neuron fate","volume":"15","author":"Borisova","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.08.011_bib43","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.cell.2010.04.008","article-title":"Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation","volume":"141","author":"Tcherkezian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe1931","article-title":"Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice","volume":"372","author":"Helseth","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuron.2008.10.055","article-title":"Translational Control of Long-Lasting Synaptic Plasticity and Memory","volume":"61","author":"Costa-Mattioli","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.chembiol.2026.08.011_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau3644","article-title":"Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments","volume":"364","author":"Hafner","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib47","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41586-020-2805-8","article-title":"eIF2\u03b1 controls memory consolidation via excitatory and somatostatin neurons","volume":"586","author":"Sharma","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.08.011_bib48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cell.2007.01.050","article-title":"eIF2\u03b1 Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory","volume":"129","author":"Costa-Mattioli","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib49","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nn.3754","article-title":"Translational control of mGluR-dependent long-term depression and object-place learning by eIF2\u03b1","volume":"17","author":"Di Prisco","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chembiol.2026.08.011_bib50","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12052","article-title":"Translational control by eIF2\u03b1 phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine","volume":"5","author":"Huang","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.chembiol.2026.08.011_bib51","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1016\/j.neuron.2023.06.017","article-title":"Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome","volume":"111","author":"Hooshmandi","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.chembiol.2026.08.011_bib52","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1523\/JNEUROSCI.3971-09.2010","article-title":"eIF2\u03b1 Phosphorylation-Dependent Translation in CA1 Pyramidal Cells Impairs Hippocampal Memory Consolidation without Affecting General Translation","volume":"30","author":"Jiang","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.chembiol.2026.08.011_bib53","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.cell.2011.11.029","article-title":"Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-\u03b3-Mediated Disinhibition","volume":"147","author":"Zhu","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/jnc.14306","article-title":"Genetic removal of eIF 2\u03b1 kinase PERK in mice enables hippocampal L- LTP independent of mTORC 1 activity","volume":"146","author":"Zimmermann","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.chembiol.2026.08.011_bib55","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/nature03897","article-title":"Translational control of hippocampal synaptic plasticity and memory by the eIF2\u03b1 kinase GCN2","volume":"436","author":"Costa-Mattioli","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.08.011_bib56","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2407472121","article-title":"The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner","volume":"121","author":"Mahmood","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.08.011_bib57","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0896-6273(03)00501-4","article-title":"Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C\/EBP proteins","volume":"39","author":"Chen","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.chembiol.2026.08.011_bib58","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2532796123","article-title":"The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior","volume":"123","author":"Mahmood","year":"2026","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.08.011_bib59","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1128\/JVI.00489-06","article-title":"PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons","volume":"80","author":"Samuel","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib60","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/sj.emboj.7601073","article-title":"Antiviral effect of the mammalian translation initiation factor 2\u03b1 kinase GCN2 against RNA viruses","volume":"25","author":"Berlanga","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.chembiol.2026.08.011_bib61","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1743-422X-11-62","article-title":"Activation of the PKR\/eIF2\u03b1 signaling cascade inhibits replication of Newcastle disease virus","volume":"11","author":"Zhang","year":"2014","journal-title":"Virol. J."},{"key":"10.1016\/j.chembiol.2026.08.011_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/science.aea8782","article-title":"Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response","volume":"392","author":"Reineke","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib63","doi-asserted-by":"crossref","first-page":"8884","DOI":"10.1128\/JVI.00792-11","article-title":"Poliovirus Switches to an eIF2-Independent Mode of Translation during Infection","volume":"85","author":"White","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib64","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0092-8674(90)90374-N","article-title":"Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon","volume":"62","author":"Meurs","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib65","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.cell.2005.06.041","article-title":"Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2\u03b1 Substrate Recognition","volume":"122","author":"Dey","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib66","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2005.06.044","article-title":"Higher-Order Substrate Recognition of eIF2\u03b1 by the RNA-Dependent Protein Kinase PKR","volume":"122","author":"Dar","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib67","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41467-023-36445-9","article-title":"APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection","volume":"14","author":"Manjunath","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.08.011_bib68","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1083\/jcb.147.7.1431","article-title":"RNA-Binding Proteins Tia-1 and Tiar Link the Phosphorylation of Eif-2\u03b1 to the Assembly of Mammalian Stress