{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:52:03Z","timestamp":1791503523815,"version":"4.3.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177101"],"award-info":[{"award-number":["22177101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Chemical Biology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.chembiol.2026.09.006","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:54:22Z","timestamp":1791384862000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting ZDHHC15-mediated S-acylation of CD155 reactivates anti-tumor immunity"],"prefix":"10.1016","author":[{"given":"Xuanpu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bokan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziye","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinglong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4959-7023","authenticated-orcid":false,"given":"Baoen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chembiol.2026.09.006_bib1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrm2457","article-title":"Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation","volume":"9","author":"Takai","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.semcancer.2019.11.013","article-title":"Tumor intrinsic and extrinsic immune functions of CD155","volume":"65","author":"O\u2019Donnell","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2017.09.001","article-title":"Poliovirus Receptor: More than a simple viral receptor","volume":"242","author":"Bowers","year":"2017","journal-title":"Virus Res."},{"key":"10.1016\/j.chembiol.2026.09.006_bib4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/gut.49.2.236","article-title":"Overexpression of the CD155 gene in human colorectal carcinoma","volume":"49","author":"Masson","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.chembiol.2026.09.006_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3948928","article-title":"Overexpression of an Immune Checkpoint (CD155) in Breast Cancer Associated with Prognostic Significance and Exhausted Tumor-Infiltrating Lymphocytes: A Cohort Study","volume":"2020","author":"Li","year":"2020","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.chembiol.2026.09.006_bib6","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.ccell.2021.07.007","article-title":"The CD155\/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer","volume":"39","author":"Freed-Pastor","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chembiol.2026.09.006_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.immuni.2022.12.010","article-title":"T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis","volume":"56","author":"Briukhovetska","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.chembiol.2026.09.006_bib8","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.ccell.2024.10.008","article-title":"Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy","volume":"42","author":"Yang","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.chembiol.2026.09.006_bib9","doi-asserted-by":"crossref","DOI":"10.1172\/JCI189920","article-title":"CAR-T cells targeting CD155 reduce tumor burden in preclinical models of leukemia and solid tumors","volume":"135","author":"Xiong","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.chembiol.2026.09.006_bib10","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s43018-025-00963-w","article-title":"MCSP(+) metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization","volume":"6","author":"Guetter","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.chembiol.2026.09.006_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/jcmm.13301","article-title":"CD155 knockdown promotes apoptosis via AKT\/Bcl-2\/Bax in colon cancer cells","volume":"22","author":"Zheng","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.chembiol.2026.09.006_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/path.2431","article-title":"Role of Necl-5 in the pathophysiology of colorectal lesions induced by dimethylhydrazine and\/or dextran sodium sulphate","volume":"217","author":"Abe","year":"2009","journal-title":"J. Pathol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/cas.14276","article-title":"CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer","volume":"111","author":"Zheng","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.chembiol.2026.09.006_bib14","first-page":"5966","article-title":"Poliovirus receptor inhibition in breast cancer cells induces antitumor immunity via T cell activation","volume":"13","author":"Song","year":"2023","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.chembiol.2026.09.006_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108884","article-title":"CD155 expression and its prognostic value in postoperative patients with breast cancer","volume":"115","author":"Yong","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.chembiol.2026.09.006_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116543","article-title":"CD155 expression in human breast cancer: Clinical significance and relevance to natural killer cell infiltration","volume":"231","author":"Triki","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.chembiol.2026.09.006_bib17","article-title":"CD155 Overexpression Correlates With Poor Prognosis in Primary Small Cell Carcinoma of the Esophagus","volume":"7","author":"Zhao","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.chembiol.2026.09.006_bib18","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.3892\/ol.2013.1280","article-title":"Prognostic significance of CD155 mRNA expression in soft tissue sarcomas","volume":"5","author":"Atsumi","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.chembiol.2026.09.006_bib19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1084\/jem.20030788","article-title":"Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule","volume":"198","author":"Bottino","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.chembiol.2026.09.006_bib20","doi-asserted-by":"crossref","first-page":"17858","DOI":"10.1073\/pnas.0903474106","article-title":"The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity","volume":"106","author":"Stanietsky","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.09.006_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/imr.12518","article-title":"TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy","volume":"276","author":"Dougall","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.chembiol.2026.09.006_bib22","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.4049\/jimmunol.172.7.3994","article-title":"Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)","volume":"172","author":"Fuchs","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ni.2850","article-title":"The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions","volume":"15","author":"Chan","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/cei.13407","article-title":"TIGIT as an emerging immune