{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:12:22Z","timestamp":1791097942993,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemosphere"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.chemosphere.2008.08.016","type":"journal-article","created":{"date-parts":[[2008,10,6]],"date-time":"2008-10-06T08:10:31Z","timestamp":1223280631000},"page":"149-154","source":"Crossref","is-referenced-by-count":66,"title":["Fluoranthene, but not benzo[a]pyrene, interacts with hypoxia resulting in pericardial effusion and lordosis in developing zebrafish"],"prefix":"10.1016","volume":"74","author":[{"given":"Cole W.","family":"Matson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia R.","family":"Timme-Laragy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Di Giulio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.chemosphere.2008.08.016_bib1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/toxsci\/kfi073","article-title":"Heart malformation is an early response to TCDD in embryonic zebrafish","volume":"84","author":"Antkiewicz","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib2","article-title":"Non-additive effects of PAHs on early vertebrate development: mechanisms and implications for risk assessment","author":"Billiard","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib3","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1002\/etc.5620180927","article-title":"Toxicity of retene to early life stages of two freshwater fish species","volume":"18","author":"Billiard","year":"1999","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/toxsci\/kfl011","article-title":"The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish","volume":"92","author":"Billiard","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/etc.5620180317","article-title":"Sensitivity of fish embryos to weathered crude oil: Part I. Low-level exposure during incubation causes malformations, genetic damage, and mortality in larval Pacific herring (Clupea pallasi)","volume":"18","author":"Carls","year":"1999","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0026-895X(24)05633-5","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin activation of the aryl hydrocarbon receptor\/aryl hydrocarbon receptor nuclear translocator pathway causes developmental toxicity through a CYP1A-independent mechanism in zebrafish","volume":"66","author":"Carney","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib7","first-page":"245","article-title":"Marine benthic hypoxia: a review of its ecological effects and the behavioural responses of benthic macrofauna","volume":"33","author":"Diaz","year":"1995","journal-title":"Oceanogr. Mar. Biol. Annu. Rev."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib8","series-title":"PAHs: An Ecotoxicological Perspective","first-page":"3","article-title":"Introduction","author":"Douben","year":"2003"},{"key":"10.1016\/j.chemosphere.2008.08.016_bib9","unstructured":"EPA, 1987. Quality Criteria for Water 1986. EPA 440\/5-86-001. US Environmental Protection Agency, Washington, DC."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/03602530600570099","article-title":"Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity","volume":"38","author":"Goldstone","year":"2006","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bcp.2006.01.007","article-title":"Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor","volume":"72","author":"Harper","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cbpc.2007.09.011","article-title":"Molecular and developmental effects of exposure to pyrene in the early life-stages of Cyprinodon variegatus","volume":"147","author":"Hendon","year":"2008","journal-title":"Comp. Biochem. Physiol. C-Toxicol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.aquatox.2006.12.012","article-title":"Inhibition of CYP1A enzymes by \u03b1-naphthoflavone causes both synergism and antagonism of retene toxicity to rainbow trout (Oncorhynchus mykiss)","volume":"81","author":"Hodson","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib14","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1289\/ehp.8230","article-title":"Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish development","volume":"113","author":"Incardona","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.taap.2006.09.018","article-title":"Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism","volume":"217","author":"Incardona","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib16","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1038\/sj.emboj.7600846","article-title":"Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression","volume":"24","author":"Kasper","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/oxfordjournals.jbchem.a021812","article-title":"CBP\/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt)","volume":"122","author":"Kobayashi","year":"1997","journal-title":"J. Biochem."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib18","series-title":"PAHs: An Ecotoxicological Perspective","first-page":"9","article-title":"The sources, transport, and fate of PAHs in the marine environment","author":"Latimer","year":"2003"},{"key":"10.1016\/j.chemosphere.2008.08.016_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.aquatox.2008.02.010","article-title":"Development of the morpholino gene knockdown technique in Fundulus heteroclitus: A tool for studying molecular mechanisms in an established environmental model","volume":"87","author":"Matson","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib20","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1002\/etc.5620171214","article-title":"Nondestructive indicator of ethoxyresorufin-O-deethylase activity in embryonic fish","volume":"17","author":"Nacci","year":"1998","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib21","series-title":"Techniques in Aquatic Toxicology","first-page":"209","article-title":"A non-destructive technique to measure cytochrome P4501A enzyme activity in living embryos of the estuarine fish Fundulus heteroclitus","author":"Nacci","year":"2005"},{"key":"10.1016\/j.chemosphere.2008.08.016_bib22","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/79951","article-title":"Effective targeted gene \u2018knockdown\u2019 in zebrafish","volume":"26","author":"Nasevicius","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib23","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1124\/mol.56.6.1127","article-title":"Analysis of aryl hydrocarbon receptor-mediated signaling during physiological hypoxia reveals lack of competition for the aryl hydrocarbon nuclear translocator transcription factor","volume":"56","author":"Pollenz","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/toxsci\/kfh053","article-title":"Interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and hypoxia signaling pathways in zebrafish: hypoxia decreases responses to TCDD in zebrafish embryos","volume":"78","author":"Prasch","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/toxsci\/kfg202","article-title":"Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish","volume":"76","author":"Prasch","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib26","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1021\/es001689a","article-title":"Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures","volume":"35","author":"Reeves","year":"2001","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1242\/jcs.01617","article-title":"Role of CBP in regulating HIF-1-mediated activation of transcription","volume":"118","author":"Ruas","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib28","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.marpolbul.2007.09.020","article-title":"Interactions between climate change and contaminants","volume":"54","author":"Schiedek","year":"2007","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib29","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s002449900544","article-title":"Comparative toxicity of fluoranthene to freshwater and saltwater species under fluorescent and ultraviolet light","volume":"37","author":"Spehar","year":"1999","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.aquatox.2007.09.005","article-title":"Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish","volume":"85","author":"Timme-Laragy","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1152\/physiolgenomics.00128.2002","article-title":"Gene expression profile of zebrafish exposed to hypoxia during development","volume":"13","author":"Ton","year":"2003","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.chemosphere.2008.08.016_bib32","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1006\/bbrc.2001.6110","article-title":"Benzo[a]pyrene-induced toxicity: paradoxical protection in cyp1a1(\u2212\/\u2212) knockout mice having increased hepatic BaP-DNA adduct levels","volume":"289","author":"Uno","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib33","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1289\/ehp.7168","article-title":"Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus","volume":"112","author":"Wassenberg","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.chemosphere.2008.08.016_bib34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0141-1136(02)00182-4","article-title":"Effects of single and combined exposures to benzo(a)pyrene and 3,3\u20324,4\u20325-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus","volume":"54","author":"Wassenberg","year":"2002","journal-title":"Mar. Environ. Res."}],"container-title":["Chemosphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565350801059X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004565350801059X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T11:12:23Z","timestamp":1738408343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004565350801059X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S004565350801059X"],"URL":"https:\/\/doi.org\/10.1016\/j.chemosphere.2008.08.016","relation":{},"ISSN":["0045-6535"],"issn-type":[{"value":"0045-6535","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}