Granules","volume":"147","author":"Kedersha","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib69","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/MCB.20.4.1278-1290.2000","article-title":"NF-\u03baB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-\u03baB-Inducing Kinase and I\u03baB Kinase","volume":"20","author":"Zamanian-Daryoush","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib70","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.chom.2010.04.007","article-title":"Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity","volume":"7","author":"Schulz","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.chembiol.2026.08.011_bib71","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1128\/JVI.80.10.5059-5064.2006","article-title":"Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses","volume":"80","author":"Weber","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib72","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.virol.2011.08.008","article-title":"West Nile virus infection does not induce PKR activation in rodent cells","volume":"421","author":"Elbahesh","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.chembiol.2026.08.011_bib73","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.virol.2003.08.010","article-title":"The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis","volume":"317","author":"Scheuner","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.chembiol.2026.08.011_bib74","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1128\/JVI.01151-07","article-title":"West Nile Virus Infection Activates the Unfolded Protein Response, Leading to CHOP Induction and Apoptosis","volume":"81","author":"Medigeshi","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib75","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/ars.2022.0123","article-title":"Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response","volume":"39","author":"Wek","year":"2023","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.chembiol.2026.08.011_bib76","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00887-19","article-title":"Japanese Encephalitis Virus Induces Apoptosis and Encephalitis by Activating the PERK Pathway","volume":"93","author":"Wang","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib77","doi-asserted-by":"crossref","first-page":"8084","DOI":"10.1007\/s12035-025-04748-1","article-title":"PARP-16 regulates the PERK and IRE-1\u03b1 Mediated Unfolded Protein Response in Japanese Encephalitis Virus\u2013Infected Neural Stem\/Progenitor Cells","volume":"62","author":"Sharma","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib78","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41593-017-0038-4","article-title":"Stress-induced unfolded protein response contributes to Zika virus\u2013associated microcephaly","volume":"21","author":"Gladwyn-Ng","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chembiol.2026.08.011_bib79","doi-asserted-by":"crossref","DOI":"10.1126\/science.ads8728","article-title":"GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling","volume":"390","author":"Zhou","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib80","doi-asserted-by":"crossref","first-page":"16514","DOI":"10.1074\/jbc.M414566200","article-title":"Polyribosome Binding by GCN1 Is Required for Full Activation of Eukaryotic Translation Initiation Factor 2\u03b1 Kinase GCN2 during Amino Acid Starvation","volume":"280","author":"Sattlegger","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.08.011_bib81","doi-asserted-by":"crossref","first-page":"10347","DOI":"10.1128\/JVI.00525-12","article-title":"Blocking Double-Stranded RNA-Activated Protein Kinase PKR by Japanese Encephalitis Virus Nonstructural Protein 2A","volume":"86","author":"Tu","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib82","doi-asserted-by":"crossref","first-page":"14226","DOI":"10.1074\/jbc.M111.222703","article-title":"Dengue Virus Modulates the Unfolded Protein Response in a Time-dependent Manner","volume":"286","author":"Pe\u00f1a","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.08.011_bib83","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1128\/JVI.79.3.1379-1388.2005","article-title":"Herpes Simplex Virus 1 Infection Activates the Endoplasmic Reticulum Resident Kinase PERK and Mediates eIF-2\u03b1 Dephosphorylation by the \u03b31 34.5 Protein","volume":"79","author":"Cheng","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib84","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1038\/s41467-021-26164-4","article-title":"Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B","volume":"12","author":"Schoof","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.08.011_bib85","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41583-024-00823-z","article-title":"The neuropathobiology of multiple sclerosis","volume":"25","author":"Woo","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.chembiol.2026.08.011_bib86","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41593-019-0385-4","article-title":"Bassoon proteinopathy drives neurodegeneration in multiple sclerosis","volume":"22","author":"Schattling","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chembiol.2026.08.011_bib87","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1177\/1352458512438455","article-title":"Increased expression of ER stress- and hypoxia-associated molecules in grey matter lesions in multiple sclerosis","volume":"18","author":"McMahon","year":"2012","journal-title":"Mult. Scler."},{"key":"10.1016\/j.chembiol.2026.08.011_bib88","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/NEN.0b013e318165b239","article-title":"Increased Expression of Endoplasmic Reticulum Stress-Related Signaling Pathway Molecules in Multiple Sclerosis Lesions","volume":"67","author":"Mh\u00e1ille","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib89","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/2051-5960-1-37","article-title":"Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination","volume":"1","author":"N\u00ed Fhlathartaigh","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.chembiol.2026.08.011_bib90","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124232","article-title":"Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis","volume":"4","author":"Stone","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.chembiol.2026.08.011_bib91","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","volume":"15","author":"Dendrou","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib92","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1128\/MCB.00980-14","article-title":"PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation","volume":"34","author":"Meares","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib93","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.embor.7400891","article-title":"Interferons induce tyrosine phosphorylation of the eIF2\u03b1 kinase PKR through activation of Jak1 and Tyk2","volume":"8","author":"Su","year":"2007","journal-title":"EMBO Rep."