checkpoint","volume":"200","author":"Harjunp\u00e4\u00e4","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib25","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1158\/2159-8290.CD-15-0944","article-title":"Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy","volume":"6","author":"Blake","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.chembiol.2026.09.006_bib26","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1158\/1078-0432.CCR-19-3925","article-title":"Tumor CD155 Expression Is Associated with Resistance to Anti-PD1 Immunotherapy in Metastatic Melanoma","volume":"26","author":"Lepletier","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.chembiol.2026.09.006_bib27","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.immuni.2020.09.010","article-title":"CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8(+) T Cells","volume":"53","author":"Braun","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.chembiol.2026.09.006_bib28","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.cell.2023.12.015","article-title":"Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death","volume":"187","author":"Li","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.09.006_bib29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrm1400","article-title":"Modulation of signalling by Sprouty: a developing story","volume":"5","author":"Kim","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib30","doi-asserted-by":"crossref","first-page":"36419","DOI":"10.1074\/jbc.M406340200","article-title":"Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5\/Tage4\/poliovirus receptor\/CD155 through the Ras-Raf-MEK-ERK signaling","volume":"279","author":"Kakunaga","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.09.006_bib31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2443.2007.01062.x","article-title":"Regulation of platelet-derived growth factor-induced Ras signaling by poliovirus receptor Necl-5 and negative growth regulator Sprouty2","volume":"12","author":"Kajita","year":"2007","journal-title":"Genes Cells"},{"key":"10.1016\/j.chembiol.2026.09.006_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111896","article-title":"CD155 as an emerging target in tumor immunotherapy","volume":"131","author":"Wu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrm2084","article-title":"Palmitoylation: policing protein stability and traffic","volume":"8","author":"Linder","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib34","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41580-024-00700-8","article-title":"Mechanisms and functions of protein S-acylation","volume":"25","author":"Mesquita","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.plipres.2016.05.002","article-title":"Fatty acylation of proteins: The long and the short of it","volume":"63","author":"Resh","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.chembiol.2026.09.006_bib36","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41568-024-00666-x","article-title":"Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets","volume":"24","author":"Tate","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.chembiol.2026.09.006_bib37","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1021\/acs.chemrev.6b00750","article-title":"Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies","volume":"118","author":"Jiang","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.chembiol.2026.09.006_bib38","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.chembiol.2018.05.003","article-title":"Protein Lipidation in Cell Signaling and Diseases: Function, Regulation, and Therapeutic Opportunities","volume":"25","author":"Chen","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202300071","article-title":"Small-Molecule Modulation of Protein Lipidation: From Chemical Probes to Therapeutics","volume":"24","author":"Wang","year":"2023","journal-title":"Chembiochem"},{"key":"10.1016\/j.chembiol.2026.09.006_bib40","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1021\/ja502109n","article-title":"Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells","volume":"137","author":"Peng","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.chembiol.2026.09.006_bib41","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1021\/acs.jproteome.8b00002","article-title":"Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites","volume":"17","author":"Thinon","year":"2018","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.chembiol.2026.09.006_bib42","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s42003-020-1063-5","article-title":"Dynamic palmitoylation events following T-cell receptor signaling","volume":"3","author":"Morrison","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib43","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2400569121","article-title":"Stearoylation cycle regulates the cell surface distribution of the PCP protein Vangl2","volume":"121","author":"Ying","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.09.006_bib44","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1073\/pnas.1602244113","article-title":"Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation","volume":"113","author":"Percher","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.09.006_bib45","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1021\/cb400380s","article-title":"Profiling targets of the irreversible palmitoylation inhibitor 2-bromopalmitate","volume":"8","author":"Davda","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib46","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cbpa.2021.07.002","article-title":"Inhibitors of DHHC family proteins","volume":"65","author":"Lan","year":"2021","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib47","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11306","article-title":"ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization","volume":"4","author":"Lin","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.chembiol.2026.09.006_bib48","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.1523\/JNEUROSCI.0419-16.2016","article-title":"Identification of PSD-95 Depalmitoylating Enzymes","volume":"36","author":"Yokoi","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.chembiol.2026.09.006_bib49","doi-asserted-by":"crossref","first-page":"43678","DOI":"10.18632\/oncotarget.18435","article-title":"Biological specificity of CDK4\/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature","volume":"8","author":"Knudsen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.chembiol.2026.09.006_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb2210","article-title":"Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4\/6 inhibition","volume":"6","author":"Fassl","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.chembiol.2026.09.006_bib51","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1038\/s41467-025-58552-5","article-title":"Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion","volume":"16","author":"Yan","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.09.006_bib52","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10549-017-4385-3","article-title":"Cyclin-dependent kinase 4\/6 inhibitors in breast cancer: palbociclib, ribociclib, and