},{"key":"10.1016\/j.chembiol.2026.08.011_bib94","doi-asserted-by":"crossref","first-page":"9934","DOI":"10.1128\/JVI.72.12.9934-9939.1998","article-title":"Mechanism of Interferon Action: Identification of Essential Positions within the Novel 15-Base-Pair KCS Element Required for Transcriptional Activation of the RNA-Dependent Protein Kinase pkr Gene","volume":"72","author":"Kuhen","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib95","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(02)00616-5","article-title":"Human Interferon-\u03b3 mRNA Autoregulates Its Translation through a Pseudoknot that Activates the Interferon-Inducible Protein Kinase PKR","volume":"108","author":"Ben-Asouli","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib96","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nchembio.234","article-title":"Dynamic refolding of IFN-\u03b3 mRNA enables it to function as PKR activator and translation template","volume":"5","author":"Cohen-Chalamish","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib97","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002708","article-title":"Induction of GADD34 Is Necessary for dsRNA-Dependent Interferon-\u03b2 Production and Participates in the Control of Chikungunya Virus Infection","volume":"8","author":"Clavarino","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.chembiol.2026.08.011_bib98","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.08.011_bib99","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2005.11.040","article-title":"Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response","volume":"124","author":"Zhang","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib100","doi-asserted-by":"crossref","first-page":"33917","DOI":"10.1074\/jbc.M505818200","article-title":"Tumor Necrosis Factor \u03b1 (TNF\u03b1) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNF\u03b1","volume":"280","author":"Xue","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.08.011_bib101","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.200502086","article-title":"Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-\u03b3","volume":"169","author":"Lin","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib102","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1002\/glia.70067","article-title":"Endoplasmic Reticulum Stress Amplifies Cytokine Responses in Astrocytes via a PERK\/eIF2\u03b1\/JAK1 Signaling Axis","volume":"73","author":"Lahiri","year":"2025","journal-title":"Glia"},{"key":"10.1016\/j.chembiol.2026.08.011_bib103","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2337\/db13-0757","article-title":"Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages","volume":"63","author":"Iwasaki","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.chembiol.2026.08.011_bib104","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.1128\/MCB.24.23.10161-10168.2004","article-title":"Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2","volume":"24","author":"Deng","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045078","article-title":"ER Stress Activates NF-\u03baB by Integrating Functions of Basal IKK Activity, IRE1 and PERK","volume":"7","author":"Tam","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2026.08.011_bib106","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41590-025-02406-1","article-title":"A GDF-15\u2013GFRAL axis controls autoimmune T cell responses during neuroinflammation","volume":"27","author":"Sonner","year":"2026","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115639","article-title":"Regulation of translation elongation and integrated stress response in heat-shocked neurons","volume":"44","author":"Seluzicki","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.chembiol.2026.08.011_bib108","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021110501","article-title":"Neuron-specific translational control shift ensures proteostatic resilience during ER stress","volume":"41","author":"Wolzak","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.chembiol.2026.08.011_bib109","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41467-024-55576-1","article-title":"Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors","volume":"16","author":"Shekhar","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.08.011_bib110","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1261\/rna.066563.118","article-title":"EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response","volume":"24","author":"Moon","year":"2018","journal-title":"RNA"},{"key":"10.1016\/j.chembiol.2026.08.011_bib111","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13024-025-00811-6","article-title":"The integrated stress response in neurodegenerative diseases","volume":"20","author":"Bravo-Jimenez","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.chembiol.2026.08.011_bib112","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1474-4422(12)70238-7","article-title":"Endoplasmic reticulum dysfunction in neurological disease","volume":"12","author":"Roussel","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib113","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00401-005-1038-0","article-title":"The unfolded protein response is activated in Alzheimer\u2019s disease","volume":"110","author":"Hoozemans","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib114","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2353\/ajpath.2009.080814","article-title":"The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer\u2019s Disease Hippocampus","volume":"174","author":"Hoozemans","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib115","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.neurobiolaging.2014.04.031","article-title":"PERK mediates eIF2\u03b1 phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer\u2019s disease","volume":"35","author":"Devi","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.chembiol.2026.08.011_bib116","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nn.3486","article-title":"Suppression of eIF2\u03b1 kinases alleviates Alzheimer\u2019s disease\u2013related plasticity and memory deficits","volume":"16","author":"Ma","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chembiol.2026.08.011_bib117","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbrc.2007.01.043","article-title":"Activation of the unfolded protein response in Parkinson\u2019s disease","volume":"354","author":"Hoozemans","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.chembiol.2026.08.011_bib118","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1471-4159.2010.07143.x","article-title":"Induction of the unfolded protein response by \u03b1-synuclein in experimental models of Parkinson\u2019s disease: \u03b1-Synuclein accumulation induces the UPR","volume":"116","author":"Bellucci","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.chembiol.2026.08.011_bib119","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1093\/brain\/awm190","article-title":"Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis","volume":"130","author":"Ilieva","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.chembiol.2026.08.011_bib120","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1101\/gad.1640108","article-title":"ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1","volume":"22","author":"Nishitoh","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.chembiol.2026.08.011_bib121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081170","article-title":"ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation","volume":"8","author":"Walker","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2026.08.011_bib122","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.neurobiolaging.2007.02.023","article-title":"Double stranded RNA activated EIF2 \u03b1 kinase (EIF2AK2; PKR) is associated with Alzheimer\u2019s disease","volume":"29","author":"Bullido","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.chembiol.2026.08.011_bib123","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/bpa.12883","article-title":"PKR kinase directly regulates tau expression and Alzheimer\u2019s disease-related tau phosphorylation","volume":"31","author":"Reimer","year":"2021","journal-title":"Brain Pathol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib124","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12887","article-title":"PKR knockout in the 5xFAD model of Alzheimer\u2019s disease reveals beneficial effects on spatial memory and brain lesions","volume":"18","author":"Tible","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.chembiol.2026.08.011_bib125","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85902","article-title":"Antisense, but not sense, repeat expanded RNAs activate PKR\/eIF2\u03b1-dependent ISR in C9ORF72 FTD\/ALS","volume":"12","author":"Parameswaran","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.chembiol.2026.08.011_bib126","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077335","article-title":"Deletion of the eIF2\u03b1 Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer\u2019s Disease","volume":"8","author":"Devi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.chembiol.2026.08.011_bib127","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw4144","article-title":"The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling","volume":"365","author":"Abdel-Nour","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.chembiol.2026.08.011_bib128","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.014415","article-title":"The eIF2\u03b1 kinase HRI triggers the autophagic clearance of cytosolic protein aggregates","volume":"296","author":"Mukherjee","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.08.011_bib129","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/brain\/awad340","article-title":"Sustained OMA1-mediated integrated stress response is beneficial for spastic ataxia type 5","volume":"147","author":"Franchino","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.chembiol.2026.08.011_bib130","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.neuron.2024.11.018","article-title":"A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion","volume":"113","author":"Flury","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.chembiol.2026.08.011_bib131","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41419-020-2601-2","article-title":"Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis","volume":"11","author":"Bugallo","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.chembiol.2026.08.011_bib132","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abc5429","article-title":"Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer\u2019s disease","volume":"14","author":"Oliveira","year":"2021","journal-title":"Sci. Signal."},{"key":"10.1016\/j.chembiol.2026.08.011_bib133","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40035-024-00441-w","article-title":"GCN2 inhibition reduces mutant SOD1 clustering and toxicity and delays disease progression in an amyotrophic lateral sclerosis mouse model","volume":"13","author":"Ortiz","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.chembiol.2026.08.011_bib134","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00401-015-1487-z","article-title":"PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia","volume":"130","author":"Radford","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.chembiol.2026.08.011_bib135","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/s41467-025-68045-0","article-title":"Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival","volume":"17","author":"Chen","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.08.011_bib136","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1038\/s41467-025-63031-y","article-title":"Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial","volume":"16","author":"Flores","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.08.011_bib137","doi-asserted-by":"crossref","first-page":"371","DOI":"10.15252\/emmm.201606664","article-title":"PERK activation mitigates tau pathology in vitro and in vivo","volume":"9","author":"Bruch","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.chembiol.2026.08.011_bib138","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/brain\/awy322","article-title":"Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis","volume":"142","author":"Chen","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.chembiol.2026.08.011_bib139","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nn.2297","article-title":"A role for motoneuron subtype\u2013selective ER stress in disease manifestations of FALS mice","volume":"12","author":"Saxena","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.chembiol.2026.08.011_bib140","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/glia.24386","article-title":"Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response","volume":"71","author":"Chen","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.chembiol.2026.08.011_bib141","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/nn.4593","article-title":"Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems","volume":"20","author":"Chan","year":"2017","journal-title":"Nat. Neurosci."}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945626003211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451945626003211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:46:08Z","timestamp":1789753568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451945626003211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":141,"alternative-id":["S2451945626003211"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2026.08.011","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuronal translational control in physiology, infection, and inflammation","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2026.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}