abemaciclib","volume":"166","author":"Kwapisz","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.chembiol.2026.09.006_bib53","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/ncb867","article-title":"Sprouty1 and Sprouty2 provide a control mechanism for the Ras\/MAPK signalling pathway","volume":"4","author":"Hanafusa","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib54","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jhep.2012.04.026","article-title":"Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways","volume":"57","author":"Wang","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib55","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ijc.23080","article-title":"The CD155\/poliovirus receptor enhances the proliferation of ras-mutated cells","volume":"122","author":"Kono","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.chembiol.2026.09.006_bib56","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2407-4-73","article-title":"CD155\/PVR plays a key role in cell motility during tumor cell invasion and migration","volume":"4","author":"Sloan","year":"2004","journal-title":"BMC Cancer"},{"key":"10.1016\/j.chembiol.2026.09.006_bib57","doi-asserted-by":"crossref","first-page":"18015","DOI":"10.1074\/jbc.M312969200","article-title":"Nectin-like molecule-5\/Tage4 enhances cell migration in an integrin-dependent, Nectin-3-independent manner","volume":"279","author":"Ikeda","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.09.006_bib58","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature20791","article-title":"Targeting metastasis-initiating cells through the fatty acid receptor CD36","volume":"541","author":"Pascual","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.09.006_bib59","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41586-021-04075-0","article-title":"Dietary palmitic acid promotes a prometastatic memory via Schwann cells","volume":"599","author":"Pascual","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.chembiol.2026.09.006_bib60","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s43018-023-00513-2","article-title":"A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-kappaB signaling","volume":"4","author":"Altea-Manzano","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.chembiol.2026.09.006_bib61","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.cell.2020.11.009","article-title":"Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity","volume":"183","author":"Ringel","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.09.006_bib62","doi-asserted-by":"crossref","first-page":"7236","DOI":"10.1074\/jbc.M111.337246","article-title":"DHHC protein S-acyltransferases use similar ping-pong kinetic mechanisms but display different acyl-CoA specificities","volume":"287","author":"Jennings","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.09.006_bib63","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1186\/s12885-023-10883-6","article-title":"ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.chembiol.2026.09.006_bib64","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2011.11.013","article-title":"alphabeta T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities","volume":"36","author":"Tikhonova","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.chembiol.2026.09.006_bib65","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.cell.2013.08.009","article-title":"Lck availability during thymic selection determines the recognition specificity of the T cell repertoire","volume":"154","author":"Van Laethem","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.chembiol.2026.09.006_bib66","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nchembio.405","article-title":"Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3","volume":"6","author":"Yount","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib67","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2119761119","article-title":"Posttranslational modifications optimize the ability of SARS-CoV-2 spike for effective interaction with host cell receptors","volume":"119","author":"Kapoor","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.09.006_bib68","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41551-019-0375-6","article-title":"Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours","volume":"3","author":"Yao","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.chembiol.2026.09.006_bib69","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.immuni.2006.03.011","article-title":"Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect","volume":"24","author":"Hundt","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.chembiol.2026.09.006_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-387664-5.00001-7","article-title":"Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy","volume":"109","author":"Ladygina","year":"2011","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.chembiol.2026.09.006_bib71","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1038\/s41467-019-09015-1","article-title":"Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model","volume":"10","author":"Piranlioglu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.chembiol.2026.09.006_bib72","doi-asserted-by":"crossref","first-page":"28167","DOI":"10.1074\/jbc.M303586200","article-title":"Tage4\/Nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule Nectin-3 and enhances cell migration","volume":"278","author":"Ikeda","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.chembiol.2026.09.006_bib73","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nmeth.1769","article-title":"Global profiling of dynamic protein palmitoylation","volume":"9","author":"Martin","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.chembiol.2026.09.006_bib74","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1073\/pnas.0912306107","article-title":"Tandem fluorescence imaging of dynamic S-acylation and protein turnover","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.chembiol.2026.09.006_bib75","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.cell.2006.01.040","article-title":"A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen","volume":"124","author":"Moffat","year":"2006","journal-title":"Cell"}],"container-title":["Cell Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245194562600334X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245194562600334X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:25:59Z","timestamp":1791501959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245194562600334X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":75,"alternative-id":["S245194562600334X"],"URL":"https:\/\/doi.org\/10.1016\/j.chembiol.2026.09.006","relation":{},"ISSN":["2451-9456"],"issn-type":[{"value":"2451-9456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting ZDHHC15-mediated S-acylation of CD155 reactivates anti-tumor immunity","name":"articletitle","label":"Article Title"},{"value":"Cell Chemical Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.chembiol.2026.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}